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Updated November 2019
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Protein Info
Short Name:
UNC13B
Full Name:
Protein unc-13 homolog B
Alias:
Hmunc13; Munc13; Munc13-2; U13B; UN13B; UNC13; Unc-13 B; UNC13, unc-13 B; Unc13h2
Type:
Cytoplasm, Plasma membrane, Synapse, Cell junction, Golgi apparatus protein
Mass (Da):
180679
Number AA:
1591
UniProt ID:
O14795
International Prot ID:
IPI00478689
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030054
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0004872
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007588
GO:0006887
GO:0006917
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
K
R
A
K
F
Q
G
S
P
D
K
F
N
T
Y
Site 2
Y23
S
P
D
K
F
N
T
Y
V
T
L
K
V
Q
N
Site 3
S33
L
K
V
Q
N
V
K
S
T
T
V
A
V
R
G
Site 4
T35
V
Q
N
V
K
S
T
T
V
A
V
R
G
D
Q
Site 5
S61
S
R
L
D
L
G
L
S
V
E
V
W
N
K
G
Site 6
T84
T
V
W
I
A
L
K
T
I
R
Q
S
D
E
E
Site 7
S88
A
L
K
T
I
R
Q
S
D
E
E
G
P
G
E
Site 8
T98
E
G
P
G
E
W
S
T
L
E
A
E
T
L
M
Site 9
T113
K
D
D
E
I
C
G
T
R
N
P
T
P
H
K
Site 10
T117
I
C
G
T
R
N
P
T
P
H
K
I
L
L
D
Site 11
T125
P
H
K
I
L
L
D
T
R
F
E
L
P
F
D
Site 12
Y140
I
P
E
E
E
A
R
Y
W
T
Y
K
W
E
Q
Site 13
Y157
A
L
G
A
D
N
E
Y
S
S
Q
E
E
S
Q
Site 14
S158
L
G
A
D
N
E
Y
S
S
Q
E
E
S
Q
R
Site 15
S159
G
A
D
N
E
Y
S
S
Q
E
E
S
Q
R
K
Site 16
S163
E
Y
S
S
Q
E
E
S
Q
R
K
P
L
P
T
Site 17
T170
S
Q
R
K
P
L
P
T
A
A
A
Q
C
S
F
Site 18
S176
P
T
A
A
A
Q
C
S
F
E
D
P
D
S
A
Site 19
S182
C
S
F
E
D
P
D
S
A
V
D
D
R
D
S
Site 20
S189
S
A
V
D
D
R
D
S
D
Y
R
S
E
T
S
Site 21
Y191
V
D
D
R
D
S
D
Y
R
S
E
T
S
N
S
Site 22
S193
D
R
D
S
D
Y
R
S
E
T
S
N
S
F
P
Site 23
T195
D
S
D
Y
R
S
E
T
S
N
S
F
P
P
P
Site 24
S196
S
D
Y
R
S
E
T
S
N
S
F
P
P
P
Y
Site 25
S198
Y
R
S
E
T
S
N
S
F
P
P
P
Y
H
T
Site 26
Y203
S
N
S
F
P
P
P
Y
H
T
A
S
Q
P
N
Site 27
T205
S
F
P
P
P
Y
H
T
A
S
Q
P
N
A
S
Site 28
S207
P
P
P
Y
H
T
A
S
Q
P
N
A
S
V
H
Site 29
S212
T
A
S
Q
P
N
A
S
V
H
Q
F
P
V
P
Site 30
S222
Q
F
P
V
P
V
R
S
P
Q
Q
L
L
L
Q
Site 31
S231
Q
Q
L
L
L
Q
G
S
S
R
D
S
C
N
D
Site 32
S232
Q
L
L
L
Q
G
S
S
R
D
S
C
N
D
S
Site 33
S235
L
Q
G
S
S
R
D
S
C
N
D
S
M
Q
S
Site 34
S239
S
R
D
S
C
N
D
S
M
Q
S
Y
D
L
D
Site 35
Y243
C
N
D
S
M
Q
S
Y
D
L
D
Y
P
E
R
Site 36
Y247
M
Q
S
Y
D
L
D
Y
P
E
R
R
A
I
S
Site 37
S254
Y
P
E
R
R
A
I
S
P
T
S
S
S
R
Y
Site 38
T256
E
R
R
A
I
S
P
T
S
S
S
R
Y
G
S
Site 39
S257
R
R
A
I
S
P
T
S
S
S
R
Y
G
S
S
Site 40
S258
R
A
I
S
P
T
S
S
S
R
Y
G
S
S
C
Site 41
S259
A
I
S
P
T
S
S
S
R
Y
G
S
S
C
N
Site 42
Y261
S
P
T
S
S
S
R
Y
G
S
S
C
N
V
S
Site 43
S263
T
S
S
S
R
Y
G
S
S
C
N
V
S
Q
G
Site 44
S264
S
S
S
R
Y
G
S
S
C
N
V
S
Q
G
S
Site 45
S268
Y
G
S
S
C
N
V
S
Q
G
S
S
Q
L
S
Site 46
S272
C
N
V
S
Q
G
S
S
Q
L
S
E
L
D
Q
Site 47
S275
S
Q
G
S
S
Q
L
S
E
L
D
Q
Y
H
E
Site 48
Y280
Q
L
S
E
L
D
Q
Y
H
E
Q
D
D
D
H
Site 49
S292
D
D
H
R
E
T
D
S
I
H
S
C
H
S
S
Site 50
S295
R
E
T
D
S
I
H
S
C
H
S
S
H
S
L
Site 51
S298
D
S
I
H
S
C
H
S
S
H
S
L
S
R
D
Site 52
S299
S
I
H
S
C
H
S
S
H
S
L
S
R
D
G
Site 53
S301
H
S
C
H
S
S
H
S
L
S
R
D
G
Q
A
Site 54
S303
C
H
S
S
H
S
L
S
R
D
G
Q
A
G
F
Site 55
T339
K
E
M
K
E
D
A
T
T
H
P
P
P
D
L
Site 56
T340
E
M
K
E
D
A
T
T
H
P
P
P
D
L
V
Site 57
S359
H
F
L
G
P
Q
E
S
F
P
E
E
N
A
S
Site 58
S366
S
F
P
E
E
N
A
S
S
P
F
T
Q
A
R
Site 59
S367
F
P
E
E
N
A
S
S
P
F
T
Q
A
R
A
Site 60
T370
E
N
A
S
S
P
F
T
Q
A
R
A
H
W
I
Site 61
T381
A
H
W
I
R
A
V
T
K
V
R
L
Q
L
Q
Site 62
S397
I
P
D
D
G
D
P
S
L
P
Q
W
L
P
E
Site 63
Y411
E
G
P
A
G
G
L
Y
G
I
D
S
M
P
D
Site 64
S415
G
G
L
Y
G
I
D
S
M
P
D
L
R
R
K
Site 65
S436
S
D
L
S
L
V
Q
S
R
K
A
G
I
T
S
Site 66
T442
Q
S
R
K
A
G
I
T
S
A
M
A
T
R
T
Site 67
T447
G
I
T
S
A
M
A
T
R
T
S
L
K
D
E
Site 68
S450
S
A
M
A
T
R
T
S
L
K
D
E
E
L
K
Site 69
S458
L
K
D
E
E
L
K
S
H
V
Y
K
K
T
L
Site 70
Y461
E
E
L
K
S
H
V
Y
K
K
T
L
Q
A
L
Site 71
T464
K
S
H
V
Y
K
K
T
L
Q
A
L
I
Y
P
Site 72
T487
F
E
V
W
T
A
T
T
P
T
Y
C
Y
E
C
Site 73
Y490
W
T
A
T
T
P
T
Y
C
Y
E
C
E
G
L
Site 74
Y492
A
T
T
P
T
Y
C
Y
E
C
E
G
L
L
W
Site 75
S535
L
Q
R
A
A
E
K
S
C
K
H
G
A
E
D
Site 76
T586
A
H
V
Q
Q
M
K
T
V
K
Q
S
V
L
D
Site 77
T595
K
Q
S
V
L
D
G
T
S
K
W
S
A
K
I
Site 78
S596
Q
S
V
L
D
G
T
S
K
W
S
A
K
I
T
Site 79
T618
G
L
Q
A
K
D
K
T
G
S
S
D
P
Y
V
Site 80
S621
A
K
D
K
T
G
S
S
D
P
Y
V
T
V
Q
Site 81
Y624
K
T
G
S
S
D
P
Y
V
T
V
Q
V
S
K
Site 82
T626
G
S
S
D
P
Y
V
T
V
Q
V
S
K
T
K
Site 83
T638
K
T
K
K
R
T
K
T
I
F
G
N
L
N
P
Site 84
S675
D
E
D
D
D
I
K
S
R
V
K
Q
R
L
K
Site 85
S685
K
Q
R
L
K
R
E
S
D
D
F
L
G
Q
T
Site 86
Y707
S
G
E
M
D
V
W
Y
N
L
E
K
R
T
D
Site 87
S716
L
E
K
R
T
D
K
S
A
V
S
G
A
I
R
Site 88
S719
R
T
D
K
S
A
V
S
G
A
I
R
L
Q
I
Site 89
S727
G
A
I
R
L
Q
I
S
V
E
I
K
G
E
E
Site 90
Y739
G
E
E
K
V
A
P
Y
H
V
Q
Y
T
C
L
Site 91
Y743
V
A
P
Y
H
V
Q
Y
T
C
L
H
E
N
L
Site 92
Y753
L
H
E
N
L
F
H
Y
L
T
D
I
Q
G
S
Site 93
T755
E
N
L
F
H
Y
L
T
D
I
Q
G
S
G
G
Site 94
Y777
G
D
D
A
W
K
V
Y
F
D
E
T
A
Q
E
Site 95
Y793
V
D
E
F
A
M
R
Y
G
I
E
S
I
Y
Q
Site 96
Y799
R
Y
G
I
E
S
I
Y
Q
A
M
T
H
F
A
Site 97
S838
Y
Y
A
H
T
T
A
S
T
N
V
S
A
S
D
Site 98
S842
T
T
A
S
T
N
V
S
A
S
D
R
F
A
A
Site 99
S844
A
S
T
N
V
S
A
S
D
R
F
A
A
S
N
Site 100
S867
L
L
D
Q
L
H
N
S
L
R
I
D
L
S
T
Site 101
S873
N
S
L
R
I
D
L
S
T
Y
R
N
N
F
P
Site 102
T874
S
L
R
I
D
L
S
T
Y
R
N
N
F
P
A
Site 103
Y875
L
R
I
D
L
S
T
Y
R
N
N
F
P
A
G
Site 104
S883
R
N
N
F
P
A
G
S
P
E
R
L
Q
D
L
Site 105
S892
E
R
L
Q
D
L
K
S
T
V
D
L
L
T
S
Site 106
T893
R
L
Q
D
L
K
S
T
V
D
L
L
T
S
I
Site 107
S912
M
K
V
Q
E
L
Q
S
P
P
R
A
S
Q
V
Site 108
S917
L
Q
S
P
P
R
A
S
Q
V
V
K
D
C
V
Site 109
Y932
K
A
C
L
N
S
T
Y
E
Y
I
F
N
N
C
Site 110
Y943
F
N
N
C
H
D
L
Y
S
R
Q
Y
Q
L
K
Site 111
Y947
H
D
L
Y
S
R
Q
Y
Q
L
K
Q
E
L
P
Site 112
S961
P
P
E
E
Q
G
P
S
I
R
N
L
D
F
W
Site 113
S985
I
I
E
E
D
K
N
S
Y
T
P
V
L
N
Q
Site 114
T987
E
E
D
K
N
S
Y
T
P
V
L
N
Q
F
P
Site 115
Y1017
L
F
A
Q
D
M
K
Y
A
L
E
E
H
E
K
Site 116
Y1033
H
L
C
K
S
A
D
Y
M
N
L
H
F
K
V
Site 117
Y1047
V
K
W
L
H
N
E
Y
V
R
D
L
P
V
L
Site 118
Y1061
L
Q
G
Q
V
P
E
Y
P
A
W
F
E
Q
F
Site 119
S1080
L
D
E
N
E
D
V
S
L
E
F
L
R
G
A
Site 120
S1132
K
L
E
C
P
D
P
S
I
L
A
H
Y
M
R
Site 121
Y1137
D
P
S
I
L
A
H
Y
M
R
R
F
A
K
T
Site 122
T1144
Y
M
R
R
F
A
K
T
I
G
K
V
L
M
Q
Site 123
Y1163
L
S
K
D
F
P
A
Y
C
T
K
E
K
L
P
Site 124
S1203
L
D
L
E
A
A
D
S
L
K
E
L
Q
V
K
Site 125
T1247
I
L
G
Q
V
R
G
T
G
N
A
S
P
D
A
Site 126
S1251
V
R
G
T
G
N
A
S
P
D
A
R
A
S
A
Site 127
S1257
A
S
P
D
A
R
A
S
A
A
Q
D
A
D
S
Site 128
S1264
S
A
A
Q
D
A
D
S
V
L
R
P
L
M
D
Site 129
T1324
T
G
T
Q
L
I
F
T
A
A
K
E
L
S
H
Site 130
S1330
F
T
A
A
K
E
L
S
H
L
S
K
L
K
D
Site 131
T1344
D
H
M
V
R
E
E
T
R
N
L
T
P
K
Q
Site 132
T1348
R
E
E
T
R
N
L
T
P
K
Q
C
A
V
L
Site 133
Y1365
A
L
D
T
I
K
Q
Y
F
H
A
G
G
N
G
Site 134
T1376
G
G
N
G
L
K
K
T
F
L
E
K
S
P
D
Site 135
S1381
K
K
T
F
L
E
K
S
P
D
L
Q
S
L
R
Site 136
S1386
E
K
S
P
D
L
Q
S
L
R
Y
A
L
S
L
Site 137
Y1389
P
D
L
Q
S
L
R
Y
A
L
S
L
Y
T
Q
Site 138
S1392
Q
S
L
R
Y
A
L
S
L
Y
T
Q
T
T
D
Site 139
Y1394
L
R
Y
A
L
S
L
Y
T
Q
T
T
D
T
L
Site 140
T1400
L
Y
T
Q
T
T
D
T
L
I
K
T
F
V
R
Site 141
T1404
T
T
D
T
L
I
K
T
F
V
R
S
Q
T
T
Site 142
S1408
L
I
K
T
F
V
R
S
Q
T
T
Q
G
S
G
Site 143
T1410
K
T
F
V
R
S
Q
T
T
Q
G
S
G
V
D
Site 144
S1414
R
S
Q
T
T
Q
G
S
G
V
D
D
P
V
G
Site 145
T1431
S
I
Q
V
D
L
F
T
H
P
G
T
G
E
H
Site 146
T1441
G
T
G
E
H
K
V
T
V
K
V
V
A
A
N
Site 147
S1472
T
M
V
G
P
H
Q
S
D
K
K
R
K
F
T
Site 148
T1479
S
D
K
K
R
K
F
T
T
K
S
K
S
N
N
Site 149
T1480
D
K
K
R
K
F
T
T
K
S
K
S
N
N
W
Site 150
S1482
K
R
K
F
T
T
K
S
K
S
N
N
W
A
P
Site 151
S1484
K
F
T
T
K
S
K
S
N
N
W
A
P
K
Y
Site 152
Y1491
S
N
N
W
A
P
K
Y
N
E
T
F
H
F
L
Site 153
S1507
G
N
E
E
G
P
E
S
Y
E
L
Q
I
C
V
Site 154
Y1517
L
Q
I
C
V
K
D
Y
C
F
A
R
E
D
R
Site 155
T1557
R
K
I
H
M
D
E
T
G
L
T
I
L
R
I
Site 156
S1566
L
T
I
L
R
I
L
S
Q
R
S
N
D
E
V
Site 157
S1582
R
E
F
V
K
L
K
S
E
S
R
S
T
E
E
Site 158
S1586
K
L
K
S
E
S
R
S
T
E
E
G
S
_
_
Site 159
T1587
L
K
S
E
S
R
S
T
E
E
G
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation