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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNK3
Full Name:
Potassium channel subfamily K member 3
Alias:
Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1
Type:
Ion channel; Plasma membrane
Mass (Da):
43518
Number AA:
394
UniProt ID:
O14649
International Prot ID:
IPI00023110
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005267
GO:0030955
GO:0005244
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Potassium channel subfamily K member 3 pan-specific antibody AB-nn273-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-nn273-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y52
Q
Q
E
L
R
A
R
Y
N
L
S
Q
G
G
Y
Site 2
S55
L
R
A
R
Y
N
L
S
Q
G
G
Y
E
E
L
Site 3
Y59
Y
N
L
S
Q
G
G
Y
E
E
L
E
R
V
V
Site 4
S102
G
Y
G
H
A
A
P
S
T
D
G
G
K
V
F
Site 5
T103
Y
G
H
A
A
P
S
T
D
G
G
K
V
F
C
Site 6
Y138
R
I
N
T
L
V
R
Y
L
L
H
R
A
K
K
Site 7
Y205
T
T
I
G
F
G
D
Y
V
A
L
Q
K
D
Q
Site 8
S278
G
G
G
G
G
G
G
S
A
H
T
T
D
T
A
Site 9
T282
G
G
G
S
A
H
T
T
D
T
A
S
S
T
A
Site 10
T284
G
S
A
H
T
T
D
T
A
S
S
T
A
A
A
Site 11
S286
A
H
T
T
D
T
A
S
S
T
A
A
A
G
G
Site 12
Y300
G
G
G
F
R
N
V
Y
A
E
V
L
H
F
Q
Site 13
Y315
S
M
C
S
C
L
W
Y
K
S
R
E
K
L
Q
Site 14
Y323
K
S
R
E
K
L
Q
Y
S
I
P
M
I
I
P
Site 15
S334
M
I
I
P
R
D
L
S
T
S
D
T
C
V
E
Site 16
T335
I
I
P
R
D
L
S
T
S
D
T
C
V
E
Q
Site 17
S336
I
P
R
D
L
S
T
S
D
T
C
V
E
Q
S
Site 18
T338
R
D
L
S
T
S
D
T
C
V
E
Q
S
H
S
Site 19
S343
S
D
T
C
V
E
Q
S
H
S
S
P
G
G
G
Site 20
S345
T
C
V
E
Q
S
H
S
S
P
G
G
G
G
R
Site 21
S346
C
V
E
Q
S
H
S
S
P
G
G
G
G
R
Y
Site 22
S354
P
G
G
G
G
R
Y
S
D
T
P
S
R
R
C
Site 23
T356
G
G
G
R
Y
S
D
T
P
S
R
R
C
L
C
Site 24
S358
G
R
Y
S
D
T
P
S
R
R
C
L
C
S
G
Site 25
S364
P
S
R
R
C
L
C
S
G
A
P
R
S
A
I
Site 26
S369
L
C
S
G
A
P
R
S
A
I
S
S
V
S
T
Site 27
S372
G
A
P
R
S
A
I
S
S
V
S
T
G
L
H
Site 28
S373
A
P
R
S
A
I
S
S
V
S
T
G
L
H
S
Site 29
S375
R
S
A
I
S
S
V
S
T
G
L
H
S
L
S
Site 30
S382
S
T
G
L
H
S
L
S
T
F
R
G
L
M
K
Site 31
T383
T
G
L
H
S
L
S
T
F
R
G
L
M
K
R
Site 32
S392
R
G
L
M
K
R
R
S
S
V
_
_
_
_
_
Site 33
S393
G
L
M
K
R
R
S
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation