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Updated November 2019
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Protein Info
Short Name:
SETD1A
Full Name:
Histone-lysine N-methyltransferase SETD1A
Alias:
Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1; KIAA0339; KMT2F; Lysine N-methyltransferase 2F; SET domain containing 1A; SET domain-containing 1A; SET domain-containing protein 1A; SET1; Set1/Ash2 histone methyltransferase complex subunit SET1; Set1/Ash2 histone methyltransferase SET1; SET1A
Type:
Amino Acid Metabolism - lysine degradation; Methyltransferase; EC 2.1.1.43
Mass (Da):
186034
Number AA:
1707
UniProt ID:
O15047
International Prot ID:
IPI00783972
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035097
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0018024
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
P
S
F
Q
W
R
N
Y
K
L
I
V
D
P
A
Site 2
S36
D
P
A
L
R
R
P
S
Q
K
V
Y
R
Y
D
Site 3
Y40
R
R
P
S
Q
K
V
Y
R
Y
D
G
V
H
F
Site 4
Y42
P
S
Q
K
V
Y
R
Y
D
G
V
H
F
S
V
Site 5
S52
V
H
F
S
V
N
D
S
K
Y
I
P
V
E
D
Site 6
Y54
F
S
V
N
D
S
K
Y
I
P
V
E
D
L
Q
Site 7
S69
D
P
R
C
H
V
R
S
K
N
R
D
F
S
L
Site 8
S75
R
S
K
N
R
D
F
S
L
P
V
P
K
F
K
Site 9
Y87
K
F
K
L
D
E
F
Y
I
G
Q
I
P
L
K
Site 10
T97
Q
I
P
L
K
E
V
T
F
A
R
L
N
D
N
Site 11
T108
L
N
D
N
V
R
E
T
F
L
K
D
M
C
R
Site 12
Y117
L
K
D
M
C
R
K
Y
G
E
V
E
E
V
E
Site 13
S144
L
A
R
V
L
F
T
S
T
R
G
A
K
E
T
Site 14
T151
S
T
R
G
A
K
E
T
V
K
N
L
H
L
T
Site 15
Y179
K
G
Q
Q
R
M
K
Y
Y
E
L
I
V
N
G
Site 16
Y180
G
Q
Q
R
M
K
Y
Y
E
L
I
V
N
G
S
Site 17
S187
Y
E
L
I
V
N
G
S
Y
T
P
Q
T
V
P
Site 18
Y188
E
L
I
V
N
G
S
Y
T
P
Q
T
V
P
T
Site 19
T192
N
G
S
Y
T
P
Q
T
V
P
T
G
G
K
A
Site 20
S201
P
T
G
G
K
A
L
S
E
K
F
Q
G
S
G
Site 21
T211
F
Q
G
S
G
A
A
T
E
T
A
E
S
R
R
Site 22
S216
A
A
T
E
T
A
E
S
R
R
R
S
S
S
D
Site 23
S220
T
A
E
S
R
R
R
S
S
S
D
T
A
A
Y
Site 24
S221
A
E
S
R
R
R
S
S
S
D
T
A
A
Y
P
Site 25
S222
E
S
R
R
R
S
S
S
D
T
A
A
Y
P
A
Site 26
T224
R
R
R
S
S
S
D
T
A
A
Y
P
A
G
T
Site 27
Y227
S
S
S
D
T
A
A
Y
P
A
G
T
T
A
V
Site 28
T236
A
G
T
T
A
V
G
T
P
G
N
G
T
P
C
Site 29
T241
V
G
T
P
G
N
G
T
P
C
S
Q
D
T
S
Site 30
S244
P
G
N
G
T
P
C
S
Q
D
T
S
F
S
S
Site 31
T247
G
T
P
C
S
Q
D
T
S
F
S
S
S
R
Q
Site 32
S248
T
P
C
S
Q
D
T
S
F
S
S
S
R
Q
D
Site 33
S250
C
S
Q
D
T
S
F
S
S
S
R
Q
D
T
P
Site 34
S251
S
Q
D
T
S
F
S
S
S
R
Q
D
T
P
S
Site 35
S252
Q
D
T
S
F
S
S
S
R
Q
D
T
P
S
S
Site 36
T256
F
S
S
S
R
Q
D
T
P
S
S
F
G
Q
F
Site 37
S258
S
S
R
Q
D
T
P
S
S
F
G
Q
F
T
P
Site 38
S259
S
R
Q
D
T
P
S
S
F
G
Q
F
T
P
Q
Site 39
T264
P
S
S
F
G
Q
F
T
P
Q
S
S
Q
G
T
Site 40
S267
F
G
Q
F
T
P
Q
S
S
Q
G
T
P
Y
T
Site 41
S268
G
Q
F
T
P
Q
S
S
Q
G
T
P
Y
T
S
Site 42
T271
T
P
Q
S
S
Q
G
T
P
Y
T
S
R
G
S
Site 43
Y273
Q
S
S
Q
G
T
P
Y
T
S
R
G
S
T
P
Site 44
T274
S
S
Q
G
T
P
Y
T
S
R
G
S
T
P
Y
Site 45
S275
S
Q
G
T
P
Y
T
S
R
G
S
T
P
Y
S
Site 46
S278
T
P
Y
T
S
R
G
S
T
P
Y
S
Q
D
S
Site 47
T279
P
Y
T
S
R
G
S
T
P
Y
S
Q
D
S
A
Site 48
Y281
T
S
R
G
S
T
P
Y
S
Q
D
S
A
Y
S
Site 49
S282
S
R
G
S
T
P
Y
S
Q
D
S
A
Y
S
S
Site 50
S285
S
T
P
Y
S
Q
D
S
A
Y
S
S
S
T
T
Site 51
Y287
P
Y
S
Q
D
S
A
Y
S
S
S
T
T
S
T
Site 52
S288
Y
S
Q
D
S
A
Y
S
S
S
T
T
S
T
S
Site 53
S289
S
Q
D
S
A
Y
S
S
S
T
T
S
T
S
F
Site 54
S290
Q
D
S
A
Y
S
S
S
T
T
S
T
S
F
K
Site 55
T291
D
S
A
Y
S
S
S
T
T
S
T
S
F
K
P
Site 56
T292
S
A
Y
S
S
S
T
T
S
T
S
F
K
P
R
Site 57
S293
A
Y
S
S
S
T
T
S
T
S
F
K
P
R
R
Site 58
T294
Y
S
S
S
T
T
S
T
S
F
K
P
R
R
S
Site 59
S295
S
S
S
T
T
S
T
S
F
K
P
R
R
S
E
Site 60
S301
T
S
F
K
P
R
R
S
E
N
S
Y
Q
D
A
Site 61
S304
K
P
R
R
S
E
N
S
Y
Q
D
A
F
S
R
Site 62
Y305
P
R
R
S
E
N
S
Y
Q
D
A
F
S
R
R
Site 63
S310
N
S
Y
Q
D
A
F
S
R
R
H
F
S
A
S
Site 64
S315
A
F
S
R
R
H
F
S
A
S
S
A
S
T
T
Site 65
S317
S
R
R
H
F
S
A
S
S
A
S
T
T
A
S
Site 66
S318
R
R
H
F
S
A
S
S
A
S
T
T
A
S
T
Site 67
T330
A
S
T
A
I
A
A
T
T
A
A
T
A
S
S
Site 68
S336
A
T
T
A
A
T
A
S
S
S
A
S
S
S
S
Site 69
S337
T
T
A
A
T
A
S
S
S
A
S
S
S
S
L
Site 70
S338
T
A
A
T
A
S
S
S
A
S
S
S
S
L
S
Site 71
S340
A
T
A
S
S
S
A
S
S
S
S
L
S
S
S
Site 72
S341
T
A
S
S
S
A
S
S
S
S
L
S
S
S
S
Site 73
S342
A
S
S
S
A
S
S
S
S
L
S
S
S
S
S
Site 74
S343
S
S
S
A
S
S
S
S
L
S
S
S
S
S
S
Site 75
S345
S
A
S
S
S
S
L
S
S
S
S
S
S
S
S
Site 76
S346
A
S
S
S
S
L
S
S
S
S
S
S
S
S
S
Site 77
S347
S
S
S
S
L
S
S
S
S
S
S
S
S
S
S
Site 78
S348
S
S
S
L
S
S
S
S
S
S
S
S
S
S
S
Site 79
S349
S
S
L
S
S
S
S
S
S
S
S
S
S
S
S
Site 80
S350
S
L
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 81
S351
L
S
S
S
S
S
S
S
S
S
S
S
S
S
Q
Site 82
S352
S
S
S
S
S
S
S
S
S
S
S
S
S
Q
F
Site 83
S353
S
S
S
S
S
S
S
S
S
S
S
S
Q
F
R
Site 84
S354
S
S
S
S
S
S
S
S
S
S
S
Q
F
R
S
Site 85
S355
S
S
S
S
S
S
S
S
S
S
Q
F
R
S
S
Site 86
S356
S
S
S
S
S
S
S
S
S
Q
F
R
S
S
D
Site 87
S357
S
S
S
S
S
S
S
S
Q
F
R
S
S
D
A
Site 88
S361
S
S
S
S
Q
F
R
S
S
D
A
N
Y
P
A
Site 89
S362
S
S
S
Q
F
R
S
S
D
A
N
Y
P
A
Y
Site 90
Y366
F
R
S
S
D
A
N
Y
P
A
Y
Y
E
S
W
Site 91
Y369
S
D
A
N
Y
P
A
Y
Y
E
S
W
N
R
Y
Site 92
Y370
D
A
N
Y
P
A
Y
Y
E
S
W
N
R
Y
Q
Site 93
Y376
Y
Y
E
S
W
N
R
Y
Q
R
H
T
S
Y
P
Site 94
T380
W
N
R
Y
Q
R
H
T
S
Y
P
P
R
R
A
Site 95
S381
N
R
Y
Q
R
H
T
S
Y
P
P
R
R
A
T
Site 96
Y382
R
Y
Q
R
H
T
S
Y
P
P
R
R
A
T
R
Site 97
T388
S
Y
P
P
R
R
A
T
R
E
E
P
P
G
A
Site 98
T401
G
A
P
F
A
E
N
T
A
E
R
F
P
P
S
Site 99
S408
T
A
E
R
F
P
P
S
Y
T
S
Y
L
P
P
Site 100
Y409
A
E
R
F
P
P
S
Y
T
S
Y
L
P
P
E
Site 101
S411
R
F
P
P
S
Y
T
S
Y
L
P
P
E
P
S
Site 102
Y412
F
P
P
S
Y
T
S
Y
L
P
P
E
P
S
R
Site 103
S418
S
Y
L
P
P
E
P
S
R
P
T
D
Q
D
Y
Site 104
T421
P
P
E
P
S
R
P
T
D
Q
D
Y
R
P
P
Site 105
Y425
S
R
P
T
D
Q
D
Y
R
P
P
A
S
E
A
Site 106
S430
Q
D
Y
R
P
P
A
S
E
A
P
P
P
E
P
Site 107
S450
G
G
G
G
G
G
P
S
P
E
R
E
E
V
R
Site 108
T458
P
E
R
E
E
V
R
T
S
P
R
P
A
S
P
Site 109
S459
E
R
E
E
V
R
T
S
P
R
P
A
S
P
A
Site 110
S464
R
T
S
P
R
P
A
S
P
A
R
S
G
S
P
Site 111
S468
R
P
A
S
P
A
R
S
G
S
P
A
P
E
T
Site 112
S470
A
S
P
A
R
S
G
S
P
A
P
E
T
T
N
Site 113
T475
S
G
S
P
A
P
E
T
T
N
E
S
V
P
F
Site 114
T476
G
S
P
A
P
E
T
T
N
E
S
V
P
F
A
Site 115
S486
S
V
P
F
A
Q
H
S
S
L
D
S
R
I
E
Site 116
S487
V
P
F
A
Q
H
S
S
L
D
S
R
I
E
M
Site 117
S490
A
Q
H
S
S
L
D
S
R
I
E
M
L
L
K
Site 118
S501
M
L
L
K
E
Q
R
S
K
F
S
F
L
A
S
Site 119
S504
K
E
Q
R
S
K
F
S
F
L
A
S
D
T
E
Site 120
S508
S
K
F
S
F
L
A
S
D
T
E
E
E
E
E
Site 121
S517
T
E
E
E
E
E
N
S
S
M
V
L
G
A
R
Site 122
S518
E
E
E
E
E
N
S
S
M
V
L
G
A
R
D
Site 123
T526
M
V
L
G
A
R
D
T
G
S
E
V
P
S
G
Site 124
S528
L
G
A
R
D
T
G
S
E
V
P
S
G
S
G
Site 125
S532
D
T
G
S
E
V
P
S
G
S
G
H
G
P
C
Site 126
S534
G
S
E
V
P
S
G
S
G
H
G
P
C
T
P
Site 127
T540
G
S
G
H
G
P
C
T
P
P
P
A
P
A
N
Site 128
S556
E
D
V
A
P
T
G
S
G
E
P
G
A
T
R
Site 129
T562
G
S
G
E
P
G
A
T
R
E
S
P
K
A
N
Site 130
S565
E
P
G
A
T
R
E
S
P
K
A
N
G
Q
N
Site 131
S575
A
N
G
Q
N
Q
A
S
P
C
S
S
G
D
D
Site 132
S579
N
Q
A
S
P
C
S
S
G
D
D
M
E
I
S
Site 133
S586
S
G
D
D
M
E
I
S
D
D
D
R
G
G
S
Site 134
S593
S
D
D
D
R
G
G
S
P
P
P
A
P
T
P
Site 135
T599
G
S
P
P
P
A
P
T
P
P
Q
Q
P
P
P
Site 136
Y617
P
P
P
P
P
P
P
Y
L
A
S
L
P
L
G
Site 137
S620
P
P
P
P
Y
L
A
S
L
P
L
G
Y
P
P
Site 138
Y625
L
A
S
L
P
L
G
Y
P
P
H
Q
P
A
Y
Site 139
Y632
Y
P
P
H
Q
P
A
Y
L
L
P
P
R
P
D
Site 140
Y646
D
G
P
P
P
P
E
Y
P
P
P
P
P
P
P
Site 141
Y657
P
P
P
P
P
H
I
Y
D
F
V
N
S
L
E
Site 142
Y726
P
P
P
Q
E
A
A
Y
G
L
P
Y
A
L
Y
Site 143
Y733
Y
G
L
P
Y
A
L
Y
A
Q
G
Q
E
G
R
Site 144
Y743
G
Q
E
G
R
G
A
Y
S
R
E
A
Y
H
L
Site 145
Y748
G
A
Y
S
R
E
A
Y
H
L
P
M
P
M
A
Site 146
S761
M
A
A
E
P
L
P
S
S
S
V
S
G
E
E
Site 147
S762
A
A
E
P
L
P
S
S
S
V
S
G
E
E
A
Site 148
S763
A
E
P
L
P
S
S
S
V
S
G
E
E
A
R
Site 149
S765
P
L
P
S
S
S
V
S
G
E
E
A
R
L
P
Site 150
S862
L
K
E
P
G
L
L
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L
V
D
W
A
K
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Site 151
S869
S
L
V
D
W
A
K
S
G
G
T
T
G
I
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Site 152
S892
R
G
A
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K
R
K
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Site 153
S904
R
K
E
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E
I
S
E
A
S
E
E
K
R
Site 154
S907
P
S
E
I
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E
A
S
E
E
K
R
P
R
P
Site 155
S915
E
E
K
R
P
R
P
S
T
P
A
E
E
D
E
Site 156
T916
E
K
R
P
R
P
S
T
P
A
E
E
D
E
D
Site 157
T939
G
E
P
G
R
P
G
T
K
P
P
K
R
D
E
Site 158
T951
R
D
E
E
R
G
K
T
Q
G
K
H
R
K
S
Site 159
S958
T
Q
G
K
H
R
K
S
F
A
L
D
S
E
G
Site 160
S963
R
K
S
F
A
L
D
S
E
G
E
E
A
S
Q
Site 161
S969
D
S
E
G
E
E
A
S
Q
E
S
S
S
E
K
Site 162
S973
E
E
A
S
Q
E
S
S
S
E
K
D
E
E
D
Site 163
S974
E
A
S
Q
E
S
S
S
E
K
D
E
E
D
D
Site 164
T996
D
R
E
E
A
V
D
T
T
K
K
E
T
E
V
Site 165
S1004
T
K
K
E
T
E
V
S
D
G
E
D
E
E
S
Site 166
S1011
S
D
G
E
D
E
E
S
D
S
S
S
K
C
S
Site 167
S1013
G
E
D
E
E
S
D
S
S
S
K
C
S
L
Y
Site 168
S1014
E
D
E
E
S
D
S
S
S
K
C
S
L
Y
A
Site 169
S1015
D
E
E
S
D
S
S
S
K
C
S
L
Y
A
D
Site 170
S1018
S
D
S
S
S
K
C
S
L
Y
A
D
S
D
G
Site 171
Y1020
S
S
S
K
C
S
L
Y
A
D
S
D
G
E
N
Site 172
S1023
K
C
S
L
Y
A
D
S
D
G
E
N
D
S
T
Site 173
S1029
D
S
D
G
E
N
D
S
T
S
D
S
E
S
S
Site 174
T1030
S
D
G
E
N
D
S
T
S
D
S
E
S
S
S
Site 175
S1031
D
G
E
N
D
S
T
S
D
S
E
S
S
S
S
Site 176
S1033
E
N
D
S
T
S
D
S
E
S
S
S
S
S
S
Site 177
S1035
D
S
T
S
D
S
E
S
S
S
S
S
S
S
S
Site 178
S1036
S
T
S
D
S
E
S
S
S
S
S
S
S
S
S
Site 179
S1037
T
S
D
S
E
S
S
S
S
S
S
S
S
S
S
Site 180
S1038
S
D
S
E
S
S
S
S
S
S
S
S
S
S
S
Site 181
S1039
D
S
E
S
S
S
S
S
S
S
S
S
S
S
S
Site 182
S1040
S
E
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 183
S1041
E
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 184
S1042
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 185
S1052
S
S
S
S
S
S
S
S
S
S
S
S
S
S
E
Site 186
S1053
S
S
S
S
S
S
S
S
S
S
S
S
S
E
S
Site 187
S1054
S
S
S
S
S
S
S
S
S
S
S
S
E
S
S
Site 188
S1055
S
S
S
S
S
S
S
S
S
S
S
E
S
S
S
Site 189
S1056
S
S
S
S
S
S
S
S
S
S
E
S
S
S
E
Site 190
S1057
S
S
S
S
S
S
S
S
S
E
S
S
S
E
D
Site 191
S1058
S
S
S
S
S
S
S
S
E
S
S
S
E
D
E
Site 192
S1060
S
S
S
S
S
S
E
S
S
S
E
D
E
E
E
Site 193
S1061
S
S
S
S
S
E
S
S
S
E
D
E
E
E
E
Site 194
S1062
S
S
S
S
E
S
S
S
E
D
E
E
E
E
E
Site 195
S1076
E
R
P
A
A
L
P
S
A
S
P
P
P
R
E
Site 196
S1078
P
A
A
L
P
S
A
S
P
P
P
R
E
V
P
Site 197
T1088
P
R
E
V
P
V
P
T
P
A
P
V
E
V
P
Site 198
S1103
V
P
E
R
V
A
G
S
P
V
T
P
L
P
E
Site 199
T1106
R
V
A
G
S
P
V
T
P
L
P
E
Q
E
A
Site 200
S1114
P
L
P
E
Q
E
A
S
P
A
R
P
A
G
P
Site 201
T1122
P
A
R
P
A
G
P
T
E
E
S
P
P
S
A
Site 202
S1125
P
A
G
P
T
E
E
S
P
P
S
A
P
L
R
Site 203
S1128
P
T
E
E
S
P
P
S
A
P
L
R
P
P
E
Site 204
S1152
P
R
P
D
E
R
P
S
S
P
I
P
L
L
P
Site 205
S1153
R
P
D
E
R
P
S
S
P
I
P
L
L
P
P
Site 206
T1167
P
P
K
K
R
R
K
T
V
S
F
S
A
I
E
Site 207
S1169
K
K
R
R
K
T
V
S
F
S
A
I
E
V
V
Site 208
T1185
A
P
E
P
P
P
A
T
P
P
Q
A
K
F
P
Site 209
S1196
A
K
F
P
G
P
A
S
R
K
A
P
R
G
V
Site 210
T1206
A
P
R
G
V
E
R
T
I
R
N
L
P
L
D
Site 211
S1216
N
L
P
L
D
H
A
S
L
V
K
S
W
P
E
Site 212
S1220
D
H
A
S
L
V
K
S
W
P
E
E
V
S
R
Site 213
S1231
E
V
S
R
G
G
R
S
R
A
G
G
R
G
R
Site 214
T1240
A
G
G
R
G
R
L
T
E
E
E
E
A
E
P
Site 215
S1277
A
L
P
A
V
E
D
S
E
A
T
E
T
S
D
Site 216
S1294
E
R
P
R
P
L
L
S
H
I
L
L
E
H
N
Site 217
S1376
G
E
E
E
E
E
E
S
S
D
S
S
S
S
S
Site 218
S1377
E
E
E
E
E
E
S
S
D
S
S
S
S
S
D
Site 219
S1379
E
E
E
E
S
S
D
S
S
S
S
S
D
G
E
Site 220
S1380
E
E
E
S
S
D
S
S
S
S
S
D
G
E
G
Site 221
S1381
E
E
S
S
D
S
S
S
S
S
D
G
E
G
A
Site 222
S1382
E
S
S
D
S
S
S
S
S
D
G
E
G
A
L
Site 223
S1383
S
S
D
S
S
S
S
S
D
G
E
G
A
L
R
Site 224
S1393
E
G
A
L
R
R
R
S
L
R
S
H
A
R
R
Site 225
S1396
L
R
R
R
S
L
R
S
H
A
R
R
R
R
P
Site 226
Y1415
P
P
P
P
P
R
A
Y
E
P
R
S
E
F
E
Site 227
S1419
P
R
A
Y
E
P
R
S
E
F
E
Q
M
T
I
Site 228
S1437
I
W
N
S
G
L
D
S
E
D
M
S
Y
L
R
Site 229
S1441
G
L
D
S
E
D
M
S
Y
L
R
L
T
Y
E
Site 230
Y1442
L
D
S
E
D
M
S
Y
L
R
L
T
Y
E
R
Site 231
T1446
D
M
S
Y
L
R
L
T
Y
E
R
L
L
Q
Q
Site 232
Y1447
M
S
Y
L
R
L
T
Y
E
R
L
L
Q
Q
T
Site 233
S1455
E
R
L
L
Q
Q
T
S
G
A
D
W
L
N
D
Site 234
T1475
H
T
I
T
N
L
T
T
P
K
R
K
R
R
P
Site 235
T1491
D
G
P
R
E
H
Q
T
G
S
A
R
S
E
G
Site 236
S1493
P
R
E
H
Q
T
G
S
A
R
S
E
G
Y
Y
Site 237
Y1500
S
A
R
S
E
G
Y
Y
P
I
S
K
K
E
K
Site 238
S1503
S
E
G
Y
Y
P
I
S
K
K
E
K
D
K
Y
Site 239
Y1510
S
K
K
E
K
D
K
Y
L
D
V
C
P
V
S
Site 240
T1526
R
Q
L
E
G
V
D
T
Q
G
T
N
R
V
L
Site 241
T1529
E
G
V
D
T
Q
G
T
N
R
V
L
S
E
R
Site 242
S1534
Q
G
T
N
R
V
L
S
E
R
R
S
E
Q
R
Site 243
S1538
R
V
L
S
E
R
R
S
E
Q
R
R
L
L
S
Site 244
S1545
S
E
Q
R
R
L
L
S
A
I
G
T
S
A
I
Site 245
S1555
G
T
S
A
I
M
D
S
D
L
L
K
L
N
Q
Site 246
S1575
K
K
L
R
F
G
R
S
R
I
H
E
W
G
L
Site 247
Y1597
A
D
E
M
V
I
E
Y
V
G
Q
N
I
R
Q
Site 248
Y1614
A
D
M
R
E
K
R
Y
V
Q
E
G
I
G
S
Site 249
S1621
Y
V
Q
E
G
I
G
S
S
Y
L
F
R
V
D
Site 250
Y1623
Q
E
G
I
G
S
S
Y
L
F
R
V
D
H
D
Site 251
T1636
H
D
T
I
I
D
A
T
K
C
G
N
L
A
R
Site 252
Y1682
G
V
D
E
E
I
T
Y
D
Y
K
F
P
L
E
Site 253
Y1684
D
E
E
I
T
Y
D
Y
K
F
P
L
E
D
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation