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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPEF2
Full Name:
Serine/threonine-protein phosphatase with EF-hands 2
Alias:
Type:
Mass (Da):
86518
Number AA:
753
UniProt ID:
O14830
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y30
A
A
L
I
Q
R
W
Y
R
R
Y
V
A
R
L
Site 2
Y33
I
Q
R
W
Y
R
R
Y
V
A
R
L
E
M
R
Site 3
T85
H
N
D
R
D
F
L
T
R
I
F
T
E
D
R
Site 4
T89
D
F
L
T
R
I
F
T
E
D
R
F
A
Q
D
Site 5
S97
E
D
R
F
A
Q
D
S
E
M
K
K
C
S
D
Site 6
S103
D
S
E
M
K
K
C
S
D
Y
E
S
I
E
V
Site 7
Y105
E
M
K
K
C
S
D
Y
E
S
I
E
V
P
D
Site 8
S107
K
K
C
S
D
Y
E
S
I
E
V
P
D
S
Y
Site 9
S113
E
S
I
E
V
P
D
S
Y
T
G
P
R
L
S
Site 10
Y114
S
I
E
V
P
D
S
Y
T
G
P
R
L
S
F
Site 11
T115
I
E
V
P
D
S
Y
T
G
P
R
L
S
F
P
Site 12
S120
S
Y
T
G
P
R
L
S
F
P
L
L
P
D
H
Site 13
Y145
K
Q
Q
L
H
A
R
Y
V
L
N
L
L
Y
E
Site 14
Y151
R
Y
V
L
N
L
L
Y
E
T
K
K
H
L
V
Site 15
S167
L
P
N
I
N
R
V
S
T
C
Y
S
E
E
I
Site 16
T168
P
N
I
N
R
V
S
T
C
Y
S
E
E
I
T
Site 17
S171
N
R
V
S
T
C
Y
S
E
E
I
T
V
C
G
Site 18
S198
F
Y
K
N
G
L
P
S
P
E
R
S
Y
V
F
Site 19
S202
G
L
P
S
P
E
R
S
Y
V
F
N
G
D
F
Site 20
Y203
L
P
S
P
E
R
S
Y
V
F
N
G
D
F
V
Site 21
T253
V
N
L
R
Y
G
F
T
K
E
V
M
N
K
Y
Site 22
Y260
T
K
E
V
M
N
K
Y
K
V
H
G
K
E
I
Site 23
T299
H
G
G
V
S
D
I
T
D
L
E
L
L
D
K
Site 24
S310
L
L
D
K
I
E
R
S
K
I
V
S
T
M
R
Site 25
S314
I
E
R
S
K
I
V
S
T
M
R
C
K
T
R
Site 26
T315
E
R
S
K
I
V
S
T
M
R
C
K
T
R
Q
Site 27
T320
V
S
T
M
R
C
K
T
R
Q
K
S
E
K
Q
Site 28
S324
R
C
K
T
R
Q
K
S
E
K
Q
M
E
E
K
Site 29
S338
K
R
R
A
N
Q
K
S
S
A
Q
G
P
I
P
Site 30
S351
I
P
W
F
L
P
E
S
R
S
L
P
S
S
P
Site 31
S353
W
F
L
P
E
S
R
S
L
P
S
S
P
L
R
Site 32
S357
E
S
R
S
L
P
S
S
P
L
R
L
G
S
Y
Site 33
S363
S
S
P
L
R
L
G
S
Y
K
A
Q
K
T
S
Site 34
Y364
S
P
L
R
L
G
S
Y
K
A
Q
K
T
S
R
Site 35
T369
G
S
Y
K
A
Q
K
T
S
R
S
S
S
I
P
Site 36
S370
S
Y
K
A
Q
K
T
S
R
S
S
S
I
P
C
Site 37
S372
K
A
Q
K
T
S
R
S
S
S
I
P
C
S
G
Site 38
S373
A
Q
K
T
S
R
S
S
S
I
P
C
S
G
S
Site 39
S374
Q
K
T
S
R
S
S
S
I
P
C
S
G
S
L
Site 40
S378
R
S
S
S
I
P
C
S
G
S
L
D
G
R
E
Site 41
S380
S
S
I
P
C
S
G
S
L
D
G
R
E
L
S
Site 42
S387
S
L
D
G
R
E
L
S
R
Q
V
R
S
S
V
Site 43
S393
L
S
R
Q
V
R
S
S
V
E
L
E
L
E
R
Site 44
S417
T
G
E
K
E
E
P
S
R
S
A
S
E
A
D
Site 45
S419
E
K
E
E
P
S
R
S
A
S
E
A
D
S
E
Site 46
S421
E
E
P
S
R
S
A
S
E
A
D
S
E
A
G
Site 47
S425
R
S
A
S
E
A
D
S
E
A
G
E
L
R
K
Site 48
T434
A
G
E
L
R
K
P
T
Q
E
E
W
R
Q
V
Site 49
S447
Q
V
V
D
I
L
W
S
D
P
M
A
Q
E
G
Site 50
T459
Q
E
G
C
K
A
N
T
I
R
G
G
G
C
Y
Site 51
Y466
T
I
R
G
G
G
C
Y
F
G
P
D
V
T
Q
Site 52
T472
C
Y
F
G
P
D
V
T
Q
Q
L
L
Q
K
Y
Site 53
Y479
T
Q
Q
L
L
Q
K
Y
N
M
Q
F
L
I
R
Site 54
T505
C
H
N
R
K
V
L
T
I
F
S
A
S
N
Y
Site 55
S508
R
K
V
L
T
I
F
S
A
S
N
Y
Y
E
V
Site 56
Y512
T
I
F
S
A
S
N
Y
Y
E
V
G
S
N
R
Site 57
Y513
I
F
S
A
S
N
Y
Y
E
V
G
S
N
R
G
Site 58
S517
S
N
Y
Y
E
V
G
S
N
R
G
A
Y
V
K
Site 59
T530
V
K
L
G
P
A
L
T
P
H
I
V
Q
Y
Q
Site 60
Y536
L
T
P
H
I
V
Q
Y
Q
A
N
K
V
T
H
Site 61
T546
N
K
V
T
H
T
L
T
M
R
Q
R
I
S
R
Site 62
S552
L
T
M
R
Q
R
I
S
R
V
E
E
S
A
L
Site 63
S557
R
I
S
R
V
E
E
S
A
L
R
A
L
R
E
Site 64
S570
R
E
K
L
F
A
H
S
S
D
L
L
S
E
F
Site 65
S571
E
K
L
F
A
H
S
S
D
L
L
S
E
F
K
Site 66
S575
A
H
S
S
D
L
L
S
E
F
K
K
H
D
A
Site 67
S617
L
R
P
Q
L
V
N
S
S
A
D
N
M
L
E
Site 68
S618
R
P
Q
L
V
N
S
S
A
D
N
M
L
E
Y
Site 69
Y625
S
A
D
N
M
L
E
Y
K
S
W
L
K
N
L
Site 70
S638
N
L
A
K
E
Q
L
S
R
E
N
I
Q
S
S
Site 71
S644
L
S
R
E
N
I
Q
S
S
L
L
E
T
L
Y
Site 72
S645
S
R
E
N
I
Q
S
S
L
L
E
T
L
Y
R
Site 73
T649
I
Q
S
S
L
L
E
T
L
Y
R
N
R
S
N
Site 74
Y651
S
S
L
L
E
T
L
Y
R
N
R
S
N
L
E
Site 75
S655
E
T
L
Y
R
N
R
S
N
L
E
T
I
F
R
Site 76
T659
R
N
R
S
N
L
E
T
I
F
R
I
I
D
S
Site 77
S669
R
I
I
D
S
D
H
S
G
F
I
S
L
D
E
Site 78
S673
S
D
H
S
G
F
I
S
L
D
E
F
R
Q
T
Site 79
T680
S
L
D
E
F
R
Q
T
W
K
L
F
S
S
H
Site 80
S727
A
F
R
L
V
E
K
S
C
P
E
G
D
A
S
Site 81
S734
S
C
P
E
G
D
A
S
E
C
P
Q
A
T
N
Site 82
S745
Q
A
T
N
A
K
D
S
G
C
S
S
P
G
A
Site 83
S748
N
A
K
D
S
G
C
S
S
P
G
A
H
_
_
Site 84
S749
A
K
D
S
G
C
S
S
P
G
A
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation