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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRF-6
Full Name:
Interferon regulatory factor 6
Alias:
Type:
Nucleus protein
Mass (Da):
53130
Number AA:
467
UniProt ID:
O14896
International Prot ID:
IPI00024290
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0060644
GO:0008285
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
W
K
H
A
T
R
H
S
P
Q
Q
E
E
E
N
Site 2
T55
P
Q
Q
E
E
E
N
T
I
F
K
A
W
A
V
Site 3
Y67
W
A
V
E
T
G
K
Y
Q
E
G
V
D
D
P
Site 4
Y97
S
R
E
F
N
L
M
Y
D
G
T
K
E
V
P
Site 5
T100
F
N
L
M
Y
D
G
T
K
E
V
P
M
N
P
Site 6
Y111
P
M
N
P
V
K
I
Y
Q
V
C
D
I
P
Q
Site 7
S122
D
I
P
Q
P
Q
G
S
I
I
N
P
G
S
T
Site 8
S128
G
S
I
I
N
P
G
S
T
G
S
A
P
W
D
Site 9
S153
E
E
D
E
L
D
Q
S
Q
H
H
V
P
I
Q
Site 10
S182
P
A
S
V
G
N
C
S
V
G
N
C
S
P
E
Site 11
S187
N
C
S
V
G
N
C
S
P
E
A
V
W
P
K
Site 12
T195
P
E
A
V
W
P
K
T
E
P
L
E
M
E
V
Site 13
Y211
Q
A
P
I
Q
P
F
Y
S
S
P
E
L
W
I
Site 14
S213
P
I
Q
P
F
Y
S
S
P
E
L
W
I
S
S
Site 15
S219
S
S
P
E
L
W
I
S
S
L
P
M
T
D
L
Site 16
S220
S
P
E
L
W
I
S
S
L
P
M
T
D
L
D
Site 17
T224
W
I
S
S
L
P
M
T
D
L
D
I
K
F
Q
Site 18
T240
R
G
K
E
Y
G
Q
T
M
T
V
S
N
P
Q
Site 19
T242
K
E
Y
G
Q
T
M
T
V
S
N
P
Q
G
C
Site 20
Y253
P
Q
G
C
R
L
F
Y
G
D
L
G
P
M
P
Site 21
S270
E
E
L
F
G
P
V
S
L
E
Q
V
K
F
P
Site 22
Y312
E
V
S
G
H
A
I
Y
A
I
R
L
C
Q
C
Site 23
Y372
K
Q
P
P
F
E
I
Y
L
C
F
G
E
E
W
Site 24
T411
E
M
F
S
G
D
F
T
R
S
F
D
S
G
S
Site 25
S413
F
S
G
D
F
T
R
S
F
D
S
G
S
V
R
Site 26
S416
D
F
T
R
S
F
D
S
G
S
V
R
L
Q
I
Site 27
S418
T
R
S
F
D
S
G
S
V
R
L
Q
I
S
T
Site 28
T425
S
V
R
L
Q
I
S
T
P
D
I
K
D
N
I
Site 29
S448
R
I
L
Q
T
Q
E
S
W
Q
P
M
Q
P
T
Site 30
T455
S
W
Q
P
M
Q
P
T
P
S
M
Q
L
P
P
Site 31
S457
Q
P
M
Q
P
T
P
S
M
Q
L
P
P
A
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation