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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENC1
Full Name:
Ectoderm-neural cortex protein 1
Alias:
CCL28; Ectodermal-neural cortex (with BTB-like domain); Ectoderm-neural cortex 1; ENC-1; Kelch-like 37; KLHL37; NRP/B; NRPB; Nuclear matrix protein NRP/B; Nuclear restricted protein, BTB domain-like (brain); P53-induced 10; PIG10; TP53I10
Type:
Actin binding protein
Mass (Da):
66130
Number AA:
589
UniProt ID:
O14682
International Prot ID:
IPI00023188
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
S
V
H
E
N
R
K
S
R
A
S
S
G
S
I
Site 2
S14
E
N
R
K
S
R
A
S
S
G
S
I
N
I
Y
Site 3
S15
N
R
K
S
R
A
S
S
G
S
I
N
I
Y
L
Site 4
S17
K
S
R
A
S
S
G
S
I
N
I
Y
L
F
H
Site 5
Y21
S
S
G
S
I
N
I
Y
L
F
H
K
S
S
Y
Site 6
S26
N
I
Y
L
F
H
K
S
S
Y
A
D
S
V
L
Site 7
S31
H
K
S
S
Y
A
D
S
V
L
T
H
L
N
L
Site 8
T46
L
R
Q
Q
R
L
F
T
D
V
L
L
H
A
G
Site 9
Y70
V
L
A
A
C
S
R
Y
F
E
A
M
F
S
G
Site 10
S76
R
Y
F
E
A
M
F
S
G
G
L
K
E
S
Q
Site 11
S82
F
S
G
G
L
K
E
S
Q
D
S
E
V
N
F
Site 12
S85
G
L
K
E
S
Q
D
S
E
V
N
F
D
N
S
Site 13
S92
S
E
V
N
F
D
N
S
I
H
P
E
V
L
E
Site 14
S108
L
L
D
Y
A
Y
S
S
R
V
I
I
N
E
E
Site 15
S119
I
N
E
E
N
A
E
S
L
L
E
A
G
D
M
Site 16
S199
M
V
V
Q
L
L
S
S
E
E
L
E
T
E
D
Site 17
T204
L
S
S
E
E
L
E
T
E
D
E
R
L
V
Y
Site 18
Y211
T
E
D
E
R
L
V
Y
E
S
A
I
N
W
I
Site 19
Y220
S
A
I
N
W
I
S
Y
D
L
K
K
R
Y
C
Site 20
Y228
D
L
K
K
R
Y
C
Y
L
P
E
L
L
Q
T
Site 21
Y245
L
A
L
L
P
A
I
Y
L
M
E
N
V
A
M
Site 22
T257
V
A
M
E
E
L
I
T
K
Q
R
K
S
K
E
Site 23
S262
L
I
T
K
Q
R
K
S
K
E
I
V
E
E
A
Site 24
S285
Q
N
D
G
V
V
T
S
L
C
A
R
P
R
K
Site 25
Y311
T
F
M
C
D
K
L
Y
L
V
D
Q
K
A
K
Site 26
S328
I
P
K
A
D
I
P
S
P
R
K
E
F
S
A
Site 27
S334
P
S
P
R
K
E
F
S
A
C
A
I
G
C
K
Site 28
T345
I
G
C
K
V
Y
I
T
G
G
R
G
S
E
N
Site 29
S350
Y
I
T
G
G
R
G
S
E
N
G
V
S
K
D
Site 30
S355
R
G
S
E
N
G
V
S
K
D
V
W
V
Y
D
Site 31
S383
V
A
R
F
G
H
G
S
A
E
L
K
H
C
L
Site 32
S406
A
T
G
C
L
P
A
S
P
S
V
S
L
K
Q
Site 33
S410
L
P
A
S
P
S
V
S
L
K
Q
V
E
H
Y
Site 34
Y417
S
L
K
Q
V
E
H
Y
D
P
T
I
N
K
W
Site 35
T452
K
L
F
A
F
G
G
T
S
V
S
H
D
K
L
Site 36
S453
L
F
A
F
G
G
T
S
V
S
H
D
K
L
P
Site 37
S455
A
F
G
G
T
S
V
S
H
D
K
L
P
K
V
Site 38
Y465
K
L
P
K
V
Q
C
Y
D
Q
C
E
N
R
W
Site 39
Y509
E
F
S
A
C
S
A
Y
K
F
N
S
E
T
Y
Site 40
S530
D
V
T
A
K
R
M
S
C
H
A
V
A
S
G
Site 41
T554
F
G
I
Q
R
C
K
T
L
D
C
Y
D
P
T
Site 42
Y558
R
C
K
T
L
D
C
Y
D
P
T
L
D
V
W
Site 43
S567
P
T
L
D
V
W
N
S
I
T
T
V
P
Y
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation