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Updated November 2019
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Protein Info
Short Name:
MLL2
Full Name:
Histone-lysine N-methyltransferase MLL2
Alias:
ALL1-related protein; ALR; CAGL114; KMT2B; Lysine N-methyltransferase 2B; MLL4; Myeloid/lymphoid or mixed-lineage leukemia 2; Myeloid/lymphoid or mixed-lineage leukemia protein 2; TNRC21
Type:
Transcription regulation; EC 2.1.1.43; Methyltransferase
Mass (Da):
564185
Number AA:
5262
UniProt ID:
O14686
International Prot ID:
IPI00297859
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035097
Uniprot
OncoNet
Molecular Function:
GO:0018024
GO:0010843
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0008284
GO:0033148
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
A
G
E
D
K
D
S
Q
P
A
A
D
G
P
Site 2
S23
A
A
D
G
P
A
A
S
E
D
P
S
A
T
E
Site 3
S27
P
A
A
S
E
D
P
S
A
T
E
S
D
L
P
Site 4
T29
A
S
E
D
P
S
A
T
E
S
D
L
P
N
P
Site 5
S31
E
D
P
S
A
T
E
S
D
L
P
N
P
H
V
Site 6
S42
N
P
H
V
G
E
V
S
V
L
S
S
G
S
P
Site 7
S45
V
G
E
V
S
V
L
S
S
G
S
P
R
L
Q
Site 8
S46
G
E
V
S
V
L
S
S
G
S
P
R
L
Q
E
Site 9
S48
V
S
V
L
S
S
G
S
P
R
L
Q
E
T
P
Site 10
T54
G
S
P
R
L
Q
E
T
P
Q
D
C
S
G
G
Site 11
S59
Q
E
T
P
Q
D
C
S
G
G
P
V
R
R
C
Site 12
S98
W
P
R
C
P
V
V
S
P
G
G
S
P
G
P
Site 13
S102
P
V
V
S
P
G
G
S
P
G
P
N
E
A
V
Site 14
S112
P
N
E
A
V
L
P
S
E
D
L
S
Q
I
G
Site 15
S116
V
L
P
S
E
D
L
S
Q
I
G
F
P
E
G
Site 16
T125
I
G
F
P
E
G
L
T
P
A
H
L
G
E
P
Site 17
S166
G
V
D
K
A
I
F
S
G
I
S
Q
R
C
S
Site 18
S173
S
G
I
S
Q
R
C
S
H
C
T
R
L
G
A
Site 19
T176
S
Q
R
C
S
H
C
T
R
L
G
A
S
I
P
Site 20
S181
H
C
T
R
L
G
A
S
I
P
C
R
S
P
G
Site 21
S186
G
A
S
I
P
C
R
S
P
G
C
P
R
L
Y
Site 22
Y193
S
P
G
C
P
R
L
Y
H
F
P
C
A
T
A
Site 23
Y223
E
H
S
E
G
A
A
Y
L
E
E
A
R
C
A
Site 24
T261
A
C
L
D
T
A
L
T
A
R
K
R
A
G
W
Site 25
T293
S
K
M
L
V
C
E
T
C
D
K
G
Y
H
T
Site 26
Y298
C
E
T
C
D
K
G
Y
H
T
F
C
L
K
P
Site 27
S314
M
E
E
L
P
A
H
S
W
K
C
K
A
C
R
Site 28
S337
S
A
E
L
N
P
N
S
E
W
F
E
N
Y
S
Site 29
S360
Q
G
G
Q
T
I
R
S
V
A
E
Q
H
T
P
Site 30
T366
R
S
V
A
E
Q
H
T
P
V
C
S
R
F
S
Site 31
S370
E
Q
H
T
P
V
C
S
R
F
S
P
P
E
P
Site 32
S373
T
P
V
C
S
R
F
S
P
P
E
P
G
D
T
Site 33
T380
S
P
P
E
P
G
D
T
P
T
D
E
P
D
A
Site 34
T382
P
E
P
G
D
T
P
T
D
E
P
D
A
L
Y
Site 35
Y389
T
D
E
P
D
A
L
Y
V
A
C
Q
G
Q
P
Site 36
S403
P
K
G
G
H
V
T
S
M
Q
P
K
E
P
G
Site 37
S447
L
L
P
P
P
E
E
S
P
L
S
P
P
P
E
Site 38
S450
P
P
E
E
S
P
L
S
P
P
P
E
E
S
P
Site 39
S456
L
S
P
P
P
E
E
S
P
T
S
P
P
P
E
Site 40
T458
P
P
P
E
E
S
P
T
S
P
P
P
E
A
S
Site 41
S459
P
P
E
E
S
P
T
S
P
P
P
E
A
S
R
Site 42
S465
T
S
P
P
P
E
A
S
R
L
S
P
P
P
E
Site 43
S468
P
P
E
A
S
R
L
S
P
P
P
E
E
L
P
Site 44
S477
P
P
E
E
L
P
A
S
P
L
P
E
A
L
H
Site 45
S486
L
P
E
A
L
H
L
S
R
P
L
E
E
S
P
Site 46
S492
L
S
R
P
L
E
E
S
P
L
S
P
P
P
E
Site 47
S495
P
L
E
E
S
P
L
S
P
P
P
E
E
S
P
Site 48
S501
L
S
P
P
P
E
E
S
P
L
S
P
P
P
E
Site 49
S504
P
P
E
E
S
P
L
S
P
P
P
E
S
S
P
Site 50
S509
P
L
S
P
P
P
E
S
S
P
F
S
P
L
E
Site 51
S510
L
S
P
P
P
E
S
S
P
F
S
P
L
E
E
Site 52
S513
P
P
E
S
S
P
F
S
P
L
E
E
S
P
L
Site 53
S518
P
F
S
P
L
E
E
S
P
L
S
P
P
E
E
Site 54
S521
P
L
E
E
S
P
L
S
P
P
E
E
S
P
P
Site 55
S526
P
L
S
P
P
E
E
S
P
P
S
P
A
L
E
Site 56
S529
P
P
E
E
S
P
P
S
P
A
L
E
T
P
L
Site 57
T534
P
P
S
P
A
L
E
T
P
L
S
P
P
P
E
Site 58
S537
P
A
L
E
T
P
L
S
P
P
P
E
A
S
P
Site 59
S543
L
S
P
P
P
E
A
S
P
L
S
P
P
F
E
Site 60
S546
P
P
E
A
S
P
L
S
P
P
F
E
E
S
P
Site 61
S552
L
S
P
P
F
E
E
S
P
L
S
P
P
P
E
Site 62
S555
P
F
E
E
S
P
L
S
P
P
P
E
E
L
P
Site 63
T563
P
P
P
E
E
L
P
T
S
P
P
P
E
A
S
Site 64
S564
P
P
E
E
L
P
T
S
P
P
P
E
A
S
R
Site 65
S573
P
P
E
A
S
R
L
S
P
P
P
E
E
S
P
Site 66
S579
L
S
P
P
P
E
E
S
P
M
S
P
P
P
E
Site 67
S582
P
P
E
E
S
P
M
S
P
P
P
E
E
S
P
Site 68
S588
M
S
P
P
P
E
E
S
P
M
S
P
P
P
E
Site 69
S591
P
P
E
E
S
P
M
S
P
P
P
E
A
S
R
Site 70
S597
M
S
P
P
P
E
A
S
R
L
F
P
P
F
E
Site 71
S606
L
F
P
P
F
E
E
S
P
L
S
P
P
P
E
Site 72
S609
P
F
E
E
S
P
L
S
P
P
P
E
E
S
P
Site 73
S618
P
P
E
E
S
P
L
S
P
P
P
E
A
S
R
Site 74
S624
L
S
P
P
P
E
A
S
R
L
S
P
P
P
E
Site 75
S627
P
P
E
A
S
R
L
S
P
P
P
E
D
S
P
Site 76
S633
L
S
P
P
P
E
D
S
P
M
S
P
P
P
E
Site 77
S636
P
P
E
D
S
P
M
S
P
P
P
E
E
S
P
Site 78
S645
P
P
E
E
S
P
M
S
P
P
P
E
V
S
R
Site 79
S651
M
S
P
P
P
E
V
S
R
L
S
P
L
P
V
Site 80
S654
P
P
E
V
S
R
L
S
P
L
P
V
V
S
R
Site 81
S660
L
S
P
L
P
V
V
S
R
L
S
P
P
P
E
Site 82
S663
L
P
V
V
S
R
L
S
P
P
P
E
E
S
P
Site 83
S669
L
S
P
P
P
E
E
S
P
L
S
P
P
A
L
Site 84
S672
P
P
E
E
S
P
L
S
P
P
A
L
S
P
L
Site 85
S677
P
L
S
P
P
A
L
S
P
L
G
E
L
E
Y
Site 86
Y684
S
P
L
G
E
L
E
Y
P
F
G
A
K
G
D
Site 87
S692
P
F
G
A
K
G
D
S
D
P
E
S
P
L
A
Site 88
S696
K
G
D
S
D
P
E
S
P
L
A
A
P
I
L
Site 89
S708
P
I
L
E
T
P
I
S
P
P
P
E
A
N
C
Site 90
T716
P
P
P
E
A
N
C
T
D
P
E
P
V
P
P
Site 91
S729
P
P
M
I
L
P
P
S
P
G
S
P
V
G
P
Site 92
S732
I
L
P
P
S
P
G
S
P
V
G
P
A
S
P
Site 93
S750
E
P
L
P
P
Q
C
S
P
L
L
Q
H
S
L
Site 94
S756
C
S
P
L
L
Q
H
S
L
V
P
Q
N
S
P
Site 95
S762
H
S
L
V
P
Q
N
S
P
P
S
Q
C
S
P
Site 96
S765
V
P
Q
N
S
P
P
S
Q
C
S
P
P
A
L
Site 97
S768
N
S
P
P
S
Q
C
S
P
P
A
L
P
L
S
Site 98
S790
I
G
K
V
V
G
V
S
D
E
A
E
L
H
E
Site 99
S814
E
C
P
A
L
E
P
S
A
T
S
P
L
P
S
Site 100
T816
P
A
L
E
P
S
A
T
S
P
L
P
S
P
M
Site 101
S817
A
L
E
P
S
A
T
S
P
L
P
S
P
M
G
Site 102
S821
S
A
T
S
P
L
P
S
P
M
G
D
L
S
C
Site 103
S827
P
S
P
M
G
D
L
S
C
P
A
P
S
P
A
Site 104
S832
D
L
S
C
P
A
P
S
P
A
P
A
L
D
D
Site 105
S841
A
P
A
L
D
D
F
S
G
L
G
E
D
T
A
Site 106
T847
F
S
G
L
G
E
D
T
A
P
L
D
G
I
D
Site 107
S858
D
G
I
D
A
P
G
S
Q
P
E
P
G
Q
T
Site 108
T865
S
Q
P
E
P
G
Q
T
P
G
S
L
A
S
E
Site 109
S868
E
P
G
Q
T
P
G
S
L
A
S
E
L
K
G
Site 110
S871
Q
T
P
G
S
L
A
S
E
L
K
G
S
P
V
Site 111
S876
L
A
S
E
L
K
G
S
P
V
L
L
D
P
E
Site 112
T889
P
E
E
L
A
P
V
T
P
M
E
V
Y
P
E
Site 113
Y894
P
V
T
P
M
E
V
Y
P
E
C
K
Q
T
A
Site 114
T900
V
Y
P
E
C
K
Q
T
A
G
R
G
S
P
C
Site 115
S905
K
Q
T
A
G
R
G
S
P
C
E
E
Q
E
E
Site 116
T920
P
R
A
P
V
A
P
T
P
P
T
L
I
K
S
Site 117
S927
T
P
P
T
L
I
K
S
D
I
V
N
E
I
S
Site 118
S937
V
N
E
I
S
N
L
S
Q
G
D
A
S
A
S
Site 119
S942
N
L
S
Q
G
D
A
S
A
S
F
P
G
S
E
Site 120
S944
S
Q
G
D
A
S
A
S
F
P
G
S
E
P
L
Site 121
S948
A
S
A
S
F
P
G
S
E
P
L
L
G
S
P
Site 122
S954
G
S
E
P
L
L
G
S
P
D
P
E
G
G
G
Site 123
S962
P
D
P
E
G
G
G
S
L
S
M
E
L
G
V
Site 124
S964
P
E
G
G
G
S
L
S
M
E
L
G
V
S
T
Site 125
S974
L
G
V
S
T
D
V
S
P
A
R
D
E
G
S
Site 126
S981
S
P
A
R
D
E
G
S
L
R
L
C
T
D
S
Site 127
T986
E
G
S
L
R
L
C
T
D
S
L
P
E
T
D
Site 128
S988
S
L
R
L
C
T
D
S
L
P
E
T
D
D
S
Site 129
T992
C
T
D
S
L
P
E
T
D
D
S
L
L
C
D
Site 130
S995
S
L
P
E
T
D
D
S
L
L
C
D
A
G
T
Site 131
S1018
G
E
K
G
R
R
R
S
S
P
A
R
S
R
I
Site 132
S1019
E
K
G
R
R
R
S
S
P
A
R
S
R
I
K
Site 133
S1023
R
R
S
S
P
A
R
S
R
I
K
Q
G
R
S
Site 134
S1030
S
R
I
K
Q
G
R
S
S
S
F
P
G
R
R
Site 135
S1031
R
I
K
Q
G
R
S
S
S
F
P
G
R
R
R
Site 136
S1032
I
K
Q
G
R
S
S
S
F
P
G
R
R
R
P
Site 137
S1056
R
G
R
A
R
L
K
S
T
A
S
S
I
E
T
Site 138
S1071
L
V
V
A
D
I
D
S
S
P
S
K
E
E
E
Site 139
S1072
V
V
A
D
I
D
S
S
P
S
K
E
E
E
E
Site 140
T1084
E
E
E
E
D
D
D
T
M
Q
N
T
V
V
L
Site 141
T1088
D
D
D
T
M
Q
N
T
V
V
L
F
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Site 445
T4244
A
A
A
R
K
P
L
T
P
K
P
K
R
V
Q
Site 446
S4254
P
K
R
V
Q
K
A
S
D
R
L
V
S
S
R
Site 447
S4259
K
A
S
D
R
L
V
S
S
R
K
K
L
R
K
Site 448
S4273
K
E
D
G
V
R
A
S
E
A
L
L
K
Q
L
Site 449
S4285
K
Q
L
K
Q
E
L
S
L
L
P
L
T
E
P
Site 450
S4314
G
C
P
V
N
G
Q
S
Q
L
R
G
A
F
G
Site 451
S4322
Q
L
R
G
A
F
G
S
G
A
L
P
T
G
P
Site 452
Y4331
A
L
P
T
G
P
D
Y
Y
S
Q
L
L
T
K
Site 453
Y4332
L
P
T
G
P
D
Y
Y
S
Q
L
L
T
K
N
Site 454
S4333
P
T
G
P
D
Y
Y
S
Q
L
L
T
K
N
N
Site 455
T4337
D
Y
Y
S
Q
L
L
T
K
N
N
L
S
N
P
Site 456
S4342
L
L
T
K
N
N
L
S
N
P
P
T
P
P
S
Site 457
T4346
N
N
L
S
N
P
P
T
P
P
S
S
L
P
P
Site 458
S4349
S
N
P
P
T
P
P
S
S
L
P
P
T
P
P
Site 459
S4350
N
P
P
T
P
P
S
S
L
P
P
T
P
P
P
Site 460
T4354
P
P
S
S
L
P
P
T
P
P
P
S
V
Q
Q
Site 461
S4358
L
P
P
T
P
P
P
S
V
Q
Q
K
M
V
N
Site 462
T4368
Q
K
M
V
N
G
V
T
P
S
E
E
L
G
E
Site 463
S4370
M
V
N
G
V
T
P
S
E
E
L
G
E
H
P
Site 464
S4382
E
H
P
K
D
A
A
S
A
R
D
S
E
R
A
Site 465
S4386
D
A
A
S
A
R
D
S
E
R
A
L
R
D
T
Site 466
T4393
S
E
R
A
L
R
D
T
S
E
V
K
S
L
D
Site 467
S4394
E
R
A
L
R
D
T
S
E
V
K
S
L
D
L
Site 468
S4398
R
D
T
S
E
V
K
S
L
D
L
L
A
A
L
Site 469
T4407
D
L
L
A
A
L
P
T
P
P
H
N
Q
T
E
Site 470
S4420
T
E
D
V
R
M
E
S
D
E
D
S
D
S
P
Site 471
S4424
R
M
E
S
D
E
D
S
D
S
P
D
S
I
V
Site 472
S4426
E
S
D
E
D
S
D
S
P
D
S
I
V
P
A
Site 473
S4429
E
D
S
D
S
P
D
S
I
V
P
A
S
S
P
Site 474
S4434
P
D
S
I
V
P
A
S
S
P
E
S
I
L
G
Site 475
S4435
D
S
I
V
P
A
S
S
P
E
S
I
L
G
E
Site 476
S4438
V
P
A
S
S
P
E
S
I
L
G
E
E
A
P
Site 477
S4452
P
R
F
P
H
L
G
S
G
R
W
E
Q
E
D
Site 478
S4463
E
Q
E
D
R
A
L
S
P
V
I
P
L
I
P
Site 479
T4480
S
I
P
V
F
P
D
T
K
P
Y
G
A
L
G
Site 480
T4497
V
P
G
K
L
P
V
T
T
W
E
K
G
K
G
Site 481
T4498
P
G
K
L
P
V
T
T
W
E
K
G
K
G
S
Site 482
S4539
L
S
M
K
I
P
N
S
Y
E
V
L
F
P
E
Site 483
Y4540
S
M
K
I
P
N
S
Y
E
V
L
F
P
E
S
Site 484
S4547
Y
E
V
L
F
P
E
S
P
A
R
G
G
T
E
Site 485
T4553
E
S
P
A
R
G
G
T
E
P
K
K
G
E
A
Site 486
S4574
E
K
G
L
E
G
K
S
P
D
T
G
P
D
W
Site 487
T4577
L
E
G
K
S
P
D
T
G
P
D
W
L
K
Q
Site 488
S4602
K
R
Q
L
D
I
L
S
L
L
K
Q
E
S
P
Site 489
S4608
L
S
L
L
K
Q
E
S
P
A
P
E
P
P
T
Site 490
T4615
S
P
A
P
E
P
P
T
Q
H
R
Y
T
Y
N
Site 491
Y4619
E
P
P
T
Q
H
R
Y
T
Y
N
V
S
N
L
Site 492
T4620
P
P
T
Q
H
R
Y
T
Y
N
V
S
N
L
D
Site 493
Y4621
P
T
Q
H
R
Y
T
Y
N
V
S
N
L
D
V
Site 494
S4624
H
R
Y
T
Y
N
V
S
N
L
D
V
R
Q
L
Site 495
S4632
N
L
D
V
R
Q
L
S
A
P
P
P
E
E
P
Site 496
S4640
A
P
P
P
E
E
P
S
P
P
P
S
P
L
A
Site 497
S4644
E
E
P
S
P
P
P
S
P
L
A
P
S
P
A
Site 498
S4649
P
P
S
P
L
A
P
S
P
A
S
P
P
T
E
Site 499
S4652
P
L
A
P
S
P
A
S
P
P
T
E
P
L
V
Site 500
T4655
P
S
P
A
S
P
P
T
E
P
L
V
E
L
P
Site 501
S4679
P
S
P
L
P
L
A
S
S
P
E
S
A
R
P
Site 502
S4680
S
P
L
P
L
A
S
S
P
E
S
A
R
P
K
Site 503
S4683
P
L
A
S
S
P
E
S
A
R
P
K
P
R
A
Site 504
T4699
P
P
E
E
G
E
D
T
R
P
P
R
L
K
K
Site 505
T4720
K
R
L
R
L
L
L
T
I
Q
K
G
S
G
R
Site 506
S4725
L
L
T
I
Q
K
G
S
G
R
Q
E
D
E
R
Site 507
T4743
E
F
M
E
Q
L
G
T
A
L
R
P
D
K
V
Site 508
T4768
H
E
E
G
D
G
A
T
D
G
P
A
R
L
L
Site 509
Y4795
A
L
W
S
T
E
V
Y
E
T
Q
G
G
A
L
Site 510
T4797
W
S
T
E
V
Y
E
T
Q
G
G
A
L
M
N
Site 511
T4815
A
L
H
R
G
L
L
T
K
C
S
L
C
Q
R
Site 512
S4818
R
G
L
L
T
K
C
S
L
C
Q
R
T
G
A
Site 513
S4828
Q
R
T
G
A
T
S
S
C
N
R
M
R
C
P
Site 514
S4872
G
P
C
E
Q
E
L
S
S
F
A
V
F
R
R
Site 515
S4873
P
C
E
Q
E
L
S
S
F
A
V
F
R
R
V
Site 516
Y4881
F
A
V
F
R
R
V
Y
I
E
R
D
E
V
K
Site 517
Y4935
T
A
L
Y
P
V
G
Y
E
A
T
R
I
Y
W
Site 518
Y4941
G
Y
E
A
T
R
I
Y
W
S
L
R
T
N
N
Site 519
S4943
E
A
T
R
I
Y
W
S
L
R
T
N
N
R
R
Site 520
S4984
D
L
V
F
T
D
A
S
P
Q
A
V
W
N
R
Site 521
Y5012
M
L
R
L
F
P
E
Y
L
K
G
E
E
L
F
Site 522
S5038
E
S
L
P
G
V
E
S
C
Q
N
Y
L
F
R
Site 523
Y5042
G
V
E
S
C
Q
N
Y
L
F
R
Y
G
R
H
Site 524
Y5046
C
Q
N
Y
L
F
R
Y
G
R
H
P
L
M
E
Site 525
S5066
N
P
T
G
C
A
R
S
E
P
K
I
L
T
H
Site 526
T5072
R
S
E
P
K
I
L
T
H
Y
K
R
P
H
T
Site 527
Y5074
E
P
K
I
L
T
H
Y
K
R
P
H
T
L
N
Site 528
T5079
T
H
Y
K
R
P
H
T
L
N
S
T
S
M
S
Site 529
S5082
K
R
P
H
T
L
N
S
T
S
M
S
K
A
Y
Site 530
S5084
P
H
T
L
N
S
T
S
M
S
K
A
Y
Q
S
Site 531
S5086
T
L
N
S
T
S
M
S
K
A
Y
Q
S
T
F
Site 532
Y5089
S
T
S
M
S
K
A
Y
Q
S
T
F
T
G
E
Site 533
T5092
M
S
K
A
Y
Q
S
T
F
T
G
E
T
N
T
Site 534
T5099
T
F
T
G
E
T
N
T
P
Y
S
K
Q
F
V
Site 535
Y5101
T
G
E
T
N
T
P
Y
S
K
Q
F
V
H
S
Site 536
S5102
G
E
T
N
T
P
Y
S
K
Q
F
V
H
S
K
Site 537
S5108
Y
S
K
Q
F
V
H
S
K
S
S
Q
Y
R
R
Site 538
S5110
K
Q
F
V
H
S
K
S
S
Q
Y
R
R
L
R
Site 539
S5111
Q
F
V
H
S
K
S
S
Q
Y
R
R
L
R
T
Site 540
T5118
S
Q
Y
R
R
L
R
T
E
W
K
N
N
V
Y
Site 541
Y5125
T
E
W
K
N
N
V
Y
L
A
R
S
R
I
Q
Site 542
S5129
N
N
V
Y
L
A
R
S
R
I
Q
G
L
G
L
Site 543
Y5137
R
I
Q
G
L
G
L
Y
A
A
K
D
L
E
K
Site 544
Y5168
A
N
R
R
E
K
I
Y
E
E
Q
N
R
G
I
Site 545
Y5176
E
E
Q
N
R
G
I
Y
M
F
R
I
N
N
E
Site 546
T5189
N
E
H
V
I
D
A
T
L
T
G
G
P
A
R
Site 547
Y5197
L
T
G
G
P
A
R
Y
I
N
H
S
C
A
P
Site 548
S5223
E
D
K
I
I
I
I
S
S
R
R
I
P
K
G
Site 549
S5224
D
K
I
I
I
I
S
S
R
R
I
P
K
G
E
Site 550
Y5235
P
K
G
E
E
L
T
Y
D
Y
Q
F
D
F
E
Site 551
Y5237
G
E
E
L
T
Y
D
Y
Q
F
D
F
E
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation