KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DYNC1I1
Full Name:
Cytoplasmic dynein 1 intermediate chain 1
Alias:
DC1I1; DH IC-1; Dynein intermediate chain 1, cytosolic
Type:
Cytoplasmic dynein complex, Microtubule, Perinuclear region cytoplasm protein
Mass (Da):
72995
Number AA:
645
UniProt ID:
O14576
International Prot ID:
IPI00022461
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005868
GO:0005874
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0008017
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0047496
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
D
K
S
D
L
K
A
E
L
E
Site 2
S50
K
E
P
V
Q
D
D
S
D
L
D
R
K
R
R
Site 3
T59
L
D
R
K
R
R
E
T
E
A
L
L
Q
S
I
Site 4
S65
E
T
E
A
L
L
Q
S
I
G
I
S
P
E
P
Site 5
S69
L
L
Q
S
I
G
I
S
P
E
P
P
L
V
Q
Site 6
T94
Y
F
H
Y
L
V
P
T
P
M
S
P
S
S
K
Site 7
S97
Y
L
V
P
T
P
M
S
P
S
S
K
S
V
S
Site 8
S99
V
P
T
P
M
S
P
S
S
K
S
V
S
T
P
Site 9
S100
P
T
P
M
S
P
S
S
K
S
V
S
T
P
S
Site 10
S102
P
M
S
P
S
S
K
S
V
S
T
P
S
E
A
Site 11
S104
S
P
S
S
K
S
V
S
T
P
S
E
A
G
S
Site 12
T105
P
S
S
K
S
V
S
T
P
S
E
A
G
S
Q
Site 13
S107
S
K
S
V
S
T
P
S
E
A
G
S
Q
D
S
Site 14
S111
S
T
P
S
E
A
G
S
Q
D
S
G
D
L
G
Site 15
T121
S
G
D
L
G
P
L
T
R
T
L
Q
W
D
T
Site 16
T128
T
R
T
L
Q
W
D
T
D
P
S
V
L
Q
L
Site 17
S131
L
Q
W
D
T
D
P
S
V
L
Q
L
Q
S
D
Site 18
S137
P
S
V
L
Q
L
Q
S
D
S
E
L
G
R
R
Site 19
S139
V
L
Q
L
Q
S
D
S
E
L
G
R
R
L
H
Site 20
S165
F
L
P
R
E
V
V
S
Y
S
K
E
T
Q
T
Site 21
Y166
L
P
R
E
V
V
S
Y
S
K
E
T
Q
T
P
Site 22
S167
P
R
E
V
V
S
Y
S
K
E
T
Q
T
P
L
Site 23
T170
V
V
S
Y
S
K
E
T
Q
T
P
L
A
T
H
Site 24
T172
S
Y
S
K
E
T
Q
T
P
L
A
T
H
Q
S
Site 25
T176
E
T
Q
T
P
L
A
T
H
Q
S
E
E
D
E
Site 26
S179
T
P
L
A
T
H
Q
S
E
E
D
E
E
D
E
Site 27
S191
E
D
E
E
M
V
E
S
K
V
G
Q
D
S
E
Site 28
T217
E
A
P
P
R
E
L
T
E
E
E
K
Q
Q
I
Site 29
S227
E
K
Q
Q
I
L
H
S
E
E
F
L
I
F
F
Site 30
S249
E
R
A
L
A
E
D
S
D
I
F
F
D
Y
S
Site 31
Y255
D
S
D
I
F
F
D
Y
S
G
R
E
L
E
E
Site 32
S256
S
D
I
F
F
D
Y
S
G
R
E
L
E
E
K
Site 33
S274
V
Q
A
G
A
N
L
S
F
N
R
Q
F
Y
D
Site 34
Y280
L
S
F
N
R
Q
F
Y
D
E
H
W
S
K
H
Site 35
Y307
P
E
L
M
V
A
S
Y
N
N
N
E
D
A
P
Site 36
T332
N
M
K
F
K
K
T
T
P
E
Y
V
F
H
C
Site 37
Y335
F
K
K
T
T
P
E
Y
V
F
H
C
Q
S
S
Site 38
S372
I
V
L
W
D
N
R
S
H
R
R
T
P
V
Q
Site 39
T376
D
N
R
S
H
R
R
T
P
V
Q
R
T
P
L
Site 40
T381
R
R
T
P
V
Q
R
T
P
L
S
A
A
A
H
Site 41
S384
P
V
Q
R
T
P
L
S
A
A
A
H
T
H
P
Site 42
T408
Q
N
A
H
N
L
I
T
V
S
T
D
G
K
M
Site 43
S410
A
H
N
L
I
T
V
S
T
D
G
K
M
C
S
Site 44
S417
S
T
D
G
K
M
C
S
W
S
L
D
M
L
S
Site 45
S419
D
G
K
M
C
S
W
S
L
D
M
L
S
T
P
Site 46
S424
S
W
S
L
D
M
L
S
T
P
Q
E
S
M
E
Site 47
T425
W
S
L
D
M
L
S
T
P
Q
E
S
M
E
L
Site 48
S437
M
E
L
V
Y
N
K
S
K
P
V
A
V
T
G
Site 49
T463
V
V
G
S
E
E
G
T
V
Y
T
A
C
R
H
Site 50
Y465
G
S
E
E
G
T
V
Y
T
A
C
R
H
G
S
Site 51
T466
S
E
E
G
T
V
Y
T
A
C
R
H
G
S
K
Site 52
S472
Y
T
A
C
R
H
G
S
K
A
G
I
G
E
V
Site 53
T488
E
G
H
Q
G
P
V
T
G
I
N
C
H
M
A
Site 54
T513
V
T
S
S
F
D
W
T
V
K
L
W
T
T
K
Site 55
Y526
T
K
H
N
K
P
L
Y
S
F
E
D
N
A
D
Site 56
S527
K
H
N
K
P
L
Y
S
F
E
D
N
A
D
Y
Site 57
Y534
S
F
E
D
N
A
D
Y
V
Y
D
V
M
W
S
Site 58
Y536
E
D
N
A
D
Y
V
Y
D
V
M
W
S
P
V
Site 59
T566
L
W
N
L
N
N
D
T
E
V
P
T
A
S
V
Site 60
S635
I
R
A
N
R
A
D
S
E
E
E
G
T
V
E
Site 61
T640
A
D
S
E
E
E
G
T
V
E
L
S
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation