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Updated November 2019
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Protein Info
Short Name:
RGS12
Full Name:
Regulator of G-protein signaling 12
Alias:
Type:
GTPase activating protein, misc.
Mass (Da):
156357
Number AA:
1447
UniProt ID:
O14924
International Prot ID:
IPI00024714
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000794
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
GO:0005057
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
F
R
A
G
E
A
S
K
R
P
L
P
G
P
Site 2
S16
K
R
P
L
P
G
P
S
P
P
R
V
R
S
V
Site 3
S22
P
S
P
P
R
V
R
S
V
E
V
A
R
G
R
Site 4
Y32
V
A
R
G
R
A
G
Y
G
F
T
L
S
G
Q
Site 5
S104
E
G
V
G
R
F
E
S
C
S
S
D
E
E
G
Site 6
S106
V
G
R
F
E
S
C
S
S
D
E
E
G
G
L
Site 7
S107
G
R
F
E
S
C
S
S
D
E
E
G
G
L
Y
Site 8
Y114
S
D
E
E
G
G
L
Y
E
G
K
G
W
L
K
Site 9
S126
W
L
K
P
K
L
D
S
K
A
L
G
I
N
R
Site 10
S155
N
M
I
F
E
N
P
S
L
C
A
S
N
S
E
Site 11
S159
E
N
P
S
L
C
A
S
N
S
E
P
L
K
L
Site 12
S161
P
S
L
C
A
S
N
S
E
P
L
K
L
K
Q
Site 13
S170
P
L
K
L
K
Q
R
S
L
S
E
S
A
A
T
Site 14
S172
K
L
K
Q
R
S
L
S
E
S
A
A
T
R
F
Site 15
S174
K
Q
R
S
L
S
E
S
A
A
T
R
F
D
V
Site 16
T177
S
L
S
E
S
A
A
T
R
F
D
V
G
H
E
Site 17
S195
N
P
N
P
N
M
L
S
K
E
E
I
S
K
V
Site 18
S210
I
H
D
D
S
V
F
S
I
G
L
E
S
H
D
Site 19
S242
L
G
S
I
E
L
P
S
T
S
S
N
L
E
S
Site 20
T243
G
S
I
E
L
P
S
T
S
S
N
L
E
S
D
Site 21
S244
S
I
E
L
P
S
T
S
S
N
L
E
S
D
S
Site 22
S245
I
E
L
P
S
T
S
S
N
L
E
S
D
S
L
Site 23
S249
S
T
S
S
N
L
E
S
D
S
L
Q
A
I
R
Site 24
S251
S
S
N
L
E
S
D
S
L
Q
A
I
R
G
C
Site 25
T319
F
G
L
V
T
M
Q
T
N
D
D
G
S
L
A
Site 26
S324
M
Q
T
N
D
D
G
S
L
A
Q
E
E
E
G
Site 27
S336
E
E
G
A
L
R
T
S
C
H
V
F
M
V
D
Site 28
T364
R
R
F
G
F
E
C
T
A
D
P
D
T
N
G
Site 29
T369
E
C
T
A
D
P
D
T
N
G
C
L
E
F
P
Site 30
S417
A
D
A
H
Q
N
N
S
T
S
S
N
S
D
S
Site 31
T418
D
A
H
Q
N
N
S
T
S
S
N
S
D
S
G
Site 32
S419
A
H
Q
N
N
S
T
S
S
N
S
D
S
G
I
Site 33
S420
H
Q
N
N
S
T
S
S
N
S
D
S
G
I
G
Site 34
S422
N
N
S
T
S
S
N
S
D
S
G
I
G
N
F
Site 35
S424
S
T
S
S
N
S
D
S
G
I
G
N
F
H
Q
Site 36
S435
N
F
H
Q
E
E
K
S
N
R
V
L
V
V
D
Site 37
S446
L
V
V
D
L
G
G
S
S
S
R
H
G
P
G
Site 38
S447
V
V
D
L
G
G
S
S
S
R
H
G
P
G
G
Site 39
S448
V
D
L
G
G
S
S
S
R
H
G
P
G
G
S
Site 40
S455
S
R
H
G
P
G
G
S
A
W
D
G
V
G
G
Site 41
S483
F
C
P
D
P
E
G
S
P
P
F
E
A
A
H
Site 42
S506
N
K
H
L
G
P
A
S
P
V
E
V
P
P
A
Site 43
S514
P
V
E
V
P
P
A
S
L
R
S
S
V
P
P
Site 44
S517
V
P
P
A
S
L
R
S
S
V
P
P
S
K
R
Site 45
S518
P
P
A
S
L
R
S
S
V
P
P
S
K
R
G
Site 46
S522
L
R
S
S
V
P
P
S
K
R
G
T
V
G
A
Site 47
T526
V
P
P
S
K
R
G
T
V
G
A
G
C
G
F
Site 48
S556
G
H
T
S
D
Q
D
S
Y
T
D
S
T
D
G
Site 49
Y557
H
T
S
D
Q
D
S
Y
T
D
S
T
D
G
W
Site 50
T558
T
S
D
Q
D
S
Y
T
D
S
T
D
G
W
S
Site 51
S560
D
Q
D
S
Y
T
D
S
T
D
G
W
S
S
I
Site 52
T561
Q
D
S
Y
T
D
S
T
D
G
W
S
S
I
N
Site 53
S566
D
S
T
D
G
W
S
S
I
N
C
G
T
L
P
Site 54
T571
W
S
S
I
N
C
G
T
L
P
P
P
M
S
K
Site 55
S577
G
T
L
P
P
P
M
S
K
I
P
A
D
R
Y
Site 56
Y584
S
K
I
P
A
D
R
Y
R
V
E
G
S
F
A
Site 57
S589
D
R
Y
R
V
E
G
S
F
A
Q
P
P
L
N
Site 58
S603
N
A
P
K
R
E
W
S
R
K
A
F
G
M
Q
Site 59
S611
R
K
A
F
G
M
Q
S
I
F
G
P
H
R
N
Site 60
T622
P
H
R
N
V
R
K
T
K
E
D
K
K
G
S
Site 61
S629
T
K
E
D
K
K
G
S
K
F
G
R
G
T
G
Site 62
T635
G
S
K
F
G
R
G
T
G
L
T
Q
P
S
Q
Site 63
T638
F
G
R
G
T
G
L
T
Q
P
S
Q
R
T
S
Site 64
S641
G
T
G
L
T
Q
P
S
Q
R
T
S
A
R
R
Site 65
S645
T
Q
P
S
Q
R
T
S
A
R
R
S
F
G
R
Site 66
S649
Q
R
T
S
A
R
R
S
F
G
R
S
K
R
F
Site 67
S653
A
R
R
S
F
G
R
S
K
R
F
S
I
T
R
Site 68
S657
F
G
R
S
K
R
F
S
I
T
R
S
L
D
D
Site 69
S661
K
R
F
S
I
T
R
S
L
D
D
L
E
S
A
Site 70
S667
R
S
L
D
D
L
E
S
A
T
V
S
D
G
E
Site 71
T669
L
D
D
L
E
S
A
T
V
S
D
G
E
L
T
Site 72
S671
D
L
E
S
A
T
V
S
D
G
E
L
T
G
A
Site 73
S685
A
D
L
K
D
C
V
S
N
N
S
L
S
S
N
Site 74
S688
K
D
C
V
S
N
N
S
L
S
S
N
A
S
L
Site 75
S690
C
V
S
N
N
S
L
S
S
N
A
S
L
P
S
Site 76
S691
V
S
N
N
S
L
S
S
N
A
S
L
P
S
V
Site 77
S694
N
S
L
S
S
N
A
S
L
P
S
V
Q
S
C
Site 78
S697
S
S
N
A
S
L
P
S
V
Q
S
C
R
R
L
Site 79
S700
A
S
L
P
S
V
Q
S
C
R
R
L
R
E
R
Site 80
S711
L
R
E
R
R
V
A
S
W
A
V
S
F
E
R
Site 81
S715
R
V
A
S
W
A
V
S
F
E
R
L
L
Q
D
Site 82
Y728
Q
D
P
V
G
V
R
Y
F
S
D
F
L
R
K
Site 83
S730
P
V
G
V
R
Y
F
S
D
F
L
R
K
E
F
Site 84
S738
D
F
L
R
K
E
F
S
E
E
N
I
L
F
W
Site 85
S763
A
H
D
K
K
E
L
S
Y
R
A
R
E
I
F
Site 86
T780
F
L
C
S
K
A
T
T
P
V
N
I
D
S
Q
Site 87
S786
T
T
P
V
N
I
D
S
Q
A
Q
L
A
D
D
Site 88
S818
F
N
L
M
K
F
D
S
Y
T
R
F
L
K
S
Site 89
Y819
N
L
M
K
F
D
S
Y
T
R
F
L
K
S
P
Site 90
T820
L
M
K
F
D
S
Y
T
R
F
L
K
S
P
L
Site 91
S825
S
Y
T
R
F
L
K
S
P
L
Y
Q
E
C
I
Site 92
Y828
R
F
L
K
S
P
L
Y
Q
E
C
I
L
A
E
Site 93
S844
E
G
R
A
L
P
D
S
Q
Q
V
P
S
S
P
Site 94
S849
P
D
S
Q
Q
V
P
S
S
P
A
S
K
H
S
Site 95
S850
D
S
Q
Q
V
P
S
S
P
A
S
K
H
S
L
Site 96
S853
Q
V
P
S
S
P
A
S
K
H
S
L
G
S
D
Site 97
S856
S
S
P
A
S
K
H
S
L
G
S
D
H
S
S
Site 98
S859
A
S
K
H
S
L
G
S
D
H
S
S
V
S
T
Site 99
S862
H
S
L
G
S
D
H
S
S
V
S
T
P
K
K
Site 100
S863
S
L
G
S
D
H
S
S
V
S
T
P
K
K
L
Site 101
S865
G
S
D
H
S
S
V
S
T
P
K
K
L
S
G
Site 102
T866
S
D
H
S
S
V
S
T
P
K
K
L
S
G
K
Site 103
S871
V
S
T
P
K
K
L
S
G
K
S
K
S
G
R
Site 104
S874
P
K
K
L
S
G
K
S
K
S
G
R
S
L
N
Site 105
S876
K
L
S
G
K
S
K
S
G
R
S
L
N
E
E
Site 106
S879
G
K
S
K
S
G
R
S
L
N
E
E
L
G
D
Site 107
S889
E
E
L
G
D
E
D
S
E
K
K
R
K
G
A
Site 108
S899
K
R
K
G
A
F
F
S
W
S
R
T
R
S
T
Site 109
S901
K
G
A
F
F
S
W
S
R
T
R
S
T
G
R
Site 110
T903
A
F
F
S
W
S
R
T
R
S
T
G
R
S
Q
Site 111
S905
F
S
W
S
R
T
R
S
T
G
R
S
Q
K
K
Site 112
T906
S
W
S
R
T
R
S
T
G
R
S
Q
K
K
R
Site 113
S909
R
T
R
S
T
G
R
S
Q
K
K
R
E
H
G
Site 114
S934
G
G
L
C
R
R
E
S
Q
G
S
V
S
S
A
Site 115
S937
C
R
R
E
S
Q
G
S
V
S
S
A
G
S
L
Site 116
S939
R
E
S
Q
G
S
V
S
S
A
G
S
L
D
L
Site 117
S940
E
S
Q
G
S
V
S
S
A
G
S
L
D
L
S
Site 118
S943
G
S
V
S
S
A
G
S
L
D
L
S
E
A
C
Site 119
T952
D
L
S
E
A
C
R
T
L
A
P
E
K
D
K
Site 120
S989
F
S
I
K
D
I
L
S
G
L
C
E
R
H
G
Site 121
S1019
P
L
V
L
H
Q
D
S
S
I
L
E
S
R
D
Site 122
S1020
L
V
L
H
Q
D
S
S
I
L
E
S
R
D
L
Site 123
S1024
Q
D
S
S
I
L
E
S
R
D
L
R
L
E
K
Site 124
T1033
D
L
R
L
E
K
R
T
L
F
R
L
D
L
V
Site 125
T1057
A
K
P
T
K
P
V
T
E
V
L
R
P
V
V
Site 126
S1079
S
G
L
L
V
R
L
S
G
E
K
E
P
L
D
Site 127
S1107
V
L
E
E
K
D
P
S
R
G
K
A
S
A
D
Site 128
T1125
G
V
P
V
K
Q
N
T
A
V
N
S
S
S
R
Site 129
S1129
K
Q
N
T
A
V
N
S
S
S
R
N
H
S
A
Site 130
S1130
Q
N
T
A
V
N
S
S
S
R
N
H
S
A
T
Site 131
S1131
N
T
A
V
N
S
S
S
R
N
H
S
A
T
G
Site 132
S1135
N
S
S
S
R
N
H
S
A
T
G
E
E
R
T
Site 133
T1137
S
S
R
N
H
S
A
T
G
E
E
R
T
L
G
Site 134
T1142
S
A
T
G
E
E
R
T
L
G
K
S
N
S
I
Site 135
S1146
E
E
R
T
L
G
K
S
N
S
I
K
I
K
G
Site 136
S1148
R
T
L
G
K
S
N
S
I
K
I
K
G
E
N
Site 137
S1165
N
A
R
D
P
R
L
S
K
R
E
E
S
I
A
Site 138
S1170
R
L
S
K
R
E
E
S
I
A
K
I
G
K
K
Site 139
Y1179
A
K
I
G
K
K
K
Y
Q
K
I
N
L
D
E
Site 140
S1199
E
L
I
S
K
A
Q
S
N
R
A
D
D
Q
R
Site 141
T1233
S
T
E
L
T
L
P
T
P
A
A
V
A
K
G
Site 142
S1242
A
A
V
A
K
G
F
S
K
R
S
A
T
G
N
Site 143
T1247
G
F
S
K
R
S
A
T
G
N
G
R
E
S
A
Site 144
S1253
A
T
G
N
G
R
E
S
A
S
Q
P
G
E
Q
Site 145
S1255
G
N
G
R
E
S
A
S
Q
P
G
E
Q
W
E
Site 146
S1267
Q
W
E
P
V
Q
E
S
S
D
S
P
S
T
S
Site 147
S1268
W
E
P
V
Q
E
S
S
D
S
P
S
T
S
P
Site 148
S1270
P
V
Q
E
S
S
D
S
P
S
T
S
P
G
S
Site 149
S1272
Q
E
S
S
D
S
P
S
T
S
P
G
S
A
S
Site 150
T1273
E
S
S
D
S
P
S
T
S
P
G
S
A
S
S
Site 151
S1274
S
S
D
S
P
S
T
S
P
G
S
A
S
S
P
Site 152
S1277
S
P
S
T
S
P
G
S
A
S
S
P
P
G
P
Site 153
S1279
S
T
S
P
G
S
A
S
S
P
P
G
P
P
G
Site 154
S1280
T
S
P
G
S
A
S
S
P
P
G
P
P
G
T
Site 155
T1287
S
P
P
G
P
P
G
T
T
P
P
G
Q
K
S
Site 156
T1288
P
P
G
P
P
G
T
T
P
P
G
Q
K
S
P
Site 157
S1294
T
T
P
P
G
Q
K
S
P
S
G
P
F
C
T
Site 158
S1296
P
P
G
Q
K
S
P
S
G
P
F
C
T
P
Q
Site 159
T1301
S
P
S
G
P
F
C
T
P
Q
S
P
V
S
L
Site 160
S1304
G
P
F
C
T
P
Q
S
P
V
S
L
A
Q
E
Site 161
S1307
C
T
P
Q
S
P
V
S
L
A
Q
E
G
T
A
Site 162
S1321
A
Q
I
W
K
R
Q
S
Q
E
V
E
A
G
G
Site 163
T1331
V
E
A
G
G
I
Q
T
V
E
D
E
H
V
A
Site 164
T1341
D
E
H
V
A
E
L
T
L
M
G
E
G
D
I
Site 165
S1349
L
M
G
E
G
D
I
S
S
P
N
S
T
L
L
Site 166
S1350
M
G
E
G
D
I
S
S
P
N
S
T
L
L
P
Site 167
S1353
G
D
I
S
S
P
N
S
T
L
L
P
P
P
S
Site 168
T1354
D
I
S
S
P
N
S
T
L
L
P
P
P
S
T
Site 169
S1360
S
T
L
L
P
P
P
S
T
P
Q
E
V
P
G
Site 170
T1361
T
L
L
P
P
P
S
T
P
Q
E
V
P
G
P
Site 171
S1369
P
Q
E
V
P
G
P
S
R
P
G
S
G
T
H
Site 172
S1373
P
G
P
S
R
P
G
S
G
T
H
G
S
R
D
Site 173
T1375
P
S
R
P
G
S
G
T
H
G
S
R
D
L
P
Site 174
S1378
P
G
S
G
T
H
G
S
R
D
L
P
V
N
R
Site 175
S1395
D
V
D
L
V
T
G
S
A
P
G
R
D
G
G
Site 176
S1413
A
Q
A
G
P
G
R
S
Q
A
S
G
G
P
P
Site 177
S1416
G
P
G
R
S
Q
A
S
G
G
P
P
T
S
D
Site 178
S1422
A
S
G
G
P
P
T
S
D
L
P
G
L
G
P
Site 179
T1439
G
E
P
A
K
P
K
T
S
A
H
H
A
T
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation