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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DCAMKL1
Full Name:
Serine/threonine-protein kinase DCLK1
Alias:
DCAK1; DCDC3A; DCLK; DCLK1; Doublecortin- like and CAM kinase-like 1; Doublecortin-like kinase 1; EC 2.7.11.1; KIAA0369; Kinase DCAMKL1
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; DCAMKL family
Mass (Da):
82224
Number AA:
740
UniProt ID:
O15075
International Prot ID:
IPI00004560
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0016197
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
GYS1 (2-11) KinSub - Glycogen synthase (muscle)-derived (P2-S11, rabbit) peptide; CaMK2 protein kinase substrate - Powder PE-01ACW95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACW95#DCAMKLSubtide - DCAMKL2 protein kinase substrate peptide - Powder PE-01BHA90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHA90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
E
R
D
K
A
Q
R
Y
S
R
G
S
R
V
N
Site 2
S22
R
D
K
A
Q
R
Y
S
R
G
S
R
V
N
G
Site 3
S25
A
Q
R
Y
S
R
G
S
R
V
N
G
L
P
S
Site 4
S32
S
R
V
N
G
L
P
S
P
T
H
S
A
H
C
Site 5
T34
V
N
G
L
P
S
P
T
H
S
A
H
C
S
F
Site 6
S36
G
L
P
S
P
T
H
S
A
H
C
S
F
Y
R
Site 7
S40
P
T
H
S
A
H
C
S
F
Y
R
T
R
T
L
Site 8
T44
A
H
C
S
F
Y
R
T
R
T
L
Q
T
L
S
Site 9
T46
C
S
F
Y
R
T
R
T
L
Q
T
L
S
S
E
Site 10
S52
R
T
L
Q
T
L
S
S
E
K
K
A
K
K
V
Site 11
Y62
K
A
K
K
V
R
F
Y
R
N
G
D
R
Y
F
Site 12
Y68
F
Y
R
N
G
D
R
Y
F
K
G
I
V
Y
A
Site 13
S77
K
G
I
V
Y
A
I
S
P
D
R
F
R
S
F
Site 14
S83
I
S
P
D
R
F
R
S
F
E
A
L
L
A
D
Site 15
T92
E
A
L
L
A
D
L
T
R
T
L
S
D
N
V
Site 16
S96
A
D
L
T
R
T
L
S
D
N
V
N
L
P
Q
Site 17
Y109
P
Q
G
V
R
T
I
Y
T
I
D
G
L
K
K
Site 18
S119
D
G
L
K
K
I
S
S
L
D
Q
L
V
E
G
Site 19
Y129
Q
L
V
E
G
E
S
Y
V
C
G
S
I
E
P
Site 20
T156
N
W
S
V
N
V
K
T
T
S
A
S
R
A
V
Site 21
S158
S
V
N
V
K
T
T
S
A
S
R
A
V
S
S
Site 22
S160
N
V
K
T
T
S
A
S
R
A
V
S
S
L
A
Site 23
S164
T
S
A
S
R
A
V
S
S
L
A
T
A
K
G
Site 24
S165
S
A
S
R
A
V
S
S
L
A
T
A
K
G
S
Site 25
T168
R
A
V
S
S
L
A
T
A
K
G
S
P
S
E
Site 26
S172
S
L
A
T
A
K
G
S
P
S
E
V
R
E
N
Site 27
S174
A
T
A
K
G
S
P
S
E
V
R
E
N
K
D
Site 28
T209
R
I
L
L
N
K
K
T
A
H
S
F
E
Q
V
Site 29
S212
L
N
K
K
T
A
H
S
F
E
Q
V
L
T
D
Site 30
T218
H
S
F
E
Q
V
L
T
D
I
T
D
A
I
K
Site 31
T221
E
Q
V
L
T
D
I
T
D
A
I
K
L
D
S
Site 32
S228
T
D
A
I
K
L
D
S
G
V
V
K
R
L
Y
Site 33
Y235
S
G
V
V
K
R
L
Y
T
L
D
G
K
Q
V
Site 34
T236
G
V
V
K
R
L
Y
T
L
D
G
K
Q
V
M
Site 35
Y265
C
G
P
E
K
F
R
Y
Q
D
D
F
L
L
D
Site 36
S274
D
D
F
L
L
D
E
S
E
C
R
V
V
K
S
Site 37
S281
S
E
C
R
V
V
K
S
T
S
Y
T
K
I
A
Site 38
T282
E
C
R
V
V
K
S
T
S
Y
T
K
I
A
S
Site 39
S283
C
R
V
V
K
S
T
S
Y
T
K
I
A
S
S
Site 40
T285
V
V
K
S
T
S
Y
T
K
I
A
S
S
S
R
Site 41
S289
T
S
Y
T
K
I
A
S
S
S
R
R
S
T
T
Site 42
S290
S
Y
T
K
I
A
S
S
S
R
R
S
T
T
K
Site 43
S291
Y
T
K
I
A
S
S
S
R
R
S
T
T
K
S
Site 44
S294
I
A
S
S
S
R
R
S
T
T
K
S
P
G
P
Site 45
T295
A
S
S
S
R
R
S
T
T
K
S
P
G
P
S
Site 46
T296
S
S
S
R
R
S
T
T
K
S
P
G
P
S
R
Site 47
S298
S
R
R
S
T
T
K
S
P
G
P
S
R
R
S
Site 48
S302
T
T
K
S
P
G
P
S
R
R
S
K
S
P
A
Site 49
S305
S
P
G
P
S
R
R
S
K
S
P
A
S
T
S
Site 50
S307
G
P
S
R
R
S
K
S
P
A
S
T
S
S
V
Site 51
S310
R
R
S
K
S
P
A
S
T
S
S
V
N
G
T
Site 52
T311
R
S
K
S
P
A
S
T
S
S
V
N
G
T
P
Site 53
S312
S
K
S
P
A
S
T
S
S
V
N
G
T
P
G
Site 54
S313
K
S
P
A
S
T
S
S
V
N
G
T
P
G
S
Site 55
T317
S
T
S
S
V
N
G
T
P
G
S
Q
L
S
T
Site 56
S320
S
V
N
G
T
P
G
S
Q
L
S
T
P
R
S
Site 57
S323
G
T
P
G
S
Q
L
S
T
P
R
S
G
K
S
Site 58
T324
T
P
G
S
Q
L
S
T
P
R
S
G
K
S
P
Site 59
S327
S
Q
L
S
T
P
R
S
G
K
S
P
S
P
S
Site 60
S330
S
T
P
R
S
G
K
S
P
S
P
S
P
T
S
Site 61
S332
P
R
S
G
K
S
P
S
P
S
P
T
S
P
G
Site 62
S334
S
G
K
S
P
S
P
S
P
T
S
P
G
S
L
Site 63
T336
K
S
P
S
P
S
P
T
S
P
G
S
L
R
K
Site 64
S337
S
P
S
P
S
P
T
S
P
G
S
L
R
K
Q
Site 65
S340
P
S
P
T
S
P
G
S
L
R
K
Q
R
S
S
Site 66
S346
G
S
L
R
K
Q
R
S
S
Q
H
G
G
S
S
Site 67
S347
S
L
R
K
Q
R
S
S
Q
H
G
G
S
S
T
Site 68
S352
R
S
S
Q
H
G
G
S
S
T
S
L
A
S
T
Site 69
S353
S
S
Q
H
G
G
S
S
T
S
L
A
S
T
K
Site 70
T354
S
Q
H
G
G
S
S
T
S
L
A
S
T
K
V
Site 71
S355
Q
H
G
G
S
S
T
S
L
A
S
T
K
V
C
Site 72
S358
G
S
S
T
S
L
A
S
T
K
V
C
S
S
M
Site 73
T359
S
S
T
S
L
A
S
T
K
V
C
S
S
M
D
Site 74
S363
L
A
S
T
K
V
C
S
S
M
D
E
N
D
G
Site 75
S364
A
S
T
K
V
C
S
S
M
D
E
N
D
G
P
Site 76
S376
D
G
P
G
E
E
V
S
E
E
G
F
Q
I
P
Site 77
T385
E
G
F
Q
I
P
A
T
I
T
E
R
Y
K
V
Site 78
T387
F
Q
I
P
A
T
I
T
E
R
Y
K
V
G
R
Site 79
S411
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
Site 80
T412
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
Site 81
Y416
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
Site 82
S424
A
L
K
I
I
K
K
S
K
C
R
G
K
E
H
Site 83
T478
G
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
Site 84
S479
D
L
F
D
A
I
T
S
T
N
K
Y
T
E
R
Site 85
Y483
A
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
Site 86
T484
I
T
S
T
N
K
Y
T
E
R
D
A
S
G
M
Site 87
S489
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
Site 88
Y493
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Site 89
S504
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
Site 90
Y520
K
P
E
N
L
L
V
Y
E
H
Q
D
G
S
K
Site 91
S526
V
Y
E
H
Q
D
G
S
K
S
L
K
L
G
D
Site 92
S528
E
H
Q
D
G
S
K
S
L
K
L
G
D
F
G
Site 93
S590
G
F
P
P
F
R
G
S
G
D
D
Q
E
V
L
Site 94
Y612
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
Site 95
S617
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
Site 96
S637
V
D
V
D
Q
R
F
S
A
V
Q
V
L
E
H
Site 97
S660
P
E
N
E
H
Q
L
S
V
A
G
K
I
K
K
Site 98
S677
N
T
G
P
K
P
N
S
T
A
A
G
V
S
V
Site 99
Y709
N
Q
D
V
R
S
R
Y
K
A
Q
P
A
P
P
Site 100
S720
P
A
P
P
E
L
N
S
E
S
E
D
Y
S
P
Site 101
S722
P
P
E
L
N
S
E
S
E
D
Y
S
P
S
S
Site 102
Y725
L
N
S
E
S
E
D
Y
S
P
S
S
S
E
T
Site 103
S726
N
S
E
S
E
D
Y
S
P
S
S
S
E
T
V
Site 104
S728
E
S
E
D
Y
S
P
S
S
S
E
T
V
R
S
Site 105
S729
S
E
D
Y
S
P
S
S
S
E
T
V
R
S
P
Site 106
S730
E
D
Y
S
P
S
S
S
E
T
V
R
S
P
N
Site 107
T732
Y
S
P
S
S
S
E
T
V
R
S
P
N
S
P
Site 108
S735
S
S
S
E
T
V
R
S
P
N
S
P
F
_
_
Site 109
S738
E
T
V
R
S
P
N
S
P
F
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation