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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
T
Full Name:
Brachyury protein
Alias:
Protein T
Type:
Mass (Da):
47443
Number AA:
435
UniProt ID:
O15178
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
S
P
G
T
E
S
A
G
K
S
L
Site 2
S8
M
S
S
P
G
T
E
S
A
G
K
S
L
Q
Y
Site 3
S22
Y
R
V
D
H
L
L
S
A
V
E
N
E
L
Q
Site 4
T38
G
S
E
K
G
D
P
T
E
R
E
L
R
V
G
Site 5
T59
W
L
R
F
K
E
L
T
N
E
M
I
V
T
K
Site 6
T65
L
T
N
E
M
I
V
T
K
N
G
R
R
M
F
Site 7
Y124
P
Q
A
P
S
C
V
Y
I
H
P
D
S
P
N
Site 8
S142
H
W
M
K
A
P
V
S
F
S
K
V
K
L
T
Site 9
S144
M
K
A
P
V
S
F
S
K
V
K
L
T
N
K
Site 10
T149
S
F
S
K
V
K
L
T
N
K
L
N
G
G
G
Site 11
S162
G
G
Q
I
M
L
N
S
L
H
K
Y
E
P
R
Site 12
Y166
M
L
N
S
L
H
K
Y
E
P
R
I
H
I
V
Site 13
T183
G
G
P
Q
R
M
I
T
S
H
C
F
P
E
T
Site 14
S224
F
L
D
A
K
E
R
S
D
H
K
E
M
M
E
Site 15
S236
M
M
E
E
P
G
D
S
Q
Q
P
G
Y
S
Q
Site 16
Y241
G
D
S
Q
Q
P
G
Y
S
Q
W
G
W
L
L
Site 17
S269
P
Q
F
G
G
A
L
S
L
P
S
T
H
S
C
Site 18
S272
G
G
A
L
S
L
P
S
T
H
S
C
D
R
Y
Site 19
T273
G
A
L
S
L
P
S
T
H
S
C
D
R
Y
P
Site 20
S275
L
S
L
P
S
T
H
S
C
D
R
Y
P
T
L
Site 21
Y279
S
T
H
S
C
D
R
Y
P
T
L
R
S
H
R
Site 22
T281
H
S
C
D
R
Y
P
T
L
R
S
H
R
S
S
Site 23
S284
D
R
Y
P
T
L
R
S
H
R
S
S
P
Y
P
Site 24
S287
P
T
L
R
S
H
R
S
S
P
Y
P
S
P
Y
Site 25
S288
T
L
R
S
H
R
S
S
P
Y
P
S
P
Y
A
Site 26
Y290
R
S
H
R
S
S
P
Y
P
S
P
Y
A
H
R
Site 27
S292
H
R
S
S
P
Y
P
S
P
Y
A
H
R
N
N
Site 28
Y294
S
S
P
Y
P
S
P
Y
A
H
R
N
N
S
P
Site 29
S300
P
Y
A
H
R
N
N
S
P
T
Y
S
D
N
S
Site 30
T302
A
H
R
N
N
S
P
T
Y
S
D
N
S
P
A
Site 31
Y303
H
R
N
N
S
P
T
Y
S
D
N
S
P
A
C
Site 32
S304
R
N
N
S
P
T
Y
S
D
N
S
P
A
C
L
Site 33
S307
S
P
T
Y
S
D
N
S
P
A
C
L
S
M
L
Site 34
S312
D
N
S
P
A
C
L
S
M
L
Q
S
H
D
N
Site 35
S316
A
C
L
S
M
L
Q
S
H
D
N
W
S
S
L
Site 36
S321
L
Q
S
H
D
N
W
S
S
L
G
M
P
A
H
Site 37
S322
Q
S
H
D
N
W
S
S
L
G
M
P
A
H
P
Site 38
S330
L
G
M
P
A
H
P
S
M
L
P
V
S
H
N
Site 39
S335
H
P
S
M
L
P
V
S
H
N
A
S
P
P
T
Site 40
S339
L
P
V
S
H
N
A
S
P
P
T
S
S
S
Q
Site 41
T342
S
H
N
A
S
P
P
T
S
S
S
Q
Y
P
S
Site 42
S343
H
N
A
S
P
P
T
S
S
S
Q
Y
P
S
L
Site 43
S344
N
A
S
P
P
T
S
S
S
Q
Y
P
S
L
W
Site 44
S345
A
S
P
P
T
S
S
S
Q
Y
P
S
L
W
S
Site 45
Y347
P
P
T
S
S
S
Q
Y
P
S
L
W
S
V
S
Site 46
S349
T
S
S
S
Q
Y
P
S
L
W
S
V
S
N
G
Site 47
S352
S
Q
Y
P
S
L
W
S
V
S
N
G
A
V
T
Site 48
S354
Y
P
S
L
W
S
V
S
N
G
A
V
T
P
G
Site 49
S362
N
G
A
V
T
P
G
S
Q
A
A
A
V
S
N
Site 50
S379
G
A
Q
F
F
R
G
S
P
A
H
Y
T
P
L
Site 51
Y383
F
R
G
S
P
A
H
Y
T
P
L
T
H
P
V
Site 52
T384
R
G
S
P
A
H
Y
T
P
L
T
H
P
V
S
Site 53
T387
P
A
H
Y
T
P
L
T
H
P
V
S
A
P
S
Site 54
S391
T
P
L
T
H
P
V
S
A
P
S
S
S
G
S
Site 55
S394
T
H
P
V
S
A
P
S
S
S
G
S
P
L
Y
Site 56
S395
H
P
V
S
A
P
S
S
S
G
S
P
L
Y
E
Site 57
S396
P
V
S
A
P
S
S
S
G
S
P
L
Y
E
G
Site 58
S398
S
A
P
S
S
S
G
S
P
L
Y
E
G
A
A
Site 59
Y401
S
S
S
G
S
P
L
Y
E
G
A
A
A
A
T
Site 60
S413
A
A
T
D
I
V
D
S
Q
Y
D
A
A
A
Q
Site 61
Y415
T
D
I
V
D
S
Q
Y
D
A
A
A
Q
G
R
Site 62
S426
A
Q
G
R
L
I
A
S
W
T
P
V
S
P
P
Site 63
T428
G
R
L
I
A
S
W
T
P
V
S
P
P
S
M
Site 64
S431
I
A
S
W
T
P
V
S
P
P
S
M
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation