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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTBN2
Full Name:
Spectrin beta chain, brain 2
Alias:
Beta-III spectrin; Non-erythroid beta chain 2; SCA5; Spectrin; Spectrin, beta, non-erythrocytic 2; Spectrin, non-erythroid beta chain 2; SPTN2
Type:
Cytoskeletal protein
Mass (Da):
271295
Number AA:
2390
UniProt ID:
O15020
International Prot ID:
IPI00012645
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0008091
GO:0008091
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005200
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
GO:0008219
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
S
T
L
S
P
T
D
F
D
S
L
Site 2
T8
M
S
S
T
L
S
P
T
D
F
D
S
L
E
I
Site 3
S12
L
S
P
T
D
F
D
S
L
E
I
Q
G
Q
Y
Site 4
S31
N
R
W
D
L
P
D
S
D
W
D
N
D
S
S
Site 5
S37
D
S
D
W
D
N
D
S
S
S
A
R
L
F
E
Site 6
S38
S
D
W
D
N
D
S
S
S
A
R
L
F
E
R
Site 7
S39
D
W
D
N
D
S
S
S
A
R
L
F
E
R
S
Site 8
S46
S
A
R
L
F
E
R
S
R
I
K
A
L
A
D
Site 9
T62
R
E
A
V
Q
K
K
T
F
T
K
W
V
N
S
Site 10
T64
A
V
Q
K
K
T
F
T
K
W
V
N
S
H
L
Site 11
T75
N
S
H
L
A
R
V
T
C
R
V
G
D
L
Y
Site 12
Y82
T
C
R
V
G
D
L
Y
S
D
L
R
D
G
R
Site 13
S83
C
R
V
G
D
L
Y
S
D
L
R
D
G
R
N
Site 14
S166
R
F
Q
I
Q
D
I
S
V
E
T
E
D
N
K
Site 15
S177
E
D
N
K
E
K
K
S
A
K
D
A
L
L
L
Site 16
Y193
C
Q
M
K
T
A
G
Y
P
N
V
N
V
H
N
Site 17
S227
P
D
L
L
D
F
E
S
L
K
K
C
N
A
H
Site 18
Y235
L
K
K
C
N
A
H
Y
N
L
Q
N
A
F
N
Site 19
T251
A
E
K
E
L
G
L
T
K
L
L
D
P
E
D
Site 20
S268
V
D
Q
P
D
E
K
S
I
I
T
Y
V
A
T
Site 21
Y272
D
E
K
S
I
I
T
Y
V
A
T
Y
Y
H
Y
Site 22
Y277
I
T
Y
V
A
T
Y
Y
H
Y
F
S
K
M
K
Site 23
Y279
Y
V
A
T
Y
Y
H
Y
F
S
K
M
K
A
L
Site 24
Y310
A
E
R
L
V
E
K
Y
E
S
L
A
S
E
L
Site 25
S312
R
L
V
E
K
Y
E
S
L
A
S
E
L
L
Q
Site 26
S315
E
K
Y
E
S
L
A
S
E
L
L
Q
W
I
E
Site 27
S336
N
D
R
Q
L
A
N
S
L
S
G
V
Q
N
Q
Site 28
S338
R
Q
L
A
N
S
L
S
G
V
Q
N
Q
L
Q
Site 29
S346
G
V
Q
N
Q
L
Q
S
F
N
S
Y
R
T
V
Site 30
S349
N
Q
L
Q
S
F
N
S
Y
R
T
V
E
K
P
Site 31
Y350
Q
L
Q
S
F
N
S
Y
R
T
V
E
K
P
P
Site 32
S374
V
L
L
F
T
I
Q
S
K
L
R
A
N
N
Q
Site 33
Y384
R
A
N
N
Q
K
V
Y
T
P
R
E
G
R
L
Site 34
T385
A
N
N
Q
K
V
Y
T
P
R
E
G
R
L
I
Site 35
S393
P
R
E
G
R
L
I
S
D
I
N
K
A
W
E
Site 36
T439
R
K
A
A
M
R
E
T
W
L
S
E
N
Q
R
Site 37
S442
A
M
R
E
T
W
L
S
E
N
Q
R
L
V
S
Site 38
S449
S
E
N
Q
R
L
V
S
Q
D
N
F
G
L
E
Site 39
T472
R
K
H
E
A
I
E
T
D
I
V
A
Y
S
G
Site 40
Y477
I
E
T
D
I
V
A
Y
S
G
R
V
Q
A
V
Site 41
S478
E
T
D
I
V
A
Y
S
G
R
V
Q
A
V
D
Site 42
Y542
K
V
F
Q
D
L
L
Y
L
M
D
W
M
E
E
Site 43
S556
E
M
K
G
R
L
Q
S
Q
D
L
G
R
H
L
Site 44
Y604
F
C
N
P
G
K
E
Y
R
P
C
D
P
Q
L
Site 45
S613
P
C
D
P
Q
L
V
S
E
R
V
A
K
L
E
Site 46
S622
R
V
A
K
L
E
Q
S
Y
E
A
L
C
E
L
Site 47
S640
R
R
A
R
L
E
E
S
R
R
L
W
R
F
L
Site 48
T669
H
L
L
A
S
A
D
T
G
R
D
L
T
G
A
Site 49
T674
A
D
T
G
R
D
L
T
G
A
L
R
L
L
N
Site 50
S691
T
A
L
R
G
E
M
S
G
R
L
G
P
L
K
Site 51
T700
R
L
G
P
L
K
L
T
L
E
Q
G
Q
Q
L
Site 52
S748
Q
R
L
A
Q
A
A
S
L
Y
Q
F
Q
A
D
Site 53
S771
V
D
A
L
R
L
V
S
S
P
E
L
G
H
D
Site 54
S772
D
A
L
R
L
V
S
S
P
E
L
G
H
D
E
Site 55
S798
A
L
E
E
E
I
R
S
H
R
P
T
L
D
A
Site 56
T802
E
I
R
S
H
R
P
T
L
D
A
L
R
E
Q
Site 57
T816
Q
A
A
A
L
P
P
T
L
S
R
T
P
E
V
Site 58
S818
A
A
L
P
P
T
L
S
R
T
P
E
V
Q
G
Site 59
T820
L
P
P
T
L
S
R
T
P
E
V
Q
G
R
V
Site 60
T829
E
V
Q
G
R
V
P
T
L
E
R
H
Y
E
E
Site 61
Y834
V
P
T
L
E
R
H
Y
E
E
L
Q
A
R
A
Site 62
T896
V
V
Q
Q
R
F
E
T
L
E
P
E
M
N
T
Site 63
T932
G
K
D
R
I
V
N
T
Q
E
Q
L
N
H
R
Site 64
T955
D
G
K
K
A
A
L
T
S
A
L
S
I
Q
N
Site 65
Y963
S
A
L
S
I
Q
N
Y
H
L
E
C
T
E
T
Site 66
T978
Q
A
W
M
R
E
K
T
K
V
I
E
S
T
Q
Site 67
T1004
L
Q
R
K
L
A
G
T
E
R
D
L
E
A
I
Site 68
T1019
A
A
R
V
G
E
L
T
R
E
A
N
A
L
A
Site 69
T1053
G
W
E
D
L
R
A
T
M
R
R
R
E
E
S
Site 70
S1060
T
M
R
R
R
E
E
S
L
G
E
A
R
R
L
Site 71
S1073
R
L
Q
D
F
L
R
S
L
D
D
F
Q
A
W
Site 72
T1086
A
W
L
G
R
T
Q
T
A
V
A
S
E
E
G
Site 73
T1096
A
S
E
E
G
P
A
T
L
P
E
A
E
A
L
Site 74
S1119
G
E
V
E
R
A
Q
S
E
Y
S
R
L
R
A
Site 75
Y1121
V
E
R
A
Q
S
E
Y
S
R
L
R
A
L
G
Site 76
T1152
Q
R
L
E
A
L
G
T
G
W
E
E
L
G
R
Site 77
S1190
Q
A
E
G
V
L
S
S
Q
E
Y
V
L
S
H
Site 78
Y1193
G
V
L
S
S
Q
E
Y
V
L
S
H
T
E
M
Site 79
S1196
S
S
Q
E
Y
V
L
S
H
T
E
M
P
G
T
Site 80
T1198
Q
E
Y
V
L
S
H
T
E
M
P
G
T
L
Q
Site 81
T1203
S
H
T
E
M
P
G
T
L
Q
A
A
D
A
A
Site 82
S1219
K
K
L
E
D
F
M
S
T
M
D
A
N
G
E
Site 83
S1240
E
A
G
R
Q
L
V
S
E
G
N
I
H
A
D
Site 84
S1255
K
I
R
E
K
A
D
S
I
E
R
R
H
K
K
Site 85
Y1306
L
T
A
Q
D
V
S
Y
D
E
A
R
N
L
H
Site 86
T1344
D
K
E
G
R
E
L
T
L
E
K
P
E
L
K
Site 87
T1371
R
W
D
E
L
E
T
T
T
Q
A
K
A
R
S
Site 88
S1397
Q
S
C
C
A
L
E
S
W
L
E
S
L
Q
A
Site 89
S1401
A
L
E
S
W
L
E
S
L
Q
A
Q
L
H
S
Site 90
S1408
S
L
Q
A
Q
L
H
S
D
D
Y
G
K
D
L
Site 91
Y1411
A
Q
L
H
S
D
D
Y
G
K
D
L
T
S
V
Site 92
T1416
D
D
Y
G
K
D
L
T
S
V
N
I
L
L
K
Site 93
S1417
D
Y
G
K
D
L
T
S
V
N
I
L
L
K
K
Site 94
T1462
G
A
G
E
V
E
R
T
S
R
A
V
E
E
K
Site 95
S1463
A
G
E
V
E
R
T
S
R
A
V
E
E
K
F
Site 96
S1487
R
C
R
R
L
Q
A
S
R
E
Q
H
Q
F
H
Site 97
T1505
E
D
E
I
L
W
V
T
E
R
L
P
M
A
S
Site 98
S1512
T
E
R
L
P
M
A
S
S
M
E
H
G
K
D
Site 99
S1513
E
R
L
P
M
A
S
S
M
E
H
G
K
D
L
Site 100
S1522
E
H
G
K
D
L
P
S
V
Q
L
L
M
K
K
Site 101
S1622
E
K
A
K
D
E
L
S
A
Q
A
E
V
K
K
Site 102
Y1640
L
E
Q
A
L
A
D
Y
A
Q
T
I
H
Q
L
Site 103
S1651
I
H
Q
L
A
A
S
S
Q
D
M
I
D
H
E
Site 104
S1662
I
D
H
E
H
P
E
S
T
R
I
S
I
R
Q
Site 105
S1666
H
P
E
S
T
R
I
S
I
R
Q
A
Q
V
D
Site 106
Y1676
Q
A
Q
V
D
K
L
Y
A
G
L
K
E
L
A
Site 107
Y1726
S
H
E
L
G
Q
D
Y
E
H
V
T
M
L
R
Site 108
S1740
R
D
K
F
R
E
F
S
R
D
T
S
T
I
G
Site 109
T1743
F
R
E
F
S
R
D
T
S
T
I
G
Q
E
R
Site 110
S1744
R
E
F
S
R
D
T
S
T
I
G
Q
E
R
V
Site 111
S1753
I
G
Q
E
R
V
D
S
A
N
A
L
A
N
G
Site 112
T1771
G
G
H
A
A
R
A
T
V
A
E
W
K
D
S
Site 113
S1778
T
V
A
E
W
K
D
S
L
N
E
A
W
A
D
Site 114
Y1801
G
Q
V
L
A
A
A
Y
E
L
Q
R
F
L
H
Site 115
Y1845
L
Q
R
R
H
C
A
Y
E
H
D
I
Q
A
L
Site 116
S1853
E
H
D
I
Q
A
L
S
P
Q
V
Q
Q
V
Q
Site 117
T1906
R
R
Q
L
L
L
D
T
T
D
K
F
R
F
F
Site 118
T1907
R
Q
L
L
L
D
T
T
D
K
F
R
F
F
K
Site 119
S1940
Q
E
R
P
R
D
V
S
S
A
D
L
V
I
K
Site 120
S1941
E
R
P
R
D
V
S
S
A
D
L
V
I
K
N
Site 121
S1964
E
A
R
A
D
R
F
S
S
C
I
D
M
G
K
Site 122
S1965
A
R
A
D
R
F
S
S
C
I
D
M
G
K
E
Site 123
Y1979
E
L
L
A
R
S
H
Y
A
A
E
E
I
S
E
Site 124
S1989
E
E
I
S
E
K
L
S
Q
L
Q
A
R
R
Q
Site 125
T1998
L
Q
A
R
R
Q
E
T
A
E
K
W
Q
E
K
Site 126
S2031
M
A
E
A
W
L
C
S
Q
E
P
L
V
R
S
Site 127
T2044
R
S
A
E
L
G
C
T
V
D
E
V
E
S
L
Site 128
S2106
P
A
P
E
P
T
A
S
V
P
P
G
D
L
V
Site 129
T2117
G
D
L
V
G
G
Q
T
A
S
D
T
T
W
D
Site 130
S2119
L
V
G
G
Q
T
A
S
D
T
T
W
D
G
T
Site 131
T2121
G
G
Q
T
A
S
D
T
T
W
D
G
T
Q
P
Site 132
T2126
S
D
T
T
W
D
G
T
Q
P
R
P
P
P
S
Site 133
S2133
T
Q
P
R
P
P
P
S
T
Q
A
P
S
V
N
Site 134
T2134
Q
P
R
P
P
P
S
T
Q
A
P
S
V
N
G
Site 135
S2138
P
P
S
T
Q
A
P
S
V
N
G
V
C
T
D
Site 136
S2149
V
C
T
D
G
E
P
S
Q
P
L
L
G
Q
Q
Site 137
S2161
G
Q
Q
R
L
E
H
S
S
F
P
E
G
P
G
Site 138
S2162
Q
Q
R
L
E
H
S
S
F
P
E
G
P
G
P
Site 139
S2171
P
E
G
P
G
P
G
S
G
D
E
A
N
G
P
Site 140
T2184
G
P
R
G
E
R
Q
T
R
T
R
G
P
A
P
Site 141
T2186
R
G
E
R
Q
T
R
T
R
G
P
A
P
S
A
Site 142
S2192
R
T
R
G
P
A
P
S
A
M
P
Q
S
R
S
Site 143
S2197
A
P
S
A
M
P
Q
S
R
S
T
E
S
A
H
Site 144
S2199
S
A
M
P
Q
S
R
S
T
E
S
A
H
A
A
Site 145
T2200
A
M
P
Q
S
R
S
T
E
S
A
H
A
A
T
Site 146
S2216
P
P
R
G
P
E
P
S
A
Q
E
Q
M
E
G
Site 147
S2254
Y
C
V
L
R
R
G
S
L
G
F
Y
K
D
A
Site 148
Y2258
R
R
G
S
L
G
F
Y
K
D
A
K
A
A
S
Site 149
S2265
Y
K
D
A
K
A
A
S
A
G
V
P
Y
H
G
Site 150
S2277
Y
H
G
E
V
P
V
S
L
A
R
A
Q
G
S
Site 151
Y2289
Q
G
S
V
A
F
D
Y
R
K
R
K
H
V
F
Site 152
S2332
A
A
I
A
T
A
S
S
A
S
G
E
P
E
E
Site 153
S2344
P
E
E
P
V
V
P
S
T
T
R
G
M
T
R
Site 154
T2345
E
E
P
V
V
P
S
T
T
R
G
M
T
R
A
Site 155
T2350
P
S
T
T
R
G
M
T
R
A
M
T
M
P
P
Site 156
T2354
R
G
M
T
R
A
M
T
M
P
P
V
S
P
V
Site 157
S2359
A
M
T
M
P
P
V
S
P
V
G
A
E
G
P
Site 158
S2384
R
E
R
E
K
R
F
S
F
F
K
K
N
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation