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Updated November 2019
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Protein Info
Short Name:
ZNF536
Full Name:
Zinc finger protein 536
Alias:
Type:
Mass (Da):
141417
Number AA:
1300
UniProt ID:
O15090
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
S
L
C
L
G
V
S
S
A
E
P
E
A
E
P
Site 2
S22
P
E
A
E
P
H
L
S
G
P
V
L
N
G
Q
Site 3
S41
Q
K
L
H
Q
I
T
S
Q
L
S
H
A
F
P
Site 4
S44
H
Q
I
T
S
Q
L
S
H
A
F
P
E
L
H
Site 5
S63
P
E
E
K
P
P
A
S
L
E
E
K
A
H
V
Site 6
S73
E
K
A
H
V
P
M
S
G
Q
P
M
G
S
Q
Site 7
S95
L
G
R
E
V
D
T
S
L
N
G
R
V
D
L
Site 8
S115
G
Q
N
L
G
I
M
S
Q
M
S
D
I
E
D
Site 9
S118
L
G
I
M
S
Q
M
S
D
I
E
D
D
A
R
Site 10
Y130
D
A
R
K
N
R
K
Y
P
C
P
L
C
G
K
Site 11
S143
G
K
R
F
R
F
N
S
I
L
S
L
H
M
R
Site 12
T151
I
L
S
L
H
M
R
T
H
T
G
E
K
P
F
Site 13
T153
S
L
H
M
R
T
H
T
G
E
K
P
F
K
C
Site 14
Y162
E
K
P
F
K
C
P
Y
C
D
H
R
A
A
Q
Site 15
S247
L
A
L
Q
A
N
H
S
V
P
D
V
A
H
P
Site 16
S257
D
V
A
H
P
V
P
S
P
K
P
A
S
V
Q
Site 17
S262
V
P
S
P
K
P
A
S
V
Q
E
D
A
V
A
Site 18
T277
P
A
A
G
F
R
C
T
F
C
K
G
K
F
K
Site 19
S310
T
L
C
D
F
A
A
S
Q
E
E
E
L
I
S
Site 20
S317
S
Q
E
E
E
L
I
S
H
V
E
K
A
H
I
Site 21
S341
P
N
G
G
G
E
Q
S
A
N
E
F
R
C
E
Site 22
S400
K
V
H
L
N
K
L
S
V
K
N
K
S
P
S
Site 23
S405
K
L
S
V
K
N
K
S
P
S
D
P
E
V
P
Site 24
S407
S
V
K
N
K
S
P
S
D
P
E
V
P
V
P
Site 25
S419
P
V
P
M
G
G
M
S
Q
E
A
H
A
N
L
Site 26
Y427
Q
E
A
H
A
N
L
Y
S
R
Y
L
S
C
L
Site 27
S428
E
A
H
A
N
L
Y
S
R
Y
L
S
C
L
Q
Site 28
Y430
H
A
N
L
Y
S
R
Y
L
S
C
L
Q
S
G
Site 29
S432
N
L
Y
S
R
Y
L
S
C
L
Q
S
G
F
M
Site 30
S436
R
Y
L
S
C
L
Q
S
G
F
M
T
P
D
K
Site 31
T440
C
L
Q
S
G
F
M
T
P
D
K
A
G
L
S
Site 32
S447
T
P
D
K
A
G
L
S
E
P
S
Q
L
Y
G
Site 33
Y453
L
S
E
P
S
Q
L
Y
G
K
G
E
L
P
M
Site 34
S487
V
P
E
G
D
K
H
S
L
L
G
C
L
N
L
Site 35
S500
N
L
V
P
P
L
K
S
S
C
I
E
R
L
Q
Site 36
Y521
E
M
D
P
V
N
S
Y
Q
A
W
Q
L
M
A
Site 37
S539
A
M
E
H
G
F
L
S
K
E
H
P
L
Q
R
Site 38
T551
L
Q
R
N
H
E
D
T
L
A
N
A
G
V
L
Site 39
Y566
F
D
K
E
K
R
E
Y
V
L
V
G
A
D
G
Site 40
T586
P
A
D
L
V
H
S
T
K
V
G
S
Q
R
D
Site 41
S590
V
H
S
T
K
V
G
S
Q
R
D
L
P
S
K
Site 42
S596
G
S
Q
R
D
L
P
S
K
L
D
P
L
E
S
Site 43
S603
S
K
L
D
P
L
E
S
S
R
D
F
L
S
H
Site 44
S604
K
L
D
P
L
E
S
S
R
D
F
L
S
H
G
Site 45
S609
E
S
S
R
D
F
L
S
H
G
L
N
Q
T
L
Site 46
T615
L
S
H
G
L
N
Q
T
L
E
Y
N
L
Q
G
Site 47
Y618
G
L
N
Q
T
L
E
Y
N
L
Q
G
P
G
N
Site 48
T631
G
N
M
K
E
K
P
T
E
C
P
D
C
G
R
Site 49
Y643
C
G
R
V
F
R
T
Y
H
Q
V
V
V
H
S
Site 50
S674
G
L
D
E
R
R
G
S
G
S
D
Q
E
S
Q
Site 51
S676
D
E
R
R
G
S
G
S
D
Q
E
S
Q
S
V
Site 52
S680
G
S
G
S
D
Q
E
S
Q
S
V
S
R
S
T
Site 53
S682
G
S
D
Q
E
S
Q
S
V
S
R
S
T
T
P
Site 54
S684
D
Q
E
S
Q
S
V
S
R
S
T
T
P
G
S
Site 55
S686
E
S
Q
S
V
S
R
S
T
T
P
G
S
S
N
Site 56
T687
S
Q
S
V
S
R
S
T
T
P
G
S
S
N
V
Site 57
T688
Q
S
V
S
R
S
T
T
P
G
S
S
N
V
T
Site 58
S691
S
R
S
T
T
P
G
S
S
N
V
T
E
E
S
Site 59
S692
R
S
T
T
P
G
S
S
N
V
T
E
E
S
G
Site 60
T695
T
P
G
S
S
N
V
T
E
E
S
G
V
G
G
Site 61
S698
S
S
N
V
T
E
E
S
G
V
G
G
G
L
S
Site 62
S705
S
G
V
G
G
G
L
S
Q
T
G
S
A
Q
E
Site 63
S709
G
G
L
S
Q
T
G
S
A
Q
E
D
S
P
H
Site 64
S714
T
G
S
A
Q
E
D
S
P
H
P
S
S
P
S
Site 65
S718
Q
E
D
S
P
H
P
S
S
P
S
S
S
D
I
Site 66
S719
E
D
S
P
H
P
S
S
P
S
S
S
D
I
G
Site 67
S721
S
P
H
P
S
S
P
S
S
S
D
I
G
E
E
Site 68
S722
P
H
P
S
S
P
S
S
S
D
I
G
E
E
A
Site 69
S723
H
P
S
S
P
S
S
S
D
I
G
E
E
A
G
Site 70
S732
I
G
E
E
A
G
R
S
A
G
V
Q
Q
P
A
Site 71
S745
P
A
L
L
R
D
R
S
L
G
S
A
M
K
D
Site 72
Y755
S
A
M
K
D
C
P
Y
C
G
K
T
F
R
T
Site 73
T774
K
V
H
L
R
I
H
T
G
E
K
P
Y
K
C
Site 74
Y779
I
H
T
G
E
K
P
Y
K
C
P
H
C
D
Y
Site 75
Y786
Y
K
C
P
H
C
D
Y
A
G
T
Q
S
A
S
Site 76
T789
P
H
C
D
Y
A
G
T
Q
S
A
S
L
K
Y
Site 77
S793
Y
A
G
T
Q
S
A
S
L
K
Y
H
L
E
R
Site 78
S813
Q
N
G
A
G
P
L
S
G
Q
P
P
N
Q
D
Site 79
S826
Q
D
H
K
D
E
M
S
S
K
A
S
L
F
I
Site 80
S827
D
H
K
D
E
M
S
S
K
A
S
L
F
I
R
Site 81
S830
D
E
M
S
S
K
A
S
L
F
I
R
P
D
I
Site 82
S856
D
F
R
G
G
P
A
S
Q
Q
W
T
S
G
V
Site 83
T860
G
P
A
S
Q
Q
W
T
S
G
V
L
S
S
G
Site 84
S861
P
A
S
Q
Q
W
T
S
G
V
L
S
S
G
D
Site 85
S865
Q
W
T
S
G
V
L
S
S
G
D
H
S
G
Q
Site 86
S866
W
T
S
G
V
L
S
S
G
D
H
S
G
Q
A
Site 87
S870
V
L
S
S
G
D
H
S
G
Q
A
T
G
M
S
Site 88
T874
G
D
H
S
G
Q
A
T
G
M
S
S
E
V
P
Site 89
S877
S
G
Q
A
T
G
M
S
S
E
V
P
S
D
A
Site 90
S878
G
Q
A
T
G
M
S
S
E
V
P
S
D
A
L
Site 91
S882
G
M
S
S
E
V
P
S
D
A
L
K
G
T
D
Site 92
T888
P
S
D
A
L
K
G
T
D
L
P
S
K
S
T
Site 93
S892
L
K
G
T
D
L
P
S
K
S
T
H
F
S
E
Site 94
S894
G
T
D
L
P
S
K
S
T
H
F
S
E
I
G
Site 95
S898
P
S
K
S
T
H
F
S
E
I
G
R
A
Y
Q
Site 96
Y904
F
S
E
I
G
R
A
Y
Q
S
I
V
S
N
G
Site 97
S906
E
I
G
R
A
Y
Q
S
I
V
S
N
G
V
N
Site 98
S917
N
G
V
N
F
Q
G
S
L
Q
A
F
M
D
S
Site 99
S928
F
M
D
S
F
V
L
S
S
L
K
K
E
K
D
Site 100
S946
K
A
L
A
D
P
P
S
M
K
V
H
G
V
D
Site 101
S960
D
G
G
E
E
K
P
S
G
K
S
S
Q
R
K
Site 102
S963
E
E
K
P
S
G
K
S
S
Q
R
K
S
E
K
Site 103
S964
E
K
P
S
G
K
S
S
Q
R
K
S
E
K
S
Site 104
S968
G
K
S
S
Q
R
K
S
E
K
S
Q
Y
E
P
Site 105
S971
S
Q
R
K
S
E
K
S
Q
Y
E
P
L
D
L
Site 106
Y973
R
K
S
E
K
S
Q
Y
E
P
L
D
L
S
V
Site 107
S979
Q
Y
E
P
L
D
L
S
V
R
P
D
A
A
S
Site 108
S986
S
V
R
P
D
A
A
S
L
P
G
S
S
V
T
Site 109
S990
D
A
A
S
L
P
G
S
S
V
T
V
Q
D
S
Site 110
T1034
K
A
K
R
K
D
N
T
I
G
V
T
V
N
C
Site 111
T1038
K
D
N
T
I
G
V
T
V
N
C
K
D
Q
A
Site 112
S1049
K
D
Q
A
R
E
A
S
K
M
A
L
L
P
S
Site 113
S1056
S
K
M
A
L
L
P
S
L
Q
S
N
K
D
L
Site 114
S1059
A
L
L
P
S
L
Q
S
N
K
D
L
G
L
S
Site 115
S1066
S
N
K
D
L
G
L
S
N
M
I
S
S
L
D
Site 116
S1071
G
L
S
N
M
I
S
S
L
D
S
A
S
E
K
Site 117
S1074
N
M
I
S
S
L
D
S
A
S
E
K
M
A
Q
Site 118
S1076
I
S
S
L
D
S
A
S
E
K
M
A
Q
G
Q
Site 119
S1093
E
T
L
G
E
Q
K
S
G
A
W
T
G
H
V
Site 120
T1097
E
Q
K
S
G
A
W
T
G
H
V
D
P
A
F
Site 121
Y1112
C
N
F
P
S
D
F
Y
K
Q
F
G
V
Y
P
Site 122
S1128
M
V
G
S
G
A
S
S
S
C
P
N
K
E
P
Site 123
S1129
V
G
S
G
A
S
S
S
C
P
N
K
E
P
D
Site 124
S1141
E
P
D
G
K
A
H
S
E
E
D
V
P
I
L
Site 125
T1152
V
P
I
L
I
P
E
T
T
S
K
N
T
T
D
Site 126
T1158
E
T
T
S
K
N
T
T
D
D
L
S
D
I
A
Site 127
S1162
K
N
T
T
D
D
L
S
D
I
A
S
S
E
D
Site 128
S1166
D
D
L
S
D
I
A
S
S
E
D
M
D
S
S
Site 129
S1167
D
L
S
D
I
A
S
S
E
D
M
D
S
S
K
Site 130
S1172
A
S
S
E
D
M
D
S
S
K
G
E
N
N
D
Site 131
S1173
S
S
E
D
M
D
S
S
K
G
E
N
N
D
E
Site 132
T1185
N
D
E
E
D
V
E
T
E
P
E
M
M
T
K
Site 133
S1195
E
M
M
T
K
P
L
S
A
L
S
K
D
S
S
Site 134
S1198
T
K
P
L
S
A
L
S
K
D
S
S
S
D
G
Site 135
S1201
L
S
A
L
S
K
D
S
S
S
D
G
G
D
S
Site 136
S1202
S
A
L
S
K
D
S
S
S
D
G
G
D
S
L
Site 137
S1203
A
L
S
K
D
S
S
S
D
G
G
D
S
L
Q
Site 138
S1208
S
S
S
D
G
G
D
S
L
Q
P
T
G
T
S
Site 139
T1212
G
G
D
S
L
Q
P
T
G
T
S
Q
P
V
Q
Site 140
T1214
D
S
L
Q
P
T
G
T
S
Q
P
V
Q
G
L
Site 141
S1215
S
L
Q
P
T
G
T
S
Q
P
V
Q
G
L
V
Site 142
S1223
Q
P
V
Q
G
L
V
S
P
L
S
Q
A
P
E
Site 143
S1226
Q
G
L
V
S
P
L
S
Q
A
P
E
K
Q
W
Site 144
S1235
A
P
E
K
Q
W
H
S
Q
G
L
L
Q
A
Q
Site 145
S1257
K
P
E
R
G
P
Q
S
L
D
K
P
M
N
M
Site 146
S1266
D
K
P
M
N
M
L
S
V
L
R
A
Y
S
S
Site 147
S1289
L
A
S
S
T
A
N
S
G
C
I
K
R
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation