KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TAF172
Full Name:
TATA-binding protein-associated factor 172
Alias:
BTAF1; BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa; Mot1; MOT1; T172; TAF(II)170; TAF-172; TAFII170; TBP-associated factor 172
Type:
Transcription initiation complex; EC 3.6.1.-; Helicase
Mass (Da):
206887
Number AA:
1849
UniProt ID:
O14981
International Prot ID:
IPI00024802
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004386
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0016481
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T87
P
R
T
R
Q
E
P
T
S
E
S
S
M
E
D
Site 2
S88
R
T
R
Q
E
P
T
S
E
S
S
M
E
D
S
Site 3
S90
R
Q
E
P
T
S
E
S
S
M
E
D
S
P
T
Site 4
S91
Q
E
P
T
S
E
S
S
M
E
D
S
P
T
T
Site 5
S95
S
E
S
S
M
E
D
S
P
T
T
E
R
L
N
Site 6
T97
S
S
M
E
D
S
P
T
T
E
R
L
N
F
D
Site 7
T98
S
M
E
D
S
P
T
T
E
R
L
N
F
D
R
Site 8
S133
F
E
V
Q
D
E
K
S
G
E
V
D
P
K
E
Site 9
S164
M
G
E
A
I
G
M
S
T
E
E
L
F
N
D
Site 10
Y176
F
N
D
E
D
L
D
Y
T
P
T
S
A
S
F
Site 11
T177
N
D
E
D
L
D
Y
T
P
T
S
A
S
F
V
Site 12
T179
E
D
L
D
Y
T
P
T
S
A
S
F
V
N
K
Site 13
S180
D
L
D
Y
T
P
T
S
A
S
F
V
N
K
Q
Site 14
S182
D
Y
T
P
T
S
A
S
F
V
N
K
Q
P
T
Site 15
S198
Q
A
A
E
L
I
D
S
E
F
R
A
G
M
S
Site 16
S205
S
E
F
R
A
G
M
S
N
R
Q
K
N
K
A
Site 17
T230
R
S
R
D
A
V
E
T
N
E
K
S
N
D
S
Site 18
S234
A
V
E
T
N
E
K
S
N
D
S
T
D
G
E
Site 19
S237
T
N
E
K
S
N
D
S
T
D
G
E
P
E
E
Site 20
T238
N
E
K
S
N
D
S
T
D
G
E
P
E
E
K
Site 21
S257
A
N
V
V
I
N
Q
S
A
N
D
S
K
V
L
Site 22
S261
I
N
Q
S
A
N
D
S
K
V
L
I
D
N
I
Site 23
S271
L
I
D
N
I
P
D
S
S
S
L
I
E
E
T
Site 24
S273
D
N
I
P
D
S
S
S
L
I
E
E
T
N
E
Site 25
T307
E
V
R
H
G
A
G
T
G
L
R
E
I
L
K
Site 26
S326
S
G
G
K
M
G
D
S
T
L
E
E
M
I
Q
Site 27
T327
G
G
K
M
G
D
S
T
L
E
E
M
I
Q
Q
Site 28
T399
D
V
L
L
K
L
L
T
Q
E
Q
W
E
V
R
Site 29
Y415
G
G
L
L
G
I
K
Y
A
L
A
V
R
Q
D
Site 30
S489
E
L
D
D
L
T
A
S
T
N
S
I
M
T
L
Site 31
S510
Y
P
Q
V
Q
Q
C
S
I
Q
Q
S
L
T
V
Site 32
S514
Q
Q
C
S
I
Q
Q
S
L
T
V
L
V
P
R
Site 33
T529
V
W
P
F
L
H
H
T
I
S
S
V
R
R
A
Site 34
S532
F
L
H
H
T
I
S
S
V
R
R
A
A
L
E
Site 35
S546
E
T
L
F
T
L
L
S
T
Q
D
Q
N
S
S
Site 36
S552
L
S
T
Q
D
Q
N
S
S
S
W
L
I
P
I
Site 37
T638
K
A
R
A
K
E
K
T
G
G
K
V
R
Q
G
Site 38
S647
G
K
V
R
Q
G
Q
S
Q
N
K
E
V
L
Q
Site 39
T662
E
Y
I
A
G
A
D
T
I
M
E
D
P
A
T
Site 40
T669
T
I
M
E
D
P
A
T
R
D
F
V
V
M
R
Site 41
T747
Q
K
E
C
K
A
V
T
L
A
V
Q
P
R
L
Site 42
S759
P
R
L
L
D
I
L
S
E
H
L
Y
Y
D
E
Site 43
Y763
D
I
L
S
E
H
L
Y
Y
D
E
I
A
V
P
Site 44
T811
D
Q
A
S
D
L
V
T
T
V
F
N
E
A
T
Site 45
S820
V
F
N
E
A
T
S
S
F
D
L
N
P
Q
V
Site 46
S833
Q
V
L
Q
Q
L
D
S
K
R
Q
Q
V
Q
M
Site 47
T841
K
R
Q
Q
V
Q
M
T
V
T
E
T
N
Q
E
Site 48
T884
I
I
K
P
L
M
E
T
I
K
K
E
E
N
T
Site 49
T909
A
K
L
L
Q
Q
C
T
T
R
T
P
C
P
N
Site 50
T910
K
L
L
Q
Q
C
T
T
R
T
P
C
P
N
S
Site 51
T912
L
Q
Q
C
T
T
R
T
P
C
P
N
S
K
I
Site 52
S950
T
Q
S
G
Q
E
N
S
K
G
S
T
S
E
K
Site 53
T954
Q
E
N
S
K
G
S
T
S
E
K
D
G
M
H
Site 54
S955
E
N
S
K
G
S
T
S
E
K
D
G
M
H
H
Site 55
T963
E
K
D
G
M
H
H
T
V
T
K
H
R
G
I
Site 56
T972
T
K
H
R
G
I
I
T
L
Y
R
H
Q
K
A
Site 57
Y974
H
R
G
I
I
T
L
Y
R
H
Q
K
A
A
F
Site 58
T984
Q
K
A
A
F
A
I
T
S
R
R
G
P
T
P
Site 59
S985
K
A
A
F
A
I
T
S
R
R
G
P
T
P
K
Site 60
T990
I
T
S
R
R
G
P
T
P
K
A
V
K
A
Q
Site 61
S1070
I
N
N
F
D
G
K
S
L
L
D
K
G
D
S
Site 62
S1077
S
L
L
D
K
G
D
S
P
A
Q
E
L
V
N
Site 63
T1091
N
S
L
Q
V
F
E
T
A
A
A
S
M
D
S
Site 64
S1095
V
F
E
T
A
A
A
S
M
D
S
E
L
H
P
Site 65
Y1112
V
Q
H
L
P
H
L
Y
M
C
L
Q
Y
P
S
Site 66
Y1117
H
L
Y
M
C
L
Q
Y
P
S
T
A
V
R
H
Site 67
S1159
W
L
G
A
I
D
D
S
V
K
Q
E
G
A
I
Site 68
S1196
V
P
V
L
G
R
M
S
D
Q
T
D
S
V
R
Site 69
T1199
L
G
R
M
S
D
Q
T
D
S
V
R
F
M
A
Site 70
S1201
R
M
S
D
Q
T
D
S
V
R
F
M
A
T
Q
Site 71
Y1256
D
G
K
K
L
E
N
Y
K
I
P
V
P
I
N
Site 72
Y1269
I
N
A
E
L
R
K
Y
Q
Q
D
G
V
N
W
Site 73
Y1316
H
C
H
R
A
Q
E
Y
A
R
S
K
L
A
E
Site 74
S1319
R
A
Q
E
Y
A
R
S
K
L
A
E
C
M
P
Site 75
Y1353
G
K
F
C
S
R
E
Y
L
N
P
L
H
Y
T
Site 76
Y1359
E
Y
L
N
P
L
H
Y
T
G
P
P
T
E
R
Site 77
T1364
L
H
Y
T
G
P
P
T
E
R
I
R
L
Q
H
Site 78
S1417
K
N
G
K
T
K
L
S
K
A
V
K
Q
L
T
Site 79
S1432
A
N
Y
R
I
I
L
S
G
T
P
I
Q
N
N
Site 80
T1457
L
M
P
G
F
L
G
T
E
R
Q
F
A
A
R
Site 81
Y1465
E
R
Q
F
A
A
R
Y
G
K
P
I
L
A
S
Site 82
S1472
Y
G
K
P
I
L
A
S
R
D
A
R
S
S
S
Site 83
S1478
A
S
R
D
A
R
S
S
S
R
E
Q
E
A
G
Site 84
S1479
S
R
D
A
R
S
S
S
R
E
Q
E
A
G
V
Site 85
Y1520
P
P
K
I
I
Q
D
Y
Y
C
T
L
S
P
L
Site 86
Y1521
P
K
I
I
Q
D
Y
Y
C
T
L
S
P
L
Q
Site 87
S1525
Q
D
Y
Y
C
T
L
S
P
L
Q
V
Q
L
Y
Site 88
Y1532
S
P
L
Q
V
Q
L
Y
E
D
F
A
K
S
R
Site 89
S1538
L
Y
E
D
F
A
K
S
R
A
K
C
D
V
D
Site 90
T1547
A
K
C
D
V
D
E
T
V
S
S
A
T
L
S
Site 91
S1550
D
V
D
E
T
V
S
S
A
T
L
S
E
E
T
Site 92
S1554
T
V
S
S
A
T
L
S
E
E
T
E
K
P
K
Site 93
Y1574
H
V
F
Q
A
L
Q
Y
L
R
K
L
C
N
H
Site 94
T1587
N
H
P
A
L
V
L
T
P
Q
H
P
E
F
K
Site 95
T1595
P
Q
H
P
E
F
K
T
T
A
E
K
L
A
V
Site 96
T1596
Q
H
P
E
F
K
T
T
A
E
K
L
A
V
Q
Site 97
S1605
E
K
L
A
V
Q
N
S
S
L
H
D
I
Q
H
Site 98
S1606
K
L
A
V
Q
N
S
S
L
H
D
I
Q
H
A
Site 99
S1632
D
C
G
L
G
N
G
S
T
S
E
S
G
T
E
Site 100
S1634
G
L
G
N
G
S
T
S
E
S
G
T
E
S
V
Site 101
S1636
G
N
G
S
T
S
E
S
G
T
E
S
V
V
A
Site 102
T1638
G
S
T
S
E
S
G
T
E
S
V
V
A
Q
H
Site 103
S1640
T
S
E
S
G
T
E
S
V
V
A
Q
H
R
I
Site 104
Y1674
P
H
L
P
S
V
T
Y
L
R
L
D
G
S
I
Site 105
S1680
T
Y
L
R
L
D
G
S
I
P
P
G
Q
R
H
Site 106
S1688
I
P
P
G
Q
R
H
S
I
V
S
R
F
N
N
Site 107
S1691
G
Q
R
H
S
I
V
S
R
F
N
N
D
P
S
Site 108
S1698
S
R
F
N
N
D
P
S
I
D
V
L
L
L
T
Site 109
Y1752
Q
K
R
V
V
N
V
Y
R
L
I
T
R
G
T
Site 110
T1756
V
N
V
Y
R
L
I
T
R
G
T
L
E
E
K
Site 111
T1759
Y
R
L
I
T
R
G
T
L
E
E
K
I
M
G
Site 112
S1780
N
I
A
N
T
V
I
S
Q
E
N
S
S
L
Q
Site 113
S1784
T
V
I
S
Q
E
N
S
S
L
Q
S
M
G
T
Site 114
S1785
V
I
S
Q
E
N
S
S
L
Q
S
M
G
T
D
Site 115
S1788
Q
E
N
S
S
L
Q
S
M
G
T
D
Q
L
L
Site 116
T1799
D
Q
L
L
D
L
F
T
L
D
K
D
G
K
A
Site 117
T1811
G
K
A
E
K
A
D
T
S
T
S
G
K
A
S
Site 118
S1812
K
A
E
K
A
D
T
S
T
S
G
K
A
S
M
Site 119
S1814
E
K
A
D
T
S
T
S
G
K
A
S
M
K
S
Site 120
S1818
T
S
T
S
G
K
A
S
M
K
S
I
L
E
N
Site 121
S1821
S
G
K
A
S
M
K
S
I
L
E
N
L
S
D
Site 122
S1827
K
S
I
L
E
N
L
S
D
L
W
D
Q
E
Q
Site 123
Y1839
Q
E
Q
Y
D
S
E
Y
S
L
E
N
F
M
H
Site 124
S1840
E
Q
Y
D
S
E
Y
S
L
E
N
F
M
H
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation