PhosphoNET

           
Protein Info 
   
Short Name:  IRS4
Full Name:  Insulin receptor substrate 4
Alias:  IRS-4; PY160
Type:  Adapter/scaffold protein
Mass (Da):  133768
Number AA:  1257
UniProt ID:  O14654
International Prot ID:  IPI00020729
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005886     Uniprot OncoNet
Molecular Function:  GO:0005070  GO:0005158   PhosphoSite+ KinaseNET
Biological Process:  GO:0007165     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T7_MASCSFTRDQATRR
Site 2T12SFTRDQATRRLRGAA
Site 3S57CPGAMWLSTATGSRS
Site 4T58PGAMWLSTATGSRSD
Site 5T60AMWLSTATGSRSDSE
Site 6S62WLSTATGSRSDSESE
Site 7S64STATGSRSDSESEEE
Site 8S66ATGSRSDSESEEEDL
Site 9S68GSRSDSESEEEDLPV
Site 10Y84EEVCKRGYLRKQKHG
Site 11Y95QKHGHRRYFVLKLET
Site 12Y111DAPARLEYYENARKF
Site 13Y112APARLEYYENARKFR
Site 14S121NARKFRHSVRAAAAA
Site 15Y151PRRVITLYQCFSVSQ
Site 16S157LYQCFSVSQRADARY
Site 17Y164SQRADARYRHLIALF
Site 18S189ENESEQESWYLLLSR
Site 19Y191ESEQESWYLLLSRLI
Site 20S201LSRLILESKRRRCGT
Site 21T208SKRRRCGTLGAQPDG
Site 22Y291RCGHSEQYFFLEVGR
Site 23Y336RALCADEYRARCRSY
Site 24S342EYRARCRSYSISIGA
Site 25Y343YRARCRSYSISIGAH
Site 26S344RARCRSYSISIGAHL
Site 27T396GEDEMLFTRRFVTPS
Site 28T401LFTRRFVTPSEPVAH
Site 29S403TRRFVTPSEPVAHSR
Site 30S409PSEPVAHSRRGRLHL
Site 31S422HLPRGRRSRRAVSVP
Site 32S427RRSRRAVSVPASFFR
Site 33S439FFRRLAPSPARPRHP
Site 34S457PNNGARLSSEVSGSG
Site 35S458NNGARLSSEVSGSGS
Site 36S461ARLSSEVSGSGSGNF
Site 37S463LSSEVSGSGSGNFGE
Site 38S465SEVSGSGSGNFGEEG
Site 39S483GKEDQEGSGGDYMPM
Site 40Y487QEGSGGDYMPMNNWG
Site 41S501GSGNGRGSGGGQGSN
Site 42S507GSGGGQGSNGQGSSS
Site 43S512QGSNGQGSSSHSSGG
Site 44S513GSNGQGSSSHSSGGN
Site 45S514SNGQGSSSHSSGGNQ
Site 46S516GQGSSSHSSGGNQCS
Site 47S517QGSSSHSSGGNQCSG
Site 48S523SSGGNQCSGEGQGSR
Site 49S529CSGEGQGSRGGQGSN
Site 50S535GSRGGQGSNGQGSGG
Site 51S540QGSNGQGSGGNQCSR
Site 52S546GSGGNQCSRDGQGTA
Site 53T552CSRDGQGTAGGHGSG
Site 54S558GTAGGHGSGGGQRPG
Site 55S570RPGGGHGSGGGQGPG
Site 56S582GPGDGHGSGGGKNSG
Site 57S588GSGGGKNSGGGKGSG
Site 58S594NSGGGKGSGSGKGSD
Site 59S596GGGKGSGSGKGSDGD
Site 60S600GSGSGKGSDGDGERG
Site 61S609GDGERGKSLKKRSYF
Site 62S614GKSLKKRSYFGKLTQ
Site 63Y615KSLKKRSYFGKLTQS
Site 64T620RSYFGKLTQSKQQQM
Site 65S622YFGKLTQSKQQQMPP
Site 66S649GTGGKGKSGGRFRLY
Site 67Y656SGGRFRLYFCVDRGA
Site 68T664FCVDRGATKECKEAK
Site 69Y700DEDEDDPYVPMRPGV
Site 70T709PMRPGVATPLVSSSD
Site 71S714VATPLVSSSDYMPMA
Site 72S715ATPLVSSSDYMPMAP
Site 73Y717PLVSSSDYMPMAPQN
Site 74S726PMAPQNVSASKKRHS
Site 75S728APQNVSASKKRHSRS
Site 76S733SASKKRHSRSPFEDS
Site 77S735SKKRHSRSPFEDSRG
Site 78Y743PFEDSRGYMMMFPRV
Site 79S751MMMFPRVSPPPAPSP
Site 80S757VSPPPAPSPPKAPDT
Site 81T764SPPKAPDTNKEDDSK
Site 82S770DTNKEDDSKDNDSES
Site 83S775DDSKDNDSESDYMFM
Site 84S777SKDNDSESDYMFMAP
Site 85Y779DNDSESDYMFMAPGA
Site 86S800PRNPQGGSSSKSWSS
Site 87S801RNPQGGSSSKSWSSY
Site 88S802NPQGGSSSKSWSSYF
Site 89S804QGGSSSKSWSSYFSL
Site 90S806GSSSKSWSSYFSLPN
Site 91S807SSSKSWSSYFSLPNP
Site 92Y808SSKSWSSYFSLPNPF
Site 93S810KSWSSYFSLPNPFRS
Site 94S817SLPNPFRSSPLGQND
Site 95S818LPNPFRSSPLGQNDN
Site 96S826PLGQNDNSEYVPMLP
Site 97Y828GQNDNSEYVPMLPGK
Site 98S846RGLDKEVSYNWDPKD
Site 99S856WDPKDAASKPSGEGS
Site 100S859KDAASKPSGEGSFSK
Site 101S863SKPSGEGSFSKPGDG
Site 102S865PSGEGSFSKPGDGGS
Site 103S872SKPGDGGSPSKPSDH
Site 104S874PGDGGSPSKPSDHEP
Site 105S877GGSPSKPSDHEPPKN
Site 106S893AKRPNRLSFITKGYK
Site 107T896PNRLSFITKGYKIKP
Site 108S917HEQREADSSSDYVNM
Site 109S918EQREADSSSDYVNMD
Site 110S919QREADSSSDYVNMDF
Site 111Y921EADSSSDYVNMDFTK
Site 112T927DYVNMDFTKRESNTP
Site 113S931MDFTKRESNTPAPST
Site 114T933FTKRESNTPAPSTQG
Site 115S937ESNTPAPSTQGLPDS
Site 116T938SNTPAPSTQGLPDSW
Site 117S944STQGLPDSWGIIAEP
Site 118S954IIAEPRQSAFSNYVN
Site 119S957EPRQSAFSNYVNVEF
Site 120Y959RQSAFSNYVNVEFGV
Site 121S976PNPANDLSDLLRAIP
Site 122S989IPRANPLSLDSARWP
Site 123S992ANPLSLDSARWPLPP
Site 124S1007LPLSATGSNAIEEEG
Site 125Y1016AIEEEGDYIEVIFNS
Site 126Y1038LADSAIRYDAETGRI
Site 127T1042AIRYDAETGRIYVVD
Site 128Y1046DAETGRIYVVDPFSE
Site 129S1059SECCMDISLSPSRCS
Site 130S1061CCMDISLSPSRCSEP
Site 131S1063MDISLSPSRCSEPPP
Site 132S1066SLSPSRCSEPPPVAR
Site 133S1087QERRRPQSRSQSFFA
Site 134S1089RRRPQSRSQSFFAAA
Site 135S1091RPQSRSQSFFAAARA
Site 136T1105AAVSAFPTDSLERDL
Site 137S1107VSAFPTDSLERDLSP
Site 138S1113DSLERDLSPSSAPAV
Site 139S1115LERDLSPSSAPAVAS
Site 140S1116ERDLSPSSAPAVASA
Site 141S1157AAAAGFDSASARWFQ
Site 142S1159AAGFDSASARWFQPV
Site 143S1185AQDVAGGSNPGAHNP
Site 144S1219APEPPPRSRRVPRPP
Site 145S1231RPPEREDSDNDDDTH
Site 146T1237DSDNDDDTHVRMDFA
Site 147S1252RRDNQFDSPKRGR__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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