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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SYNJ2
Full Name:
Synaptojanin-2
Alias:
EC 3.1.3.36; INPP5H; Synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2; Synaptic inositol-1;4;5-trisphosphate 5-phosphatase 2; Synaptojanin 2
Type:
EC 3.1.3.36; Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate
Mass (Da):
165538
Number AA:
1496
UniProt ID:
O15056
International Prot ID:
IPI00515001
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004439
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T58
K
G
Q
Y
G
K
L
T
D
A
Y
G
C
L
G
Site 2
Y61
Y
G
K
L
T
D
A
Y
G
C
L
G
E
L
R
Site 3
S71
L
G
E
L
R
L
K
S
G
G
T
S
L
S
F
Site 4
Y105
K
I
T
A
T
D
F
Y
P
L
Q
E
E
A
K
Site 5
Y130
I
L
S
S
G
V
F
Y
F
S
W
P
N
D
G
Site 6
S132
S
S
G
V
F
Y
F
S
W
P
N
D
G
S
R
Site 7
T143
D
G
S
R
F
D
L
T
V
R
T
Q
K
Q
G
Site 8
S153
T
Q
K
Q
G
D
D
S
S
E
W
G
N
S
F
Site 9
S154
Q
K
Q
G
D
D
S
S
E
W
G
N
S
F
F
Site 10
Y195
V
V
T
I
R
T
V
Y
A
S
H
K
Q
A
K
Site 11
S210
A
C
L
V
S
R
V
S
C
E
R
T
G
T
R
Site 12
T214
S
R
V
S
C
E
R
T
G
T
R
F
H
T
R
Site 13
T216
V
S
C
E
R
T
G
T
R
F
H
T
R
G
V
Site 14
T220
R
T
G
T
R
F
H
T
R
G
V
N
D
D
G
Site 15
Y240
V
E
T
E
Q
M
I
Y
M
D
D
G
V
S
S
Site 16
S247
Y
M
D
D
G
V
S
S
F
V
Q
I
R
G
S
Site 17
S268
Q
P
G
L
Q
V
G
S
H
H
L
R
L
H
R
Site 18
T351
G
K
L
E
K
L
E
T
L
L
R
P
Q
L
K
Site 19
S374
F
T
K
G
E
N
V
S
P
R
F
Q
K
G
T
Site 20
T381
S
P
R
F
Q
K
G
T
L
R
M
N
C
L
D
Site 21
S415
Q
L
K
T
L
G
L
S
S
K
P
I
V
D
R
Site 22
S432
E
S
F
K
A
M
W
S
L
N
G
H
S
L
S
Site 23
S437
M
W
S
L
N
G
H
S
L
S
K
V
F
T
G
Site 24
S439
S
L
N
G
H
S
L
S
K
V
F
T
G
S
R
Site 25
T443
H
S
L
S
K
V
F
T
G
S
R
A
L
E
G
Site 26
S463
K
L
K
D
G
A
R
S
M
S
R
T
I
Q
S
Site 27
S465
K
D
G
A
R
S
M
S
R
T
I
Q
S
N
F
Site 28
T467
G
A
R
S
M
S
R
T
I
Q
S
N
F
F
D
Site 29
T518
P
R
I
L
K
A
M
T
E
R
Q
S
E
F
T
Site 30
S522
K
A
M
T
E
R
Q
S
E
F
T
N
F
K
R
Site 31
T536
R
I
R
I
A
M
G
T
W
N
V
N
G
G
K
Site 32
S547
N
G
G
K
Q
F
R
S
N
V
L
R
T
A
E
Site 33
S562
L
T
D
W
L
L
D
S
P
Q
L
S
G
A
T
Site 34
S566
L
L
D
S
P
Q
L
S
G
A
T
D
S
Q
D
Site 35
S571
Q
L
S
G
A
T
D
S
Q
D
D
S
S
P
A
Site 36
S575
A
T
D
S
Q
D
D
S
S
P
A
D
I
F
A
Site 37
S576
T
D
S
Q
D
D
S
S
P
A
D
I
F
A
V
Site 38
S616
E
Q
L
Q
K
A
I
S
R
S
H
R
Y
I
L
Site 39
S618
L
Q
K
A
I
S
R
S
H
R
Y
I
L
L
T
Site 40
S691
S
H
L
T
A
G
Q
S
Q
V
K
E
R
N
E
Site 41
Y700
V
K
E
R
N
E
D
Y
K
E
I
T
Q
K
L
Site 42
Y735
N
Y
R
I
D
L
T
Y
E
E
V
F
Y
F
V
Site 43
Y740
L
T
Y
E
E
V
F
Y
F
V
K
R
Q
D
W
Site 44
S761
D
Q
L
Q
L
Q
K
S
S
G
K
I
F
K
D
Site 45
Y780
A
I
N
F
G
P
T
Y
K
Y
D
V
G
S
A
Site 46
Y782
N
F
G
P
T
Y
K
Y
D
V
G
S
A
A
Y
Site 47
S786
T
Y
K
Y
D
V
G
S
A
A
Y
D
T
S
D
Site 48
T797
D
T
S
D
K
C
R
T
P
A
W
T
D
R
V
Site 49
T816
K
K
H
P
F
D
K
T
A
G
E
L
N
L
L
Site 50
S825
G
E
L
N
L
L
D
S
D
L
D
V
D
T
K
Site 51
T831
D
S
D
L
D
V
D
T
K
V
R
H
T
W
S
Site 52
T836
V
D
T
K
V
R
H
T
W
S
P
G
A
L
Q
Site 53
S838
T
K
V
R
H
T
W
S
P
G
A
L
Q
Y
Y
Site 54
Y845
S
P
G
A
L
Q
Y
Y
G
R
A
E
L
Q
A
Site 55
S853
G
R
A
E
L
Q
A
S
D
H
R
P
V
L
A
Site 56
S883
R
V
F
Q
E
V
S
S
F
Q
G
P
L
D
A
Site 57
S898
T
V
V
V
N
L
Q
S
P
T
L
E
E
K
N
Site 58
T913
E
F
P
E
D
L
R
T
E
L
M
Q
T
L
G
Site 59
T918
L
R
T
E
L
M
Q
T
L
G
S
Y
G
T
I
Site 60
T938
N
Q
G
Q
M
L
V
T
F
A
D
S
H
S
A
Site 61
T967
A
V
K
I
R
P
K
T
K
D
W
L
K
G
L
Site 62
S984
E
I
I
R
K
R
D
S
M
A
P
V
S
P
T
Site 63
S989
R
D
S
M
A
P
V
S
P
T
A
N
S
C
L
Site 64
Y1008
F
D
F
T
S
L
D
Y
E
S
E
G
D
I
L
Site 65
S1010
F
T
S
L
D
Y
E
S
E
G
D
I
L
E
D
Site 66
Y1021
I
L
E
D
D
E
D
Y
L
V
D
E
F
N
Q
Site 67
S1032
E
F
N
Q
P
G
V
S
D
S
E
L
G
G
D
Site 68
S1034
N
Q
P
G
V
S
D
S
E
L
G
G
D
D
L
Site 69
S1042
E
L
G
G
D
D
L
S
D
V
P
G
P
T
A
Site 70
S1054
P
T
A
L
A
P
P
S
K
S
P
A
L
T
K
Site 71
S1056
A
L
A
P
P
S
K
S
P
A
L
T
K
K
K
Site 72
T1060
P
S
K
S
P
A
L
T
K
K
K
Q
H
P
T
Site 73
S1091
V
G
E
F
R
H
R
S
P
S
R
S
L
S
V
Site 74
S1093
E
F
R
H
R
S
P
S
R
S
L
S
V
P
N
Site 75
S1095
R
H
R
S
P
S
R
S
L
S
V
P
N
R
P
Site 76
S1097
R
S
P
S
R
S
L
S
V
P
N
R
P
R
P
Site 77
T1115
P
Q
R
P
P
P
P
T
G
L
M
V
K
K
S
Site 78
S1122
T
G
L
M
V
K
K
S
A
S
D
A
S
I
S
Site 79
S1124
L
M
V
K
K
S
A
S
D
A
S
I
S
S
G
Site 80
S1127
K
K
S
A
S
D
A
S
I
S
S
G
T
H
G
Site 81
S1129
S
A
S
D
A
S
I
S
S
G
T
H
G
Q
Y
Site 82
S1130
A
S
D
A
S
I
S
S
G
T
H
G
Q
Y
S
Site 83
Y1136
S
S
G
T
H
G
Q
Y
S
I
L
Q
T
A
R
Site 84
S1137
S
G
T
H
G
Q
Y
S
I
L
Q
T
A
R
L
Site 85
S1191
L
E
A
R
G
G
A
S
E
E
A
L
S
A
V
Site 86
S1196
G
A
S
E
E
A
L
S
A
V
A
P
R
D
L
Site 87
S1206
A
P
R
D
L
E
A
S
S
E
P
E
P
T
P
Site 88
S1207
P
R
D
L
E
A
S
S
E
P
E
P
T
P
G
Site 89
T1212
A
S
S
E
P
E
P
T
P
G
A
A
K
P
E
Site 90
T1220
P
G
A
A
K
P
E
T
P
Q
A
P
P
L
L
Site 91
T1242
V
P
A
I
K
K
P
T
L
R
R
T
G
K
P
Site 92
T1246
K
K
P
T
L
R
R
T
G
K
P
L
S
P
E
Site 93
S1251
R
R
T
G
K
P
L
S
P
E
E
Q
F
E
Q
Site 94
T1291
P
P
V
P
K
P
R
T
F
Q
P
G
K
A
A
Site 95
S1302
G
K
A
A
E
R
P
S
H
R
K
P
A
S
D
Site 96
S1308
P
S
H
R
K
P
A
S
D
E
A
P
P
G
A
Site 97
S1318
A
P
P
G
A
G
A
S
V
P
P
P
L
E
A
Site 98
S1339
V
P
P
R
R
K
K
S
A
P
A
A
F
H
L
Site 99
S1351
F
H
L
Q
V
L
Q
S
N
S
Q
L
L
Q
G
Site 100
T1360
S
Q
L
L
Q
G
L
T
Y
N
S
S
D
S
P
Site 101
Y1361
Q
L
L
Q
G
L
T
Y
N
S
S
D
S
P
S
Site 102
S1363
L
Q
G
L
T
Y
N
S
S
D
S
P
S
G
H
Site 103
S1364
Q
G
L
T
Y
N
S
S
D
S
P
S
G
H
P
Site 104
S1366
L
T
Y
N
S
S
D
S
P
S
G
H
P
P
A
Site 105
S1368
Y
N
S
S
D
S
P
S
G
H
P
P
A
A
G
Site 106
T1376
G
H
P
P
A
A
G
T
V
F
P
Q
G
D
F
Site 107
S1385
F
P
Q
G
D
F
L
S
T
S
S
A
T
S
P
Site 108
T1386
P
Q
G
D
F
L
S
T
S
S
A
T
S
P
D
Site 109
S1387
Q
G
D
F
L
S
T
S
S
A
T
S
P
D
S
Site 110
S1388
G
D
F
L
S
T
S
S
A
T
S
P
D
S
D
Site 111
S1391
L
S
T
S
S
A
T
S
P
D
S
D
G
T
K
Site 112
S1394
S
S
A
T
S
P
D
S
D
G
T
K
A
M
K
Site 113
Y1411
A
A
P
L
L
G
D
Y
Q
D
P
F
W
N
L
Site 114
T1428
H
P
K
L
L
N
N
T
W
L
S
K
S
S
D
Site 115
S1431
L
L
N
N
T
W
L
S
K
S
S
D
P
L
D
Site 116
S1433
N
N
T
W
L
S
K
S
S
D
P
L
D
S
G
Site 117
S1434
N
T
W
L
S
K
S
S
D
P
L
D
S
G
T
Site 118
S1439
K
S
S
D
P
L
D
S
G
T
R
S
P
K
R
Site 119
T1441
S
D
P
L
D
S
G
T
R
S
P
K
R
D
P
Site 120
S1443
P
L
D
S
G
T
R
S
P
K
R
D
P
I
D
Site 121
S1453
R
D
P
I
D
P
V
S
A
G
A
S
A
A
K
Site 122
S1457
D
P
V
S
A
G
A
S
A
A
K
A
E
L
P
Site 123
T1477
K
T
L
G
H
W
V
T
I
S
D
Q
E
K
R
Site 124
S1479
L
G
H
W
V
T
I
S
D
Q
E
K
R
T
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation