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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APAF
Full Name:
Apoptotic protease-activating factor 1
Alias:
APAF1; Apaf-1; Apoptotic peptidase activating factor 1; Apoptotic protease activating factor 1; CED4; KIAA0413
Type:
Apoptosis
Mass (Da):
141840
Number AA:
1248
UniProt ID:
O14727
International Prot ID:
IPI00023630
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005622
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008656
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008635
GO:0006952
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
A
L
E
K
D
I
K
T
S
Y
I
M
D
H
M
Site 2
Y24
E
K
D
I
K
T
S
Y
I
M
D
H
M
I
S
Site 3
S38
S
D
G
F
L
T
I
S
E
E
E
K
V
R
N
Site 4
S67
I
L
K
K
D
N
D
S
Y
V
S
F
Y
N
A
Site 5
Y68
L
K
K
D
N
D
S
Y
V
S
F
Y
N
A
L
Site 6
S70
K
D
N
D
S
Y
V
S
F
Y
N
A
L
L
H
Site 7
S95
H
D
G
I
P
V
V
S
S
S
S
G
K
D
S
Site 8
S96
D
G
I
P
V
V
S
S
S
S
G
K
D
S
V
Site 9
S97
G
I
P
V
V
S
S
S
S
G
K
D
S
V
S
Site 10
S98
I
P
V
V
S
S
S
S
G
K
D
S
V
S
G
Site 11
S102
S
S
S
S
G
K
D
S
V
S
G
I
T
S
Y
Site 12
S104
S
S
G
K
D
S
V
S
G
I
T
S
Y
V
R
Site 13
T151
K
G
E
P
G
W
V
T
I
H
G
M
A
G
C
Site 14
S172
A
E
A
V
R
D
H
S
L
L
E
G
C
F
P
Site 15
S186
P
G
G
V
H
W
V
S
V
G
K
Q
D
K
S
Site 16
S193
S
V
G
K
Q
D
K
S
G
L
L
M
K
L
Q
Site 17
T204
M
K
L
Q
N
L
C
T
R
L
D
Q
D
E
S
Site 18
S211
T
R
L
D
Q
D
E
S
F
S
Q
R
L
P
L
Site 19
S213
L
D
Q
D
E
S
F
S
Q
R
L
P
L
N
I
Site 20
S238
M
L
R
K
H
P
R
S
L
L
I
L
D
D
V
Site 21
S248
I
L
D
D
V
W
D
S
W
V
L
K
A
F
D
Site 22
T263
S
Q
C
Q
I
L
L
T
T
R
D
K
S
V
T
Site 23
S268
L
L
T
T
R
D
K
S
V
T
D
S
V
M
G
Site 24
T270
T
T
R
D
K
S
V
T
D
S
V
M
G
P
K
Site 25
S272
R
D
K
S
V
T
D
S
V
M
G
P
K
Y
V
Site 26
Y278
D
S
V
M
G
P
K
Y
V
V
P
V
E
S
S
Site 27
S312
D
L
P
E
Q
A
H
S
I
I
K
E
C
K
G
Site 28
S320
I
I
K
E
C
K
G
S
P
L
V
V
S
L
I
Site 29
Y340
D
F
P
N
R
W
E
Y
Y
L
K
Q
L
Q
N
Site 30
Y341
F
P
N
R
W
E
Y
Y
L
K
Q
L
Q
N
K
Site 31
S356
Q
F
K
R
I
R
K
S
S
S
Y
D
Y
E
A
Site 32
S357
F
K
R
I
R
K
S
S
S
Y
D
Y
E
A
L
Site 33
S358
K
R
I
R
K
S
S
S
Y
D
Y
E
A
L
D
Site 34
Y359
R
I
R
K
S
S
S
Y
D
Y
E
A
L
D
E
Site 35
Y361
R
K
S
S
S
Y
D
Y
E
A
L
D
E
A
M
Site 36
S371
L
D
E
A
M
S
I
S
V
E
M
L
R
E
D
Site 37
Y382
L
R
E
D
I
K
D
Y
Y
T
D
L
S
I
L
Site 38
Y383
R
E
D
I
K
D
Y
Y
T
D
L
S
I
L
Q
Site 39
T384
E
D
I
K
D
Y
Y
T
D
L
S
I
L
Q
K
Site 40
S387
K
D
Y
Y
T
D
L
S
I
L
Q
K
D
V
K
Site 41
S422
L
Q
E
F
V
N
K
S
L
L
F
C
D
R
N
Site 42
Y435
R
N
G
K
S
F
R
Y
Y
L
H
D
L
Q
V
Site 43
Y436
N
G
K
S
F
R
Y
Y
L
H
D
L
Q
V
D
Site 44
T446
D
L
Q
V
D
F
L
T
E
K
N
C
S
Q
L
Site 45
S451
F
L
T
E
K
N
C
S
Q
L
Q
D
L
H
K
Site 46
Y467
I
I
T
Q
F
Q
R
Y
H
Q
P
H
T
L
S
Site 47
T472
Q
R
Y
H
Q
P
H
T
L
S
P
D
Q
E
D
Site 48
T514
L
D
W
I
K
A
K
T
E
L
V
G
P
A
H
Site 49
Y529
L
I
H
E
F
V
E
Y
R
H
I
L
D
E
K
Site 50
S549
E
N
F
Q
E
F
L
S
L
N
G
H
L
L
G
Site 51
T573
L
G
L
C
E
P
E
T
S
E
V
Y
Q
Q
A
Site 52
S574
G
L
C
E
P
E
T
S
E
V
Y
Q
Q
A
K
Site 53
Y594
E
V
D
N
G
M
L
Y
L
E
W
I
N
K
K
Site 54
T615
R
L
V
V
R
P
H
T
D
A
V
Y
H
A
C
Site 55
Y619
R
P
H
T
D
A
V
Y
H
A
C
F
S
E
D
Site 56
S632
E
D
G
Q
R
I
A
S
C
G
A
D
K
T
L
Site 57
T638
A
S
C
G
A
D
K
T
L
Q
V
F
K
A
E
Site 58
S676
D
R
F
I
A
T
C
S
V
D
K
K
V
K
I
Site 59
T694
M
T
G
E
L
V
H
T
Y
D
E
H
S
E
Q
Site 60
Y695
T
G
E
L
V
H
T
Y
D
E
H
S
E
Q
V
Site 61
S752
S
V
N
H
C
R
F
S
P
D
D
K
L
L
A
Site 62
S760
P
D
D
K
L
L
A
S
C
S
A
D
G
T
L
Site 63
T766
A
S
C
S
A
D
G
T
L
K
L
W
D
A
T
Site 64
S774
L
K
L
W
D
A
T
S
A
N
E
R
K
S
I
Site 65
S780
T
S
A
N
E
R
K
S
I
N
V
K
Q
F
F
Site 66
T837
G
L
L
G
E
I
H
T
G
H
H
S
T
I
Q
Site 67
Y845
G
H
H
S
T
I
Q
Y
C
D
F
S
P
Q
N
Site 68
T869
Y
C
V
E
L
W
N
T
D
S
R
S
K
V
A
Site 69
S871
V
E
L
W
N
T
D
S
R
S
K
V
A
D
C
Site 70
S873
L
W
N
T
D
S
R
S
K
V
A
D
C
R
G
Site 71
S895
V
M
F
S
P
D
G
S
S
F
L
T
S
S
D
Site 72
S896
M
F
S
P
D
G
S
S
F
L
T
S
S
D
D
Site 73
T899
P
D
G
S
S
F
L
T
S
S
D
D
Q
T
I
Site 74
S900
D
G
S
S
F
L
T
S
S
D
D
Q
T
I
R
Site 75
S901
G
S
S
F
L
T
S
S
D
D
Q
T
I
R
L
Site 76
T905
L
T
S
S
D
D
Q
T
I
R
L
W
E
T
K
Site 77
Y958
G
R
T
G
Q
I
D
Y
L
T
E
A
Q
V
S
Site 78
T1017
Q
F
T
A
D
E
K
T
L
I
S
S
S
D
D
Site 79
S1022
E
K
T
L
I
S
S
S
D
D
A
E
I
Q
V
Site 80
T1046
F
L
R
G
H
Q
E
T
V
K
D
F
R
L
L
Site 81
S1056
D
F
R
L
L
K
N
S
R
L
L
S
W
S
F
Site 82
S1060
L
K
N
S
R
L
L
S
W
S
F
D
G
T
V
Site 83
S1062
N
S
R
L
L
S
W
S
F
D
G
T
V
K
V
Site 84
S1094
T
V
L
S
C
D
I
S
H
D
A
T
K
F
S
Site 85
T1098
C
D
I
S
H
D
A
T
K
F
S
S
T
S
A
Site 86
T1103
D
A
T
K
F
S
S
T
S
A
D
K
T
A
K
Site 87
T1108
S
S
T
S
A
D
K
T
A
K
I
W
S
F
D
Site 88
S1157
E
I
R
I
W
N
V
S
N
G
E
L
L
H
L
Site 89
T1175
L
S
E
E
G
A
A
T
H
G
G
W
V
T
D
Site 90
T1181
A
T
H
G
G
W
V
T
D
L
C
F
S
P
D
Site 91
S1210
N
V
V
T
G
E
S
S
Q
T
F
Y
T
N
G
Site 92
T1212
V
T
G
E
S
S
Q
T
F
Y
T
N
G
T
N
Site 93
Y1214
G
E
S
S
Q
T
F
Y
T
N
G
T
N
L
K
Site 94
S1226
N
L
K
K
I
H
V
S
P
D
F
K
T
Y
V
Site 95
T1231
H
V
S
P
D
F
K
T
Y
V
T
V
D
N
L
Site 96
Y1232
V
S
P
D
F
K
T
Y
V
T
V
D
N
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation