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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MDM4
Full Name:
Protein Mdm4
Alias:
Mdm2-like p53-binding protein; Mdm4 p53 binding protein; MDMX; P53-binding protein Mdm4
Type:
Inhibitor protein
Mass (Da):
54864
Number AA:
490
UniProt ID:
O15151
International Prot ID:
IPI00005170
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045023
GO:0006915
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
T
S
F
S
T
S
A
Q
C
S
T
S
D
Site 2
S13
T
S
A
Q
C
S
T
S
D
S
A
C
R
I
S
Site 3
S15
A
Q
C
S
T
S
D
S
A
C
R
I
S
P
G
Site 4
S20
S
D
S
A
C
R
I
S
P
G
Q
I
N
Q
V
Site 5
Y55
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
Site 6
Y66
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
Site 7
S89
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
Site 8
S91
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Site 9
S96
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
Site 10
Y99
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
Site 11
T119
A
T
T
D
A
A
Q
T
L
A
L
A
Q
D
H
Site 12
S127
L
A
L
A
Q
D
H
S
M
D
I
P
S
Q
D
Site 13
S132
D
H
S
M
D
I
P
S
Q
D
Q
L
K
Q
S
Site 14
S139
S
Q
D
Q
L
K
Q
S
A
E
E
S
S
T
S
Site 15
S143
L
K
Q
S
A
E
E
S
S
T
S
R
K
R
T
Site 16
S144
K
Q
S
A
E
E
S
S
T
S
R
K
R
T
T
Site 17
T145
Q
S
A
E
E
S
S
T
S
R
K
R
T
T
E
Site 18
S146
S
A
E
E
S
S
T
S
R
K
R
T
T
E
D
Site 19
T150
S
S
T
S
R
K
R
T
T
E
D
D
I
P
T
Site 20
T151
S
T
S
R
K
R
T
T
E
D
D
I
P
T
L
Site 21
T157
T
T
E
D
D
I
P
T
L
P
T
S
E
H
K
Site 22
S161
D
I
P
T
L
P
T
S
E
H
K
C
I
H
S
Site 23
S168
S
E
H
K
C
I
H
S
R
E
D
E
D
L
I
Site 24
T183
E
N
L
A
Q
D
E
T
S
R
L
D
L
G
F
Site 25
S208
W
F
L
G
N
L
R
S
N
Y
T
P
R
S
N
Site 26
Y210
L
G
N
L
R
S
N
Y
T
P
R
S
N
G
S
Site 27
T211
G
N
L
R
S
N
Y
T
P
R
S
N
G
S
T
Site 28
S214
R
S
N
Y
T
P
R
S
N
G
S
T
D
L
Q
Site 29
T218
T
P
R
S
N
G
S
T
D
L
Q
T
N
Q
D
Site 30
T222
N
G
S
T
D
L
Q
T
N
Q
D
V
G
T
A
Site 31
T228
Q
T
N
Q
D
V
G
T
A
I
V
S
D
T
T
Site 32
T260
I
K
V
E
A
A
D
T
E
Q
T
S
E
E
V
Site 33
S271
S
E
E
V
G
K
V
S
D
K
K
V
I
E
V
Site 34
S287
K
N
D
D
L
E
D
S
K
S
L
S
D
D
T
Site 35
S289
D
D
L
E
D
S
K
S
L
S
D
D
T
D
V
Site 36
S291
L
E
D
S
K
S
L
S
D
D
T
D
V
E
V
Site 37
T294
S
K
S
L
S
D
D
T
D
V
E
V
T
S
E
Site 38
S314
T
E
C
K
K
F
N
S
P
S
K
R
Y
C
F
Site 39
Y331
W
A
L
R
K
D
W
Y
S
D
C
S
K
L
T
Site 40
S332
A
L
R
K
D
W
Y
S
D
C
S
K
L
T
H
Site 41
S335
K
D
W
Y
S
D
C
S
K
L
T
H
S
L
S
Site 42
T338
Y
S
D
C
S
K
L
T
H
S
L
S
T
S
D
Site 43
S340
D
C
S
K
L
T
H
S
L
S
T
S
D
I
T
Site 44
S342
S
K
L
T
H
S
L
S
T
S
D
I
T
A
I
Site 45
S344
L
T
H
S
L
S
T
S
D
I
T
A
I
P
E
Site 46
T347
S
L
S
T
S
D
I
T
A
I
P
E
K
E
N
Site 47
T365
D
V
P
D
C
R
R
T
I
S
A
P
V
V
R
Site 48
S367
P
D
C
R
R
T
I
S
A
P
V
V
R
P
K
Site 49
Y377
V
V
R
P
K
D
A
Y
I
K
K
E
N
S
K
Site 50
S400
E
F
L
D
L
A
H
S
S
E
S
Q
E
T
I
Site 51
S401
F
L
D
L
A
H
S
S
E
S
Q
E
T
I
S
Site 52
S403
D
L
A
H
S
S
E
S
Q
E
T
I
S
S
M
Site 53
T406
H
S
S
E
S
Q
E
T
I
S
S
M
G
E
Q
Site 54
S409
E
S
Q
E
T
I
S
S
M
G
E
Q
L
D
N
Site 55
S418
G
E
Q
L
D
N
L
S
E
Q
R
T
D
T
E
Site 56
T422
D
N
L
S
E
Q
R
T
D
T
E
N
M
E
D
Site 57
T424
L
S
E
Q
R
T
D
T
E
N
M
E
D
C
Q
Site 58
S438
Q
N
L
L
K
P
C
S
L
C
E
K
R
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation