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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KMO
Full Name:
Kynurenine 3-monooxygenase
Alias:
Kynurenine 3-hydroxylase
Type:
Enzyme, oxidoreductase
Mass (Da):
55810
Number AA:
486
UniProt ID:
O15229
International Prot ID:
IPI00021157
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016021
GO:0005741
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0016174
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0019674
GO:0070189
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
R
N
F
Q
I
D
V
Y
E
A
R
E
D
T
R
Site 2
T43
V
Y
E
A
R
E
D
T
R
V
A
T
F
T
R
Site 3
T47
R
E
D
T
R
V
A
T
F
T
R
G
R
S
I
Site 4
T49
D
T
R
V
A
T
F
T
R
G
R
S
I
N
L
Site 5
S53
A
T
F
T
R
G
R
S
I
N
L
A
L
S
H
Site 6
S59
R
S
I
N
L
A
L
S
H
R
G
R
Q
A
L
Site 7
S89
M
R
A
R
M
I
H
S
L
S
G
K
K
S
A
Site 8
S91
A
R
M
I
H
S
L
S
G
K
K
S
A
I
P
Site 9
S95
H
S
L
S
G
K
K
S
A
I
P
Y
G
T
K
Site 10
Y99
G
K
K
S
A
I
P
Y
G
T
K
S
Q
Y
I
Site 11
Y105
P
Y
G
T
K
S
Q
Y
I
L
S
V
S
R
E
Site 12
S108
T
K
S
Q
Y
I
L
S
V
S
R
E
N
L
N
Site 13
T120
N
L
N
K
D
L
L
T
A
A
E
K
Y
P
N
Site 14
Y125
L
L
T
A
A
E
K
Y
P
N
V
K
M
H
F
Site 15
T147
N
P
E
E
G
M
I
T
V
L
G
S
D
K
V
Site 16
T172
G
C
D
G
A
Y
S
T
V
R
S
H
L
M
K
Site 17
S175
G
A
Y
S
T
V
R
S
H
L
M
K
K
P
R
Site 18
Y185
M
K
K
P
R
F
D
Y
S
Q
Q
Y
I
P
H
Site 19
S186
K
K
P
R
F
D
Y
S
Q
Q
Y
I
P
H
G
Site 20
Y189
R
F
D
Y
S
Q
Q
Y
I
P
H
G
Y
M
E
Site 21
T198
P
H
G
Y
M
E
L
T
I
P
P
K
N
G
D
Site 22
Y206
I
P
P
K
N
G
D
Y
A
M
E
P
N
Y
L
Site 23
Y212
D
Y
A
M
E
P
N
Y
L
H
I
W
P
R
N
Site 24
T249
E
E
F
E
K
L
L
T
S
N
D
V
V
D
F
Site 25
S335
D
E
L
M
D
K
F
S
N
D
L
S
L
C
L
Site 26
Y362
A
I
S
D
L
S
M
Y
N
Y
I
E
M
R
A
Site 27
Y364
S
D
L
S
M
Y
N
Y
I
E
M
R
A
H
V
Site 28
T399
S
T
F
I
P
L
Y
T
M
V
T
F
S
R
I
Site 29
Y408
V
T
F
S
R
I
R
Y
H
E
A
V
Q
R
W
Site 30
S449
I
H
Y
M
S
P
R
S
F
L
R
L
R
R
P
Site 31
S476
F
P
A
K
A
V
D
S
L
E
Q
I
S
N
L
Site 32
S481
V
D
S
L
E
Q
I
S
N
L
I
S
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation