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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TIEG2
Full Name:
Krueppel-like factor 11
Alias:
Transforming growth factor-beta-inducible early growth response protein 2
Type:
Transcription protein
Mass (Da):
55139
Number AA:
512
UniProt ID:
O14901
International Prot ID:
IPI00024692
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008285
GO:0000122
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
E
R
K
R
H
D
S
E
R
S
T
C
S
I
Site 2
S35
K
R
H
D
S
E
R
S
T
C
S
I
L
E
Q
Site 3
T36
R
H
D
S
E
R
S
T
C
S
I
L
E
Q
T
Site 4
S56
E
A
L
V
C
M
S
S
W
G
Q
R
S
Q
K
Site 5
S61
M
S
S
W
G
Q
R
S
Q
K
G
D
L
L
R
Site 6
T73
L
L
R
I
R
P
L
T
P
V
S
D
S
G
D
Site 7
S76
I
R
P
L
T
P
V
S
D
S
G
D
V
T
T
Site 8
S78
P
L
T
P
V
S
D
S
G
D
V
T
T
T
V
Site 9
T82
V
S
D
S
G
D
V
T
T
T
V
H
M
D
A
Site 10
T83
S
D
S
G
D
V
T
T
T
V
H
M
D
A
A
Site 11
T84
D
S
G
D
V
T
T
T
V
H
M
D
A
A
T
Site 12
T91
T
V
H
M
D
A
A
T
P
E
L
P
K
D
F
Site 13
S102
P
K
D
F
H
S
L
S
T
L
C
I
T
P
P
Site 14
T103
K
D
F
H
S
L
S
T
L
C
I
T
P
P
Q
Site 15
T107
S
L
S
T
L
C
I
T
P
P
Q
S
P
D
L
Site 16
S111
L
C
I
T
P
P
Q
S
P
D
L
V
E
P
S
Site 17
S118
S
P
D
L
V
E
P
S
T
R
T
P
V
S
P
Site 18
T119
P
D
L
V
E
P
S
T
R
T
P
V
S
P
Q
Site 19
T121
L
V
E
P
S
T
R
T
P
V
S
P
Q
V
T
Site 20
S124
P
S
T
R
T
P
V
S
P
Q
V
T
D
S
K
Site 21
T128
T
P
V
S
P
Q
V
T
D
S
K
A
C
T
A
Site 22
S130
V
S
P
Q
V
T
D
S
K
A
C
T
A
T
D
Site 23
T134
V
T
D
S
K
A
C
T
A
T
D
V
L
Q
S
Site 24
S165
L
G
L
E
P
V
P
S
S
P
C
R
A
K
G
Site 25
S166
G
L
E
P
V
P
S
S
P
C
R
A
K
G
T
Site 26
S174
P
C
R
A
K
G
T
S
V
I
R
H
T
G
E
Site 27
T179
G
T
S
V
I
R
H
T
G
E
S
P
A
A
C
Site 28
S182
V
I
R
H
T
G
E
S
P
A
A
C
F
P
T
Site 29
T192
A
C
F
P
T
I
Q
T
P
D
C
R
L
S
D
Site 30
S198
Q
T
P
D
C
R
L
S
D
S
R
E
G
E
E
Site 31
S200
P
D
C
R
L
S
D
S
R
E
G
E
E
Q
L
Site 32
T220
T
L
Q
D
T
H
L
T
D
S
L
L
S
T
N
Site 33
S222
Q
D
T
H
L
T
D
S
L
L
S
T
N
L
V
Site 34
T244
K
S
G
G
L
L
L
T
D
K
G
Q
Q
A
G
Site 35
T258
G
W
P
G
A
V
Q
T
C
S
P
K
N
Y
E
Site 36
S260
P
G
A
V
Q
T
C
S
P
K
N
Y
E
N
D
Site 37
Y264
Q
T
C
S
P
K
N
Y
E
N
D
L
P
R
K
Site 38
T272
E
N
D
L
P
R
K
T
T
P
L
I
S
V
S
Site 39
T273
N
D
L
P
R
K
T
T
P
L
I
S
V
S
V
Site 40
S277
R
K
T
T
P
L
I
S
V
S
V
P
A
P
P
Site 41
S310
L
K
P
P
P
Q
L
S
V
G
T
V
R
P
I
Site 42
Y394
D
F
S
R
R
R
N
Y
V
C
S
F
P
G
C
Site 43
S397
R
R
R
N
Y
V
C
S
F
P
G
C
R
K
T
Site 44
T404
S
F
P
G
C
R
K
T
Y
F
K
S
S
H
L
Site 45
Y405
F
P
G
C
R
K
T
Y
F
K
S
S
H
L
K
Site 46
S408
C
R
K
T
Y
F
K
S
S
H
L
K
A
H
L
Site 47
T417
H
L
K
A
H
L
R
T
H
T
G
E
K
P
F
Site 48
T419
K
A
H
L
R
T
H
T
G
E
K
P
F
N
C
Site 49
S438
C
D
K
K
F
A
R
S
D
E
L
S
R
H
R
Site 50
S442
F
A
R
S
D
E
L
S
R
H
R
R
T
H
T
Site 51
T447
E
L
S
R
H
R
R
T
H
T
G
E
K
K
F
Site 52
T449
S
R
H
R
R
T
H
T
G
E
K
K
F
V
C
Site 53
T478
K
H
A
R
R
H
M
T
T
K
K
I
P
G
W
Site 54
S497
G
K
L
N
R
I
A
S
A
E
S
P
G
S
P
Site 55
S500
N
R
I
A
S
A
E
S
P
G
S
P
L
V
S
Site 56
S503
A
S
A
E
S
P
G
S
P
L
V
S
M
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation