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Updated November 2019
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Protein Info
Short Name:
KIAA0329
Full Name:
Tectonin beta-propeller repeat-containing protein 2
Alias:
K0329; tectonin beta-propeller repeat containing 2
Type:
Unknown function
Mass (Da):
153862
Number AA:
1411
UniProt ID:
O15040
International Prot ID:
IPI00784482
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
G
F
R
S
I
V
V
Y
L
T
A
L
D
T
N
Site 2
Y47
A
L
D
T
N
G
D
Y
I
A
V
G
S
S
I
Site 3
Y58
G
S
S
I
G
M
L
Y
L
Y
C
R
H
L
N
Site 4
Y60
S
I
G
M
L
Y
L
Y
C
R
H
L
N
Q
M
Site 5
Y70
H
L
N
Q
M
R
K
Y
N
F
E
G
K
T
E
Site 6
S109
A
V
F
Q
L
V
S
S
L
P
G
R
N
K
Q
Site 7
T123
Q
L
R
R
F
D
V
T
G
I
H
K
N
S
I
Site 8
S154
D
K
G
K
I
V
Y
S
S
L
D
L
D
Q
G
Site 9
S155
K
G
K
I
V
Y
S
S
L
D
L
D
Q
G
L
Site 10
S165
L
D
Q
G
L
C
N
S
Q
L
V
L
E
E
P
Site 11
Y197
L
Q
R
S
L
L
F
Y
T
E
E
K
S
V
R
Site 12
T198
Q
R
S
L
L
F
Y
T
E
E
K
S
V
R
Q
Site 13
S202
L
F
Y
T
E
E
K
S
V
R
Q
I
G
T
Q
Site 14
T208
K
S
V
R
Q
I
G
T
Q
P
R
K
S
T
G
Site 15
S213
I
G
T
Q
P
R
K
S
T
G
K
F
G
A
C
Site 16
T214
G
T
Q
P
R
K
S
T
G
K
F
G
A
C
F
Site 17
T232
L
C
K
Q
S
D
L
T
L
Y
A
S
R
P
G
Site 18
Y234
K
Q
S
D
L
T
L
Y
A
S
R
P
G
L
R
Site 19
S236
S
D
L
T
L
Y
A
S
R
P
G
L
R
L
W
Site 20
S276
E
L
H
P
R
L
E
S
P
N
S
G
S
C
S
Site 21
S279
P
R
L
E
S
P
N
S
G
S
C
S
L
P
E
Site 22
S281
L
E
S
P
N
S
G
S
C
S
L
P
E
R
H
Site 23
S283
S
P
N
S
G
S
C
S
L
P
E
R
H
L
G
Site 24
Y310
S
W
N
E
Y
S
I
Y
L
L
D
T
V
N
Q
Site 25
S331
E
G
S
G
D
I
V
S
V
S
C
T
E
N
E
Site 26
S352
D
R
N
I
I
R
I
S
S
R
P
E
G
L
T
Site 27
S353
R
N
I
I
R
I
S
S
R
P
E
G
L
T
S
Site 28
T359
S
S
R
P
E
G
L
T
S
T
V
R
D
G
L
Site 29
S360
S
R
P
E
G
L
T
S
T
V
R
D
G
L
E
Site 30
T361
R
P
E
G
L
T
S
T
V
R
D
G
L
E
M
Site 31
S369
V
R
D
G
L
E
M
S
G
C
S
E
R
V
H
Site 32
S389
K
L
P
G
A
T
V
S
E
T
R
L
R
G
S
Site 33
T391
P
G
A
T
V
S
E
T
R
L
R
G
S
S
M
Site 34
S396
S
E
T
R
L
R
G
S
S
M
A
S
S
V
A
Site 35
S397
E
T
R
L
R
G
S
S
M
A
S
S
V
A
S
Site 36
S400
L
R
G
S
S
M
A
S
S
V
A
S
E
P
R
Site 37
S401
R
G
S
S
M
A
S
S
V
A
S
E
P
R
S
Site 38
S404
S
M
A
S
S
V
A
S
E
P
R
S
R
S
S
Site 39
S408
S
V
A
S
E
P
R
S
R
S
S
S
L
N
S
Site 40
S410
A
S
E
P
R
S
R
S
S
S
L
N
S
T
D
Site 41
S411
S
E
P
R
S
R
S
S
S
L
N
S
T
D
S
Site 42
S412
E
P
R
S
R
S
S
S
L
N
S
T
D
S
G
Site 43
S415
S
R
S
S
S
L
N
S
T
D
S
G
S
G
L
Site 44
T416
R
S
S
S
L
N
S
T
D
S
G
S
G
L
L
Site 45
S418
S
S
L
N
S
T
D
S
G
S
G
L
L
P
P
Site 46
S420
L
N
S
T
D
S
G
S
G
L
L
P
P
G
L
Site 47
T430
L
P
P
G
L
Q
A
T
P
E
L
G
K
G
S
Site 48
S437
T
P
E
L
G
K
G
S
Q
P
L
S
Q
R
F
Site 49
S441
G
K
G
S
Q
P
L
S
Q
R
F
N
A
I
S
Site 50
S448
S
Q
R
F
N
A
I
S
S
E
D
F
D
Q
E
Site 51
S449
Q
R
F
N
A
I
S
S
E
D
F
D
Q
E
L
Site 52
T472
R
K
K
K
K
K
K
T
E
G
G
S
R
S
T
Site 53
S476
K
K
K
T
E
G
G
S
R
S
T
C
H
S
S
Site 54
S478
K
T
E
G
G
S
R
S
T
C
H
S
S
L
E
Site 55
T479
T
E
G
G
S
R
S
T
C
H
S
S
L
E
S
Site 56
S482
G
S
R
S
T
C
H
S
S
L
E
S
T
P
C
Site 57
S483
S
R
S
T
C
H
S
S
L
E
S
T
P
C
S
Site 58
S486
T
C
H
S
S
L
E
S
T
P
C
S
E
F
P
Site 59
T487
C
H
S
S
L
E
S
T
P
C
S
E
F
P
G
Site 60
S490
S
L
E
S
T
P
C
S
E
F
P
G
D
S
P
Site 61
S496
C
S
E
F
P
G
D
S
P
Q
S
L
N
T
D
Site 62
S499
F
P
G
D
S
P
Q
S
L
N
T
D
L
L
S
Site 63
T502
D
S
P
Q
S
L
N
T
D
L
L
S
M
T
S
Site 64
S515
T
S
S
V
L
G
S
S
V
D
Q
L
S
A
E
Site 65
S520
G
S
S
V
D
Q
L
S
A
E
S
P
D
Q
E
Site 66
S523
V
D
Q
L
S
A
E
S
P
D
Q
E
S
S
F
Site 67
S529
E
S
P
D
Q
E
S
S
F
N
G
E
V
N
G
Site 68
T546
Q
E
N
T
D
P
E
T
F
N
V
L
E
V
S
Site 69
S555
N
V
L
E
V
S
G
S
M
P
D
S
L
A
E
Site 70
S559
V
S
G
S
M
P
D
S
L
A
E
E
D
D
I
Site 71
S592
A
R
E
D
V
G
G
S
D
V
T
G
L
G
D
Site 72
S610
P
A
D
D
G
P
N
S
T
Q
L
P
F
Q
E
Site 73
T611
A
D
D
G
P
N
S
T
Q
L
P
F
Q
E
Q
Site 74
S620
L
P
F
Q
E
Q
D
S
S
P
G
A
H
D
G
Site 75
S621
P
F
Q
E
Q
D
S
S
P
G
A
H
D
G
E
Site 76
S653
N
S
L
T
V
P
S
S
L
S
W
A
P
S
A
Site 77
S655
L
T
V
P
S
S
L
S
W
A
P
S
A
E
Q
Site 78
S659
S
S
L
S
W
A
P
S
A
E
Q
W
L
P
G
Site 79
T667
A
E
Q
W
L
P
G
T
R
A
D
E
G
S
P
Site 80
S673
G
T
R
A
D
E
G
S
P
V
E
P
S
Q
E
Site 81
S678
E
G
S
P
V
E
P
S
Q
E
Q
D
I
L
T
Site 82
T685
S
Q
E
Q
D
I
L
T
S
M
E
A
S
G
H
Site 83
S686
Q
E
Q
D
I
L
T
S
M
E
A
S
G
H
L
Site 84
T702
T
N
L
W
H
A
V
T
D
D
D
T
G
Q
K
Site 85
T706
H
A
V
T
D
D
D
T
G
Q
K
E
I
P
I
Site 86
S714
G
Q
K
E
I
P
I
S
E
R
V
L
G
S
V
Site 87
T748
E
Q
P
P
R
D
Q
T
L
T
S
S
D
E
E
Site 88
T750
P
P
R
D
Q
T
L
T
S
S
D
E
E
D
I
Site 89
S751
P
R
D
Q
T
L
T
S
S
D
E
E
D
I
Y
Site 90
S752
R
D
Q
T
L
T
S
S
D
E
E
D
I
Y
A
Site 91
Y758
S
S
D
E
E
D
I
Y
A
H
G
L
P
S
S
Site 92
S764
I
Y
A
H
G
L
P
S
S
S
S
E
T
S
V
Site 93
S765
Y
A
H
G
L
P
S
S
S
S
E
T
S
V
T
Site 94
S766
A
H
G
L
P
S
S
S
S
E
T
S
V
T
E
Site 95
S767
H
G
L
P
S
S
S
S
E
T
S
V
T
E
L
Site 96
T769
L
P
S
S
S
S
E
T
S
V
T
E
L
G
P
Site 97
S770
P
S
S
S
S
E
T
S
V
T
E
L
G
P
S
Site 98
T772
S
S
S
E
T
S
V
T
E
L
G
P
S
C
S
Site 99
S777
S
V
T
E
L
G
P
S
C
S
Q
Q
D
L
S
Site 100
S779
T
E
L
G
P
S
C
S
Q
Q
D
L
S
R
L
Site 101
S784
S
C
S
Q
Q
D
L
S
R
L
G
A
E
D
A
Site 102
S802
K
P
D
Q
F
A
E
S
W
M
G
Y
S
G
P
Site 103
Y806
F
A
E
S
W
M
G
Y
S
G
P
G
Y
G
I
Site 104
S807
A
E
S
W
M
G
Y
S
G
P
G
Y
G
I
L
Site 105
S859
Q
Q
V
A
V
S
P
S
G
A
L
L
W
K
I
Site 106
Y888
I
K
G
K
R
H
W
Y
E
A
L
P
Q
A
V
Site 107
S920
L
Y
L
Q
T
G
L
S
V
D
R
P
C
A
R
Site 108
S938
V
D
C
P
Y
P
L
S
Q
I
T
A
R
N
N
Site 109
Y958
T
E
Q
R
A
L
L
Y
R
E
G
V
S
S
F
Site 110
S964
L
Y
R
E
G
V
S
S
F
C
P
E
G
E
Q
Site 111
T1009
H
G
N
L
W
F
R
T
G
I
I
S
K
K
P
Site 112
S1013
W
F
R
T
G
I
I
S
K
K
P
Q
G
D
D
Site 113
S1079
Q
Q
L
Q
C
Q
P
S
L
L
G
V
N
N
S
Site 114
S1103
E
F
H
V
A
K
G
S
L
I
G
T
Y
W
N
Site 115
Y1108
K
G
S
L
I
G
T
Y
W
N
H
V
V
P
R
Site 116
T1117
N
H
V
V
P
R
G
T
A
S
A
T
K
W
A
Site 117
S1137
A
A
P
T
K
E
G
S
F
L
W
L
C
Q
S
Site 118
S1150
Q
S
S
K
D
L
C
S
V
S
A
Q
S
A
Q
Site 119
S1152
S
K
D
L
C
S
V
S
A
Q
S
A
Q
S
R
Site 120
S1155
L
C
S
V
S
A
Q
S
A
Q
S
R
P
S
T
Site 121
S1161
Q
S
A
Q
S
R
P
S
T
V
Q
L
P
P
E
Site 122
T1162
S
A
Q
S
R
P
S
T
V
Q
L
P
P
E
A
Site 123
Y1174
P
E
A
E
M
R
A
Y
A
A
C
Q
D
A
L
Site 124
S1211
H
W
T
R
L
D
L
S
Q
L
G
A
V
K
L
Site 125
Y1238
C
D
S
R
G
G
V
Y
F
R
V
G
T
Q
P
Site 126
T1243
G
V
Y
F
R
V
G
T
Q
P
L
N
P
S
L
Site 127
S1271
P
A
G
V
S
L
V
S
V
H
S
S
P
N
D
Site 128
S1274
V
S
L
V
S
V
H
S
S
P
N
D
Q
M
L
Site 129
S1275
S
L
V
S
V
H
S
S
P
N
D
Q
M
L
W
Site 130
S1320
Q
A
C
Q
L
A
L
S
T
R
T
V
W
A
R
Site 131
Y1337
N
G
D
L
A
R
R
Y
G
V
T
D
K
N
P
Site 132
T1340
L
A
R
R
Y
G
V
T
D
K
N
P
A
G
D
Site 133
Y1348
D
K
N
P
A
G
D
Y
W
K
K
I
P
G
S
Site 134
Y1375
W
A
V
G
P
P
G
Y
L
L
Q
R
L
T
K
Site 135
T1381
G
Y
L
L
Q
R
L
T
K
T
F
S
H
S
H
Site 136
T1383
L
L
Q
R
L
T
K
T
F
S
H
S
H
G
T
Site 137
S1385
Q
R
L
T
K
T
F
S
H
S
H
G
T
Q
K
Site 138
S1387
L
T
K
T
F
S
H
S
H
G
T
Q
K
S
S
Site 139
S1393
H
S
H
G
T
Q
K
S
S
Q
A
A
M
P
H
Site 140
S1394
S
H
G
T
Q
K
S
S
Q
A
A
M
P
H
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation