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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIP5K1B
Full Name:
Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
Alias:
EC 2.7.1.68; MSS4; PI51B; PIPK I-alpha; STM7; STM-7
Type:
Kinase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68
Mass (Da):
61036
Number AA:
540
UniProt ID:
O14986
International Prot ID:
IPI00465236
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0012505
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0016308
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0046488
GO:0016310
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
G
K
Q
N
E
E
K
T
Y
K
K
T
A
S
S
Site 2
Y21
K
Q
N
E
E
K
T
Y
K
K
T
A
S
S
A
Site 3
S26
K
T
Y
K
K
T
A
S
S
A
I
K
G
A
I
Site 4
S67
V
E
S
V
F
L
P
S
E
G
S
N
L
T
P
Site 5
S70
V
F
L
P
S
E
G
S
N
L
T
P
A
H
H
Site 6
T73
P
S
E
G
S
N
L
T
P
A
H
H
Y
P
D
Site 7
Y78
N
L
T
P
A
H
H
Y
P
D
F
R
F
K
T
Site 8
T85
Y
P
D
F
R
F
K
T
Y
A
P
L
A
F
R
Site 9
Y86
P
D
F
R
F
K
T
Y
A
P
L
A
F
R
Y
Site 10
Y105
F
G
I
K
P
D
D
Y
L
Y
S
I
C
S
E
Site 11
Y107
I
K
P
D
D
Y
L
Y
S
I
C
S
E
P
L
Site 12
S108
K
P
D
D
Y
L
Y
S
I
C
S
E
P
L
I
Site 13
S118
S
E
P
L
I
E
L
S
N
P
G
A
S
G
S
Site 14
S125
S
N
P
G
A
S
G
S
L
F
F
V
T
S
D
Site 15
T139
D
D
E
F
I
I
K
T
V
Q
H
K
E
A
E
Site 16
Y155
L
Q
K
L
L
P
G
Y
Y
M
N
L
N
Q
N
Site 17
T165
N
L
N
Q
N
P
R
T
L
L
P
K
F
Y
G
Site 18
Y202
S
M
R
M
H
F
T
Y
D
L
K
G
S
T
Y
Site 19
Y209
Y
D
L
K
G
S
T
Y
K
R
R
A
S
R
K
Site 20
S214
S
T
Y
K
R
R
A
S
R
K
E
R
E
K
S
Site 21
S221
S
R
K
E
R
E
K
S
N
P
T
F
K
D
L
Site 22
T224
E
R
E
K
S
N
P
T
F
K
D
L
D
F
L
Site 23
Y239
Q
D
M
H
E
G
L
Y
F
D
T
E
T
Y
N
Site 24
T244
G
L
Y
F
D
T
E
T
Y
N
A
L
M
K
T
Site 25
T251
T
Y
N
A
L
M
K
T
L
Q
R
D
C
R
V
Site 26
S279
G
I
H
F
L
D
H
S
L
K
E
K
E
E
E
Site 27
T287
L
K
E
K
E
E
E
T
P
Q
N
V
P
D
A
Site 28
S305
G
M
Q
K
V
L
Y
S
T
A
M
E
S
I
Q
Site 29
S310
L
Y
S
T
A
M
E
S
I
Q
G
P
G
K
S
Site 30
S317
S
I
Q
G
P
G
K
S
G
D
G
I
I
T
E
Site 31
T323
K
S
G
D
G
I
I
T
E
N
P
D
T
M
G
Site 32
T328
I
I
T
E
N
P
D
T
M
G
G
I
P
A
K
Site 33
S336
M
G
G
I
P
A
K
S
H
R
G
E
K
L
L
Site 34
Y370
H
S
W
K
A
L
V
Y
D
G
D
T
V
S
V
Site 35
T374
A
L
V
Y
D
G
D
T
V
S
V
H
R
P
S
Site 36
S376
V
Y
D
G
D
T
V
S
V
H
R
P
S
F
Y
Site 37
S381
T
V
S
V
H
R
P
S
F
Y
A
D
R
F
L
Site 38
Y383
S
V
H
R
P
S
F
Y
A
D
R
F
L
K
F
Site 39
S405
K
I
Q
A
L
K
A
S
P
S
K
K
R
C
N
Site 40
S407
Q
A
L
K
A
S
P
S
K
K
R
C
N
S
I
Site 41
S413
P
S
K
K
R
C
N
S
I
A
A
L
K
A
T
Site 42
S427
T
S
Q
E
I
V
S
S
I
S
Q
E
W
K
D
Site 43
S429
Q
E
I
V
S
S
I
S
Q
E
W
K
D
E
K
Site 44
T441
D
E
K
R
D
L
L
T
E
G
Q
S
F
S
S
Site 45
S445
D
L
L
T
E
G
Q
S
F
S
S
L
D
E
E
Site 46
S447
L
T
E
G
Q
S
F
S
S
L
D
E
E
A
L
Site 47
S448
T
E
G
Q
S
F
S
S
L
D
E
E
A
L
G
Site 48
S456
L
D
E
E
A
L
G
S
R
H
R
P
D
L
V
Site 49
S465
H
R
P
D
L
V
P
S
T
P
S
L
F
E
A
Site 50
T466
R
P
D
L
V
P
S
T
P
S
L
F
E
A
A
Site 51
S483
A
T
T
I
S
S
S
S
L
Y
V
N
E
H
Y
Site 52
Y485
T
I
S
S
S
S
L
Y
V
N
E
H
Y
P
H
Site 53
Y490
S
L
Y
V
N
E
H
Y
P
H
D
R
P
T
L
Site 54
T496
H
Y
P
H
D
R
P
T
L
Y
S
N
S
K
G
Site 55
Y498
P
H
D
R
P
T
L
Y
S
N
S
K
G
L
P
Site 56
S499
H
D
R
P
T
L
Y
S
N
S
K
G
L
P
S
Site 57
S501
R
P
T
L
Y
S
N
S
K
G
L
P
S
S
S
Site 58
S506
S
N
S
K
G
L
P
S
S
S
T
F
T
L
E
Site 59
S507
N
S
K
G
L
P
S
S
S
T
F
T
L
E
E
Site 60
S508
S
K
G
L
P
S
S
S
T
F
T
L
E
E
G
Site 61
T509
K
G
L
P
S
S
S
T
F
T
L
E
E
G
T
Site 62
T511
L
P
S
S
S
T
F
T
L
E
E
G
T
I
Y
Site 63
Y518
T
L
E
E
G
T
I
Y
L
T
A
E
P
N
T
Site 64
T520
E
E
G
T
I
Y
L
T
A
E
P
N
T
L
E
Site 65
S534
E
V
Q
D
D
N
A
S
V
L
D
V
Y
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation