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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smad7
Full Name:
Mothers against decapentaplegic homolog 7
Alias:
hSMAD7; MADH7; MADH8; Mothers against DPP homologue 7
Type:
Intracellular, Cytoplasm, Nucleus, Transcription protein complex protein
Mass (Da):
46426
Number AA:
426
UniProt ID:
O15105
International Prot ID:
IPI00005079
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005886
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0070411
GO:0048185
GO:0008013
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0034333
GO:0048844
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
V
R
R
L
W
R
S
R
A
P
G
G
E
D
Site 2
T43
E
L
R
G
E
G
A
T
D
S
R
A
H
G
A
Site 3
S45
R
G
E
G
A
T
D
S
R
A
H
G
A
G
G
Site 4
T96
E
A
D
L
K
A
L
T
H
S
V
L
K
K
L
Site 5
S98
D
L
K
A
L
T
H
S
V
L
K
K
L
K
E
Site 6
T121
A
V
E
S
R
G
G
T
R
T
A
C
L
L
L
Site 7
T123
E
S
R
G
G
T
R
T
A
C
L
L
L
P
G
Site 8
S151
A
Q
P
A
Q
P
P
S
S
Y
S
L
P
L
L
Site 9
S152
Q
P
A
Q
P
P
S
S
Y
S
L
P
L
L
L
Site 10
S171
R
W
P
D
L
R
H
S
S
E
V
K
R
L
C
Site 11
S172
W
P
D
L
R
H
S
S
E
V
K
R
L
C
C
Site 12
S206
S
R
L
C
E
L
E
S
P
P
P
P
Y
S
R
Site 13
Y211
L
E
S
P
P
P
P
Y
S
R
Y
P
M
D
F
Site 14
S212
E
S
P
P
P
P
Y
S
R
Y
P
M
D
F
L
Site 15
Y214
P
P
P
P
Y
S
R
Y
P
M
D
F
L
K
P
Site 16
S231
D
C
P
D
A
V
P
S
S
A
E
T
G
G
T
Site 17
S232
C
P
D
A
V
P
S
S
A
E
T
G
G
T
N
Site 18
T238
S
S
A
E
T
G
G
T
N
Y
L
A
P
G
G
Site 19
Y240
A
E
T
G
G
T
N
Y
L
A
P
G
G
L
S
Site 20
S249
A
P
G
G
L
S
D
S
Q
L
L
L
E
P
G
Site 21
T271
V
A
Y
W
E
E
K
T
R
V
G
R
L
Y
C
Site 22
Y277
K
T
R
V
G
R
L
Y
C
V
Q
E
P
S
L
Site 23
Y288
E
P
S
L
D
I
F
Y
D
L
P
Q
G
N
G
Site 24
S303
F
C
L
G
Q
L
N
S
D
N
K
S
Q
L
V
Site 25
S307
Q
L
N
S
D
N
K
S
Q
L
V
Q
K
V
R
Site 26
S315
Q
L
V
Q
K
V
R
S
K
I
G
C
G
I
Q
Site 27
Y333
E
V
D
G
V
W
V
Y
N
R
S
S
Y
P
I
Site 28
Y338
W
V
Y
N
R
S
S
Y
P
I
F
I
K
S
A
Site 29
S344
S
Y
P
I
F
I
K
S
A
T
L
D
N
P
D
Site 30
T346
P
I
F
I
K
S
A
T
L
D
N
P
D
S
R
Site 31
S352
A
T
L
D
N
P
D
S
R
T
L
L
V
H
K
Site 32
T354
L
D
N
P
D
S
R
T
L
L
V
H
K
V
F
Site 33
S365
H
K
V
F
P
G
F
S
I
K
A
F
D
Y
E
Site 34
Y371
F
S
I
K
A
F
D
Y
E
K
A
Y
S
L
Q
Site 35
S376
F
D
Y
E
K
A
Y
S
L
Q
R
P
N
D
H
Site 36
T394
Q
Q
P
W
T
G
F
T
V
Q
I
S
F
V
K
Site 37
Y407
V
K
G
W
G
Q
C
Y
T
R
Q
F
I
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation