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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XPO1
Full Name:
Exportin-1
Alias:
Chromosome region maintenance 1 protein homologue; Exp1
Type:
Karyopherin
Mass (Da):
123386
Number AA:
1071
UniProt ID:
O14980
International Prot ID:
IPI00298961
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005642
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0005215
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0051028
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
A
R
Q
L
L
D
F
S
Q
K
L
D
I
N
L
Site 2
Y36
D
N
V
V
N
C
L
Y
H
G
E
G
A
Q
Q
Site 3
T65
D
A
W
T
R
V
D
T
I
L
E
F
S
Q
N
Site 4
Y77
S
Q
N
M
N
T
K
Y
Y
G
L
Q
I
L
E
Site 5
S115
G
L
I
I
K
T
S
S
D
P
T
C
V
E
K
Site 6
T118
I
K
T
S
S
D
P
T
C
V
E
K
E
K
V
Site 7
S160
I
V
G
A
S
R
T
S
E
S
L
C
Q
N
N
Site 8
S162
G
A
S
R
T
S
E
S
L
C
Q
N
N
M
V
Site 9
S182
S
E
E
V
F
D
F
S
S
G
Q
I
T
Q
V
Site 10
T187
D
F
S
S
G
Q
I
T
Q
V
K
S
K
H
L
Site 11
S191
G
Q
I
T
Q
V
K
S
K
H
L
K
D
S
M
Site 12
S197
K
S
K
H
L
K
D
S
M
C
N
E
F
S
Q
Site 13
Y252
K
L
I
S
T
L
I
Y
K
F
L
N
V
P
M
Site 14
S264
V
P
M
F
R
N
V
S
L
K
C
L
T
E
I
Site 15
S277
E
I
A
G
V
S
V
S
Q
Y
E
E
Q
F
V
Site 16
Y308
N
T
N
I
R
L
A
Y
S
N
G
K
D
D
E
Site 17
T328
N
L
S
L
F
L
C
T
F
L
K
E
H
D
Q
Site 18
T346
K
R
L
N
L
R
E
T
L
M
E
A
L
H
Y
Site 19
Y381
N
H
L
A
A
E
L
Y
R
E
S
P
F
S
T
Site 20
S384
A
A
E
L
Y
R
E
S
P
F
S
T
S
A
S
Site 21
S387
L
Y
R
E
S
P
F
S
T
S
A
S
P
L
L
Site 22
T388
Y
R
E
S
P
F
S
T
S
A
S
P
L
L
S
Site 23
S389
R
E
S
P
F
S
T
S
A
S
P
L
L
S
G
Site 24
S391
S
P
F
S
T
S
A
S
P
L
L
S
G
S
Q
Site 25
S395
T
S
A
S
P
L
L
S
G
S
Q
H
F
D
V
Site 26
S397
A
S
P
L
L
S
G
S
Q
H
F
D
V
P
P
Site 27
Y409
V
P
P
R
R
Q
L
Y
L
P
M
L
F
K
V
Site 28
S422
K
V
R
L
L
M
V
S
R
M
A
K
P
E
E
Site 29
T448
V
R
E
F
M
K
D
T
D
S
I
N
L
Y
K
Site 30
S450
E
F
M
K
D
T
D
S
I
N
L
Y
K
N
M
Site 31
Y454
D
T
D
S
I
N
L
Y
K
N
M
R
E
T
L
Site 32
T460
L
Y
K
N
M
R
E
T
L
V
Y
L
T
H
L
Site 33
Y463
N
M
R
E
T
L
V
Y
L
T
H
L
D
Y
V
Site 34
Y469
V
Y
L
T
H
L
D
Y
V
D
T
E
R
I
M
Site 35
T472
T
H
L
D
Y
V
D
T
E
R
I
M
T
E
K
Site 36
T477
V
D
T
E
R
I
M
T
E
K
L
H
N
Q
V
Site 37
T519
D
E
K
R
F
L
V
T
V
I
K
D
L
L
G
Site 38
T564
A
H
W
K
F
L
K
T
V
V
N
K
L
F
E
Site 39
T632
L
Q
P
Q
Q
V
H
T
F
Y
E
A
V
G
Y
Site 40
Y634
P
Q
Q
V
H
T
F
Y
E
A
V
G
Y
M
I
Site 41
T648
I
G
A
Q
T
D
Q
T
V
Q
E
H
L
I
E
Site 42
T684
D
I
L
K
D
P
E
T
V
K
Q
L
G
S
I
Site 43
T694
Q
L
G
S
I
L
K
T
N
V
R
A
C
K
A
Site 44
S729
K
C
L
S
E
N
I
S
A
A
I
Q
A
N
G
Site 45
S747
T
K
Q
P
L
I
R
S
M
R
T
V
K
R
E
Site 46
T755
M
R
T
V
K
R
E
T
L
K
L
I
S
G
W
Site 47
S760
R
E
T
L
K
L
I
S
G
W
V
S
R
S
N
Site 48
S764
K
L
I
S
G
W
V
S
R
S
N
D
P
Q
M
Site 49
S766
I
S
G
W
V
S
R
S
N
D
P
Q
M
V
A
Site 50
Y841
I
N
K
D
F
E
E
Y
P
E
H
R
T
N
F
Site 51
Y918
A
Q
S
F
Y
Q
T
Y
F
C
D
I
L
Q
H
Site 52
S959
L
V
E
E
G
K
I
S
T
S
L
N
P
G
N
Site 53
S961
E
E
G
K
I
S
T
S
L
N
P
G
N
P
V
Site 54
Y977
N
Q
I
F
L
Q
E
Y
V
A
N
L
L
K
S
Site 55
S984
Y
V
A
N
L
L
K
S
A
F
P
H
L
Q
D
Site 56
T1030
K
E
F
A
G
E
D
T
S
D
L
F
L
E
E
Site 57
S1031
E
F
A
G
E
D
T
S
D
L
F
L
E
E
R
Site 58
S1055
E
K
H
K
R
Q
M
S
V
P
G
I
F
N
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation