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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LBA1
Full Name:
TPR and ankyrin repeat-containing protein 1
Alias:
KIAA0342; lupus brain antigen 1; tetratricopeptide repeat and ankyrin repeat containing 1
Type:
Mass (Da):
283690
Number AA:
UniProt ID:
O15050
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y48
C
L
Q
W
D
P
T
Y
V
K
G
Y
Y
R
A
Site 2
Y52
D
P
T
Y
V
K
G
Y
Y
R
A
G
Y
S
L
Site 3
Y53
P
T
Y
V
K
G
Y
Y
R
A
G
Y
S
L
L
Site 4
Y57
K
G
Y
Y
R
A
G
Y
S
L
L
R
L
H
Q
Site 5
S58
G
Y
Y
R
A
G
Y
S
L
L
R
L
H
Q
P
Site 6
Y66
L
L
R
L
H
Q
P
Y
E
A
A
R
M
F
F
Site 7
S82
G
L
R
L
V
Q
R
S
Q
D
Q
A
P
V
A
Site 8
S128
F
P
T
E
V
W
Q
S
V
I
E
K
L
A
K
Site 9
S146
W
H
S
F
L
L
L
S
A
K
K
D
R
L
P
Site 10
S162
N
I
H
V
P
E
L
S
L
K
S
L
F
E
K
Site 11
Y176
K
Y
V
F
I
G
L
Y
E
K
M
E
Q
V
P
Site 12
Y202
S
V
E
T
I
G
P
Y
P
L
H
A
L
M
R
Site 13
Y255
V
A
A
H
S
P
G
Y
L
V
K
R
Q
T
E
Site 14
T261
G
Y
L
V
K
R
Q
T
E
D
V
Q
M
L
L
Site 15
T275
L
R
F
G
A
D
P
T
L
L
D
R
Q
S
R
Site 16
S281
P
T
L
L
D
R
Q
S
R
S
V
V
D
V
L
Site 17
S283
L
L
D
R
Q
S
R
S
V
V
D
V
L
K
R
Site 18
S302
K
A
I
E
K
I
N
S
H
L
E
K
L
A
T
Site 19
T309
S
H
L
E
K
L
A
T
C
S
K
D
L
S
G
Site 20
S311
L
E
K
L
A
T
C
S
K
D
L
S
G
F
S
Site 21
S315
A
T
C
S
K
D
L
S
G
F
S
N
G
D
G
Site 22
S318
S
K
D
L
S
G
F
S
N
G
D
G
P
T
S
Site 23
S325
S
N
G
D
G
P
T
S
E
N
D
I
F
R
K
Site 24
Y340
V
L
E
Q
L
V
K
Y
M
N
S
G
N
R
L
Site 25
S343
Q
L
V
K
Y
M
N
S
G
N
R
L
L
H
K
Site 26
S366
Q
R
F
L
R
L
L
S
T
L
Q
E
I
P
P
Site 27
T367
R
F
L
R
L
L
S
T
L
Q
E
I
P
P
D
Site 28
S409
L
L
L
T
R
K
V
S
G
E
P
P
L
G
D
Site 29
S463
L
P
D
G
L
Q
E
S
Q
E
R
P
V
V
T
Site 30
S494
G
A
D
P
R
A
I
S
L
T
E
G
D
T
P
Site 31
T496
D
P
R
A
I
S
L
T
E
G
D
T
P
L
H
Site 32
Y537
S
N
P
T
E
F
D
Y
L
N
P
N
V
Q
D
Site 33
S545
L
N
P
N
V
Q
D
S
N
G
N
T
L
M
H
Site 34
S596
H
R
I
K
K
N
D
S
L
L
L
A
W
N
K
Site 35
S612
L
M
E
N
R
R
R
S
R
Q
D
S
A
A
H
Site 36
S616
R
R
R
S
R
Q
D
S
A
A
H
L
G
K
L
Site 37
S624
A
A
H
L
G
K
L
S
K
S
T
A
P
G
H
Site 38
S626
H
L
G
K
L
S
K
S
T
A
P
G
H
T
S
Site 39
S633
S
T
A
P
G
H
T
S
Q
L
K
S
Q
G
S
Site 40
S637
G
H
T
S
Q
L
K
S
Q
G
S
F
K
S
V
Site 41
S640
S
Q
L
K
S
Q
G
S
F
K
S
V
P
C
G
Site 42
S643
K
S
Q
G
S
F
K
S
V
P
C
G
A
T
A
Site 43
T649
K
S
V
P
C
G
A
T
A
R
T
L
P
E
G
Site 44
T652
P
C
G
A
T
A
R
T
L
P
E
G
S
A
V
Site 45
S657
A
R
T
L
P
E
G
S
A
V
P
D
S
W
E
Site 46
S662
E
G
S
A
V
P
D
S
W
E
T
L
P
G
T
Site 47
T669
S
W
E
T
L
P
G
T
Q
V
T
R
K
E
P
Site 48
S683
P
G
A
L
R
P
C
S
L
R
D
C
L
M
Q
Site 49
S704
Q
Q
V
E
V
D
P
S
F
P
E
D
C
L
Q
Site 50
S713
P
E
D
C
L
Q
S
S
E
P
L
E
A
G
A
Site 51
T731
G
K
K
D
D
K
P
T
L
G
A
G
A
P
D
Site 52
S740
G
A
G
A
P
D
C
S
E
V
G
E
G
H
A
Site 53
T775
D
D
Q
D
D
W
S
T
Q
E
I
E
A
C
L
Site 54
T795
M
T
W
E
I
E
C
T
S
E
M
L
K
K
L
Site 55
S864
W
E
L
A
I
D
F
S
P
R
C
S
E
N
P
Site 56
S868
I
D
F
S
P
R
C
S
E
N
P
E
K
I
I
Site 57
Y891
M
E
K
S
G
R
I
Y
T
E
I
I
R
I
W
Site 58
T892
E
K
S
G
R
I
Y
T
E
I
I
R
I
W
D
Site 59
Y918
I
K
A
I
C
N
A
Y
N
R
G
L
S
C
V
Site 60
S923
N
A
Y
N
R
G
L
S
C
V
L
R
K
K
L
Site 61
Y952
Q
K
R
I
P
R
C
Y
V
E
D
T
E
A
E
Site 62
T956
P
R
C
Y
V
E
D
T
E
A
E
K
G
R
E
Site 63
Y969
R
E
H
V
N
P
E
Y
F
P
P
A
S
A
V
Site 64
S974
P
E
Y
F
P
P
A
S
A
V
E
T
E
Y
N
Site 65
T978
P
P
A
S
A
V
E
T
E
Y
N
I
M
K
F
Site 66
Y980
A
S
A
V
E
T
E
Y
N
I
M
K
F
H
S
Site 67
T1000
A
F
N
I
L
N
D
T
T
A
T
V
E
Y
P
Site 68
Y1006
D
T
T
A
T
V
E
Y
P
F
R
V
G
E
L
Site 69
T1039
G
R
S
G
T
G
K
T
T
C
C
L
Y
R
L
Site 70
Y1053
L
W
K
K
F
H
V
Y
W
E
K
A
E
Q
A
Site 71
S1062
E
K
A
E
Q
A
G
S
P
L
L
A
K
Q
V
Site 72
S1083
E
V
E
P
G
K
E
S
P
G
G
E
E
E
E
Site 73
S1100
E
D
E
E
E
E
D
S
I
E
V
E
T
V
E
Site 74
S1108
I
E
V
E
T
V
E
S
I
D
E
Q
E
Y
E
Site 75
Y1114
E
S
I
D
E
Q
E
Y
E
A
C
A
G
G
A
Site 76
S1169
Q
R
N
F
I
E
L
S
K
S
T
K
A
T
S
Site 77
S1171
N
F
I
E
L
S
K
S
T
K
A
T
S
H
Y
Site 78
T1175
L
S
K
S
T
K
A
T
S
H
Y
K
P
L
D
Site 79
S1176
S
K
S
T
K
A
T
S
H
Y
K
P
L
D
P
Site 80
Y1178
S
T
K
A
T
S
H
Y
K
P
L
D
P
N
I
Site 81
S1225
F
L
R
N
E
D
G
S
L
K
R
T
I
I
G
Site 82
T1229
E
D
G
S
L
K
R
T
I
I
G
W
S
A
Q
Site 83
S1234
K
R
T
I
I
G
W
S
A
Q
E
E
S
T
I
Site 84
S1239
G
W
S
A
Q
E
E
S
T
I
P
S
W
Q
E
Site 85
S1243
Q
E
E
S
T
I
P
S
W
Q
E
D
E
E
E
Site 86
Y1257
E
A
E
V
D
G
D
Y
S
E
E
D
K
A
V
Site 87
S1258
A
E
V
D
G
D
Y
S
E
E
D
K
A
V
E
Site 88
S1271
V
E
M
R
T
G
D
S
D
P
R
V
Y
V
T
Site 89
Y1276
G
D
S
D
P
R
V
Y
V
T
F
E
V
F
K
Site 90
T1278
S
D
P
R
V
Y
V
T
F
E
V
F
K
N
E
Site 91
Y1297
M
T
K
G
R
T
A
Y
N
P
A
L
I
W
K
Site 92
S1308
L
I
W
K
E
I
K
S
F
L
K
G
S
F
E
Site 93
S1318
K
G
S
F
E
A
L
S
C
P
H
G
R
L
T
Site 94
T1325
S
C
P
H
G
R
L
T
E
E
V
Y
K
K
L
Site 95
Y1329
G
R
L
T
E
E
V
Y
K
K
L
G
R
K
R
Site 96
S1345
P
N
F
K
E
D
R
S
E
I
Y
S
L
F
S
Site 97
Y1348
K
E
D
R
S
E
I
Y
S
L
F
S
L
Y
Q
Site 98
S1349
E
D
R
S
E
I
Y
S
L
F
S
L
Y
Q
Q
Site 99
S1352
S
E
I
Y
S
L
F
S
L
Y
Q
Q
I
R
S
Site 100
Y1354
I
Y
S
L
F
S
L
Y
Q
Q
I
R
S
Q
K
Site 101
S1359
S
L
Y
Q
Q
I
R
S
Q
K
G
Y
F
D
E
Site 102
Y1363
Q
I
R
S
Q
K
G
Y
F
D
E
E
D
V
L
Site 103
Y1371
F
D
E
E
D
V
L
Y
N
I
S
R
R
L
S
Site 104
S1374
E
D
V
L
Y
N
I
S
R
R
L
S
K
L
R
Site 105
S1378
Y
N
I
S
R
R
L
S
K
L
R
V
L
P
W
Site 106
S1386
K
L
R
V
L
P
W
S
I
H
E
L
Y
G
D
Site 107
Y1391
P
W
S
I
H
E
L
Y
G
D
E
I
Q
D
F
Site 108
T1399
G
D
E
I
Q
D
F
T
Q
A
E
L
A
L
L
Site 109
T1419
D
P
N
S
M
F
L
T
G
D
T
A
Q
S
I
Site 110
S1435
K
G
V
A
F
R
F
S
D
L
R
S
L
F
H
Site 111
S1439
F
R
F
S
D
L
R
S
L
F
H
Y
A
S
R
Site 112
Y1443
D
L
R
S
L
F
H
Y
A
S
R
N
T
I
D
Site 113
S1445
R
S
L
F
H
Y
A
S
R
N
T
I
D
K
Q
Site 114
Y1465
P
K
K
I
H
Q
L
Y
Q
N
Y
R
S
H
S
Site 115
Y1468
I
H
Q
L
Y
Q
N
Y
R
S
H
S
G
I
L
Site 116
S1472
Y
Q
N
Y
R
S
H
S
G
I
L
N
L
A
S
Site 117
S1492
L
Q
F
Y
F
P
E
S
F
D
R
L
P
R
D
Site 118
S1500
F
D
R
L
P
R
D
S
G
L
F
D
G
P
K
Site 119
T1530
L
R
G
N
K
R
K
T
Q
P
I
E
F
G
A
Site 120
Y1578
E
F
D
D
V
L
L
Y
N
F
F
T
D
S
E
Site 121
S1595
K
E
W
K
I
I
S
S
F
T
P
T
S
T
D
Site 122
T1597
W
K
I
I
S
S
F
T
P
T
S
T
D
S
R
Site 123
T1599
I
I
S
S
F
T
P
T
S
T
D
S
R
E
E
Site 124
S1600
I
S
S
F
T
P
T
S
T
D
S
R
E
E
N
Site 125
T1601
S
S
F
T
P
T
S
T
D
S
R
E
E
N
R
Site 126
S1603
F
T
P
T
S
T
D
S
R
E
E
N
R
P
L
Site 127
S1620
V
P
L
D
K
P
G
S
S
Q
G
R
S
L
M
Site 128
S1621
P
L
D
K
P
G
S
S
Q
G
R
S
L
M
V
Site 129
S1625
P
G
S
S
Q
G
R
S
L
M
V
N
P
E
M
Site 130
Y1644
N
G
E
L
K
Q
L
Y
T
A
I
T
R
A
R
Site 131
T1648
K
Q
L
Y
T
A
I
T
R
A
R
V
N
L
W
Site 132
Y1670
K
R
A
P
A
F
K
Y
F
I
R
R
D
F
V
Site 133
T1682
D
F
V
Q
V
V
K
T
D
E
N
K
D
F
D
Site 134
S1691
E
N
K
D
F
D
D
S
M
F
V
K
T
S
T
Site 135
T1698
S
M
F
V
K
T
S
T
P
A
E
W
I
A
Q
Site 136
S1742
L
A
H
D
T
A
L
S
M
K
S
K
K
V
S
Site 137
S1745
D
T
A
L
S
M
K
S
K
K
V
S
P
K
E
Site 138
S1749
S
M
K
S
K
K
V
S
P
K
E
K
Q
L
E
Site 139
Y1757
P
K
E
K
Q
L
E
Y
L
E
L
A
K
T
Y
Site 140
T1763
E
Y
L
E
L
A
K
T
Y
L
E
C
K
E
P
Site 141
S1773
E
C
K
E
P
T
L
S
L
K
C
L
S
Y
A
Site 142
Y1779
L
S
L
K
C
L
S
Y
A
K
E
F
Q
L
S
Site 143
S1786
Y
A
K
E
F
Q
L
S
A
Q
L
C
E
R
L
Site 144
Y1801
G
K
I
R
D
A
A
Y
F
Y
K
R
S
Q
C
Site 145
Y1803
I
R
D
A
A
Y
F
Y
K
R
S
Q
C
Y
K
Site 146
Y1829
F
D
L
A
L
K
M
Y
C
Q
E
E
L
F
E
Site 147
Y1845
A
A
I
A
V
E
K
Y
E
E
M
L
K
T
K
Site 148
T1851
K
Y
E
E
M
L
K
T
K
T
L
P
I
S
K
Site 149
T1853
E
E
M
L
K
T
K
T
L
P
I
S
K
L
S
Site 150
S1857
K
T
K
T
L
P
I
S
K
L
S
Y
S
A
S
Site 151
S1860
T
L
P
I
S
K
L
S
Y
S
A
S
Q
F
Y
Site 152
S1862
P
I
S
K
L
S
Y
S
A
S
Q
F
Y
L
E
Site 153
S1864
S
K
L
S
Y
S
A
S
Q
F
Y
L
E
A
A
Site 154
Y1874
Y
L
E
A
A
A
K
Y
L
S
A
N
K
M
K
Site 155
S1901
D
Q
L
V
F
L
K
S
R
K
R
L
A
E
A
Site 156
T1938
L
L
E
A
A
R
L
T
A
D
K
D
F
Q
A
Site 157
S1960
R
L
N
V
A
R
D
S
D
I
E
H
T
K
D
Site 158
Y1977
R
E
A
L
D
I
C
Y
Q
T
G
Q
L
S
G
Site 159
T2011
D
A
F
F
K
F
D
T
L
N
H
S
A
G
V
Site 160
S2027
E
A
L
Y
E
A
A
S
Q
C
E
A
E
P
E
Site 161
T2058
V
R
A
L
K
R
V
T
N
N
A
E
K
E
M
Site 162
Y2082
I
S
Q
V
D
A
K
Y
C
Q
I
A
Q
N
D
Site 163
T2109
L
N
L
R
E
K
K
T
K
D
H
F
L
I
M
Site 164
S2138
R
L
C
Q
I
T
R
S
L
L
G
K
T
Y
R
Site 165
T2143
T
R
S
L
L
G
K
T
Y
R
G
V
C
M
R
Site 166
Y2144
R
S
L
L
G
K
T
Y
R
G
V
C
M
R
F
Site 167
Y2211
E
E
L
K
E
I
D
Y
I
L
S
T
D
M
Y
Site 168
Y2253
K
E
I
L
K
P
N
Y
K
S
F
R
F
Y
R
Site 169
Y2259
N
Y
K
S
F
R
F
Y
R
F
A
L
K
E
Y
Site 170
S2275
H
F
L
F
E
N
E
S
A
R
N
R
R
E
S
Site 171
S2282
S
A
R
N
R
R
E
S
T
D
L
W
L
S
A
Site 172
T2283
A
R
N
R
R
E
S
T
D
L
W
L
S
A
M
Site 173
S2296
A
M
Q
A
F
L
L
S
S
N
Y
P
E
E
F
Site 174
S2297
M
Q
A
F
L
L
S
S
N
Y
P
E
E
F
E
Site 175
Y2299
A
F
L
L
S
S
N
Y
P
E
E
F
E
K
L
Site 176
Y2314
L
H
Q
E
E
D
N
Y
N
R
E
L
K
A
L
Site 177
S2323
R
E
L
K
A
L
E
S
E
K
D
E
R
G
R
Site 178
S2334
E
R
G
R
G
R
G
S
R
I
K
G
I
E
G
Site 179
Y2374
E
N
C
I
D
Q
F
Y
V
Y
R
N
P
E
D
Site 180
Y2376
C
I
D
Q
F
Y
V
Y
R
N
P
E
D
Y
K
Site 181
Y2382
V
Y
R
N
P
E
D
Y
K
R
L
F
F
R
F
Site 182
T2408
L
I
P
S
I
G
N
T
V
A
L
L
E
F
Q
Site 183
S2461
K
E
L
G
D
V
F
S
I
I
Q
E
Y
K
P
Site 184
T2472
E
Y
K
P
K
D
V
T
R
A
I
Q
D
F
R
Site 185
Y2509
D
A
F
S
E
I
D
Y
V
V
S
G
E
A
E
Site 186
Y2536
A
E
E
I
L
Q
P
Y
C
K
P
L
L
Y
R
Site 187
Y2542
P
Y
C
K
P
L
L
Y
R
H
F
R
E
I
E
Site 188
S2550
R
H
F
R
E
I
E
S
R
L
Q
L
M
S
M
Site 189
S2556
E
S
R
L
Q
L
M
S
M
D
C
P
G
Q
V
Site 190
Y2598
L
F
E
R
D
E
E
Y
L
M
D
C
D
W
R
Site 191
S2614
D
P
V
H
T
K
G
S
I
V
R
G
L
Y
Y
Site 192
Y2620
G
S
I
V
R
G
L
Y
Y
E
E
V
R
L
N
Site 193
Y2621
S
I
V
R
G
L
Y
Y
E
E
V
R
L
N
R
Site 194
Y2637
L
C
L
D
P
V
D
Y
F
A
E
P
E
C
E
Site 195
S2667
H
V
L
A
T
I
L
S
Q
K
Q
R
K
A
S
Site 196
S2674
S
Q
K
Q
R
K
A
S
I
Q
R
K
L
R
R
Site 197
T2698
S
W
R
R
R
V
G
T
Q
M
E
R
V
R
E
Site 198
T2723
K
K
A
D
V
D
R
T
Q
C
D
L
C
G
V
Site 199
Y2739
F
T
R
G
P
E
N
Y
F
S
P
S
K
A
F
Site 200
S2741
R
G
P
E
N
Y
F
S
P
S
K
A
F
E
G
Site 201
S2771
E
E
C
Q
E
R
N
S
E
S
Y
E
Q
H
I
Site 202
Y2774
Q
E
R
N
S
E
S
Y
E
Q
H
I
H
L
E
Site 203
Y2790
H
Q
R
Q
Q
V
A
Y
Q
K
Y
S
E
F
F
Site 204
Y2793
Q
Q
V
A
Y
Q
K
Y
S
E
F
F
H
E
K
Site 205
S2823
E
Q
S
V
W
I
H
S
H
V
G
S
K
E
H
Site 206
S2831
H
V
G
S
K
E
H
S
H
M
L
Q
K
V
Q
Site 207
S2845
Q
E
H
I
K
R
V
S
D
M
V
E
D
L
Y
Site 208
Y2852
S
D
M
V
E
D
L
Y
R
R
K
A
W
A
G
Site 209
T2885
A
R
D
W
L
M
K
T
E
T
R
L
K
K
E
Site 210
Y2900
G
I
V
Q
E
D
D
Y
E
N
E
V
E
D
F
Site 211
S2916
E
L
R
P
R
R
R
S
R
K
C
G
K
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation