PhosphoNET

           
Protein Info 
   
Short Name:  NHERF
Full Name:  Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Alias:  EBP50; Ezrin-radixin-moesin binding phosphoprotein-50; NHERF1; NHERF-1; Similar to solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulatory factor 1; Solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1; Solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulatory factor 1
Type:  Adapter/scaffold protein
Mass (Da):  38868
Number AA:  358
UniProt ID:  O14745
International Prot ID:  IPI00003527
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0015629  GO:0019898  GO:0030175 Uniprot OncoNet
Molecular Function:  GO:0030165  GO:0031698  GO:0008022 PhosphoSite+ KinaseNET
Biological Process:  GO:0016055  GO:0006461  GO:0032415 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S2______MSADAAAGA
Site 2Y38EKGKLGQYIRLVEPG
Site 3S46IRLVEPGSPAEKAGL
Site 4S77ETHQQVVSRIRAALN
Site 5T95LLVVDPETDEQLQKL
Site 6S143EPREADKSHPEQREL
Site 7T156ELRPRLCTMKKGPSG
Site 8S162CTMKKGPSGYGFNLH
Site 9Y164MKKGPSGYGFNLHSD
Site 10S170GYGFNLHSDKSKPGQ
Site 11S173FNLHSDKSKPGQFIR
Site 12S181KPGQFIRSVDPDSPA
Site 13S186IRSVDPDSPAEASGL
Site 14S217KQHGDVVSAIRAGGD
Site 15T235LLVVDRETDEFFKKC
Site 16S247KKCRVIPSQEHLNGP
Site 17T260GPLPVPFTNGEIQKE
Site 18S269GEIQKENSREALAEA
Site 19S280LAEAALESPRPALVR
Site 20S288PRPALVRSASSDTSE
Site 21S290PALVRSASSDTSEEL
Site 22S291ALVRSASSDTSEELN
Site 23T293VRSASSDTSEELNSQ
Site 24S294RSASSDTSEELNSQD
Site 25S299DTSEELNSQDSPPKQ
Site 26S302EELNSQDSPPKQDST
Site 27S308DSPPKQDSTAPSSTS
Site 28T309SPPKQDSTAPSSTSS
Site 29S312KQDSTAPSSTSSSDP
Site 30S313QDSTAPSSTSSSDPI
Site 31S315STAPSSTSSSDPILD
Site 32S316APSSTSSSDPILDFN
Site 33S317APSSTSSSDPILDFN
Site 34S326PILDFNISLAMAKER
Site 35S339ERAHQKRSSKRAPQM
Site 36S340RAHQKRSSKRAPQMD
Site 37S349RAPQMDWSKKNELFS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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