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Updated November 2019
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Protein Info
Short Name:
NACAD
Full Name:
NAC-alpha domain-containing protein 1
Alias:
Kiaa0363; NAC alpha domain containing; NACAK; Nascent polypeptide-associated complex subunit alpha-like
Type:
Mass (Da):
161082
Number AA:
1562
UniProt ID:
O15069
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
A
D
R
P
G
P
R
T
D
L
S
C
D
A
A
Site 2
S25
P
G
P
R
T
D
L
S
C
D
A
A
A
A
T
Site 3
T46
R
R
E
P
C
A
L
T
P
G
P
S
H
L
A
Site 4
T55
G
P
S
H
L
A
L
T
F
L
P
S
K
P
G
Site 5
S59
L
A
L
T
F
L
P
S
K
P
G
A
R
P
Q
Site 6
S71
R
P
Q
P
E
G
A
S
W
D
A
G
P
G
G
Site 7
S81
A
G
P
G
G
A
P
S
A
W
A
D
P
G
E
Site 8
S92
D
P
G
E
G
G
P
S
P
M
L
L
P
E
G
Site 9
T107
L
S
S
Q
A
L
S
T
E
A
P
L
P
A
T
Site 10
S131
E
T
C
Q
A
L
L
S
P
R
A
A
R
T
A
Site 11
S148
D
Q
E
G
G
H
A
S
P
D
P
P
P
E
L
Site 12
S157
D
P
P
P
E
L
C
S
Q
G
D
L
S
V
P
Site 13
S162
L
C
S
Q
G
D
L
S
V
P
S
P
P
P
D
Site 14
S165
Q
G
D
L
S
V
P
S
P
P
P
D
P
D
S
Site 15
S172
S
P
P
P
D
P
D
S
F
F
T
P
P
S
T
Site 16
T175
P
D
P
D
S
F
F
T
P
P
S
T
P
T
K
Site 17
S178
D
S
F
F
T
P
P
S
T
P
T
K
T
T
Y
Site 18
T179
S
F
F
T
P
P
S
T
P
T
K
T
T
Y
A
Site 19
T181
F
T
P
P
S
T
P
T
K
T
T
Y
A
L
L
Site 20
T183
P
P
S
T
P
T
K
T
T
Y
A
L
L
P
A
Site 21
S200
P
H
G
D
A
R
D
S
E
A
E
L
R
D
E
Site 22
S211
L
R
D
E
L
L
D
S
P
P
A
S
P
S
G
Site 23
S215
L
L
D
S
P
P
A
S
P
S
G
S
Y
I
T
Site 24
S217
D
S
P
P
A
S
P
S
G
S
Y
I
T
A
D
Site 25
S219
P
P
A
S
P
S
G
S
Y
I
T
A
D
G
D
Site 26
S227
Y
I
T
A
D
G
D
S
W
A
S
S
P
S
C
Site 27
S230
A
D
G
D
S
W
A
S
S
P
S
C
S
L
S
Site 28
S231
D
G
D
S
W
A
S
S
P
S
C
S
L
S
L
Site 29
S249
A
E
G
L
D
F
P
S
G
W
G
L
S
P
Q
Site 30
S254
F
P
S
G
W
G
L
S
P
Q
G
S
M
V
D
Site 31
S258
W
G
L
S
P
Q
G
S
M
V
D
E
R
E
L
Site 32
T270
R
E
L
H
P
A
G
T
P
E
P
P
S
S
E
Site 33
S275
A
G
T
P
E
P
P
S
S
E
S
S
L
S
A
Site 34
S276
G
T
P
E
P
P
S
S
E
S
S
L
S
A
D
Site 35
S279
E
P
P
S
S
E
S
S
L
S
A
D
S
S
S
Site 36
S281
P
S
S
E
S
S
L
S
A
D
S
S
S
S
W
Site 37
S284
E
S
S
L
S
A
D
S
S
S
S
W
G
Q
E
Site 38
S285
S
S
L
S
A
D
S
S
S
S
W
G
Q
E
G
Site 39
S286
S
L
S
A
D
S
S
S
S
W
G
Q
E
G
H
Site 40
S287
L
S
A
D
S
S
S
S
W
G
Q
E
G
H
F
Site 41
T327
Q
V
E
A
V
E
V
T
P
L
S
P
E
E
E
Site 42
S330
A
V
E
V
T
P
L
S
P
E
E
E
E
E
E
Site 43
S356
A
G
E
G
E
E
D
S
T
S
A
S
F
L
Q
Site 44
T357
G
E
G
E
E
D
S
T
S
A
S
F
L
Q
S
Site 45
S358
E
G
E
E
D
S
T
S
A
S
F
L
Q
S
L
Site 46
S360
E
E
D
S
T
S
A
S
F
L
Q
S
L
S
D
Site 47
T384
A
F
A
F
R
D
D
T
S
A
A
S
S
D
S
Site 48
S385
F
A
F
R
D
D
T
S
A
A
S
S
D
S
D
Site 49
S388
R
D
D
T
S
A
A
S
S
D
S
D
S
A
S
Site 50
S389
D
D
T
S
A
A
S
S
D
S
D
S
A
S
Y
Site 51
S391
T
S
A
A
S
S
D
S
D
S
A
S
Y
A
E
Site 52
S393
A
A
S
S
D
S
D
S
A
S
Y
A
E
A
D
Site 53
S395
S
S
D
S
D
S
A
S
Y
A
E
A
D
D
E
Site 54
Y405
E
A
D
D
E
R
L
Y
S
G
E
P
H
A
Q
Site 55
S406
A
D
D
E
R
L
Y
S
G
E
P
H
A
Q
A
Site 56
S419
Q
A
T
L
L
Q
D
S
V
Q
K
T
E
E
E
Site 57
T423
L
Q
D
S
V
Q
K
T
E
E
E
S
G
G
G
Site 58
T440
G
L
Q
A
Q
D
G
T
V
S
W
A
V
E
A
Site 59
S442
Q
A
Q
D
G
T
V
S
W
A
V
E
A
A
P
Site 60
Y457
Q
T
S
D
R
G
A
Y
L
S
Q
R
Q
E
L
Site 61
S459
S
D
R
G
A
Y
L
S
Q
R
Q
E
L
I
S
Site 62
S466
S
Q
R
Q
E
L
I
S
E
V
T
E
E
G
L
Site 63
T480
L
A
L
G
Q
E
S
T
A
T
V
T
P
H
T
Site 64
T482
L
G
Q
E
S
T
A
T
V
T
P
H
T
L
Q
Site 65
T484
Q
E
S
T
A
T
V
T
P
H
T
L
Q
V
A
Site 66
T503
V
E
V
A
T
R
V
T
P
Q
A
G
E
E
E
Site 67
S513
A
G
E
E
E
T
D
S
T
A
G
Q
E
S
A
Site 68
T514
G
E
E
E
T
D
S
T
A
G
Q
E
S
A
A
Site 69
S528
A
M
A
M
P
Q
P
S
Q
E
G
I
S
E
I
Site 70
S540
S
E
I
L
G
Q
E
S
V
T
A
E
K
L
P
Site 71
T548
V
T
A
E
K
L
P
T
P
Q
E
E
T
S
L
Site 72
S554
P
T
P
Q
E
E
T
S
L
T
L
C
P
D
S
Site 73
T556
P
Q
E
E
T
S
L
T
L
C
P
D
S
P
Q
Site 74
S561
S
L
T
L
C
P
D
S
P
Q
N
L
K
E
E
Site 75
S575
E
G
G
L
D
L
P
S
G
R
K
P
V
A
A
Site 76
T584
R
K
P
V
A
A
A
T
I
V
P
R
Q
A
K
Site 77
T595
R
Q
A
K
E
D
L
T
L
P
Q
D
S
A
M
Site 78
T603
L
P
Q
D
S
A
M
T
P
P
L
P
L
Q
D
Site 79
T611
P
P
L
P
L
Q
D
T
D
L
S
S
A
P
K
Site 80
S614
P
L
Q
D
T
D
L
S
S
A
P
K
P
V
A
Site 81
S615
L
Q
D
T
D
L
S
S
A
P
K
P
V
A
A
Site 82
T635
Q
Q
A
E
E
G
L
T
L
P
Q
D
S
V
M
Site 83
T643
L
P
Q
D
S
V
M
T
P
P
L
P
L
Q
D
Site 84
T651
P
P
L
P
L
Q
D
T
E
L
S
S
A
P
K
Site 85
S654
P
L
Q
D
T
E
L
S
S
A
P
K
P
V
A
Site 86
T675
Q
Q
A
E
E
G
L
T
L
P
Q
D
S
A
M
Site 87
T864
P
K
P
V
A
A
A
T
P
V
S
Q
Q
A
E
Site 88
T931
A
P
L
P
L
Q
D
T
G
P
T
S
G
P
E
Site 89
S935
L
Q
D
T
G
P
T
S
G
P
E
P
L
A
V
Site 90
T944
P
E
P
L
A
V
A
T
P
Q
T
L
Q
A
E
Site 91
T963
P
G
T
E
P
V
A
T
M
A
Q
Q
E
V
G
Site 92
T1011
Q
P
A
A
E
A
G
T
P
W
A
A
Q
E
D
Site 93
S1021
A
A
Q
E
D
A
D
S
T
L
G
M
E
A
L
Site 94
T1022
A
Q
E
D
A
D
S
T
L
G
M
E
A
L
S
Site 95
S1035
L
S
L
P
E
P
A
S
G
A
G
E
E
I
A
Site 96
S1046
E
E
I
A
E
A
L
S
R
P
G
R
E
A
C
Site 97
T1060
C
L
E
A
R
A
H
T
G
D
G
A
K
P
D
Site 98
S1068
G
D
G
A
K
P
D
S
P
Q
K
E
T
L
E
Site 99
S1095
A
Q
E
H
G
P
R
S
A
L
G
G
A
R
E
Site 100
S1115
P
A
A
C
P
E
V
S
Q
A
R
L
L
S
P
Site 101
S1121
V
S
Q
A
R
L
L
S
P
A
R
E
E
R
G
Site 102
S1130
A
R
E
E
R
G
L
S
G
K
S
T
P
E
P
Site 103
S1133
E
R
G
L
S
G
K
S
T
P
E
P
T
L
P
Site 104
T1134
R
G
L
S
G
K
S
T
P
E
P
T
L
P
S
Site 105
S1148
S
A
V
A
T
E
A
S
L
D
S
C
P
E
S
Site 106
S1151
A
T
E
A
S
L
D
S
C
P
E
S
S
V
G
Site 107
S1155
S
L
D
S
C
P
E
S
S
V
G
A
V
S
S
Site 108
S1161
E
S
S
V
G
A
V
S
S
L
D
R
G
C
P
Site 109
S1162
S
S
V
G
A
V
S
S
L
D
R
G
C
P
D
Site 110
S1175
P
D
A
P
A
P
T
S
A
P
T
S
Q
Q
P
Site 111
S1179
A
P
T
S
A
P
T
S
Q
Q
P
E
P
V
L
Site 112
S1190
E
P
V
L
G
L
G
S
V
E
Q
P
H
E
V
Site 113
S1199
E
Q
P
H
E
V
P
S
V
L
G
T
P
L
L
Site 114
T1203
E
V
P
S
V
L
G
T
P
L
L
Q
P
P
E
Site 115
T1219
L
A
K
G
Q
P
S
T
P
V
D
R
P
L
G
Site 116
S1230
R
P
L
G
P
D
P
S
A
P
G
T
L
A
G
Site 117
S1258
C
Q
D
P
Q
E
D
S
V
E
D
E
E
P
P
Site 118
S1267
E
D
E
E
P
P
G
S
L
G
L
P
P
P
Q
Site 119
T1293
G
T
T
Q
P
L
G
T
G
P
R
V
S
L
S
Site 120
S1298
L
G
T
G
P
R
V
S
L
S
P
H
S
P
L
Site 121
S1300
T
G
P
R
V
S
L
S
P
H
S
P
L
L
S
Site 122
S1303
R
V
S
L
S
P
H
S
P
L
L
S
P
K
V
Site 123
S1307
S
P
H
S
P
L
L
S
P
K
V
A
S
M
D
Site 124
S1332
P
C
Q
V
P
P
P
S
G
P
Q
S
P
A
G
Site 125
S1336
P
P
P
S
G
P
Q
S
P
A
G
P
Q
G
L
Site 126
S1344
P
A
G
P
Q
G
L
S
A
P
E
Q
Q
E
D
Site 127
S1354
E
Q
Q
E
D
E
D
S
L
E
E
D
S
P
R
Site 128
S1359
E
D
S
L
E
E
D
S
P
R
A
L
G
S
G
Site 129
S1365
D
S
P
R
A
L
G
S
G
Q
H
S
D
S
H
Site 130
S1369
A
L
G
S
G
Q
H
S
D
S
H
G
E
S
S
Site 131
S1371
G
S
G
Q
H
S
D
S
H
G
E
S
S
A
E
Site 132
S1375
H
S
D
S
H
G
E
S
S
A
E
L
D
E
Q
Site 133
S1376
S
D
S
H
G
E
S
S
A
E
L
D
E
Q
D
Site 134
T1389
Q
D
I
L
A
P
Q
T
V
Q
C
P
A
Q
A
Site 135
S1413
A
K
A
K
Q
S
R
S
E
K
K
A
R
K
A
Site 136
S1422
K
K
A
R
K
A
M
S
K
L
G
L
R
Q
I
Site 137
T1433
L
R
Q
I
Q
G
V
T
R
I
T
I
Q
K
S
Site 138
T1436
I
Q
G
V
T
R
I
T
I
Q
K
S
K
N
I
Site 139
S1455
A
K
P
D
V
F
K
S
P
A
S
D
T
Y
V
Site 140
T1460
F
K
S
P
A
S
D
T
Y
V
V
F
G
E
A
Site 141
Y1461
K
S
P
A
S
D
T
Y
V
V
F
G
E
A
K
Site 142
S1473
E
A
K
I
E
D
L
S
Q
Q
V
H
K
A
A
Site 143
S1488
A
E
K
F
K
V
P
S
E
P
S
A
L
V
P
Site 144
S1497
P
S
A
L
V
P
E
S
A
P
R
P
R
V
R
Site 145
S1551
R
A
L
R
D
N
H
S
D
I
V
N
A
I
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation