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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIOK3
Full Name:
Serine/threonine-protein kinase RIO3
Alias:
EC 2.7.11.1; RIO kinase 3; SudD
Type:
Protein-serine kinase, Atypical group, RIO family, RIO3 subfamily
Mass (Da):
59093
Number AA:
519
UniProt ID:
O14730
International Prot ID:
IPI00298199
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0007059
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
P
W
A
I
P
Q
N
T
I
S
C
S
L
A
D
Site 2
S34
P
Q
N
T
I
S
C
S
L
A
D
V
M
S
E
Site 3
S75
T
G
E
N
I
D
T
S
S
D
L
M
L
A
Q
Site 4
S76
G
E
N
I
D
T
S
S
D
L
M
L
A
Q
M
Site 5
Y88
A
Q
M
L
Q
M
E
Y
D
R
E
Y
D
A
Q
Site 6
Y92
Q
M
E
Y
D
R
E
Y
D
A
Q
L
R
R
E
Site 7
S107
E
K
K
F
N
G
D
S
K
V
S
I
S
F
E
Site 8
S110
F
N
G
D
S
K
V
S
I
S
F
E
N
Y
R
Site 9
S112
G
D
S
K
V
S
I
S
F
E
N
Y
R
K
V
Site 10
Y116
V
S
I
S
F
E
N
Y
R
K
V
H
P
Y
E
Site 11
Y122
N
Y
R
K
V
H
P
Y
E
D
S
D
S
S
E
Site 12
S125
K
V
H
P
Y
E
D
S
D
S
S
E
D
E
V
Site 13
S127
H
P
Y
E
D
S
D
S
S
E
D
E
V
D
W
Site 14
S128
P
Y
E
D
S
D
S
S
E
D
E
V
D
W
Q
Site 15
Y142
Q
D
T
R
D
D
P
Y
R
P
A
K
P
V
P
Site 16
T150
R
P
A
K
P
V
P
T
P
K
K
G
F
I
G
Site 17
T163
I
G
K
G
K
D
I
T
T
K
H
D
E
V
V
Site 18
T164
G
K
G
K
D
I
T
T
K
H
D
E
V
V
C
Site 19
T176
V
V
C
G
R
K
N
T
A
R
M
E
N
F
A
Site 20
S212
A
L
K
Q
H
A
Y
S
E
E
R
R
S
A
R
Site 21
S217
A
Y
S
E
E
R
R
S
A
R
L
H
E
K
K
Site 22
T237
E
K
A
V
D
P
K
T
R
L
L
M
Y
K
M
Site 23
Y242
P
K
T
R
L
L
M
Y
K
M
V
N
S
G
M
Site 24
S280
M
E
D
E
K
E
D
S
K
V
I
P
T
E
C
Site 25
Y305
E
F
K
N
R
D
K
Y
I
K
D
D
F
R
F
Site 26
S317
F
R
F
K
D
R
F
S
K
L
N
P
R
K
I
Site 27
S379
L
K
E
V
K
L
N
S
E
E
M
K
E
A
Y
Site 28
Y386
S
E
E
M
K
E
A
Y
Y
Q
T
L
H
L
M
Site 29
Y387
E
E
M
K
E
A
Y
Y
Q
T
L
H
L
M
R
Site 30
T401
R
Q
L
Y
H
E
C
T
L
V
H
A
D
L
S
Site 31
S425
K
V
W
L
I
D
V
S
Q
S
V
E
P
T
H
Site 32
S427
W
L
I
D
V
S
Q
S
V
E
P
T
H
P
H
Site 33
T431
V
S
Q
S
V
E
P
T
H
P
H
G
L
E
F
Site 34
S460
G
G
V
K
E
A
L
S
E
R
E
L
F
N
A
Site 35
S505
K
N
G
R
K
A
A
S
F
L
K
D
D
G
D
Site 36
Y517
D
G
D
P
P
L
L
Y
D
E
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation