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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OPLAH
Full Name:
5-oxoprolinase
Alias:
5-oxo-L-prolinase
Type:
Mass (Da):
137439
Number AA:
1288
UniProt ID:
O14841
International Prot ID:
IPI00418382
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0016787
GO:0016810
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
I
D
R
G
G
T
F
T
D
V
F
A
Q
C
P
Site 2
S37
V
R
V
L
K
L
L
S
E
D
P
A
N
Y
A
Site 3
S71
P
R
D
Q
P
L
D
S
S
H
I
A
S
I
R
Site 4
S72
R
D
Q
P
L
D
S
S
H
I
A
S
I
R
M
Site 5
T81
I
A
S
I
R
M
G
T
T
V
A
T
N
A
L
Site 6
T82
A
S
I
R
M
G
T
T
V
A
T
N
A
L
L
Site 7
T112
R
D
L
L
H
I
G
T
Q
A
R
G
D
L
F
Site 8
T149
L
H
R
G
E
A
G
T
G
T
P
V
K
G
R
Site 9
T151
R
G
E
A
G
T
G
T
P
V
K
G
R
T
G
Site 10
T214
L
A
R
E
L
G
F
T
H
V
S
L
S
S
E
Site 11
Y240
H
T
A
C
A
D
A
Y
L
T
P
A
I
Q
R
Site 12
Y248
L
T
P
A
I
Q
R
Y
V
Q
G
F
C
R
G
Site 13
S283
P
M
D
T
F
S
G
S
S
A
V
L
S
G
P
Site 14
Y302
V
G
Y
S
A
T
T
Y
Q
Q
E
G
G
Q
P
Site 15
S319
G
F
D
M
G
G
T
S
T
D
V
S
R
Y
A
Site 16
S323
G
G
T
S
T
D
V
S
R
Y
A
G
E
F
E
Site 17
Y383
A
H
P
G
P
A
C
Y
R
K
G
G
P
V
T
Site 18
S419
P
G
E
N
Q
P
L
S
P
E
A
S
R
K
A
Site 19
S423
Q
P
L
S
P
E
A
S
R
K
A
L
E
A
V
Site 20
T439
T
E
V
N
S
F
L
T
N
G
P
C
P
A
S
Site 21
S446
T
N
G
P
C
P
A
S
P
L
S
L
E
E
V
Site 22
T473
C
R
P
I
R
A
L
T
Q
A
R
G
H
D
P
Site 23
S481
Q
A
R
G
H
D
P
S
A
H
V
L
A
C
F
Site 24
T507
A
R
A
L
G
M
D
T
V
H
I
H
R
H
S
Site 25
S536
H
E
A
Q
E
P
C
S
L
L
Y
A
P
E
T
Site 26
T543
S
L
L
Y
A
P
E
T
F
V
Q
L
D
Q
R
Site 27
S552
V
Q
L
D
Q
R
L
S
R
L
E
E
Q
C
V
Site 28
S570
Q
A
Q
G
F
P
R
S
Q
I
S
T
E
S
F
Site 29
S573
G
F
P
R
S
Q
I
S
T
E
S
F
L
H
L
Site 30
T574
F
P
R
S
Q
I
S
T
E
S
F
L
H
L
R
Site 31
S576
R
S
Q
I
S
T
E
S
F
L
H
L
R
Y
Q
Site 32
T599
S
A
H
Q
H
P
A
T
A
R
S
P
R
A
G
Site 33
S602
Q
H
P
A
T
A
R
S
P
R
A
G
D
F
G
Site 34
T639
D
D
V
R
V
R
G
T
G
R
S
G
L
R
L
Site 35
S642
R
V
R
G
T
G
R
S
G
L
R
L
E
D
A
Site 36
Y666
V
D
K
M
T
Q
C
Y
F
E
G
G
Y
Q
E
Site 37
T674
F
E
G
G
Y
Q
E
T
P
V
Y
L
L
A
E
Site 38
Y677
G
Y
Q
E
T
P
V
Y
L
L
A
E
L
G
Y
Site 39
S747
I
F
S
H
R
F
M
S
I
A
E
Q
M
G
R
Site 40
T759
M
G
R
I
L
Q
R
T
A
I
S
T
N
I
K
Site 41
T763
L
Q
R
T
A
I
S
T
N
I
K
E
R
L
D
Site 42
S772
I
K
E
R
L
D
F
S
C
A
L
F
G
P
D
Site 43
S819
H
P
G
D
V
L
L
S
N
H
P
S
A
G
G
Site 44
S823
V
L
L
S
N
H
P
S
A
G
G
S
H
L
P
Site 45
S827
N
H
P
S
A
G
G
S
H
L
P
D
L
T
V
Site 46
Y849
G
Q
T
R
P
V
F
Y
V
A
S
R
G
H
H
Site 47
T863
H
A
D
I
G
G
I
T
P
G
S
M
P
P
H
Site 48
S866
I
G
G
I
T
P
G
S
M
P
P
H
S
T
M
Site 49
S871
P
G
S
M
P
P
H
S
T
M
L
Q
Q
E
G
Site 50
T898
V
F
Q
E
E
A
V
T
E
A
L
R
A
P
G
Site 51
S911
P
G
K
V
P
N
C
S
G
T
R
N
L
H
D
Site 52
S921
R
N
L
H
D
N
L
S
D
L
R
A
Q
V
A
Site 53
T973
D
M
L
R
A
F
G
T
S
R
Q
A
R
G
L
Site 54
S974
M
L
R
A
F
G
T
S
R
Q
A
R
G
L
P
Site 55
S985
R
G
L
P
L
E
V
S
S
E
D
H
M
D
D
Site 56
S994
E
D
H
M
D
D
G
S
P
I
R
L
R
V
Q
Site 57
S1065
R
V
V
I
P
R
G
S
I
L
D
P
S
P
E
Site 58
Y1116
L
G
N
A
H
M
G
Y
Y
E
T
V
A
G
G
Site 59
Y1117
G
N
A
H
M
G
Y
Y
E
T
V
A
G
G
A
Site 60
S1129
G
G
A
G
A
G
P
S
W
H
G
R
S
G
V
Site 61
S1134
G
P
S
W
H
G
R
S
G
V
H
S
H
M
T
Site 62
S1138
H
G
R
S
G
V
H
S
H
M
T
N
T
R
I
Site 63
T1141
S
G
V
H
S
H
M
T
N
T
R
I
T
D
P
Site 64
T1146
H
M
T
N
T
R
I
T
D
P
E
I
L
E
S
Site 65
S1153
T
D
P
E
I
L
E
S
R
Y
P
V
I
L
R
Site 66
Y1155
P
E
I
L
E
S
R
Y
P
V
I
L
R
R
F
Site 67
S1168
R
F
E
L
R
R
G
S
G
G
R
G
R
F
R
Site 68
S1193
F
R
E
E
A
L
L
S
V
L
T
E
R
R
A
Site 69
T1196
E
A
L
L
S
V
L
T
E
R
R
A
F
R
P
Site 70
Y1204
E
R
R
A
F
R
P
Y
G
L
H
G
G
E
P
Site 71
T1226
L
I
R
K
N
G
R
T
V
N
L
G
G
K
T
Site 72
S1234
V
N
L
G
G
K
T
S
V
T
V
Y
P
G
D
Site 73
Y1253
H
T
P
G
G
G
G
Y
G
D
P
E
D
P
A
Site 74
S1265
D
P
A
P
P
P
G
S
P
P
Q
A
L
A
F
Site 75
S1277
L
A
F
P
E
H
G
S
V
Y
E
Y
R
R
A
Site 76
Y1279
F
P
E
H
G
S
V
Y
E
Y
R
R
A
Q
E
Site 77
Y1281
E
H
G
S
V
Y
E
Y
R
R
A
Q
E
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation