PhosphoNET

           
Protein Info 
   
Short Name:  SOCS3
Full Name:  Suppressor of cytokine signaling 3
Alias:  Cytokine-inducible SH2 protein 3;STAT-induced STAT inhibitor 3
Type:  Inhibitor protein
Mass (Da):  24770
Number AA:  225
UniProt ID:  O14543
International Prot ID:  IPI00297349
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0004860     PhosphoSite+ KinaseNET
Biological Process:  GO:0007259  GO:0006916  GO:0019941 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S13KFPAAGMSRPLDTSL
Site 2S19MSRPLDTSLRLKTFS
Site 3T24DTSLRLKTFSSKSEY
Site 4S26SLRLKTFSSKSEYQL
Site 5S27LRLKTFSSKSEYQLV
Site 6S29LKTFSSKSEYQLVVN
Site 7Y31TFSSKSEYQLVVNAV
Site 8S44AVRKLQESGFYWSAV
Site 9Y47KLQESGFYWSAVTGG
Site 10S49QESGFYWSAVTGGEA
Site 11T67LSAEPAGTFLIRDSS
Site 12S73GTFLIRDSSDQRHFF
Site 13S74TFLIRDSSDQRHFFT
Site 14T81SDQRHFFTLSVKTQS
Site 15S83QRHFFTLSVKTQSGT
Site 16S88TLSVKTQSGTKNLRI
Site 17S101RIQCEGGSFSLQSDP
Site 18S103QCEGGSFSLQSDPRS
Site 19S106GGSFSLQSDPRSTQP
Site 20S110SLQSDPRSTQPVPRF
Site 21T111LQSDPRSTQPVPRFD
Site 22S135MPPPGAPSFPSPPTE
Site 23S138PGAPSFPSPPTEPSS
Site 24T141PSFPSPPTEPSSEVP
Site 25S144PSPPTEPSSEVPEQP
Site 26S145SPPTEPSSEVPEQPS
Site 27S152SEVPEQPSAQPLPGS
Site 28S159SAQPLPGSPPRRAYY
Site 29Y165GSPPRRAYYIYSGGE
Site 30Y166SPPRRAYYIYSGGEK
Site 31Y168PRRAYYIYSGGEKIP
Site 32S169RRAYYIYSGGEKIPL
Site 33S184VLSRPLSSNVATLQH
Site 34T188PLSSNVATLQHLCRK
Site 35T196LQHLCRKTVNGHLDS
Site 36S203TVNGHLDSYEKVTQL
Site 37Y204VNGHLDSYEKVTQLP
Site 38T208LDSYEKVTQLPGPIR
Site 39Y221IREFLDQYDAPL___
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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