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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FCHO1
Full Name:
FCH domain only protein 1
Alias:
FCH domain only 1; KIAA0290
Type:
Uncharacterized protein
Mass (Da):
96861
Number AA:
889
UniProt ID:
O14526
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
N
H
G
F
E
V
L
Y
H
S
V
K
Q
G
P
Site 2
S22
G
F
E
V
L
Y
H
S
V
K
Q
G
P
I
S
Site 3
S29
S
V
K
Q
G
P
I
S
T
K
E
L
A
D
F
Site 4
T30
V
K
Q
G
P
I
S
T
K
E
L
A
D
F
I
Site 5
T42
D
F
I
R
E
R
A
T
I
E
E
T
Y
S
K
Site 6
S55
S
K
A
M
A
K
L
S
K
L
A
S
N
G
T
Site 7
S59
A
K
L
S
K
L
A
S
N
G
T
P
M
G
T
Site 8
T62
S
K
L
A
S
N
G
T
P
M
G
T
F
A
P
Site 9
T66
S
N
G
T
P
M
G
T
F
A
P
L
W
E
V
Site 10
S78
W
E
V
F
R
V
S
S
D
K
L
A
L
C
H
Site 11
T109
Y
G
E
E
Q
L
K
T
H
K
K
C
K
E
E
Site 12
S137
V
S
Q
L
L
P
K
S
R
E
N
Y
L
N
R
Site 13
Y141
L
P
K
S
R
E
N
Y
L
N
R
C
M
D
Q
Site 14
S155
Q
E
R
L
R
R
E
S
T
S
Q
K
E
M
D
Site 15
T156
E
R
L
R
R
E
S
T
S
Q
K
E
M
D
K
Site 16
S157
R
L
R
R
E
S
T
S
Q
K
E
M
D
K
A
Site 17
S174
K
T
K
K
A
A
E
S
L
R
R
S
V
E
K
Site 18
S178
A
A
E
S
L
R
R
S
V
E
K
Y
N
S
A
Site 19
Y182
L
R
R
S
V
E
K
Y
N
S
A
R
A
D
F
Site 20
S184
R
S
V
E
K
Y
N
S
A
R
A
D
F
E
Q
Site 21
S196
F
E
Q
K
M
L
D
S
A
L
R
F
Q
A
M
Site 22
T206
R
F
Q
A
M
E
E
T
H
L
R
H
M
K
A
Site 23
S217
H
M
K
A
L
L
G
S
Y
A
H
S
V
E
D
Site 24
S221
L
L
G
S
Y
A
H
S
V
E
D
T
H
V
Q
Site 25
T225
Y
A
H
S
V
E
D
T
H
V
Q
I
G
Q
V
Site 26
S255
L
L
R
K
F
A
E
S
K
G
T
G
R
E
K
Site 27
T258
K
F
A
E
S
K
G
T
G
R
E
K
P
G
P
Site 28
S295
A
F
R
L
P
G
L
S
R
R
E
R
E
P
E
Site 29
S314
V
D
F
L
E
P
D
S
G
T
C
P
E
V
D
Site 30
T326
E
V
D
E
E
G
F
T
V
R
P
D
V
T
Q
Site 31
T332
F
T
V
R
P
D
V
T
Q
N
S
T
A
E
P
Site 32
S335
R
P
D
V
T
Q
N
S
T
A
E
P
S
R
F
Site 33
T336
P
D
V
T
Q
N
S
T
A
E
P
S
R
F
S
Site 34
S340
Q
N
S
T
A
E
P
S
R
F
S
S
S
D
S
Site 35
S343
T
A
E
P
S
R
F
S
S
S
D
S
D
F
D
Site 36
S344
A
E
P
S
R
F
S
S
S
D
S
D
F
D
D
Site 37
S345
E
P
S
R
F
S
S
S
D
S
D
F
D
D
E
Site 38
S347
S
R
F
S
S
S
D
S
D
F
D
D
E
E
P
Site 39
Y358
D
E
E
P
R
K
F
Y
V
H
I
K
P
A
P
Site 40
S372
P
A
R
A
P
A
C
S
P
E
A
A
A
A
Q
Site 41
S386
Q
L
R
A
T
A
G
S
L
I
L
P
P
G
P
Site 42
T396
L
P
P
G
P
G
G
T
M
K
R
H
S
S
R
Site 43
S401
G
G
T
M
K
R
H
S
S
R
D
A
A
G
K
Site 44
S402
G
T
M
K
R
H
S
S
R
D
A
A
G
K
P
Site 45
S414
G
K
P
Q
R
P
R
S
A
P
R
T
S
S
C
Site 46
T418
R
P
R
S
A
P
R
T
S
S
C
A
E
R
L
Site 47
S419
P
R
S
A
P
R
T
S
S
C
A
E
R
L
Q
Site 48
S420
R
S
A
P
R
T
S
S
C
A
E
R
L
Q
S
Site 49
S427
S
C
A
E
R
L
Q
S
E
E
Q
V
S
K
N
Site 50
S432
L
Q
S
E
E
Q
V
S
K
N
L
F
G
P
P
Site 51
T450
A
F
D
H
E
D
F
T
G
S
S
S
L
G
F
Site 52
S454
E
D
F
T
G
S
S
S
L
G
F
T
S
S
P
Site 53
T458
G
S
S
S
L
G
F
T
S
S
P
S
P
F
S
Site 54
S459
S
S
S
L
G
F
T
S
S
P
S
P
F
S
S
Site 55
S460
S
S
L
G
F
T
S
S
P
S
P
F
S
S
S
Site 56
S462
L
G
F
T
S
S
P
S
P
F
S
S
S
S
P
Site 57
S465
T
S
S
P
S
P
F
S
S
S
S
P
E
N
V
Site 58
S466
S
S
P
S
P
F
S
S
S
S
P
E
N
V
E
Site 59
S467
S
P
S
P
F
S
S
S
S
P
E
N
V
E
D
Site 60
S468
P
S
P
F
S
S
S
S
P
E
N
V
E
D
S
Site 61
S475
S
P
E
N
V
E
D
S
G
L
D
S
P
S
H
Site 62
S479
V
E
D
S
G
L
D
S
P
S
H
A
A
P
G
Site 63
S481
D
S
G
L
D
S
P
S
H
A
A
P
G
P
S
Site 64
S488
S
H
A
A
P
G
P
S
P
D
S
W
V
P
R
Site 65
S491
A
P
G
P
S
P
D
S
W
V
P
R
P
G
T
Site 66
T498
S
W
V
P
R
P
G
T
P
Q
S
P
P
S
C
Site 67
S501
P
R
P
G
T
P
Q
S
P
P
S
C
R
A
P
Site 68
S504
G
T
P
Q
S
P
P
S
C
R
A
P
P
P
E
Site 69
S523
R
A
P
P
L
P
D
S
P
Q
P
L
A
S
S
Site 70
S529
D
S
P
Q
P
L
A
S
S
P
G
P
W
G
L
Site 71
S530
S
P
Q
P
L
A
S
S
P
G
P
W
G
L
E
Site 72
T552
M
P
A
P
A
D
P
T
A
R
E
G
L
A
A
Site 73
S566
A
P
P
R
R
L
R
S
R
K
V
S
C
P
L
Site 74
S570
R
L
R
S
R
K
V
S
C
P
L
T
R
S
N
Site 75
T574
R
K
V
S
C
P
L
T
R
S
N
G
D
L
S
Site 76
S576
V
S
C
P
L
T
R
S
N
G
D
L
S
R
S
Site 77
S581
T
R
S
N
G
D
L
S
R
S
L
S
P
S
P
Site 78
S583
S
N
G
D
L
S
R
S
L
S
P
S
P
L
G
Site 79
S585
G
D
L
S
R
S
L
S
P
S
P
L
G
S
S
Site 80
S587
L
S
R
S
L
S
P
S
P
L
G
S
S
A
A
Site 81
S592
S
P
S
P
L
G
S
S
A
A
S
T
A
L
E
Site 82
S595
P
L
G
S
S
A
A
S
T
A
L
E
R
P
S
Site 83
T596
L
G
S
S
A
A
S
T
A
L
E
R
P
S
F
Site 84
S602
S
T
A
L
E
R
P
S
F
L
S
Q
T
G
H
Site 85
S605
L
E
R
P
S
F
L
S
Q
T
G
H
G
V
S
Site 86
T607
R
P
S
F
L
S
Q
T
G
H
G
V
S
R
G
Site 87
S612
S
Q
T
G
H
G
V
S
R
G
P
S
P
V
V
Site 88
S616
H
G
V
S
R
G
P
S
P
V
V
L
G
S
Q
Site 89
Y639
F
T
E
Y
V
H
A
Y
F
R
G
H
S
P
S
Site 90
S644
H
A
Y
F
R
G
H
S
P
S
C
L
A
R
V
Site 91
S646
Y
F
R
G
H
S
P
S
C
L
A
R
V
T
G
Site 92
T684
S
F
R
L
V
H
T
T
A
I
E
H
F
Q
P
Site 93
S698
P
N
A
D
L
L
F
S
D
P
S
Q
S
D
P
Site 94
S701
D
L
L
F
S
D
P
S
Q
S
D
P
E
T
K
Site 95
S703
L
F
S
D
P
S
Q
S
D
P
E
T
K
D
F
Site 96
T707
P
S
Q
S
D
P
E
T
K
D
F
W
L
N
M
Site 97
T730
R
Q
A
E
Q
N
P
T
A
S
Y
Y
N
V
V
Site 98
Y733
E
Q
N
P
T
A
S
Y
Y
N
V
V
L
L
R
Site 99
Y734
Q
N
P
T
A
S
Y
Y
N
V
V
L
L
R
Y
Site 100
Y741
Y
N
V
V
L
L
R
Y
Q
F
S
R
P
G
P
Site 101
S744
V
L
L
R
Y
Q
F
S
R
P
G
P
Q
S
V
Site 102
S750
F
S
R
P
G
P
Q
S
V
P
L
Q
L
S
A
Site 103
S756
Q
S
V
P
L
Q
L
S
A
H
W
Q
C
G
A
Site 104
T766
W
Q
C
G
A
T
L
T
Q
V
S
V
E
Y
G
Site 105
T779
Y
G
Y
R
P
G
A
T
A
V
P
T
P
L
T
Site 106
T817
N
L
E
E
K
R
L
T
W
R
L
P
D
V
S
Site 107
S824
T
W
R
L
P
D
V
S
E
A
G
G
S
G
R
Site 108
S829
D
V
S
E
A
G
G
S
G
R
L
S
A
S
W
Site 109
S833
A
G
G
S
G
R
L
S
A
S
W
E
P
L
S
Site 110
S835
G
S
G
R
L
S
A
S
W
E
P
L
S
G
P
Site 111
S840
S
A
S
W
E
P
L
S
G
P
S
T
P
S
P
Site 112
T844
E
P
L
S
G
P
S
T
P
S
P
V
A
A
Q
Site 113
S846
L
S
G
P
S
T
P
S
P
V
A
A
Q
F
T
Site 114
T858
Q
F
T
S
E
G
T
T
L
S
G
V
D
L
E
Site 115
S874
V
G
S
G
Y
R
M
S
L
V
K
R
R
F
A
Site 116
S888
A
T
G
M
Y
L
V
S
C
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation