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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRIK
Full Name:
Citron Rho-interacting kinase
Alias:
CIT; Citron; Citron protein; CTRO; EC 2.7.11.1; KIAA0949; Rho-interacting, serine/threonine kinase 21; STK21
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family
Mass (Da):
231431
Number AA:
2027
UniProt ID:
O14578
International Prot ID:
IPI00022465
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0017124
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0048699
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
G
A
A
E
P
I
A
S
R
A
S
R
L
N
L
Site 2
S25
E
P
I
A
S
R
A
S
R
L
N
L
F
F
Q
Site 3
T39
Q
G
K
P
P
F
M
T
Q
Q
Q
M
S
P
L
Site 4
S44
F
M
T
Q
Q
Q
M
S
P
L
S
R
E
G
I
Site 5
S47
Q
Q
Q
M
S
P
L
S
R
E
G
I
L
D
A
Site 6
Y80
V
S
N
F
V
R
K
Y
S
D
T
I
A
E
L
Site 7
S81
S
N
F
V
R
K
Y
S
D
T
I
A
E
L
Q
Site 8
T83
F
V
R
K
Y
S
D
T
I
A
E
L
Q
E
L
Site 9
S93
E
L
Q
E
L
Q
P
S
A
K
D
F
E
V
R
Site 10
Y123
E
K
A
T
G
D
I
Y
A
M
K
V
M
K
K
Site 11
S140
L
L
A
Q
E
Q
V
S
F
F
E
E
E
R
N
Site 12
S150
E
E
E
R
N
I
L
S
R
S
T
S
P
W
I
Site 13
S152
E
R
N
I
L
S
R
S
T
S
P
W
I
P
Q
Site 14
T153
R
N
I
L
S
R
S
T
S
P
W
I
P
Q
L
Site 15
S154
N
I
L
S
R
S
T
S
P
W
I
P
Q
L
Q
Site 16
Y171
F
Q
D
K
N
H
L
Y
L
V
M
E
Y
Q
P
Site 17
S184
Q
P
G
G
D
L
L
S
L
L
N
R
Y
E
D
Site 18
Y217
H
S
V
H
L
M
G
Y
V
H
R
D
I
K
P
Site 19
T232
E
N
I
L
V
D
R
T
G
H
I
K
L
V
D
Site 20
S242
I
K
L
V
D
F
G
S
A
A
K
M
N
S
N
Site 21
T260
N
A
K
L
P
I
G
T
P
D
Y
M
A
P
E
Site 22
T270
Y
M
A
P
E
V
L
T
V
M
N
G
D
G
K
Site 23
Y280
N
G
D
G
K
G
T
Y
G
L
D
C
D
W
W
Site 24
S301
Y
E
M
I
Y
G
R
S
P
F
A
E
G
T
S
Site 25
T307
R
S
P
F
A
E
G
T
S
A
R
T
F
N
N
Site 26
S308
S
P
F
A
E
G
T
S
A
R
T
F
N
N
I
Site 27
T311
A
E
G
T
S
A
R
T
F
N
N
I
M
N
F
Site 28
S332
P
D
D
P
K
V
S
S
D
F
L
D
L
I
Q
Site 29
S371
D
W
N
N
I
R
N
S
P
P
P
F
V
P
T
Site 30
S381
P
F
V
P
T
L
K
S
D
D
D
T
S
N
F
Site 31
T385
T
L
K
S
D
D
D
T
S
N
F
D
E
P
E
Site 32
S386
L
K
S
D
D
D
T
S
N
F
D
E
P
E
K
Site 33
S395
F
D
E
P
E
K
N
S
W
V
S
S
S
P
C
Site 34
S398
P
E
K
N
S
W
V
S
S
S
P
C
Q
L
S
Site 35
S399
E
K
N
S
W
V
S
S
S
P
C
Q
L
S
P
Site 36
S400
K
N
S
W
V
S
S
S
P
C
Q
L
S
P
S
Site 37
S405
S
S
S
P
C
Q
L
S
P
S
G
F
S
G
E
Site 38
S407
S
P
C
Q
L
S
P
S
G
F
S
G
E
E
L
Site 39
S433
G
I
L
G
R
S
E
S
V
V
S
G
L
D
S
Site 40
S436
G
R
S
E
S
V
V
S
G
L
D
S
P
A
K
Site 41
S440
S
V
V
S
G
L
D
S
P
A
K
T
S
S
M
Site 42
T444
G
L
D
S
P
A
K
T
S
S
M
E
K
K
L
Site 43
S446
D
S
P
A
K
T
S
S
M
E
K
K
L
L
I
Site 44
S455
E
K
K
L
L
I
K
S
K
E
L
Q
D
S
Q
Site 45
S461
K
S
K
E
L
Q
D
S
Q
D
K
C
H
K
M
Site 46
S480
T
R
L
H
R
R
V
S
E
V
E
A
V
L
S
Site 47
S487
S
E
V
E
A
V
L
S
Q
K
E
V
E
L
K
Site 48
S496
K
E
V
E
L
K
A
S
E
T
Q
R
S
L
L
Site 49
T498
V
E
L
K
A
S
E
T
Q
R
S
L
L
E
Q
Site 50
S501
K
A
S
E
T
Q
R
S
L
L
E
Q
D
L
A
Site 51
T509
L
L
E
Q
D
L
A
T
Y
I
T
E
C
S
S
Site 52
Y510
L
E
Q
D
L
A
T
Y
I
T
E
C
S
S
L
Site 53
T512
Q
D
L
A
T
Y
I
T
E
C
S
S
L
K
R
Site 54
S515
A
T
Y
I
T
E
C
S
S
L
K
R
S
L
E
Site 55
S516
T
Y
I
T
E
C
S
S
L
K
R
S
L
E
Q
Site 56
S520
E
C
S
S
L
K
R
S
L
E
Q
A
R
M
E
Site 57
S546
L
H
D
I
R
E
Q
S
R
K
L
Q
E
I
K
Site 58
Y557
Q
E
I
K
E
Q
E
Y
Q
A
Q
V
E
E
M
Site 59
S577
Q
L
E
E
D
L
V
S
A
R
R
R
S
D
L
Site 60
S582
L
V
S
A
R
R
R
S
D
L
Y
E
S
E
L
Site 61
Y585
A
R
R
R
S
D
L
Y
E
S
E
L
R
E
S
Site 62
S587
R
R
S
D
L
Y
E
S
E
L
R
E
S
R
L
Site 63
S592
Y
E
S
E
L
R
E
S
R
L
A
A
E
E
F
Site 64
T604
E
E
F
K
R
K
A
T
E
C
Q
H
K
L
L
Site 65
Y624
G
K
P
E
V
G
E
Y
A
K
L
E
K
I
N
Site 66
S682
K
L
Q
N
R
E
D
S
S
E
G
I
R
K
K
Site 67
S706
K
H
R
E
A
Q
V
S
A
Q
H
L
E
V
H
Site 68
T741
K
D
L
A
D
K
E
T
L
E
N
M
M
Q
R
Site 69
S761
H
E
K
G
K
I
L
S
E
Q
K
A
M
I
N
Site 70
S772
A
M
I
N
A
M
D
S
K
I
R
S
L
E
Q
Site 71
S776
A
M
D
S
K
I
R
S
L
E
Q
R
I
V
E
Site 72
S785
E
Q
R
I
V
E
L
S
E
A
N
K
L
A
A
Site 73
S795
N
K
L
A
A
N
S
S
L
F
T
Q
R
N
M
Site 74
T798
A
A
N
S
S
L
F
T
Q
R
N
M
K
A
Q
Site 75
S810
K
A
Q
E
E
M
I
S
E
L
R
Q
Q
K
F
Site 76
Y818
E
L
R
Q
Q
K
F
Y
L
E
T
Q
A
G
K
Site 77
S846
K
I
S
H
Q
D
H
S
D
K
N
R
L
L
E
Site 78
S862
E
T
R
L
R
E
V
S
L
E
H
E
E
Q
K
Site 79
T877
L
E
L
K
R
Q
L
T
E
L
Q
L
S
L
Q
Site 80
S882
Q
L
T
E
L
Q
L
S
L
Q
E
R
E
S
Q
Site 81
S888
L
S
L
Q
E
R
E
S
Q
L
T
A
L
Q
A
Site 82
T891
Q
E
R
E
S
Q
L
T
A
L
Q
A
A
R
A
Site 83
S902
A
A
R
A
A
L
E
S
Q
L
R
Q
A
K
T
Site 84
T909
S
Q
L
R
Q
A
K
T
E
L
E
E
T
T
A
Site 85
T944
D
A
L
R
N
S
C
T
V
I
T
D
L
E
E
Site 86
Y969
E
L
N
N
Q
N
F
Y
L
S
K
Q
L
D
E
Site 87
S989
D
E
I
V
Q
L
R
S
E
V
D
H
L
R
R
Site 88
T999
D
H
L
R
R
E
I
T
E
R
E
M
Q
L
T
Site 89
T1006
T
E
R
E
M
Q
L
T
S
Q
K
Q
T
M
E
Site 90
S1007
E
R
E
M
Q
L
T
S
Q
K
Q
T
M
E
A
Site 91
T1017
Q
T
M
E
A
L
K
T
T
C
T
M
L
E
E
Site 92
S1048
R
Q
W
E
A
W
R
S
V
L
G
D
E
K
S
Site 93
S1055
S
V
L
G
D
E
K
S
Q
F
E
C
R
V
R
Site 94
T1070
E
L
Q
R
M
L
D
T
E
K
Q
S
R
A
R
Site 95
T1083
A
R
A
D
Q
R
I
T
E
S
R
Q
V
V
E
Site 96
S1116
E
Q
K
L
K
A
E
S
L
S
D
K
L
N
D
Site 97
T1144
S
L
Q
Q
K
L
E
T
E
R
E
L
K
Q
R
Site 98
T1174
K
N
H
I
F
R
L
T
Q
G
L
Q
E
A
L
Site 99
T1189
D
R
A
D
L
L
K
T
E
R
S
D
L
E
Y
Site 100
S1192
D
L
L
K
T
E
R
S
D
L
E
Y
Q
L
E
Site 101
Y1196
T
E
R
S
D
L
E
Y
Q
L
E
N
I
Q
V
Site 102
S1217
V
K
M
E
G
T
I
S
Q
Q
T
K
L
I
D
Site 103
S1242
K
K
K
K
G
L
F
S
R
R
K
E
D
P
A
Site 104
T1252
K
E
D
P
A
L
P
T
Q
V
P
L
Q
Y
N
Site 105
S1288
K
T
R
I
E
L
R
S
A
R
E
E
A
A
H
Site 106
T1299
E
A
A
H
R
K
A
T
D
H
P
H
P
S
T
Site 107
S1305
A
T
D
H
P
H
P
S
T
P
A
T
A
R
Q
Site 108
T1306
T
D
H
P
H
P
S
T
P
A
T
A
R
Q
Q
Site 109
T1309
P
H
P
S
T
P
A
T
A
R
Q
Q
I
A
M
Site 110
S1317
A
R
Q
Q
I
A
M
S
A
I
V
R
S
P
E
Site 111
S1322
A
M
S
A
I
V
R
S
P
E
H
Q
P
S
A
Site 112
S1328
R
S
P
E
H
Q
P
S
A
M
S
L
L
A
P
Site 113
S1331
E
H
Q
P
S
A
M
S
L
L
A
P
P
S
S
Site 114
S1337
M
S
L
L
A
P
P
S
S
R
R
K
E
S
S
Site 115
S1338
S
L
L
A
P
P
S
S
R
R
K
E
S
S
T
Site 116
S1343
P
S
S
R
R
K
E
S
S
T
P
E
E
F
S
Site 117
S1344
S
S
R
R
K
E
S
S
T
P
E
E
F
S
R
Site 118
T1345
S
R
R
K
E
S
S
T
P
E
E
F
S
R
R
Site 119
S1350
S
S
T
P
E
E
F
S
R
R
L
K
E
R
M
Site 120
Y1417
T
C
G
L
P
A
E
Y
A
T
H
F
T
E
A
Site 121
T1419
G
L
P
A
E
Y
A
T
H
F
T
E
A
F
C
Site 122
S1432
F
C
R
D
K
M
N
S
P
G
L
Q
T
K
E
Site 123
T1437
M
N
S
P
G
L
Q
T
K
E
P
S
S
S
L
Site 124
S1441
G
L
Q
T
K
E
P
S
S
S
L
H
L
E
G
Site 125
S1442
L
Q
T
K
E
P
S
S
S
L
H
L
E
G
W
Site 126
S1443
Q
T
K
E
P
S
S
S
L
H
L
E
G
W
M
Site 127
Y1467
Q
Q
G
W
D
R
K
Y
I
V
L
E
G
S
K
Site 128
S1473
K
Y
I
V
L
E
G
S
K
V
L
I
Y
D
N
Site 129
Y1478
E
G
S
K
V
L
I
Y
D
N
E
A
R
E
A
Site 130
T1516
G
A
S
E
L
A
N
T
A
K
A
D
V
P
Y
Site 131
Y1523
T
A
K
A
D
V
P
Y
I
L
K
M
E
S
H
Site 132
T1533
K
M
E
S
H
P
H
T
T
C
W
P
G
R
T
Site 133
S1547
T
L
Y
L
L
A
P
S
F
P
D
K
Q
R
W
Site 134
T1556
P
D
K
Q
R
W
V
T
A
L
E
S
V
V
A
Site 135
S1568
V
V
A
G
G
R
V
S
R
E
K
A
E
A
D
Site 136
S1582
D
A
K
L
L
G
N
S
L
L
K
L
E
G
D
Site 137
T1597
D
R
L
D
M
N
C
T
L
P
F
S
D
Q
V
Site 138
S1665
D
V
K
K
V
K
Q
S
L
A
Q
S
H
L
P
Site 139
S1669
V
K
Q
S
L
A
Q
S
H
L
P
A
Q
P
D
Site 140
Y1715
S
K
V
V
I
L
R
Y
N
E
N
L
S
K
Y
Site 141
Y1722
Y
N
E
N
L
S
K
Y
C
I
R
K
E
I
E
Site 142
T1730
C
I
R
K
E
I
E
T
S
E
P
C
S
C
I
Site 143
Y1752
L
I
G
T
N
K
F
Y
E
I
D
M
K
Q
Y
Site 144
Y1759
Y
E
I
D
M
K
Q
Y
T
L
E
E
F
L
D
Site 145
T1760
E
I
D
M
K
Q
Y
T
L
E
E
F
L
D
K
Site 146
Y1800
S
A
G
Q
R
E
E
Y
L
L
C
F
H
E
F
Site 147
S1813
E
F
G
V
F
V
D
S
Y
G
R
R
S
R
T
Site 148
Y1814
F
G
V
F
V
D
S
Y
G
R
R
S
R
T
D
Site 149
S1818
V
D
S
Y
G
R
R
S
R
T
D
D
L
K
W
Site 150
T1820
S
Y
G
R
R
S
R
T
D
D
L
K
W
S
R
Site 151
Y1838
A
F
A
Y
R
E
P
Y
L
F
V
T
H
F
N
Site 152
T1842
R
E
P
Y
L
F
V
T
H
F
N
S
L
E
V
Site 153
S1856
V
I
E
I
Q
A
R
S
S
A
G
T
P
A
R
Site 154
S1857
I
E
I
Q
A
R
S
S
A
G
T
P
A
R
A
Site 155
T1860
Q
A
R
S
S
A
G
T
P
A
R
A
Y
L
D
Site 156
Y1865
A
G
T
P
A
R
A
Y
L
D
I
P
N
P
R
Site 157
Y1873
L
D
I
P
N
P
R
Y
L
G
P
A
I
S
S
Site 158
S1906
K
G
N
L
V
K
E
S
G
T
E
H
H
R
G
Site 159
S1915
T
E
H
H
R
G
P
S
T
S
R
S
S
P
N
Site 160
T1916
E
H
H
R
G
P
S
T
S
R
S
S
P
N
K
Site 161
S1917
H
H
R
G
P
S
T
S
R
S
S
P
N
K
R
Site 162
S1919
R
G
P
S
T
S
R
S
S
P
N
K
R
G
P
Site 163
S1920
G
P
S
T
S
R
S
S
P
N
K
R
G
P
P
Site 164
T1928
P
N
K
R
G
P
P
T
Y
N
E
H
I
T
K
Site 165
Y1929
N
K
R
G
P
P
T
Y
N
E
H
I
T
K
R
Site 166
S1939
H
I
T
K
R
V
A
S
S
P
A
P
P
E
G
Site 167
S1940
I
T
K
R
V
A
S
S
P
A
P
P
E
G
P
Site 168
S1948
P
A
P
P
E
G
P
S
H
P
R
E
P
S
T
Site 169
S1954
P
S
H
P
R
E
P
S
T
P
H
R
Y
R
E
Site 170
T1955
S
H
P
R
E
P
S
T
P
H
R
Y
R
E
G
Site 171
S1971
T
E
L
R
R
D
K
S
P
G
R
P
L
E
R
Site 172
S1981
R
P
L
E
R
E
K
S
P
G
R
M
L
S
T
Site 173
S1987
K
S
P
G
R
M
L
S
T
R
R
E
R
S
P
Site 174
T1988
S
P
G
R
M
L
S
T
R
R
E
R
S
P
G
Site 175
S1993
L
S
T
R
R
E
R
S
P
G
R
L
F
E
D
Site 176
S2001
P
G
R
L
F
E
D
S
S
R
G
R
L
P
A
Site 177
S2002
G
R
L
F
E
D
S
S
R
G
R
L
P
A
G
Site 178
T2013
L
P
A
G
A
V
R
T
P
L
S
Q
V
N
K
Site 179
S2016
G
A
V
R
T
P
L
S
Q
V
N
K
V
W
D
Site 180
S2025
V
N
K
V
W
D
Q
S
S
V
_
_
_
_
_
Site 181
S2026
N
K
V
W
D
Q
S
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation