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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTLC1
Full Name:
Serine palmitoyltransferase 1
Alias:
HSAN; HSAN1; HSN1; LBC1; LCB 1; LCB1; Long chain base biosynthesis protein 1; Serine palmitoyltransferase, long chain base subunit 1; SPT1; SPTC1; SPTI
Type:
Transferase; Lipid Metabolism - sphingolipid; EC 2.3.1.50
Mass (Da):
52744
Number AA:
473
UniProt ID:
O15269
International Prot ID:
IPI00005745
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0017059
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0030170
GO:0004758
PhosphoSite+
KinaseNET
Biological Process:
GO:0030148
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
I
R
L
L
F
S
K
T
Y
K
L
Q
E
R
S
Site 2
Y44
R
L
L
F
S
K
T
Y
K
L
Q
E
R
S
D
Site 3
S50
T
Y
K
L
Q
E
R
S
D
L
T
V
K
E
K
Site 4
T53
L
Q
E
R
S
D
L
T
V
K
E
K
E
E
L
Site 5
Y82
K
D
H
P
A
L
N
Y
N
I
V
S
G
P
P
Site 6
S86
A
L
N
Y
N
I
V
S
G
P
P
S
H
K
T
Site 7
S90
N
I
V
S
G
P
P
S
H
K
T
V
V
N
G
Site 8
T93
S
G
P
P
S
H
K
T
V
V
N
G
K
E
C
Site 9
T132
L
K
K
Y
G
V
G
T
C
G
P
R
G
F
Y
Site 10
Y139
T
C
G
P
R
G
F
Y
G
T
F
D
V
H
L
Site 11
T141
G
P
R
G
F
Y
G
T
F
D
V
H
L
D
L
Site 12
T158
R
L
A
K
F
M
K
T
E
E
A
I
I
Y
S
Site 13
S202
I
Q
K
G
L
Q
A
S
R
S
D
I
K
L
F
Site 14
S204
K
G
L
Q
A
S
R
S
D
I
K
L
F
K
H
Site 15
T238
N
P
R
K
A
R
V
T
R
R
F
I
V
V
E
Site 16
Y265
P
E
L
V
K
L
K
Y
K
Y
K
A
R
I
F
Site 17
Y267
L
V
K
L
K
Y
K
Y
K
A
R
I
F
L
E
Site 18
T290
G
E
H
G
R
G
V
T
E
H
Y
G
I
N
I
Site 19
Y335
Q
R
L
S
G
Q
G
Y
C
F
S
A
S
L
P
Site 20
T427
M
N
R
S
I
A
L
T
Q
A
R
Y
L
E
K
Site 21
Y431
I
A
L
T
Q
A
R
Y
L
E
K
E
E
K
C
Site 22
S443
E
K
C
L
P
P
P
S
I
R
V
V
V
T
V
Site 23
T449
P
S
I
R
V
V
V
T
V
E
Q
T
E
E
E
Site 24
S462
E
E
L
E
R
A
A
S
T
I
K
E
V
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation