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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIMBP2
Full Name:
RIMS-binding protein 2
Alias:
KIAA0318; MGC15831; RBP2; RIMB2; RIM-binding protein 2; RIM-BP2; RIMS binding protein 2
Type:
Mass (Da):
116007
Number AA:
1052
UniProt ID:
O15034
International Prot ID:
IPI00183206
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0045202
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
E
I
D
L
L
Q
K
S
K
V
R
E
L
E
E
Site 2
T46
E
L
E
E
K
C
R
T
Q
S
E
Q
F
N
L
Site 3
S48
E
E
K
C
R
T
Q
S
E
Q
F
N
L
L
S
Site 4
S55
S
E
Q
F
N
L
L
S
R
D
L
E
K
F
R
Site 5
S86
L
D
I
S
T
A
P
S
K
P
F
P
Q
F
M
Site 6
S99
F
M
N
G
L
A
T
S
L
G
K
G
Q
E
S
Site 7
S106
S
L
G
K
G
Q
E
S
A
I
G
G
S
S
A
Site 8
Y117
G
S
S
A
I
G
E
Y
I
R
P
L
P
Q
P
Site 9
S132
G
D
R
P
E
P
L
S
A
K
P
T
F
L
S
Site 10
T136
E
P
L
S
A
K
P
T
F
L
S
R
S
G
S
Site 11
S139
S
A
K
P
T
F
L
S
R
S
G
S
A
R
C
Site 12
S141
K
P
T
F
L
S
R
S
G
S
A
R
C
R
S
Site 13
S143
T
F
L
S
R
S
G
S
A
R
C
R
S
E
S
Site 14
S148
S
G
S
A
R
C
R
S
E
S
D
M
E
N
E
Site 15
S150
S
A
R
C
R
S
E
S
D
M
E
N
E
R
N
Site 16
S158
D
M
E
N
E
R
N
S
N
T
S
K
Q
R
Y
Site 17
S161
N
E
R
N
S
N
T
S
K
Q
R
Y
S
G
K
Site 18
S166
N
T
S
K
Q
R
Y
S
G
K
V
H
L
C
V
Site 19
Y178
L
C
V
A
R
Y
S
Y
N
P
F
D
G
P
N
Site 20
Y201
L
T
A
G
K
Y
L
Y
V
Y
G
D
M
D
E
Site 21
Y203
A
G
K
Y
L
Y
V
Y
G
D
M
D
E
D
G
Site 22
Y212
D
M
D
E
D
G
F
Y
E
G
E
L
L
D
G
Site 23
S226
G
Q
R
G
L
V
P
S
N
F
V
D
F
V
Q
Site 24
S237
D
F
V
Q
D
N
E
S
R
L
A
S
T
L
G
Site 25
S241
D
N
E
S
R
L
A
S
T
L
G
N
E
Q
D
Site 26
S269
E
H
I
L
D
L
H
S
P
T
H
I
D
A
G
Site 27
T304
V
P
Y
P
R
K
I
T
L
I
K
Q
L
A
K
Site 28
S330
P
P
G
W
G
T
V
S
S
Y
N
V
L
V
D
Site 29
S331
P
G
W
G
T
V
S
S
Y
N
V
L
V
D
K
Site 30
T345
K
E
T
R
M
N
L
T
L
G
S
R
T
K
A
Site 31
T372
R
I
S
V
Q
C
V
T
S
R
G
S
S
D
E
Site 32
S373
I
S
V
Q
C
V
T
S
R
G
S
S
D
E
L
Site 33
S376
Q
C
V
T
S
R
G
S
S
D
E
L
Q
C
T
Site 34
S377
C
V
T
S
R
G
S
S
D
E
L
Q
C
T
L
Site 35
T383
S
S
D
E
L
Q
C
T
L
L
V
G
K
D
V
Site 36
T403
H
L
R
V
D
N
I
T
Q
I
S
A
Q
L
S
Site 37
S410
T
Q
I
S
A
Q
L
S
W
L
P
T
N
S
N
Site 38
T414
A
Q
L
S
W
L
P
T
N
S
N
Y
S
H
V
Site 39
S419
L
P
T
N
S
N
Y
S
H
V
I
F
L
N
E
Site 40
Y439
V
K
A
A
R
Y
K
Y
Q
F
F
N
L
R
P
Site 41
Y450
N
L
R
P
N
M
A
Y
K
V
K
V
L
A
K
Site 42
T494
P
A
P
P
Q
D
V
T
V
Q
A
G
V
T
P
Site 43
T503
Q
A
G
V
T
P
A
T
I
R
V
S
W
R
P
Site 44
S507
T
P
A
T
I
R
V
S
W
R
P
P
V
L
T
Site 45
T514
S
W
R
P
P
V
L
T
P
T
G
L
S
N
G
Site 46
Y527
N
G
A
N
V
T
G
Y
G
V
Y
A
K
G
Q
Site 47
T563
S
L
E
A
K
G
V
T
V
R
T
L
S
A
Q
Site 48
T566
A
K
G
V
T
V
R
T
L
S
A
Q
G
E
S
Site 49
S568
G
V
T
V
R
T
L
S
A
Q
G
E
S
V
D
Site 50
T590
P
E
L
L
V
P
P
T
P
H
P
R
P
A
P
Site 51
S599
H
P
R
P
A
P
Q
S
K
P
L
A
S
S
G
Site 52
S605
Q
S
K
P
L
A
S
S
G
V
P
E
T
K
D
Site 53
S649
P
V
G
P
G
R
R
S
P
S
P
S
R
I
L
Site 54
S651
G
P
G
R
R
S
P
S
P
S
R
I
L
P
Q
Site 55
S653
G
R
R
S
P
S
P
S
R
I
L
P
Q
P
Q
Site 56
S665
Q
P
Q
G
T
P
V
S
T
T
V
A
K
A
M
Site 57
T667
Q
G
T
P
V
S
T
T
V
A
K
A
M
A
R
Site 58
S683
A
A
Q
R
V
A
E
S
S
R
L
E
K
R
S
Site 59
S684
A
Q
R
V
A
E
S
S
R
L
E
K
R
S
V
Site 60
S690
S
S
R
L
E
K
R
S
V
F
L
E
R
S
S
Site 61
S696
R
S
V
F
L
E
R
S
S
A
G
Q
Y
A
A
Site 62
S697
S
V
F
L
E
R
S
S
A
G
Q
Y
A
A
S
Site 63
Y701
E
R
S
S
A
G
Q
Y
A
A
S
D
E
E
D
Site 64
S704
S
A
G
Q
Y
A
A
S
D
E
E
D
A
Y
D
Site 65
Y710
A
S
D
E
E
D
A
Y
D
S
P
D
F
K
R
Site 66
S712
D
E
E
D
A
Y
D
S
P
D
F
K
R
R
G
Site 67
S721
D
F
K
R
R
G
A
S
V
D
D
F
L
K
G
Site 68
Y743
H
C
C
H
G
D
E
Y
H
T
E
S
S
R
G
Site 69
T745
C
H
G
D
E
Y
H
T
E
S
S
R
G
S
D
Site 70
S747
G
D
E
Y
H
T
E
S
S
R
G
S
D
L
S
Site 71
S748
D
E
Y
H
T
E
S
S
R
G
S
D
L
S
D
Site 72
S751
H
T
E
S
S
R
G
S
D
L
S
D
I
M
E
Site 73
S754
S
S
R
G
S
D
L
S
D
I
M
E
E
D
E
Site 74
Y765
E
E
D
E
E
E
L
Y
S
E
M
Q
L
E
D
Site 75
S766
E
D
E
E
E
L
Y
S
E
M
Q
L
E
D
G
Site 76
S779
D
G
G
R
R
R
P
S
G
T
S
H
N
A
L
Site 77
T781
G
R
R
R
P
S
G
T
S
H
N
A
L
K
I
Site 78
S782
R
R
R
P
S
G
T
S
H
N
A
L
K
I
L
Site 79
S794
K
I
L
G
N
P
A
S
A
G
R
V
D
H
M
Site 80
S809
G
R
R
F
P
R
G
S
A
G
P
Q
R
S
R
Site 81
S815
G
S
A
G
P
Q
R
S
R
P
V
T
V
P
S
Site 82
T819
P
Q
R
S
R
P
V
T
V
P
S
I
D
D
Y
Site 83
Y826
T
V
P
S
I
D
D
Y
G
R
D
R
L
S
P
Site 84
S832
D
Y
G
R
D
R
L
S
P
D
F
Y
E
E
S
Site 85
Y836
D
R
L
S
P
D
F
Y
E
E
S
E
T
D
P
Site 86
S839
S
P
D
F
Y
E
E
S
E
T
D
P
G
A
E
Site 87
T841
D
F
Y
E
E
S
E
T
D
P
G
A
E
E
L
Site 88
T863
L
F
D
Y
D
P
L
T
M
S
P
N
P
D
A
Site 89
S865
D
Y
D
P
L
T
M
S
P
N
P
D
A
A
E
Site 90
Y886
E
G
Q
I
I
K
V
Y
G
D
K
D
A
D
G
Site 91
Y895
D
K
D
A
D
G
F
Y
R
G
E
T
C
A
R
Site 92
T899
D
G
F
Y
R
G
E
T
C
A
R
L
G
L
I
Site 93
T935
Q
G
F
L
P
L
N
T
P
V
E
K
I
E
R
Site 94
S943
P
V
E
K
I
E
R
S
R
R
S
G
R
R
H
Site 95
S946
K
I
E
R
S
R
R
S
G
R
R
H
S
V
S
Site 96
S951
R
R
S
G
R
R
H
S
V
S
T
R
R
M
V
Site 97
S953
S
G
R
R
H
S
V
S
T
R
R
M
V
A
L
Site 98
T954
G
R
R
H
S
V
S
T
R
R
M
V
A
L
Y
Site 99
Y961
T
R
R
M
V
A
L
Y
D
Y
D
P
R
E
S
Site 100
Y963
R
M
V
A
L
Y
D
Y
D
P
R
E
S
S
P
Site 101
S968
Y
D
Y
D
P
R
E
S
S
P
N
V
D
V
E
Site 102
S969
D
Y
D
P
R
E
S
S
P
N
V
D
V
E
A
Site 103
Y998
E
I
D
E
D
G
F
Y
Y
G
E
L
N
G
Q
Site 104
Y999
I
D
E
D
G
F
Y
Y
G
E
L
N
G
Q
K
Site 105
Y1024
V
P
D
D
V
E
V
Y
L
S
D
A
P
S
H
Site 106
S1026
D
D
V
E
V
Y
L
S
D
A
P
S
H
Y
S
Site 107
S1030
V
Y
L
S
D
A
P
S
H
Y
S
Q
D
T
P
Site 108
Y1032
L
S
D
A
P
S
H
Y
S
Q
D
T
P
M
R
Site 109
S1033
S
D
A
P
S
H
Y
S
Q
D
T
P
M
R
S
Site 110
T1036
P
S
H
Y
S
Q
D
T
P
M
R
S
K
A
K
Site 111
S1047
S
K
A
K
R
K
K
S
V
H
F
T
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation