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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACOT8
Full Name:
Acyl-coenzyme A thioesterase 8
Alias:
ACTEIII; ACTE-III; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; HACTE-III; HIV-Nef-associated acyl coA thioesterase; HIV-Nef-associated acyl-CoA thioesterase; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long-chain acyl-coA thioesterase 1; Peroxisomal long-chain acyl-CoA thioesterase 1; PTE1; PTE-1; PTE-2; TE; Thioesterase II
Type:
Hydrolase; EC 3.1.2.27
Mass (Da):
35914
Number AA:
319
UniProt ID:
O14734
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005777
Uniprot
OncoNet
Molecular Function:
GO:0016291
GO:0004091
GO:0033882
PhosphoSite+
KinaseNET
Biological Process:
GO:0033540
GO:0044419
GO:0007031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
S
P
Q
A
P
E
D
Site 2
S3
_
_
_
_
_
M
S
S
P
Q
A
P
E
D
G
Site 3
Y47
D
L
F
R
G
R
H
Y
W
V
P
A
K
R
L
Site 4
Y83
H
V
H
S
L
H
C
Y
F
V
R
A
G
D
P
Site 5
Y96
D
P
K
L
P
V
L
Y
Q
V
E
R
T
R
T
Site 6
T101
V
L
Y
Q
V
E
R
T
R
T
G
S
S
F
S
Site 7
T103
Y
Q
V
E
R
T
R
T
G
S
S
F
S
V
R
Site 8
S105
V
E
R
T
R
T
G
S
S
F
S
V
R
S
V
Site 9
S106
E
R
T
R
T
G
S
S
F
S
V
R
S
V
K
Site 10
S108
T
R
T
G
S
S
F
S
V
R
S
V
K
A
V
Site 11
S111
G
S
S
F
S
V
R
S
V
K
A
V
Q
H
G
Site 12
S127
P
I
F
I
C
Q
A
S
F
Q
Q
A
Q
P
S
Site 13
S134
S
F
Q
Q
A
Q
P
S
P
M
Q
H
Q
F
S
Site 14
S141
S
P
M
Q
H
Q
F
S
M
P
T
V
P
P
P
Site 15
T144
Q
H
Q
F
S
M
P
T
V
P
P
P
E
E
L
Site 16
T156
E
E
L
L
D
C
E
T
L
I
D
Q
Y
L
R
Site 17
Y161
C
E
T
L
I
D
Q
Y
L
R
D
P
N
L
Q
Site 18
S193
E
I
K
P
V
N
P
S
P
L
S
Q
L
Q
R
Site 19
S196
P
V
N
P
S
P
L
S
Q
L
Q
R
M
E
P
Site 20
Y214
F
W
V
R
A
R
G
Y
I
G
E
G
D
M
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation