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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF10
Full Name:
Rho guanine nucleotide exchange factor 10
Alias:
ARHGA; GEF10; KIAA0294; Rho guanine nucleotide exchange factor (GEF) 10
Type:
Guanine nucleotide exchange factor, Rac/Rho
Mass (Da):
151612
Number AA:
1369
UniProt ID:
O15013
International Prot ID:
IPI00413517
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
P
P
G
F
L
S
R
A
P
S
L
N
R
Site 2
S12
G
F
L
S
R
A
P
S
L
N
R
A
E
R
G
Site 3
Y42
P
A
E
N
E
M
K
Y
D
T
N
N
N
E
E
Site 4
T44
E
N
E
M
K
Y
D
T
N
N
N
E
E
E
E
Site 5
S59
G
E
Q
F
D
F
D
S
G
D
E
I
P
E
A
Site 6
S72
E
A
D
R
Q
A
P
S
A
P
E
T
G
G
A
Site 7
T76
Q
A
P
S
A
P
E
T
G
G
A
G
A
S
E
Site 8
S82
E
T
G
G
A
G
A
S
E
A
P
A
P
T
G
Site 9
T99
D
G
A
G
A
E
T
T
P
V
A
E
P
T
K
Site 10
T122
P
Y
S
V
I
D
I
T
P
F
Q
E
D
Q
P
Site 11
T131
F
Q
E
D
Q
P
P
T
P
V
P
S
A
E
E
Site 12
T187
S
L
D
E
E
A
E
T
P
E
V
T
E
D
R
Site 13
S198
T
E
D
R
Q
P
N
S
L
S
S
E
E
P
P
Site 14
S200
D
R
Q
P
N
S
L
S
S
E
E
P
P
T
S
Site 15
S201
R
Q
P
N
S
L
S
S
E
E
P
P
T
S
E
Site 16
T206
L
S
S
E
E
P
P
T
S
E
D
Q
V
G
R
Site 17
S207
S
S
E
E
P
P
T
S
E
D
Q
V
G
R
E
Site 18
S216
D
Q
V
G
R
E
D
S
A
L
A
R
W
A
A
Site 19
Y239
E
N
P
E
E
A
I
Y
D
D
V
P
R
E
N
Site 20
S247
D
D
V
P
R
E
N
S
D
S
E
P
D
E
M
Site 21
S249
V
P
R
E
N
S
D
S
E
P
D
E
M
I
Y
Site 22
Y256
S
E
P
D
E
M
I
Y
D
D
V
E
N
G
D
Site 23
S268
N
G
D
E
G
G
N
S
S
L
E
Y
G
W
S
Site 24
S269
G
D
E
G
G
N
S
S
L
E
Y
G
W
S
S
Site 25
Y272
G
G
N
S
S
L
E
Y
G
W
S
S
S
E
F
Site 26
S275
S
S
L
E
Y
G
W
S
S
S
E
F
E
S
Y
Site 27
S276
S
L
E
Y
G
W
S
S
S
E
F
E
S
Y
E
Site 28
S277
L
E
Y
G
W
S
S
S
E
F
E
S
Y
E
E
Site 29
S281
W
S
S
S
E
F
E
S
Y
E
E
Q
S
D
S
Site 30
Y282
S
S
S
E
F
E
S
Y
E
E
Q
S
D
S
E
Site 31
S288
S
Y
E
E
Q
S
D
S
E
C
K
N
G
I
P
Site 32
S297
C
K
N
G
I
P
R
S
F
L
R
S
N
H
K
Site 33
S301
I
P
R
S
F
L
R
S
N
H
K
K
Q
L
S
Site 34
T312
K
Q
L
S
H
D
L
T
R
L
K
E
H
Y
E
Site 35
Y318
L
T
R
L
K
E
H
Y
E
K
K
M
R
D
L
Site 36
S373
A
A
V
K
R
G
R
S
F
I
R
T
K
S
L
Site 37
T377
R
G
R
S
F
I
R
T
K
S
L
I
A
Q
D
Site 38
S379
R
S
F
I
R
T
K
S
L
I
A
Q
D
H
R
Site 39
S387
L
I
A
Q
D
H
R
S
S
L
E
E
E
Q
N
Site 40
S388
I
A
Q
D
H
R
S
S
L
E
E
E
Q
N
L
Site 41
T409
K
H
P
E
A
I
L
T
P
M
P
E
G
L
S
Site 42
S416
T
P
M
P
E
G
L
S
Q
Q
Q
V
V
R
R
Site 43
Y424
Q
Q
Q
V
V
R
R
Y
I
L
G
S
V
V
D
Site 44
S428
V
R
R
Y
I
L
G
S
V
V
D
S
E
K
N
Site 45
S432
I
L
G
S
V
V
D
S
E
K
N
Y
V
D
A
Site 46
Y436
V
V
D
S
E
K
N
Y
V
D
A
L
K
R
I
Site 47
Y447
L
K
R
I
L
E
Q
Y
E
K
P
L
S
E
M
Site 48
S452
E
Q
Y
E
K
P
L
S
E
M
E
P
K
V
L
Site 49
S460
E
M
E
P
K
V
L
S
E
R
K
L
K
T
V
Site 50
T466
L
S
E
R
K
L
K
T
V
F
Y
R
V
K
E
Site 51
Y469
R
K
L
K
T
V
F
Y
R
V
K
E
I
L
Q
Site 52
S494
S
R
V
S
E
W
D
S
V
E
M
I
G
D
V
Site 53
Y515
K
S
M
V
L
D
A
Y
S
E
Y
V
N
N
F
Site 54
S516
S
M
V
L
D
A
Y
S
E
Y
V
N
N
F
S
Site 55
Y518
V
L
D
A
Y
S
E
Y
V
N
N
F
S
T
A
Site 56
S550
L
K
Q
E
Q
E
A
S
P
D
R
T
T
L
Y
Site 57
T554
Q
E
A
S
P
D
R
T
T
L
Y
S
L
M
M
Site 58
T555
E
A
S
P
D
R
T
T
L
Y
S
L
M
M
K
Site 59
Y557
S
P
D
R
T
T
L
Y
S
L
M
M
K
P
I
Site 60
S558
P
D
R
T
T
L
Y
S
L
M
M
K
P
I
Q
Site 61
Y629
A
K
A
I
N
E
R
Y
L
N
K
L
L
S
S
Site 62
S635
R
Y
L
N
K
L
L
S
S
G
S
R
Y
L
I
Site 63
S636
Y
L
N
K
L
L
S
S
G
S
R
Y
L
I
R
Site 64
S638
N
K
L
L
S
S
G
S
R
Y
L
I
R
S
D
Site 65
Y640
L
L
S
S
G
S
R
Y
L
I
R
S
D
D
M
Site 66
S644
G
S
R
Y
L
I
R
S
D
D
M
I
E
T
V
Site 67
Y652
D
D
M
I
E
T
V
Y
N
D
R
G
E
I
V
Site 68
T661
D
R
G
E
I
V
K
T
K
E
R
R
V
F
M
Site 69
T677
N
D
V
L
M
C
A
T
V
S
S
R
P
S
H
Site 70
S679
V
L
M
C
A
T
V
S
S
R
P
S
H
D
S
Site 71
S680
L
M
C
A
T
V
S
S
R
P
S
H
D
S
R
Site 72
S683
A
T
V
S
S
R
P
S
H
D
S
R
V
M
S
Site 73
S686
S
S
R
P
S
H
D
S
R
V
M
S
S
Q
R
Site 74
S690
S
H
D
S
R
V
M
S
S
Q
R
Y
L
L
K
Site 75
S691
H
D
S
R
V
M
S
S
Q
R
Y
L
L
K
W
Site 76
Y694
R
V
M
S
S
Q
R
Y
L
L
K
W
S
V
P
Site 77
S699
Q
R
Y
L
L
K
W
S
V
P
L
G
H
V
D
Site 78
Y710
G
H
V
D
A
I
E
Y
G
S
S
A
G
T
G
Site 79
S713
D
A
I
E
Y
G
S
S
A
G
T
G
E
H
S
Site 80
T716
E
Y
G
S
S
A
G
T
G
E
H
S
R
H
L
Site 81
Y743
N
A
K
P
N
K
V
Y
M
G
P
G
Q
L
Y
Site 82
Y750
Y
M
G
P
G
Q
L
Y
Q
D
L
Q
N
L
L
Site 83
Y777
I
G
N
L
K
G
N
Y
Q
N
L
N
Q
S
V
Site 84
S822
L
P
G
K
Q
D
K
S
G
R
P
T
F
F
T
Site 85
T826
Q
D
K
S
G
R
P
T
F
F
T
A
V
F
N
Site 86
S846
I
K
E
S
W
V
N
S
L
Q
M
A
K
L
A
Site 87
Y901
F
K
I
E
C
A
A
Y
N
P
E
P
Y
L
N
Site 88
Y906
A
A
Y
N
P
E
P
Y
L
N
N
E
S
Q
P
Site 89
S911
E
P
Y
L
N
N
E
S
Q
P
D
S
F
S
T
Site 90
S915
N
N
E
S
Q
P
D
S
F
S
T
A
H
G
F
Site 91
S917
E
S
Q
P
D
S
F
S
T
A
H
G
F
L
W
Site 92
T918
S
Q
P
D
S
F
S
T
A
H
G
F
L
W
I
Site 93
S939
M
G
Q
I
A
I
V
S
F
Q
N
S
T
P
K
Site 94
Y962
S
R
I
L
C
M
L
Y
V
P
V
E
E
K
R
Site 95
T980
G
A
P
P
D
P
E
T
P
A
V
R
A
S
D
Site 96
S1001
G
T
E
E
G
S
I
S
I
Y
K
S
S
Q
G
Site 97
Y1003
E
E
G
S
I
S
I
Y
K
S
S
Q
G
S
K
Site 98
S1005
G
S
I
S
I
Y
K
S
S
Q
G
S
K
K
V
Site 99
S1006
S
I
S
I
Y
K
S
S
Q
G
S
K
K
V
R
Site 100
S1009
I
Y
K
S
S
Q
G
S
K
K
V
R
L
Q
H
Site 101
T1019
V
R
L
Q
H
F
F
T
P
E
K
S
T
V
M
Site 102
S1027
P
E
K
S
T
V
M
S
L
A
C
T
S
Q
S
Site 103
Y1036
A
C
T
S
Q
S
L
Y
A
G
L
V
N
G
A
Site 104
S1054
Y
A
R
A
P
D
G
S
W
D
S
E
P
Q
K
Site 105
S1057
A
P
D
G
S
W
D
S
E
P
Q
K
V
I
K
Site 106
T1137
S
T
L
R
L
F
H
T
E
T
L
K
H
L
Q
Site 107
T1198
L
Q
G
I
P
K
V
T
G
R
G
M
V
S
Y
Site 108
Y1205
T
G
R
G
M
V
S
Y
H
A
H
N
S
P
V
Site 109
S1229
H
E
K
D
K
D
K
S
R
D
S
L
A
P
G
Site 110
S1232
D
K
D
K
S
R
D
S
L
A
P
G
P
E
P
Site 111
S1256
P
S
G
G
A
G
S
S
L
S
Q
G
D
P
D
Site 112
S1258
G
G
A
G
S
S
L
S
Q
G
D
P
D
A
A
Site 113
T1276
G
D
S
L
G
S
M
T
Q
K
S
D
L
S
S
Site 114
S1279
L
G
S
M
T
Q
K
S
D
L
S
S
S
S
G
Site 115
S1282
M
T
Q
K
S
D
L
S
S
S
S
G
S
L
S
Site 116
S1283
T
Q
K
S
D
L
S
S
S
S
G
S
L
S
L
Site 117
S1284
Q
K
S
D
L
S
S
S
S
G
S
L
S
L
S
Site 118
S1285
K
S
D
L
S
S
S
S
G
S
L
S
L
S
H
Site 119
S1287
D
L
S
S
S
S
G
S
L
S
L
S
H
G
S
Site 120
S1289
S
S
S
S
G
S
L
S
L
S
H
G
S
S
S
Site 121
S1291
S
S
G
S
L
S
L
S
H
G
S
S
S
L
E
Site 122
S1294
S
L
S
L
S
H
G
S
S
S
L
E
H
R
S
Site 123
S1295
L
S
L
S
H
G
S
S
S
L
E
H
R
S
E
Site 124
S1296
S
L
S
H
G
S
S
S
L
E
H
R
S
E
D
Site 125
S1301
S
S
S
L
E
H
R
S
E
D
S
T
I
Y
D
Site 126
T1305
E
H
R
S
E
D
S
T
I
Y
D
L
L
K
D
Site 127
Y1307
R
S
E
D
S
T
I
Y
D
L
L
K
D
P
V
Site 128
S1315
D
L
L
K
D
P
V
S
L
R
S
K
A
R
R
Site 129
S1318
K
D
P
V
S
L
R
S
K
A
R
R
A
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation