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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smad8
Full Name:
Mothers against decapentaplegic homolog 9
Alias:
Madh6; MADH8; MADH9; Mothers against DPP homolog 9; SMAD family member 9; Smad9
Type:
Transcription, coactivator/corepressor
Mass (Da):
52493
Number AA:
467
UniProt ID:
O15198
International Prot ID:
IPI00005223
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005667
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003700
GO:0030618
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0030509
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
H
S
T
T
P
I
S
S
L
F
S
F
T
S
P
Site 2
S40
W
A
E
K
A
V
D
S
L
V
K
K
L
K
K
Site 3
S60
D
E
L
E
R
A
L
S
C
P
G
Q
P
S
K
Site 4
S66
L
S
C
P
G
Q
P
S
K
C
V
T
I
P
R
Site 5
T70
G
Q
P
S
K
C
V
T
I
P
R
S
L
D
G
Site 6
S74
K
C
V
T
I
P
R
S
L
D
G
R
L
Q
V
Site 7
S82
L
D
G
R
L
Q
V
S
H
R
K
G
L
P
H
Site 8
Y92
K
G
L
P
H
V
I
Y
C
R
V
W
R
W
P
Site 9
Y129
K
E
V
C
I
N
P
Y
H
Y
R
R
V
E
T
Site 10
Y131
V
C
I
N
P
Y
H
Y
R
R
V
E
T
P
V
Site 11
T136
Y
H
Y
R
R
V
E
T
P
V
L
P
P
V
L
Site 12
S148
P
V
L
V
P
R
H
S
E
Y
N
P
Q
L
S
Site 13
Y150
L
V
P
R
H
S
E
Y
N
P
Q
L
S
L
L
Site 14
S155
S
E
Y
N
P
Q
L
S
L
L
A
K
F
R
S
Site 15
S162
S
L
L
A
K
F
R
S
A
S
L
H
S
E
P
Site 16
S164
L
A
K
F
R
S
A
S
L
H
S
E
P
L
M
Site 17
S167
F
R
S
A
S
L
H
S
E
P
L
M
P
H
N
Site 18
T176
P
L
M
P
H
N
A
T
Y
P
D
S
F
Q
Q
Site 19
Y177
L
M
P
H
N
A
T
Y
P
D
S
F
Q
Q
P
Site 20
S180
H
N
A
T
Y
P
D
S
F
Q
Q
P
P
C
S
Site 21
S187
S
F
Q
Q
P
P
C
S
A
L
P
P
S
P
S
Site 22
S192
P
C
S
A
L
P
P
S
P
S
H
A
F
S
Q
Site 23
S194
S
A
L
P
P
S
P
S
H
A
F
S
Q
S
P
Site 24
S198
P
S
P
S
H
A
F
S
Q
S
P
C
T
A
S
Site 25
S200
P
S
H
A
F
S
Q
S
P
C
T
A
S
Y
P
Site 26
T203
A
F
S
Q
S
P
C
T
A
S
Y
P
H
S
P
Site 27
S205
S
Q
S
P
C
T
A
S
Y
P
H
S
P
G
S
Site 28
Y206
Q
S
P
C
T
A
S
Y
P
H
S
P
G
S
P
Site 29
S209
C
T
A
S
Y
P
H
S
P
G
S
P
S
E
P
Site 30
S212
S
Y
P
H
S
P
G
S
P
S
E
P
E
S
P
Site 31
S214
P
H
S
P
G
S
P
S
E
P
E
S
P
Y
Q
Site 32
S218
G
S
P
S
E
P
E
S
P
Y
Q
H
S
V
D
Site 33
Y220
P
S
E
P
E
S
P
Y
Q
H
S
V
D
T
P
Site 34
S223
P
E
S
P
Y
Q
H
S
V
D
T
P
P
L
P
Site 35
T226
P
Y
Q
H
S
V
D
T
P
P
L
P
Y
H
A
Site 36
T234
P
P
L
P
Y
H
A
T
E
A
S
E
T
Q
S
Site 37
S237
P
Y
H
A
T
E
A
S
E
T
Q
S
G
Q
P
Site 38
T239
H
A
T
E
A
S
E
T
Q
S
G
Q
P
V
D
Site 39
S241
T
E
A
S
E
T
Q
S
G
Q
P
V
D
A
T
Site 40
T248
S
G
Q
P
V
D
A
T
A
D
R
H
V
V
L
Site 41
S256
A
D
R
H
V
V
L
S
I
P
N
G
D
F
R
Site 42
Y279
H
W
C
S
V
A
Y
Y
E
L
N
N
R
V
G
Site 43
T288
L
N
N
R
V
G
E
T
F
Q
A
S
S
R
S
Site 44
S292
V
G
E
T
F
Q
A
S
S
R
S
V
L
I
D
Site 45
S293
G
E
T
F
Q
A
S
S
R
S
V
L
I
D
G
Site 46
T302
S
V
L
I
D
G
F
T
D
P
S
N
N
R
N
Site 47
S317
R
F
C
L
G
L
L
S
N
V
N
R
N
S
T
Site 48
S323
L
S
N
V
N
R
N
S
T
I
E
N
T
R
R
Site 49
T324
S
N
V
N
R
N
S
T
I
E
N
T
R
R
H
Site 50
T328
R
N
S
T
I
E
N
T
R
R
H
I
G
K
G
Site 51
S353
Y
A
E
C
V
S
D
S
S
I
F
V
Q
S
R
Site 52
S354
A
E
C
V
S
D
S
S
I
F
V
Q
S
R
N
Site 53
Y364
V
Q
S
R
N
C
N
Y
Q
H
G
F
H
P
A
Site 54
T372
Q
H
G
F
H
P
A
T
V
C
K
I
P
S
G
Site 55
Y406
H
H
G
F
E
V
V
Y
E
L
T
K
M
C
T
Site 56
Y426
V
K
G
W
G
A
E
Y
H
R
Q
D
V
T
S
Site 57
T432
E
Y
H
R
Q
D
V
T
S
T
P
C
W
I
E
Site 58
T454
Q
W
L
D
K
V
L
T
Q
M
G
S
P
H
N
Site 59
S458
K
V
L
T
Q
M
G
S
P
H
N
P
I
S
S
Site 60
S464
G
S
P
H
N
P
I
S
S
V
S
_
_
_
_
Site 61
S465
S
P
H
N
P
I
S
S
V
S
_
_
_
_
_
Site 62
S467
H
N
P
I
S
S
V
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation