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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRMT5
Full Name:
Protein arginine N-methyltransferase 5
Alias:
ANM5; HRMT1L5; IBP72; JBP1; protein arginine methyltransferase 5; SKB1; SKB1Hs
Type:
EC 2.1.1.-; EC 2.1.1.125; Cell cycle regulation; Methyltransferase; RNA processing
Mass (Da):
72684
Number AA:
637
UniProt ID:
O14744
International Prot ID:
IPI00441473
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008469
GO:0005515
GO:0035243
PhosphoSite+
KinaseNET
Biological Process:
GO:0008283
GO:0043985
GO:0035246
Phosida
TranscriptoNet
STRING
Kinexus Products
Protein arginine N-methyltransferase 5 T634 phosphosite-specific antibody AB-PN549#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN549
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
V
G
G
A
G
G
S
R
V
S
S
G
R
D
Site 2
S15
G
A
G
G
S
R
V
S
S
G
R
D
L
N
C
Site 3
S16
A
G
G
S
R
V
S
S
G
R
D
L
N
C
V
Site 4
T29
C
V
P
E
I
A
D
T
L
G
A
V
A
K
Q
Site 5
T67
K
N
R
P
G
P
Q
T
R
S
D
L
L
L
S
Site 6
S69
R
P
G
P
Q
T
R
S
D
L
L
L
S
G
R
Site 7
S74
T
R
S
D
L
L
L
S
G
R
D
W
N
T
L
Site 8
T80
L
S
G
R
D
W
N
T
L
I
V
G
K
L
S
Site 9
S87
T
L
I
V
G
K
L
S
P
W
I
R
P
D
S
Site 10
S94
S
P
W
I
R
P
D
S
K
V
E
K
I
R
R
Site 11
S103
V
E
K
I
R
R
N
S
E
A
A
M
L
Q
E
Site 12
T139
T
N
L
A
R
V
L
T
N
H
I
H
T
G
H
Site 13
T144
V
L
T
N
H
I
H
T
G
H
H
S
S
M
F
Site 14
T173
D
I
I
E
N
A
P
T
T
H
T
E
E
Y
S
Site 15
T176
E
N
A
P
T
T
H
T
E
E
Y
S
G
E
E
Site 16
Y179
P
T
T
H
T
E
E
Y
S
G
E
E
K
T
W
Site 17
Y198
N
F
R
T
L
C
D
Y
S
K
R
I
A
V
A
Site 18
S247
K
K
G
F
P
V
L
S
K
M
H
Q
R
L
I
Site 19
S279
H
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
Site 20
Y280
S
E
K
E
F
C
S
Y
L
Q
Y
L
E
Y
L
Site 21
Y283
E
F
C
S
Y
L
Q
Y
L
E
Y
L
S
Q
N
Site 22
Y286
S
Y
L
Q
Y
L
E
Y
L
S
Q
N
R
P
P
Site 23
S288
L
Q
Y
L
E
Y
L
S
Q
N
R
P
P
P
N
Site 24
Y297
N
R
P
P
P
N
A
Y
E
L
F
A
K
G
Y
Site 25
Y304
Y
E
L
F
A
K
G
Y
E
D
Y
L
Q
S
P
Site 26
Y307
F
A
K
G
Y
E
D
Y
L
Q
S
P
L
Q
P
Site 27
S310
G
Y
E
D
Y
L
Q
S
P
L
Q
P
L
M
D
Site 28
S321
P
L
M
D
N
L
E
S
Q
T
Y
E
V
F
E
Site 29
Y324
D
N
L
E
S
Q
T
Y
E
V
F
E
K
D
P
Site 30
Y342
S
Q
Y
Q
Q
A
I
Y
K
C
L
L
D
R
V
Site 31
T356
V
P
E
E
E
K
D
T
N
V
Q
V
L
M
V
Site 32
S375
R
G
P
L
V
N
A
S
L
R
A
A
K
Q
A
Site 33
Y389
A
D
R
R
I
K
L
Y
A
V
E
K
N
P
N
Site 34
S411
W
Q
F
E
E
W
G
S
Q
V
T
V
V
S
S
Site 35
T414
E
E
W
G
S
Q
V
T
V
V
S
S
D
M
R
Site 36
S418
S
Q
V
T
V
V
S
S
D
M
R
E
W
V
A
Site 37
S446
S
F
A
D
N
E
L
S
P
E
C
L
D
G
A
Site 38
S463
F
L
K
D
D
G
V
S
I
P
G
E
Y
T
S
Site 39
T469
V
S
I
P
G
E
Y
T
S
F
L
A
P
I
S
Site 40
S476
T
S
F
L
A
P
I
S
S
S
K
L
Y
N
E
Site 41
Y481
P
I
S
S
S
K
L
Y
N
E
V
R
A
C
R
Site 42
Y502
E
A
Q
F
E
M
P
Y
V
V
R
L
H
N
F
Site 43
T520
S
A
P
Q
P
C
F
T
F
S
H
P
N
R
D
Site 44
Y535
P
M
I
D
N
N
R
Y
C
T
L
E
F
P
V
Site 45
T537
I
D
N
N
R
Y
C
T
L
E
F
P
V
E
V
Site 46
T564
T
V
L
Y
Q
D
I
T
L
S
I
R
P
E
T
Site 47
S566
L
Y
Q
D
I
T
L
S
I
R
P
E
T
H
S
Site 48
T571
T
L
S
I
R
P
E
T
H
S
P
G
M
F
S
Site 49
S573
S
I
R
P
E
T
H
S
P
G
M
F
S
W
F
Site 50
T591
F
P
I
K
Q
P
I
T
V
R
E
G
Q
T
I
Site 51
Y613
S
N
S
K
K
V
W
Y
E
W
A
V
T
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation