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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPC1
Full Name:
Niemann-Pick C1 protein
Alias:
Type:
Mass (Da):
142149
Number AA:
1278
UniProt ID:
O15118
International Prot ID:
IPI00005107
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000323
GO:0005635
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0004872
GO:0004888
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006629
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y35
Y
G
E
C
G
I
A
Y
G
D
K
R
Y
N
C
Site 2
Y40
I
A
Y
G
D
K
R
Y
N
C
E
Y
S
G
P
Site 3
Y44
D
K
R
Y
N
C
E
Y
S
G
P
P
K
P
L
Site 4
S45
K
R
Y
N
C
E
Y
S
G
P
P
K
P
L
P
Site 5
Y56
K
P
L
P
K
D
G
Y
D
L
V
Q
E
L
C
Site 6
T112
L
N
L
F
C
E
L
T
C
S
P
R
Q
S
Q
Site 7
S118
L
T
C
S
P
R
Q
S
Q
F
L
N
V
T
A
Site 8
Y129
N
V
T
A
T
E
D
Y
V
D
P
V
T
N
Q
Site 9
T134
E
D
Y
V
D
P
V
T
N
Q
T
K
T
N
V
Site 10
T139
P
V
T
N
Q
T
K
T
N
V
K
E
L
Q
Y
Site 11
Y146
T
N
V
K
E
L
Q
Y
Y
V
G
Q
S
F
A
Site 12
Y147
N
V
K
E
L
Q
Y
Y
V
G
Q
S
F
A
N
Site 13
S168
R
D
V
E
A
P
S
S
N
D
K
A
L
G
L
Site 14
T204
D
N
G
Q
A
P
F
T
I
T
P
V
F
S
D
Site 15
S230
A
T
K
G
C
D
E
S
V
D
E
V
T
A
P
Site 16
T235
D
E
S
V
D
E
V
T
A
P
C
S
C
Q
D
Site 17
Y297
V
W
C
Y
R
K
R
Y
F
V
S
E
Y
T
P
Site 18
Y302
K
R
Y
F
V
S
E
Y
T
P
I
D
S
N
I
Site 19
T303
R
Y
F
V
S
E
Y
T
P
I
D
S
N
I
A
Site 20
S307
S
E
Y
T
P
I
D
S
N
I
A
F
S
V
N
Site 21
S312
I
D
S
N
I
A
F
S
V
N
A
S
D
K
G
Site 22
S316
I
A
F
S
V
N
A
S
D
K
G
E
A
S
C
Site 23
S322
A
S
D
K
G
E
A
S
C
C
D
P
V
S
A
Site 24
S344
R
L
F
T
R
W
G
S
F
C
V
R
N
P
G
Site 25
S382
T
N
P
V
D
L
W
S
A
P
S
S
Q
A
R
Site 26
S385
V
D
L
W
S
A
P
S
S
Q
A
R
L
E
K
Site 27
S386
D
L
W
S
A
P
S
S
Q
A
R
L
E
K
E
Site 28
Y394
Q
A
R
L
E
K
E
Y
F
D
Q
H
F
G
P
Site 29
T415
L
I
I
R
A
P
L
T
D
K
H
I
Y
Q
P
Site 30
Y420
P
L
T
D
K
H
I
Y
Q
P
Y
P
S
G
A
Site 31
Y423
D
K
H
I
Y
Q
P
Y
P
S
G
A
D
V
P
Site 32
S425
H
I
Y
Q
P
Y
P
S
G
A
D
V
P
F
G
Site 33
T461
T
A
S
Y
D
N
E
T
V
T
L
Q
D
I
C
Site 34
T463
S
Y
D
N
E
T
V
T
L
Q
D
I
C
L
A
Site 35
T480
S
P
Y
N
T
N
C
T
I
L
S
V
L
N
Y
Site 36
S493
N
Y
F
Q
N
S
H
S
V
L
D
H
K
K
G
Site 37
Y506
K
G
D
D
F
F
V
Y
A
D
Y
H
T
H
F
Site 38
Y515
D
Y
H
T
H
F
L
Y
C
V
R
A
P
A
S
Site 39
T526
A
P
A
S
L
N
D
T
S
L
L
H
D
P
C
Site 40
S527
P
A
S
L
N
D
T
S
L
L
H
D
P
C
L
Site 41
Y550
P
W
L
V
L
G
G
Y
D
D
Q
N
Y
N
N
Site 42
Y555
G
G
Y
D
D
Q
N
Y
N
N
A
T
A
L
V
Site 43
Y570
I
T
F
P
V
N
N
Y
Y
N
D
T
E
K
L
Site 44
Y571
T
F
P
V
N
N
Y
Y
N
D
T
E
K
L
Q
Site 45
Y594
F
I
N
F
V
K
N
Y
K
N
P
N
L
T
I
Site 46
S602
K
N
P
N
L
T
I
S
F
T
A
E
R
S
I
Site 47
T604
P
N
L
T
I
S
F
T
A
E
R
S
I
E
D
Site 48
S608
I
S
F
T
A
E
R
S
I
E
D
E
L
N
R
Site 49
S617
E
D
E
L
N
R
E
S
D
S
D
V
F
T
V
Site 50
S619
E
L
N
R
E
S
D
S
D
V
F
T
V
V
I
Site 51
Y709
I
F
I
L
V
Q
A
Y
Q
R
D
E
R
L
Q
Site 52
T719
D
E
R
L
Q
G
E
T
L
D
Q
Q
L
G
R
Site 53
S809
R
G
A
E
D
G
T
S
V
Q
A
S
E
S
C
Site 54
S813
D
G
T
S
V
Q
A
S
E
S
C
L
F
R
F
Site 55
S826
R
F
F
K
N
S
Y
S
P
L
L
L
K
D
W
Site 56
S863
V
D
I
G
L
D
Q
S
L
S
M
P
D
D
S
Site 57
S865
I
G
L
D
Q
S
L
S
M
P
D
D
S
Y
M
Site 58
S870
S
L
S
M
P
D
D
S
Y
M
V
D
Y
F
K
Site 59
Y871
L
S
M
P
D
D
S
Y
M
V
D
Y
F
K
S
Site 60
Y875
D
D
S
Y
M
V
D
Y
F
K
S
I
S
Q
Y
Site 61
S880
V
D
Y
F
K
S
I
S
Q
Y
L
H
A
G
P
Site 62
Y882
Y
F
K
S
I
S
Q
Y
L
H
A
G
P
P
V
Site 63
Y899
V
L
E
E
G
H
D
Y
T
S
S
K
G
Q
N
Site 64
T900
L
E
E
G
H
D
Y
T
S
S
K
G
Q
N
M
Site 65
Y932
N
A
A
Q
L
D
N
Y
T
R
I
G
F
A
P
Site 66
Y946
P
S
S
W
I
D
D
Y
F
D
W
V
K
P
Q
Site 67
T983
C
V
R
C
R
P
L
T
P
E
G
K
Q
R
P
Site 68
T1043
T
Y
F
M
T
Y
H
T
V
L
Q
T
S
A
D
Site 69
S1063
K
K
A
R
L
I
A
S
N
V
T
E
T
M
G
Site 70
T1176
S
H
I
T
R
A
F
T
V
S
M
K
G
S
R
Site 71
S1178
I
T
R
A
F
T
V
S
M
K
G
S
R
V
E
Site 72
S1182
F
T
V
S
M
K
G
S
R
V
E
R
A
E
E
Site 73
S1260
P
S
V
N
K
A
K
S
C
A
T
E
E
R
Y
Site 74
T1270
T
E
E
R
Y
K
G
T
E
R
E
R
L
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation