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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNPO2
Full Name:
Transportin-2
Alias:
Karyopherin beta-2b
Type:
Mass (Da):
101388
Number AA:
897
UniProt ID:
O14787
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
V
L
Q
L
L
K
D
S
Q
S
P
N
T
A
T
Site 2
S22
Q
L
L
K
D
S
Q
S
P
N
T
A
T
Q
R
Site 3
T27
S
Q
S
P
N
T
A
T
Q
R
I
V
Q
D
K
Site 4
T53
N
Y
L
I
F
V
L
T
R
L
K
S
E
D
E
Site 5
S57
F
V
L
T
R
L
K
S
E
D
E
P
T
R
S
Site 6
T62
L
K
S
E
D
E
P
T
R
S
L
S
G
L
I
Site 7
S64
S
E
D
E
P
T
R
S
L
S
G
L
I
L
K
Site 8
S66
D
E
P
T
R
S
L
S
G
L
I
L
K
N
N
Site 9
Y78
K
N
N
V
K
A
H
Y
Q
S
F
P
P
P
V
Site 10
S80
N
V
K
A
H
Y
Q
S
F
P
P
P
V
A
D
Site 11
Y140
N
L
L
N
S
E
D
Y
N
T
C
E
G
A
F
Site 12
T142
L
N
S
E
D
Y
N
T
C
E
G
A
F
G
A
Site 13
S158
Q
K
I
C
E
D
S
S
E
L
L
D
S
D
A
Site 14
S163
D
S
S
E
L
L
D
S
D
A
L
N
R
P
L
Site 15
S185
L
Q
F
F
K
H
C
S
P
K
I
R
S
H
A
Site 16
S329
E
D
E
A
V
P
D
S
E
Q
D
I
K
P
R
Site 17
S340
I
K
P
R
F
H
K
S
R
T
V
T
L
P
H
Site 18
T342
P
R
F
H
K
S
R
T
V
T
L
P
H
E
A
Site 19
T344
F
H
K
S
R
T
V
T
L
P
H
E
A
E
R
Site 20
S355
E
A
E
R
P
D
G
S
E
D
A
E
D
D
D
Site 21
S368
D
D
D
D
D
A
L
S
D
W
N
L
R
K
C
Site 22
S445
P
H
L
I
Q
C
L
S
D
K
K
A
L
V
R
Site 23
S499
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
Site 24
T510
T
L
E
E
E
A
C
T
E
L
V
P
Y
L
S
Site 25
S548
A
I
G
T
L
A
D
S
V
G
H
H
L
N
Q
Site 26
Y558
H
H
L
N
Q
P
E
Y
I
Q
K
L
M
P
P
Site 27
Y601
L
Q
S
G
F
L
P
Y
C
E
P
V
Y
Q
R
Site 28
Y630
Y
T
Q
H
P
E
Q
Y
E
A
P
D
K
D
F
Site 29
S676
L
F
Q
C
M
Q
D
S
M
P
E
V
R
Q
S
Site 30
S683
S
M
P
E
V
R
Q
S
S
F
A
L
L
G
D
Site 31
Y743
M
G
A
E
M
Q
P
Y
V
Q
M
V
L
N
N
Site 32
T760
E
I
I
N
R
P
N
T
P
K
T
L
L
E
N
Site 33
T763
N
R
P
N
T
P
K
T
L
L
E
N
T
G
R
Site 34
T768
P
K
T
L
L
E
N
T
G
R
L
T
S
P
S
Site 35
T772
L
E
N
T
G
R
L
T
S
P
S
A
I
P
A
Site 36
S773
E
N
T
G
R
L
T
S
P
S
A
I
P
A
I
Site 37
S851
D
A
V
A
S
W
V
S
P
K
D
D
L
R
D
Site 38
Y861
D
D
L
R
D
M
F
Y
K
I
L
H
G
F
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation