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Updated November 2019
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Protein Info
Short Name:
ASTN1
Full Name:
Astrotactin-1
Alias:
ASTN; Astrotactin 1; Astrotactin-1
Type:
Mass (Da):
144913
Number AA:
1302
UniProt ID:
O14525
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016477
GO:0007158
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
A
A
G
D
V
D
P
S
K
E
L
E
C
K
L
Site 2
S54
F
L
R
E
N
D
L
S
I
M
H
S
P
S
A
Site 3
S58
N
D
L
S
I
M
H
S
P
S
A
S
E
P
K
Site 4
S60
L
S
I
M
H
S
P
S
A
S
E
P
K
L
L
Site 5
S62
I
M
H
S
P
S
A
S
E
P
K
L
L
F
S
Site 6
S69
S
E
P
K
L
L
F
S
V
R
N
D
F
P
G
Site 7
S130
H
H
Q
D
G
A
P
S
L
P
G
Q
D
P
T
Site 8
T137
S
L
P
G
Q
D
P
T
E
E
P
Q
H
E
S
Site 9
S192
R
V
P
Q
P
Q
K
S
A
S
A
E
A
A
N
Site 10
S216
I
G
G
H
G
R
E
S
L
R
N
A
R
V
Q
Site 11
S227
A
R
V
Q
G
H
N
S
S
G
T
L
S
I
R
Site 12
S228
R
V
Q
G
H
N
S
S
G
T
L
S
I
R
E
Site 13
T230
Q
G
H
N
S
S
G
T
L
S
I
R
E
T
P
Site 14
S232
H
N
S
S
G
T
L
S
I
R
E
T
P
I
L
Site 15
T236
G
T
L
S
I
R
E
T
P
I
L
D
G
Y
E
Site 16
Y242
E
T
P
I
L
D
G
Y
E
Y
D
I
T
D
L
Site 17
Y244
P
I
L
D
G
Y
E
Y
D
I
T
D
L
R
H
Site 18
S266
N
G
G
E
D
F
A
S
Q
V
T
R
T
L
D
Site 19
S274
Q
V
T
R
T
L
D
S
L
Q
G
C
N
E
K
Site 20
S282
L
Q
G
C
N
E
K
S
G
M
D
L
T
P
G
Site 21
T287
E
K
S
G
M
D
L
T
P
G
S
D
N
A
K
Site 22
S290
G
M
D
L
T
P
G
S
D
N
A
K
L
S
L
Site 23
S296
G
S
D
N
A
K
L
S
L
M
N
K
Y
K
D
Site 24
S309
K
D
N
I
I
A
T
S
P
V
D
S
N
H
Q
Site 25
S313
I
A
T
S
P
V
D
S
N
H
Q
Q
A
T
L
Site 26
T319
D
S
N
H
Q
Q
A
T
L
L
S
H
T
S
S
Site 27
S322
H
Q
Q
A
T
L
L
S
H
T
S
S
S
Q
R
Site 28
S325
A
T
L
L
S
H
T
S
S
S
Q
R
K
R
I
Site 29
S326
T
L
L
S
H
T
S
S
S
Q
R
K
R
I
N
Site 30
S327
L
L
S
H
T
S
S
S
Q
R
K
R
I
N
N
Site 31
S340
N
N
K
A
R
A
G
S
A
F
L
N
P
E
G
Site 32
T360
A
E
N
D
P
Q
L
T
F
Y
T
D
P
S
R
Site 33
Y362
N
D
P
Q
L
T
F
Y
T
D
P
S
R
S
R
Site 34
T363
D
P
Q
L
T
F
Y
T
D
P
S
R
S
R
R
Site 35
S366
L
T
F
Y
T
D
P
S
R
S
R
R
R
S
R
Site 36
S368
F
Y
T
D
P
S
R
S
R
R
R
S
R
V
G
Site 37
S372
P
S
R
S
R
R
R
S
R
V
G
S
P
R
S
Site 38
S376
R
R
R
S
R
V
G
S
P
R
S
P
V
N
K
Site 39
S379
S
R
V
G
S
P
R
S
P
V
N
K
T
T
L
Site 40
S433
R
F
I
L
L
E
G
S
Q
L
D
A
S
D
W
Site 41
S438
E
G
S
Q
L
D
A
S
D
W
L
N
P
A
Q
Site 42
S450
P
A
Q
V
V
L
F
S
Q
Q
N
S
S
G
P
Site 43
S454
V
L
F
S
Q
Q
N
S
S
G
P
W
A
M
D
Site 44
S455
L
F
S
Q
Q
N
S
S
G
P
W
A
M
D
L
Site 45
T479
E
H
Q
C
D
P
E
T
G
R
R
E
H
R
A
Site 46
Y493
A
A
G
E
C
L
C
Y
E
G
Y
M
K
D
P
Site 47
Y496
E
C
L
C
Y
E
G
Y
M
K
D
P
V
H
K
Site 48
S536
L
V
L
G
E
Q
P
S
D
K
I
F
R
F
T
Site 49
T543
S
D
K
I
F
R
F
T
Y
T
L
G
E
G
M
Site 50
Y544
D
K
I
F
R
F
T
Y
T
L
G
E
G
M
W
Site 51
S570
A
E
L
A
I
N
P
S
A
K
C
K
T
D
M
Site 52
T578
A
K
C
K
T
D
M
T
V
M
E
D
A
V
E
Site 53
T592
E
V
R
E
E
L
M
T
S
S
S
F
D
S
L
Site 54
S593
V
R
E
E
L
M
T
S
S
S
F
D
S
L
E
Site 55
S594
R
E
E
L
M
T
S
S
S
F
D
S
L
E
V
Site 56
S595
E
E
L
M
T
S
S
S
F
D
S
L
E
V
L
Site 57
S613
F
G
P
V
R
D
C
S
K
D
N
G
G
C
S
Site 58
S627
S
K
N
F
R
C
I
S
D
R
K
L
D
S
T
Site 59
S633
I
S
D
R
K
L
D
S
T
G
C
V
C
P
S
Site 60
T634
S
D
R
K
L
D
S
T
G
C
V
C
P
S
G
Site 61
S640
S
T
G
C
V
C
P
S
G
L
S
P
M
K
D
Site 62
S643
C
V
C
P
S
G
L
S
P
M
K
D
S
S
G
Site 63
S649
L
S
P
M
K
D
S
S
G
C
Y
D
R
H
I
Site 64
Y652
M
K
D
S
S
G
C
Y
D
R
H
I
G
V
D
Site 65
Y698
F
C
G
C
I
E
D
Y
K
L
G
V
D
G
R
Site 66
T713
S
C
Q
L
I
T
E
T
C
P
E
G
S
D
C
Site 67
S718
T
E
T
C
P
E
G
S
D
C
G
E
S
R
E
Site 68
T731
R
E
L
P
M
N
Q
T
L
F
G
E
M
F
F
Site 69
Y740
F
G
E
M
F
F
G
Y
N
N
H
S
K
E
V
Site 70
T756
A
G
Q
V
L
K
G
T
F
R
Q
N
N
F
A
Site 71
T793
L
E
E
I
S
E
P
T
P
D
P
D
F
L
T
Site 72
T800
T
P
D
P
D
F
L
T
G
M
V
N
F
S
E
Site 73
Y811
N
F
S
E
V
S
G
Y
P
V
L
Q
H
W
K
Site 74
S838
V
A
I
S
Q
A
L
S
N
A
L
H
S
L
D
Site 75
S843
A
L
S
N
A
L
H
S
L
D
G
A
T
S
R
Site 76
Y870
H
Y
I
Q
E
A
I
Y
G
F
E
E
S
C
S
Site 77
Y880
E
E
S
C
S
I
W
Y
P
N
K
Q
V
Q
R
Site 78
Y893
Q
R
R
L
W
L
E
Y
E
D
I
S
K
G
N
Site 79
S897
W
L
E
Y
E
D
I
S
K
G
N
S
P
S
D
Site 80
S901
E
D
I
S
K
G
N
S
P
S
D
E
S
E
E
Site 81
S903
I
S
K
G
N
S
P
S
D
E
S
E
E
R
E
Site 82
S906
G
N
S
P
S
D
E
S
E
E
R
E
R
D
P
Site 83
T917
E
R
D
P
K
V
L
T
F
P
E
Y
I
T
S
Site 84
Y921
K
V
L
T
F
P
E
Y
I
T
S
L
S
D
S
Site 85
S924
T
F
P
E
Y
I
T
S
L
S
D
S
G
T
K
Site 86
S926
P
E
Y
I
T
S
L
S
D
S
G
T
K
H
M
Site 87
S928
Y
I
T
S
L
S
D
S
G
T
K
H
M
A
A
Site 88
T930
T
S
L
S
D
S
G
T
K
H
M
A
A
G
V
Site 89
S943
G
V
R
M
E
C
H
S
K
G
R
C
P
S
S
Site 90
S949
H
S
K
G
R
C
P
S
S
C
P
L
C
H
V
Site 91
S950
S
K
G
R
C
P
S
S
C
P
L
C
H
V
T
Site 92
T957
S
C
P
L
C
H
V
T
S
S
P
D
T
P
A
Site 93
S958
C
P
L
C
H
V
T
S
S
P
D
T
P
A
E
Site 94
S959
P
L
C
H
V
T
S
S
P
D
T
P
A
E
P
Site 95
T962
H
V
T
S
S
P
D
T
P
A
E
P
V
L
L
Site 96
Y978
V
T
K
A
A
P
I
Y
E
L
V
T
N
N
Q
Site 97
T994
Q
R
L
L
Q
E
A
T
M
S
S
L
W
C
S
Site 98
S997
L
Q
E
A
T
M
S
S
L
W
C
S
G
T
G
Site 99
T1003
S
S
L
W
C
S
G
T
G
D
V
I
E
D
W
Site 100
S1037
P
Q
P
V
L
R
L
S
T
V
H
E
P
S
S
Site 101
T1038
Q
P
V
L
R
L
S
T
V
H
E
P
S
S
T
Site 102
T1045
T
V
H
E
P
S
S
T
L
V
V
L
E
W
E
Site 103
S1054
V
V
L
E
W
E
H
S
E
P
P
I
G
V
Q
Site 104
T1073
L
L
R
Q
E
K
V
T
D
R
M
D
H
S
K
Site 105
S1079
V
T
D
R
M
D
H
S
K
V
E
T
E
T
V
Site 106
T1083
M
D
H
S
K
V
E
T
E
T
V
L
S
F
V
Site 107
S1088
V
E
T
E
T
V
L
S
F
V
D
D
I
I
S
Site 108
S1095
S
F
V
D
D
I
I
S
G
A
K
S
P
C
A
Site 109
S1099
D
I
I
S
G
A
K
S
P
C
A
M
P
S
Q
Site 110
S1105
K
S
P
C
A
M
P
S
Q
V
P
D
K
Q
L
Site 111
T1138
T
L
W
G
V
D
N
T
G
R
R
S
R
P
S
Site 112
S1142
V
D
N
T
G
R
R
S
R
P
S
D
V
I
V
Site 113
S1145
T
G
R
R
S
R
P
S
D
V
I
V
K
T
P
Site 114
Y1169
Q
E
I
A
D
K
I
Y
N
L
F
N
G
Y
T
Site 115
Y1201
P
T
L
H
R
V
L
Y
H
Y
N
Q
H
Y
E
Site 116
Y1203
L
H
R
V
L
Y
H
Y
N
Q
H
Y
E
S
F
Site 117
Y1207
L
Y
H
Y
N
Q
H
Y
E
S
F
G
E
F
T
Site 118
S1231
R
K
A
G
L
I
L
S
Q
L
G
D
L
S
S
Site 119
S1237
L
S
Q
L
G
D
L
S
S
W
C
N
G
L
L
Site 120
S1238
S
Q
L
G
D
L
S
S
W
C
N
G
L
L
Q
Site 121
S1250
L
L
Q
E
P
K
I
S
L
R
R
S
S
L
K
Site 122
S1254
P
K
I
S
L
R
R
S
S
L
K
Y
L
G
C
Site 123
S1255
K
I
S
L
R
R
S
S
L
K
Y
L
G
C
R
Site 124
Y1258
L
R
R
S
S
L
K
Y
L
G
C
R
Y
S
E
Site 125
Y1263
L
K
Y
L
G
C
R
Y
S
E
I
K
P
Y
G
Site 126
S1264
K
Y
L
G
C
R
Y
S
E
I
K
P
Y
G
L
Site 127
Y1269
R
Y
S
E
I
K
P
Y
G
L
D
W
A
E
L
Site 128
S1277
G
L
D
W
A
E
L
S
R
D
L
R
K
T
C
Site 129
T1283
L
S
R
D
L
R
K
T
C
E
E
Q
T
L
S
Site 130
Y1296
L
S
I
P
Y
N
D
Y
G
D
S
K
E
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation