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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTLC2
Full Name:
Serine palmitoyltransferase 2
Alias:
KIAA0526; LCB 2; LCB2; Long chain base biosynthesis protein 2; Serine palmitoyltransferase, long chain base subunit 2; Serine-palmitoyl-CoA transferase 2; SPT 2; SPT2; SPTC2
Type:
EC 2.3.1.50; Lipid Metabolism - sphingolipid; Transferase
Mass (Da):
62924
Number AA:
562
UniProt ID:
O15270
International Prot ID:
IPI00005751
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0017059
Uniprot
OncoNet
Molecular Function:
GO:0030170
GO:0004758
GO:0016769
PhosphoSite+
KinaseNET
Biological Process:
GO:0030148
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y29
N
G
E
V
R
N
G
Y
V
R
S
S
A
A
A
Site 2
S33
R
N
G
Y
V
R
S
S
A
A
A
A
A
A
A
Site 3
T49
A
G
Q
I
H
H
V
T
Q
N
G
G
L
Y
K
Site 4
Y55
V
T
Q
N
G
G
L
Y
K
R
P
F
N
E
A
Site 5
Y93
Y
L
R
D
F
L
R
Y
W
R
I
E
K
C
H
Site 6
S113
E
E
Q
K
D
F
V
S
L
Y
Q
D
F
E
N
Site 7
Y115
Q
K
D
F
V
S
L
Y
Q
D
F
E
N
F
Y
Site 8
Y122
Y
Q
D
F
E
N
F
Y
T
R
N
L
Y
M
R
Site 9
Y127
N
F
Y
T
R
N
L
Y
M
R
I
R
D
N
W
Site 10
Y156
M
E
R
Q
S
H
D
Y
N
W
S
F
K
Y
T
Site 11
Y162
D
Y
N
W
S
F
K
Y
T
G
N
I
I
K
G
Site 12
Y176
G
V
I
N
M
G
S
Y
N
Y
L
G
F
A
R
Site 13
T185
Y
L
G
F
A
R
N
T
G
S
C
Q
E
A
A
Site 14
S187
G
F
A
R
N
T
G
S
C
Q
E
A
A
A
K
Site 15
S205
E
Y
G
A
G
V
C
S
T
R
Q
E
I
G
N
Site 16
S258
G
K
G
C
L
I
L
S
D
E
L
N
H
A
S
Site 17
T276
G
A
R
L
S
G
A
T
I
R
I
F
K
H
N
Site 18
S287
F
K
H
N
N
M
Q
S
L
E
K
L
L
K
D
Site 19
Y298
L
L
K
D
A
I
V
Y
G
Q
P
R
T
R
R
Site 20
T303
I
V
Y
G
Q
P
R
T
R
R
P
W
K
K
I
Site 21
Y342
K
K
Y
K
A
Y
L
Y
L
D
E
A
H
S
I
Site 22
Y362
T
G
R
G
V
V
E
Y
F
G
L
D
P
E
D
Site 23
S380
M
M
G
T
F
T
K
S
F
G
A
S
G
G
Y
Site 24
S384
F
T
K
S
F
G
A
S
G
G
Y
I
G
G
K
Site 25
Y387
S
F
G
A
S
G
G
Y
I
G
G
K
K
E
L
Site 26
Y397
G
K
K
E
L
I
D
Y
L
R
T
H
S
H
S
Site 27
T400
E
L
I
D
Y
L
R
T
H
S
H
S
A
V
Y
Site 28
S402
I
D
Y
L
R
T
H
S
H
S
A
V
Y
A
T
Site 29
S404
Y
L
R
T
H
S
H
S
A
V
Y
A
T
S
L
Site 30
T409
S
H
S
A
V
Y
A
T
S
L
S
P
P
V
V
Site 31
S412
A
V
Y
A
T
S
L
S
P
P
V
V
E
Q
I
Site 32
S433
I
M
G
Q
D
G
T
S
L
G
K
E
C
V
Q
Site 33
Y448
Q
L
A
E
N
T
R
Y
F
R
R
R
L
K
E
Site 34
Y461
K
E
M
G
F
I
I
Y
G
N
E
D
S
P
V
Site 35
Y474
P
V
V
P
L
M
L
Y
M
P
A
K
I
G
A
Site 36
S513
S
R
A
R
F
C
L
S
A
A
H
T
K
E
I
Site 37
T523
H
T
K
E
I
L
D
T
A
L
K
E
I
D
E
Site 38
Y539
G
D
L
L
Q
L
K
Y
S
R
H
R
L
V
P
Site 39
S540
D
L
L
Q
L
K
Y
S
R
H
R
L
V
P
L
Site 40
T555
L
D
R
P
F
D
E
T
T
Y
E
E
T
E
D
Site 41
T556
D
R
P
F
D
E
T
T
Y
E
E
T
E
D
_
Site 42
Y557
R
P
F
D
E
T
T
Y
E
E
T
E
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation