KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TBX3
Full Name:
T-box transcription factor TBX3
Alias:
T-box 3; T-box protein 3; TBX3-ISO; UMS; XHL
Type:
Transcription factor
Mass (Da):
79389
Number AA:
743
UniProt ID:
O15119
International Prot ID:
IPI00005110
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0016565
GO:0043565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0007569
GO:0008595
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
R
D
P
V
I
P
G
T
S
M
A
Y
H
P
F
Site 2
Y17
I
P
G
T
S
M
A
Y
H
P
F
L
P
H
R
Site 3
S79
A
E
T
G
I
P
F
S
S
L
G
P
Q
A
H
Site 4
S80
E
T
G
I
P
F
S
S
L
G
P
Q
A
H
L
Site 5
T92
A
H
L
R
P
L
K
T
M
E
P
E
E
E
V
Site 6
T121
D
Q
F
H
K
R
G
T
E
M
V
I
T
K
S
Site 7
T126
R
G
T
E
M
V
I
T
K
S
G
R
R
M
F
Site 8
S141
P
P
F
K
V
R
C
S
G
L
D
K
K
A
K
Site 9
Y163
I
A
A
D
D
C
R
Y
K
F
H
N
S
R
W
Site 10
Y185
P
E
M
P
K
R
M
Y
I
H
P
D
S
P
A
Site 11
S190
R
M
Y
I
H
P
D
S
P
A
T
G
E
Q
W
Site 12
T203
Q
W
M
S
K
V
V
T
F
H
K
L
K
L
T
Site 13
T210
T
F
H
K
L
K
L
T
N
N
I
S
D
K
H
Site 14
S214
L
K
L
T
N
N
I
S
D
K
H
G
F
T
L
Site 15
T220
I
S
D
K
H
G
F
T
L
A
F
P
S
D
H
Site 16
T229
A
F
P
S
D
H
A
T
W
Q
G
N
Y
S
F
Site 17
T240
N
Y
S
F
G
T
Q
T
I
L
N
S
M
H
K
Site 18
Y248
I
L
N
S
M
H
K
Y
Q
P
R
F
H
I
V
Site 19
Y265
N
D
I
L
K
L
P
Y
S
T
F
R
T
Y
L
Site 20
T270
L
P
Y
S
T
F
R
T
Y
L
F
P
E
T
E
Site 21
Y271
P
Y
S
T
F
R
T
Y
L
F
P
E
T
E
F
Site 22
Y284
E
F
I
A
V
T
A
Y
Q
N
D
K
I
T
Q
Site 23
T306
F
A
K
G
F
R
D
T
G
N
G
R
R
E
K
Site 24
T318
R
E
K
R
K
Q
L
T
L
Q
S
M
R
V
F
Site 25
S321
R
K
Q
L
T
L
Q
S
M
R
V
F
D
E
R
Site 26
T335
R
H
K
K
E
N
G
T
S
D
E
S
S
S
E
Site 27
S336
H
K
K
E
N
G
T
S
D
E
S
S
S
E
Q
Site 28
S340
N
G
T
S
D
E
S
S
S
E
Q
A
A
F
N
Site 29
S341
G
T
S
D
E
S
S
S
E
Q
A
A
F
N
C
Site 30
S358
Q
A
S
S
P
A
A
S
T
V
G
T
S
N
L
Site 31
T359
A
S
S
P
A
A
S
T
V
G
T
S
N
L
K
Site 32
S371
N
L
K
D
L
C
P
S
E
G
E
S
D
A
E
Site 33
S375
L
C
P
S
E
G
E
S
D
A
E
A
E
S
K
Site 34
S381
E
S
D
A
E
A
E
S
K
E
E
H
G
P
E
Site 35
S396
A
C
D
A
A
K
I
S
T
T
T
S
E
E
P
Site 36
S400
A
K
I
S
T
T
T
S
E
E
P
C
R
D
K
Site 37
S409
E
P
C
R
D
K
G
S
P
A
V
K
A
H
L
Site 38
S425
A
A
E
R
P
R
D
S
G
R
L
D
K
A
S
Site 39
S432
S
G
R
L
D
K
A
S
P
D
S
R
H
S
P
Site 40
S435
L
D
K
A
S
P
D
S
R
H
S
P
A
T
I
Site 41
S438
A
S
P
D
S
R
H
S
P
A
T
I
S
S
S
Site 42
T441
D
S
R
H
S
P
A
T
I
S
S
S
T
R
G
Site 43
S443
R
H
S
P
A
T
I
S
S
S
T
R
G
L
G
Site 44
S444
H
S
P
A
T
I
S
S
S
T
R
G
L
G
A
Site 45
S445
S
P
A
T
I
S
S
S
T
R
G
L
G
A
E
Site 46
T446
P
A
T
I
S
S
S
T
R
G
L
G
A
E
E
Site 47
S456
L
G
A
E
E
R
R
S
P
V
R
E
G
T
A
Site 48
T462
R
S
P
V
R
E
G
T
A
P
A
K
V
E
E
Site 49
S620
A
A
S
S
A
A
A
S
S
S
V
H
R
H
P
Site 50
S622
S
S
A
A
A
S
S
S
V
H
R
H
P
F
L
Site 51
T633
H
P
F
L
N
L
N
T
M
R
P
R
L
R
Y
Site 52
Y640
T
M
R
P
R
L
R
Y
S
P
Y
S
I
P
V
Site 53
S641
M
R
P
R
L
R
Y
S
P
Y
S
I
P
V
P
Site 54
Y643
P
R
L
R
Y
S
P
Y
S
I
P
V
P
V
P
Site 55
S644
R
L
R
Y
S
P
Y
S
I
P
V
P
V
P
D
Site 56
S688
P
A
S
V
A
V
D
S
G
S
E
L
N
S
R
Site 57
S690
S
V
A
V
D
S
G
S
E
L
N
S
R
S
S
Site 58
S694
D
S
G
S
E
L
N
S
R
S
S
T
L
S
S
Site 59
S696
G
S
E
L
N
S
R
S
S
T
L
S
S
S
S
Site 60
S697
S
E
L
N
S
R
S
S
T
L
S
S
S
S
M
Site 61
T698
E
L
N
S
R
S
S
T
L
S
S
S
S
M
S
Site 62
S700
N
S
R
S
S
T
L
S
S
S
S
M
S
L
S
Site 63
S701
S
R
S
S
T
L
S
S
S
S
M
S
L
S
P
Site 64
S702
R
S
S
T
L
S
S
S
S
M
S
L
S
P
K
Site 65
S703
S
S
T
L
S
S
S
S
M
S
L
S
P
K
L
Site 66
S707
S
S
S
S
M
S
L
S
P
K
L
C
A
E
K
Site 67
S719
A
E
K
E
A
A
T
S
E
L
Q
S
I
Q
R
Site 68
S723
A
A
T
S
E
L
Q
S
I
Q
R
L
V
S
G
Site 69
S729
Q
S
I
Q
R
L
V
S
G
L
E
A
K
P
D
Site 70
S738
L
E
A
K
P
D
R
S
R
S
A
S
P
_
_
Site 71
S740
A
K
P
D
R
S
R
S
A
S
P
_
_
_
_
Site 72
S742
P
D
R
S
R
S
A
S
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation