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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NKRF
Full Name:
NF-kappa-B-repressing factor
Alias:
ITBA4; NF-kappa B repressing factor; NFKB repressing factor; NFkB-repressing factor; NFKB-repressing factor; NRF
Type:
Transcription, coactivator/corepressor
Mass (Da):
77673
Number AA:
690
UniProt ID:
O15226
International Prot ID:
IPI00005675
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003725
GO:0016566
PhosphoSite+
KinaseNET
Biological Process:
GO:0016481
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
D
I
G
E
M
P
S
Y
D
L
V
L
S
K
P
Site 2
S24
P
S
Y
D
L
V
L
S
K
P
S
K
G
Q
K
Site 3
S35
K
G
Q
K
R
H
L
S
T
C
D
G
Q
N
P
Site 4
T36
G
Q
K
R
H
L
S
T
C
D
G
Q
N
P
P
Site 5
S65
E
P
V
H
F
V
A
S
S
S
K
D
E
R
Q
Site 6
S67
V
H
F
V
A
S
S
S
K
D
E
R
Q
E
D
Site 7
Y76
D
E
R
Q
E
D
P
Y
G
P
Q
T
K
E
V
Site 8
Y97
A
S
M
P
R
D
I
Y
Q
D
Y
T
Q
D
S
Site 9
Y100
P
R
D
I
Y
Q
D
Y
T
Q
D
S
F
S
I
Site 10
T101
R
D
I
Y
Q
D
Y
T
Q
D
S
F
S
I
Q
Site 11
S106
D
Y
T
Q
D
S
F
S
I
Q
D
G
N
S
Q
Site 12
S112
F
S
I
Q
D
G
N
S
Q
Y
C
D
S
S
G
Site 13
Y114
I
Q
D
G
N
S
Q
Y
C
D
S
S
G
F
I
Site 14
S117
G
N
S
Q
Y
C
D
S
S
G
F
I
L
T
K
Site 15
S118
N
S
Q
Y
C
D
S
S
G
F
I
L
T
K
D
Site 16
Y133
Q
P
V
T
A
N
M
Y
F
D
S
G
N
P
A
Site 17
S136
T
A
N
M
Y
F
D
S
G
N
P
A
P
S
T
Site 18
S142
D
S
G
N
P
A
P
S
T
T
S
Q
Q
A
N
Site 19
T143
S
G
N
P
A
P
S
T
T
S
Q
Q
A
N
S
Site 20
S145
N
P
A
P
S
T
T
S
Q
Q
A
N
S
Q
S
Site 21
S150
T
T
S
Q
Q
A
N
S
Q
S
T
P
E
P
S
Site 22
S152
S
Q
Q
A
N
S
Q
S
T
P
E
P
S
P
S
Site 23
T153
Q
Q
A
N
S
Q
S
T
P
E
P
S
P
S
Q
Site 24
S157
S
Q
S
T
P
E
P
S
P
S
Q
T
F
P
E
Site 25
S159
S
T
P
E
P
S
P
S
Q
T
F
P
E
S
V
Site 26
T161
P
E
P
S
P
S
Q
T
F
P
E
S
V
V
A
Site 27
S165
P
S
Q
T
F
P
E
S
V
V
A
E
K
Q
Y
Site 28
S186
A
T
I
W
K
N
L
S
N
P
E
M
T
S
G
Site 29
S192
L
S
N
P
E
M
T
S
G
S
D
K
I
N
Y
Site 30
Y199
S
G
S
D
K
I
N
Y
T
Y
M
L
T
R
C
Site 31
Y201
S
D
K
I
N
Y
T
Y
M
L
T
R
C
I
Q
Site 32
Y216
A
C
K
T
N
P
E
Y
I
Y
A
P
L
K
E
Site 33
T237
P
K
N
K
K
L
L
T
D
G
Y
A
C
E
V
Site 34
Y240
K
K
L
L
T
D
G
Y
A
C
E
V
R
C
Q
Site 35
Y250
E
V
R
C
Q
N
I
Y
L
T
T
G
Y
A
G
Site 36
T252
R
C
Q
N
I
Y
L
T
T
G
Y
A
G
S
K
Site 37
T253
C
Q
N
I
Y
L
T
T
G
Y
A
G
S
K
N
Site 38
Y255
N
I
Y
L
T
T
G
Y
A
G
S
K
N
G
S
Site 39
S258
L
T
T
G
Y
A
G
S
K
N
G
S
R
D
R
Site 40
S262
Y
A
G
S
K
N
G
S
R
D
R
A
T
E
L
Site 41
T267
N
G
S
R
D
R
A
T
E
L
A
V
K
L
L
Site 42
T290
V
R
R
K
F
K
H
T
F
G
E
D
L
V
V
Site 43
Y305
C
Q
I
G
M
S
S
Y
E
F
P
P
A
L
K
Site 44
S358
G
I
L
N
N
S
A
S
F
N
K
M
S
I
E
Site 45
Y366
F
N
K
M
S
I
E
Y
K
Y
E
M
M
P
N
Site 46
Y368
K
M
S
I
E
Y
K
Y
E
M
M
P
N
R
T
Site 47
T393
C
L
A
E
G
Y
G
T
K
K
T
S
K
H
A
Site 48
T412
A
L
K
I
L
Q
K
T
Q
P
T
Y
P
S
V
Site 49
Y416
L
Q
K
T
Q
P
T
Y
P
S
V
K
S
S
Q
Site 50
S418
K
T
Q
P
T
Y
P
S
V
K
S
S
Q
C
H
Site 51
S421
P
T
Y
P
S
V
K
S
S
Q
C
H
T
G
S
Site 52
S422
T
Y
P
S
V
K
S
S
Q
C
H
T
G
S
S
Site 53
T426
V
K
S
S
Q
C
H
T
G
S
S
P
R
G
S
Site 54
S428
S
S
Q
C
H
T
G
S
S
P
R
G
S
G
K
Site 55
S429
S
Q
C
H
T
G
S
S
P
R
G
S
G
K
K
Site 56
S433
T
G
S
S
P
R
G
S
G
K
K
K
D
I
K
Site 57
Y445
D
I
K
D
L
V
V
Y
E
N
S
S
N
P
V
Site 58
T465
T
A
Q
F
N
R
M
T
V
E
Y
V
Y
E
R
Site 59
Y468
F
N
R
M
T
V
E
Y
V
Y
E
R
M
T
G
Site 60
Y470
R
M
T
V
E
Y
V
Y
E
R
M
T
G
L
R
Site 61
S486
K
C
K
V
I
L
E
S
E
V
I
A
E
A
V
Site 62
T498
E
A
V
G
V
K
K
T
V
K
Y
E
A
A
G
Site 63
Y501
G
V
K
K
T
V
K
Y
E
A
A
G
E
A
V
Site 64
T510
A
A
G
E
A
V
K
T
L
K
K
T
Q
P
T
Site 65
S532
G
A
V
E
D
V
I
S
R
N
E
I
Q
G
R
Site 66
T565
L
L
R
K
M
G
W
T
G
G
G
L
G
K
S
Site 67
S572
T
G
G
G
L
G
K
S
G
E
G
I
R
E
P
Site 68
S581
E
G
I
R
E
P
I
S
V
K
E
Q
H
K
R
Site 69
Y613
I
E
Q
I
I
R
N
Y
A
R
S
E
S
H
T
Site 70
S616
I
I
R
N
Y
A
R
S
E
S
H
T
D
L
T
Site 71
S618
R
N
Y
A
R
S
E
S
H
T
D
L
T
F
S
Site 72
T620
Y
A
R
S
E
S
H
T
D
L
T
F
S
R
E
Site 73
T623
S
E
S
H
T
D
L
T
F
S
R
E
L
T
N
Site 74
T629
L
T
F
S
R
E
L
T
N
D
E
R
K
Q
I
Site 75
Y643
I
H
Q
I
A
Q
K
Y
G
L
K
S
K
S
H
Site 76
S647
A
Q
K
Y
G
L
K
S
K
S
H
G
V
G
H
Site 77
S649
K
Y
G
L
K
S
K
S
H
G
V
G
H
D
R
Site 78
Y657
H
G
V
G
H
D
R
Y
L
V
V
G
R
K
R
Site 79
Y682
Q
E
G
Q
V
G
H
Y
E
L
V
M
P
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation