KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ADAMTS3
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 3
Alias:
Procollagen II N-proteinase;Procollagen II amino propeptide-processing enzyme
Type:
Mass (Da):
135575
Number AA:
1205
UniProt ID:
O15072
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
A
L
V
E
V
R
T
S
A
D
G
Q
A
G
N
Site 2
Y42
P
I
K
R
Y
R
E
Y
E
L
V
T
P
V
S
Site 3
T46
Y
R
E
Y
E
L
V
T
P
V
S
T
N
L
E
Site 4
S49
Y
E
L
V
T
P
V
S
T
N
L
E
G
R
Y
Site 5
Y56
S
T
N
L
E
G
R
Y
L
S
H
T
L
S
A
Site 6
S58
N
L
E
G
R
Y
L
S
H
T
L
S
A
S
H
Site 7
T60
E
G
R
Y
L
S
H
T
L
S
A
S
H
K
K
Site 8
S62
R
Y
L
S
H
T
L
S
A
S
H
K
K
R
S
Site 9
S64
L
S
H
T
L
S
A
S
H
K
K
R
S
A
R
Site 10
S69
S
A
S
H
K
K
R
S
A
R
D
V
S
S
N
Site 11
S74
K
R
S
A
R
D
V
S
S
N
P
E
Q
L
F
Site 12
S75
R
S
A
R
D
V
S
S
N
P
E
Q
L
F
F
Site 13
T99
H
L
R
L
K
P
N
T
Q
L
V
A
P
G
A
Site 14
S131
I
N
N
H
Q
P
G
S
A
T
Y
R
I
R
K
Site 15
T139
A
T
Y
R
I
R
K
T
E
P
L
Q
T
N
C
Site 16
T144
R
K
T
E
P
L
Q
T
N
C
A
Y
V
G
D
Site 17
S174
G
L
A
G
M
I
K
S
D
N
E
E
Y
F
I
Site 18
Y179
I
K
S
D
N
E
E
Y
F
I
E
P
L
E
R
Site 19
Y201
K
G
R
I
H
V
V
Y
K
R
S
A
V
E
Q
Site 20
Y219
D
M
S
K
D
F
H
Y
R
E
S
D
L
E
G
Site 21
S222
K
D
F
H
Y
R
E
S
D
L
E
G
L
D
D
Site 22
T232
E
G
L
D
D
L
G
T
V
Y
G
N
I
H
Q
Site 23
Y234
L
D
D
L
G
T
V
Y
G
N
I
H
Q
Q
L
Site 24
T244
I
H
Q
Q
L
N
E
T
M
R
R
R
R
H
A
Site 25
Y256
R
H
A
G
E
N
D
Y
N
I
E
V
L
L
G
Site 26
Y280
G
K
E
H
V
Q
N
Y
L
L
T
L
M
N
I
Site 27
Y292
M
N
I
V
N
E
I
Y
H
D
E
S
L
G
V
Site 28
S318
L
G
Y
A
K
S
I
S
L
I
E
R
G
N
P
Site 29
S328
E
R
G
N
P
S
R
S
L
E
N
V
C
R
W
Site 30
S337
E
N
V
C
R
W
A
S
Q
Q
Q
R
S
D
L
Site 31
S342
W
A
S
Q
Q
Q
R
S
D
L
N
H
S
E
H
Site 32
T419
G
N
R
C
G
D
E
T
A
M
G
S
V
M
A
Site 33
Y449
S
G
Q
E
L
K
R
Y
I
H
S
Y
D
C
L
Site 34
S452
E
L
K
R
Y
I
H
S
Y
D
C
L
L
D
D
Site 35
Y453
L
K
R
Y
I
H
S
Y
D
C
L
L
D
D
P
Site 36
Y476
P
E
L
P
G
I
N
Y
S
M
D
E
Q
C
R
Site 37
Y490
R
F
D
F
G
V
G
Y
K
M
C
T
A
F
R
Site 38
Y514
C
S
H
P
D
N
P
Y
F
C
K
T
K
K
G
Site 39
T518
D
N
P
Y
F
C
K
T
K
K
G
P
P
L
D
Site 40
T527
K
G
P
P
L
D
G
T
E
C
A
A
G
K
W
Site 41
S562
G
S
W
T
K
F
G
S
C
S
R
T
C
G
T
Site 42
T566
K
F
G
S
C
S
R
T
C
G
T
G
V
R
F
Site 43
T575
G
T
G
V
R
F
R
T
R
Q
C
N
N
P
M
Site 44
Y636
T
K
H
H
W
L
P
Y
E
H
P
D
P
K
K
Site 45
Y648
P
K
K
R
C
H
L
Y
C
Q
S
K
E
T
G
Site 46
Y659
K
E
T
G
D
V
A
Y
M
K
Q
L
V
H
D
Site 47
T668
K
Q
L
V
H
D
G
T
H
C
S
Y
K
D
P
Site 48
Y676
H
C
S
Y
K
D
P
Y
S
I
C
V
R
G
E
Site 49
T714
G
D
N
S
H
C
R
T
V
K
G
T
F
T
R
Site 50
T718
H
C
R
T
V
K
G
T
F
T
R
T
P
R
K
Site 51
T720
R
T
V
K
G
T
F
T
R
T
P
R
K
L
G
Site 52
T722
V
K
G
T
F
T
R
T
P
R
K
L
G
Y
L
Site 53
Y728
R
T
P
R
K
L
G
Y
L
K
M
F
D
I
P
Site 54
S749
L
I
Q
E
D
E
A
S
P
H
I
L
A
I
K
Site 55
S774
G
K
G
E
E
A
K
S
R
T
F
I
D
L
G
Site 56
T776
G
E
E
A
K
S
R
T
F
I
D
L
G
V
E
Site 57
Y786
D
L
G
V
E
W
D
Y
N
I
E
D
D
I
E
Site 58
S794
N
I
E
D
D
I
E
S
L
H
T
D
G
P
L
Site 59
T797
D
D
I
E
S
L
H
T
D
G
P
L
H
D
P
Site 60
T816
I
I
P
Q
E
N
D
T
R
S
S
L
T
Y
K
Site 61
S819
Q
E
N
D
T
R
S
S
L
T
Y
K
Y
I
I
Site 62
Y822
D
T
R
S
S
L
T
Y
K
Y
I
I
H
E
D
Site 63
Y824
R
S
S
L
T
Y
K
Y
I
I
H
E
D
S
V
Site 64
S830
K
Y
I
I
H
E
D
S
V
P
T
I
N
S
N
Site 65
T846
V
I
Q
E
E
L
D
T
F
E
W
A
L
K
S
Site 66
Y867
P
C
G
G
G
F
Q
Y
T
K
Y
G
C
R
R
Site 67
Y870
G
G
F
Q
Y
T
K
Y
G
C
R
R
K
S
D
Site 68
S876
K
Y
G
C
R
R
K
S
D
N
K
M
V
H
R
Site 69
T930
S
S
G
Y
Q
L
R
T
V
R
C
L
Q
P
L
Site 70
T941
L
Q
P
L
L
D
G
T
N
R
S
V
H
S
K
Site 71
Y949
N
R
S
V
H
S
K
Y
C
M
G
D
R
P
E
Site 72
S957
C
M
G
D
R
P
E
S
R
R
P
C
N
R
V
Site 73
S979
T
G
P
W
S
E
C
S
V
T
C
G
E
G
T
Site 74
T981
P
W
S
E
C
S
V
T
C
G
E
G
T
E
V
Site 75
Y1036
Q
M
E
V
L
A
R
Y
C
S
I
P
G
Y
N
Site 76
S1038
E
V
L
A
R
Y
C
S
I
P
G
Y
N
K
L
Site 77
Y1042
R
Y
C
S
I
P
G
Y
N
K
L
C
C
E
S
Site 78
S1049
Y
N
K
L
C
C
E
S
C
S
K
R
S
S
T
Site 79
S1051
K
L
C
C
E
S
C
S
K
R
S
S
T
L
P
Site 80
S1055
E
S
C
S
K
R
S
S
T
L
P
P
P
Y
L
Site 81
T1056
S
C
S
K
R
S
S
T
L
P
P
P
Y
L
L
Site 82
Y1061
S
S
T
L
P
P
P
Y
L
L
E
A
A
E
T
Site 83
T1068
Y
L
L
E
A
A
E
T
H
D
D
V
I
S
N
Site 84
S1074
E
T
H
D
D
V
I
S
N
P
S
D
L
P
R
Site 85
S1082
N
P
S
D
L
P
R
S
L
V
M
P
T
S
L
Site 86
S1088
R
S
L
V
M
P
T
S
L
V
P
Y
H
S
E
Site 87
Y1092
M
P
T
S
L
V
P
Y
H
S
E
T
P
A
K
Site 88
S1094
T
S
L
V
P
Y
H
S
E
T
P
A
K
K
M
Site 89
T1096
L
V
P
Y
H
S
E
T
P
A
K
K
M
S
L
Site 90
S1102
E
T
P
A
K
K
M
S
L
S
S
I
S
S
V
Site 91
S1104
P
A
K
K
M
S
L
S
S
I
S
S
V
G
G
Site 92
S1105
A
K
K
M
S
L
S
S
I
S
S
V
G
G
P
Site 93
S1107
K
M
S
L
S
S
I
S
S
V
G
G
P
N
A
Site 94
Y1115
S
V
G
G
P
N
A
Y
A
A
F
R
P
N
S
Site 95
S1122
Y
A
A
F
R
P
N
S
K
P
D
G
A
N
L
Site 96
S1133
G
A
N
L
R
Q
R
S
A
Q
Q
A
G
S
K
Site 97
S1139
R
S
A
Q
Q
A
G
S
K
T
V
R
L
V
T
Site 98
T1141
A
Q
Q
A
G
S
K
T
V
R
L
V
T
V
P
Site 99
T1146
S
K
T
V
R
L
V
T
V
P
S
S
P
P
T
Site 100
S1149
V
R
L
V
T
V
P
S
S
P
P
T
K
R
V
Site 101
S1150
R
L
V
T
V
P
S
S
P
P
T
K
R
V
H
Site 102
T1153
T
V
P
S
S
P
P
T
K
R
V
H
L
S
S
Site 103
S1159
P
T
K
R
V
H
L
S
S
A
S
Q
M
A
A
Site 104
S1160
T
K
R
V
H
L
S
S
A
S
Q
M
A
A
A
Site 105
S1179
A
S
D
S
I
G
A
S
S
Q
A
R
T
S
K
Site 106
S1180
S
D
S
I
G
A
S
S
Q
A
R
T
S
K
K
Site 107
T1184
G
A
S
S
Q
A
R
T
S
K
K
D
G
K
I
Site 108
S1185
A
S
S
Q
A
R
T
S
K
K
D
G
K
I
I
Site 109
T1198
I
I
D
N
R
R
P
T
R
S
S
T
L
E
R
Site 110
S1200
D
N
R
R
P
T
R
S
S
T
L
E
R
_
_
Site 111
S1201
N
R
R
P
T
R
S
S
T
L
E
R
_
_
_
Site 112
T1202
R
R
P
T
R
S
S
T
L
E
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation