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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR1C
Full Name:
DNA-directed RNA polymerases I and III subunit RPAC1
Alias:
DNA-directed RNA polymerase I 40 kDa polypeptide; DNA-directed RNA polymerases I and III 40 kDa polypeptide; POLR1E; Polymerase (RNA) I polypeptide C; RNA polymerases I and III subunit AC1; RPA39; RPA5; RPAC1
Type:
Transferase; Transcription initiation complex; Nucleotide Metabolism - purine; EC 2.7.7.6; Nucleotide Metabolism - pyrimidine
Mass (Da):
39250
Number AA:
346
UniProt ID:
O15160
International Prot ID:
IPI00005179
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005736
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
GO:0046983
PhosphoSite+
KinaseNET
Biological Process:
GO:0006360
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
A
S
Q
A
V
E
E
M
R
Site 2
T26
F
G
V
R
N
V
H
T
T
D
F
P
G
N
Y
Site 3
T27
G
V
R
N
V
H
T
T
D
F
P
G
N
Y
S
Site 4
Y33
T
T
D
F
P
G
N
Y
S
G
Y
D
D
A
W
Site 5
S34
T
D
F
P
G
N
Y
S
G
Y
D
D
A
W
D
Site 6
Y36
F
P
G
N
Y
S
G
Y
D
D
A
W
D
Q
D
Site 7
Y124
A
D
P
R
L
F
E
Y
R
N
Q
G
D
E
E
Site 8
T137
E
E
G
T
E
I
D
T
L
Q
F
R
L
Q
V
Site 9
T147
F
R
L
Q
V
R
C
T
R
N
P
H
A
A
K
Site 10
S157
P
H
A
A
K
D
S
S
D
P
N
E
L
Y
V
Site 11
Y163
S
S
D
P
N
E
L
Y
V
N
H
K
V
Y
T
Site 12
T189
A
D
L
F
P
E
G
T
I
R
P
V
H
D
D
Site 13
S226
G
K
D
H
A
K
F
S
P
V
A
T
A
S
Y
Site 14
S254
G
E
A
A
E
E
L
S
R
C
F
S
P
G
V
Site 15
S258
E
E
L
S
R
C
F
S
P
G
V
I
E
V
Q
Site 16
T282
V
A
N
P
R
L
D
T
F
S
R
E
I
F
R
Site 17
S284
N
P
R
L
D
T
F
S
R
E
I
F
R
N
E
Site 18
Y306
L
A
R
V
R
D
H
Y
I
F
S
V
E
S
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation