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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CSPG3
Full Name:
Neurocan core protein
Alias:
Chondroitin sulfate proteoglycan 3; NCAN; NEUR; Neurocan; Neurocan core; Neurocan proteoglycan
Type:
Adhesion
Mass (Da):
143093
Number AA:
1321
UniProt ID:
O14594
International Prot ID:
IPI00159927
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005540
GO:0005529
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
E
Q
G
T
Q
D
I
T
D
A
S
E
R
G
L
Site 2
S33
T
Q
D
I
T
D
A
S
E
R
G
L
H
M
Q
Site 3
S68
F
T
L
Q
P
R
P
S
A
A
R
D
A
P
R
Site 4
S85
W
T
K
V
R
T
A
S
G
Q
R
Q
D
L
P
Site 5
S106
N
V
V
R
V
A
K
S
W
Q
G
R
V
S
L
Site 6
S112
K
S
W
Q
G
R
V
S
L
P
S
Y
P
R
R
Site 7
S115
Q
G
R
V
S
L
P
S
Y
P
R
R
R
A
N
Site 8
Y116
G
R
V
S
L
P
S
Y
P
R
R
R
A
N
A
Site 9
T124
P
R
R
R
A
N
A
T
L
L
L
G
P
L
R
Site 10
S133
L
L
G
P
L
R
A
S
D
S
G
L
Y
R
C
Site 11
S135
G
P
L
R
A
S
D
S
G
L
Y
R
C
Q
V
Site 12
Y138
R
A
S
D
S
G
L
Y
R
C
Q
V
V
R
G
Site 13
Y164
V
T
G
V
V
F
H
Y
R
S
A
R
D
R
Y
Site 14
S166
G
V
V
F
H
Y
R
S
A
R
D
R
Y
A
L
Site 15
Y171
Y
R
S
A
R
D
R
Y
A
L
T
F
A
E
A
Site 16
T174
A
R
D
R
Y
A
L
T
F
A
E
A
Q
E
A
Site 17
T215
A
G
W
L
S
D
R
T
V
R
Y
P
I
T
Q
Site 18
Y218
L
S
D
R
T
V
R
Y
P
I
T
Q
S
R
P
Site 19
T221
R
T
V
R
Y
P
I
T
Q
S
R
P
G
C
Y
Site 20
S223
V
R
Y
P
I
T
Q
S
R
P
G
C
Y
G
D
Site 21
Y228
T
Q
S
R
P
G
C
Y
G
D
R
S
S
L
P
Site 22
S232
P
G
C
Y
G
D
R
S
S
L
P
G
V
R
S
Site 23
S233
G
C
Y
G
D
R
S
S
L
P
G
V
R
S
Y
Site 24
S239
S
S
L
P
G
V
R
S
Y
G
R
R
N
P
Q
Site 25
Y240
S
L
P
G
V
R
S
Y
G
R
R
N
P
Q
E
Site 26
Y249
R
R
N
P
Q
E
L
Y
D
V
Y
C
F
A
R
Site 27
Y252
P
Q
E
L
Y
D
V
Y
C
F
A
R
E
L
G
Site 28
Y264
E
L
G
G
E
V
F
Y
V
G
P
A
R
R
L
Site 29
T272
V
G
P
A
R
R
L
T
L
A
G
A
R
A
Q
Site 30
S313
P
G
W
L
A
D
G
S
V
R
Y
P
I
Q
T
Site 31
Y316
L
A
D
G
S
V
R
Y
P
I
Q
T
P
R
R
Site 32
T320
S
V
R
Y
P
I
Q
T
P
R
R
R
C
G
G
Site 33
T334
G
P
A
P
G
V
R
T
V
Y
R
F
A
N
R
Site 34
Y336
A
P
G
V
R
T
V
Y
R
F
A
N
R
T
G
Site 35
T342
V
Y
R
F
A
N
R
T
G
F
P
S
P
A
E
Site 36
S346
A
N
R
T
G
F
P
S
P
A
E
R
F
D
A
Site 37
Y354
P
A
E
R
F
D
A
Y
C
F
R
A
H
H
P
Site 38
S363
F
R
A
H
H
P
T
S
Q
H
G
D
L
E
T
Site 39
T370
S
Q
H
G
D
L
E
T
P
S
S
G
D
E
G
Site 40
S372
H
G
D
L
E
T
P
S
S
G
D
E
G
E
I
Site 41
S373
G
D
L
E
T
P
S
S
G
D
E
G
E
I
L
Site 42
S381
G
D
E
G
E
I
L
S
A
E
G
P
P
V
R
Site 43
T393
P
V
R
E
L
E
P
T
L
E
E
E
E
V
V
Site 44
T401
L
E
E
E
E
V
V
T
P
D
F
Q
E
P
L
Site 45
S410
D
F
Q
E
P
L
V
S
S
G
E
E
E
T
L
Site 46
S425
I
L
E
E
K
Q
E
S
Q
Q
T
L
S
P
T
Site 47
T428
E
K
Q
E
S
Q
Q
T
L
S
P
T
P
G
D
Site 48
S430
Q
E
S
Q
Q
T
L
S
P
T
P
G
D
P
M
Site 49
T432
S
Q
Q
T
L
S
P
T
P
G
D
P
M
L
A
Site 50
S440
P
G
D
P
M
L
A
S
W
P
T
G
E
V
W
Site 51
S449
P
T
G
E
V
W
L
S
T
V
A
P
S
P
S
Site 52
T450
T
G
E
V
W
L
S
T
V
A
P
S
P
S
D
Site 53
S454
W
L
S
T
V
A
P
S
P
S
D
M
G
A
G
Site 54
T462
P
S
D
M
G
A
G
T
A
A
S
S
H
T
E
Site 55
T473
S
H
T
E
V
A
P
T
D
P
M
P
R
R
R
Site 56
Y490
F
K
G
L
N
G
R
Y
F
Q
Q
Q
E
P
E
Site 57
S507
L
Q
G
G
M
E
A
S
A
Q
P
P
T
S
E
Site 58
S513
A
S
A
Q
P
P
T
S
E
A
A
V
N
Q
M
Site 59
S534
A
V
T
E
M
L
G
S
G
Q
S
R
S
P
W
Site 60
S537
E
M
L
G
S
G
Q
S
R
S
P
W
A
D
L
Site 61
S539
L
G
S
G
Q
S
R
S
P
W
A
D
L
T
N
Site 62
T545
R
S
P
W
A
D
L
T
N
E
V
D
M
P
G
Site 63
S555
V
D
M
P
G
A
G
S
A
G
G
K
S
S
P
Site 64
S560
A
G
S
A
G
G
K
S
S
P
E
P
W
L
W
Site 65
S561
G
S
A
G
G
K
S
S
P
E
P
W
L
W
P
Site 66
T570
E
P
W
L
W
P
P
T
M
V
P
P
S
I
S
Site 67
S575
P
P
T
M
V
P
P
S
I
S
G
H
S
R
A
Site 68
S577
T
M
V
P
P
S
I
S
G
H
S
R
A
P
V
Site 69
S580
P
P
S
I
S
G
H
S
R
A
P
V
L
E
L
Site 70
T599
G
P
S
A
R
P
A
T
P
D
L
F
W
S
P
Site 71
S612
S
P
L
E
A
T
V
S
A
P
S
P
A
P
W
Site 72
S615
E
A
T
V
S
A
P
S
P
A
P
W
E
A
F
Site 73
T648
E
W
M
L
P
H
P
T
P
I
S
T
E
A
N
Site 74
S651
L
P
H
P
T
P
I
S
T
E
A
N
R
V
E
Site 75
T666
A
H
G
E
A
T
A
T
A
P
P
S
P
A
A
Site 76
S670
A
T
A
T
A
P
P
S
P
A
A
E
T
K
V
Site 77
T675
P
P
S
P
A
A
E
T
K
V
Y
S
L
P
L
Site 78
S683
K
V
Y
S
L
P
L
S
L
T
P
T
G
Q
G
Site 79
T685
Y
S
L
P
L
S
L
T
P
T
G
Q
G
G
E
Site 80
T696
Q
G
G
E
A
M
P
T
T
P
E
S
P
R
A
Site 81
T697
G
G
E
A
M
P
T
T
P
E
S
P
R
A
D
Site 82
S700
A
M
P
T
T
P
E
S
P
R
A
D
F
R
E
Site 83
T708
P
R
A
D
F
R
E
T
G
E
T
S
P
A
Q
Site 84
T711
D
F
R
E
T
G
E
T
S
P
A
Q
V
N
K
Site 85
S712
F
R
E
T
G
E
T
S
P
A
Q
V
N
K
A
Site 86
S722
Q
V
N
K
A
E
H
S
S
S
S
P
W
P
S
Site 87
S723
V
N
K
A
E
H
S
S
S
S
P
W
P
S
V
Site 88
S724
N
K
A
E
H
S
S
S
S
P
W
P
S
V
N
Site 89
S725
K
A
E
H
S
S
S
S
P
W
P
S
V
N
R
Site 90
S729
S
S
S
S
P
W
P
S
V
N
R
N
V
A
V
Site 91
S756
G
L
R
G
I
P
G
S
E
S
G
V
F
D
T
Site 92
S758
R
G
I
P
G
S
E
S
G
V
F
D
T
A
E
Site 93
T763
S
E
S
G
V
F
D
T
A
E
S
P
T
S
G
Site 94
S766
G
V
F
D
T
A
E
S
P
T
S
G
L
Q
A
Site 95
S769
D
T
A
E
S
P
T
S
G
L
Q
A
T
V
D
Site 96
S784
E
V
Q
D
P
W
P
S
V
Y
S
K
G
L
D
Site 97
S793
Y
S
K
G
L
D
A
S
S
P
S
A
P
L
G
Site 98
S794
S
K
G
L
D
A
S
S
P
S
A
P
L
G
S
Site 99
S796
G
L
D
A
S
S
P
S
A
P
L
G
S
P
G
Site 100
T825
V
A
T
D
E
G
P
T
V
N
P
M
D
S
T
Site 101
S831
P
T
V
N
P
M
D
S
T
V
T
P
A
P
S
Site 102
T832
T
V
N
P
M
D
S
T
V
T
P
A
P
S
D
Site 103
T834
N
P
M
D
S
T
V
T
P
A
P
S
D
A
S
Site 104
S838
S
T
V
T
P
A
P
S
D
A
S
G
I
W
E
Site 105
S848
S
G
I
W
E
P
G
S
Q
V
F
E
E
A
E
Site 106
S856
Q
V
F
E
E
A
E
S
T
T
L
S
P
Q
V
Site 107
T858
F
E
E
A
E
S
T
T
L
S
P
Q
V
A
L
Site 108
S860
E
A
E
S
T
T
L
S
P
Q
V
A
L
D
T
Site 109
T874
T
S
I
V
T
P
L
T
T
L
E
Q
G
D
K
Site 110
S892
P
A
M
S
T
L
G
S
S
S
S
Q
P
H
P
Site 111
S894
M
S
T
L
G
S
S
S
S
Q
P
H
P
E
P
Site 112
S895
S
T
L
G
S
S
S
S
Q
P
H
P
E
P
E
Site 113
T910
D
Q
V
E
T
Q
G
T
S
G
A
S
V
P
P
Site 114
S914
T
Q
G
T
S
G
A
S
V
P
P
H
Q
S
S
Site 115
S921
S
V
P
P
H
Q
S
S
P
L
G
K
P
A
V
Site 116
T932
K
P
A
V
P
P
G
T
P
T
A
A
S
V
G
Site 117
S937
P
G
T
P
T
A
A
S
V
G
E
S
A
S
V
Site 118
S941
T
A
A
S
V
G
E
S
A
S
V
S
S
G
E
Site 119
S943
A
S
V
G
E
S
A
S
V
S
S
G
E
P
T
Site 120
S945
V
G
E
S
A
S
V
S
S
G
E
P
T
V
P
Site 121
S946
G
E
S
A
S
V
S
S
G
E
P
T
V
P
W
Site 122
T950
S
V
S
S
G
E
P
T
V
P
W
D
P
S
S
Site 123
S956
P
T
V
P
W
D
P
S
S
T
L
L
P
V
T
Site 124
S982
A
G
S
P
G
V
E
S
F
W
E
E
V
A
S
Site 125
S989
S
F
W
E
E
V
A
S
G
E
E
P
A
L
P
Site 126
T998
E
E
P
A
L
P
G
T
P
M
N
A
G
A
E
Site 127
S1009
A
G
A
E
E
V
H
S
D
P
C
E
N
N
P
Site 128
T1060
S
P
C
E
N
G
G
T
C
I
D
E
V
N
G
Site 129
S1079
C
L
P
S
Y
G
G
S
F
C
E
K
D
T
E
Site 130
S1120
E
K
D
C
R
R
R
S
G
H
L
T
S
V
H
Site 131
T1124
R
R
R
S
G
H
L
T
S
V
H
S
P
E
E
Site 132
S1125
R
R
S
G
H
L
T
S
V
H
S
P
E
E
H
Site 133
S1128
G
H
L
T
S
V
H
S
P
E
E
H
S
F
I
Site 134
S1133
V
H
S
P
E
E
H
S
F
I
N
S
F
G
H
Site 135
Y1206
P
C
N
Y
N
L
P
Y
V
C
K
K
G
T
V
Site 136
T1212
P
Y
V
C
K
K
G
T
V
L
C
G
P
P
P
Site 137
Y1234
I
G
A
R
K
A
K
Y
N
V
H
A
T
V
R
Site 138
Y1242
N
V
H
A
T
V
R
Y
Q
C
N
E
G
F
A
Site 139
T1255
F
A
Q
H
H
V
A
T
I
R
C
R
S
N
G
Site 140
S1260
V
A
T
I
R
C
R
S
N
G
K
W
D
R
P
Site 141
T1272
D
R
P
Q
I
V
C
T
K
P
R
R
S
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation