KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPM1D
Full Name:
Protein phosphatase 1D
Alias:
P53-induced PP1; PP2C-delta; Protein phosphatase magnesium-dependent 1 delta; WIP1
Type:
Protein-serine phosphatase
Mass (Da):
66675
Number AA:
605
UniProt ID:
O15297
International Prot ID:
IPI00005782
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0008287
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0030145
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008285
GO:0006470
GO:0009314
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
S
L
G
V
S
V
F
S
D
Q
G
G
R
K
Y
Site 2
Y20
S
D
Q
G
G
R
K
Y
M
E
D
V
T
Q
I
Site 3
T25
R
K
Y
M
E
D
V
T
Q
I
V
V
E
P
E
Site 4
T34
I
V
V
E
P
E
P
T
A
E
E
K
P
S
P
Site 5
S40
P
T
A
E
E
K
P
S
P
R
R
S
L
S
Q
Site 6
S44
E
K
P
S
P
R
R
S
L
S
Q
P
L
P
P
Site 7
S46
P
S
P
R
R
S
L
S
Q
P
L
P
P
R
P
Site 8
S54
Q
P
L
P
P
R
P
S
P
A
A
L
P
G
G
Site 9
S85
P
L
P
D
A
G
A
S
P
A
P
S
R
C
C
Site 10
S89
A
G
A
S
P
A
P
S
R
C
C
R
R
R
S
Site 11
S96
S
R
C
C
R
R
R
S
S
V
A
F
F
A
V
Site 12
S133
K
Q
K
G
F
T
S
S
E
P
A
K
V
C
A
Site 13
T163
K
L
A
E
W
P
K
T
M
T
G
L
P
S
T
Site 14
T165
A
E
W
P
K
T
M
T
G
L
P
S
T
S
G
Site 15
S169
K
T
M
T
G
L
P
S
T
S
G
T
T
A
S
Site 16
T214
F
V
R
A
V
E
V
T
Q
D
H
K
P
E
L
Site 17
S234
R
I
E
G
L
G
G
S
V
M
N
K
S
G
V
Site 18
S239
G
G
S
V
M
N
K
S
G
V
N
R
V
V
W
Site 19
T252
V
W
K
R
P
R
L
T
H
N
G
P
V
R
R
Site 20
S260
H
N
G
P
V
R
R
S
T
V
I
D
Q
I
P
Site 21
T261
N
G
P
V
R
R
S
T
V
I
D
Q
I
P
F
Site 22
S280
R
A
L
G
D
L
W
S
Y
D
F
F
S
G
E
Site 23
S291
F
S
G
E
F
V
V
S
P
E
P
D
T
S
V
Site 24
T296
V
V
S
P
E
P
D
T
S
V
H
T
L
D
P
Site 25
S297
V
S
P
E
P
D
T
S
V
H
T
L
D
P
Q
Site 26
T300
E
P
D
T
S
V
H
T
L
D
P
Q
K
H
K
Site 27
Y308
L
D
P
Q
K
H
K
Y
I
I
L
G
S
D
G
Site 28
S327
I
P
P
Q
D
A
I
S
M
C
Q
D
Q
E
E
Site 29
Y337
Q
D
Q
E
E
K
K
Y
L
M
G
E
H
G
Q
Site 30
Y392
F
T
N
E
D
E
L
Y
L
N
L
T
D
S
P
Site 31
T396
D
E
L
Y
L
N
L
T
D
S
P
S
Y
N
S
Site 32
S398
L
Y
L
N
L
T
D
S
P
S
Y
N
S
Q
E
Site 33
S400
L
N
L
T
D
S
P
S
Y
N
S
Q
E
T
C
Site 34
Y401
N
L
T
D
S
P
S
Y
N
S
Q
E
T
C
V
Site 35
T406
P
S
Y
N
S
Q
E
T
C
V
M
T
P
S
P
Site 36
T410
S
Q
E
T
C
V
M
T
P
S
P
C
S
T
P
Site 37
S412
E
T
C
V
M
T
P
S
P
C
S
T
P
P
V
Site 38
S415
V
M
T
P
S
P
C
S
T
P
P
V
K
S
L
Site 39
T416
M
T
P
S
P
C
S
T
P
P
V
K
S
L
E
Site 40
S421
C
S
T
P
P
V
K
S
L
E
E
D
P
W
P
Site 41
S432
D
P
W
P
R
V
N
S
K
D
H
I
P
A
L
Site 42
S442
H
I
P
A
L
V
R
S
N
A
F
S
E
N
F
Site 43
S446
L
V
R
S
N
A
F
S
E
N
F
L
E
V
S
Site 44
T483
E
N
C
A
K
A
L
T
L
R
I
H
D
S
L
Site 45
S489
L
T
L
R
I
H
D
S
L
N
N
S
L
P
I
Site 46
S503
I
G
L
V
P
T
N
S
T
N
T
V
M
D
Q
Site 47
T517
Q
K
N
L
K
M
S
T
P
G
Q
M
K
A
Q
Site 48
T529
K
A
Q
E
I
E
R
T
P
P
T
N
F
K
R
Site 49
T537
P
P
T
N
F
K
R
T
L
E
E
S
N
S
G
Site 50
S541
F
K
R
T
L
E
E
S
N
S
G
P
L
M
K
Site 51
S543
R
T
L
E
E
S
N
S
G
P
L
M
K
K
H
Site 52
S556
K
H
R
R
N
G
L
S
R
S
S
G
A
Q
P
Site 53
S558
R
R
N
G
L
S
R
S
S
G
A
Q
P
A
S
Site 54
S559
R
N
G
L
S
R
S
S
G
A
Q
P
A
S
L
Site 55
S565
S
S
G
A
Q
P
A
S
L
P
T
T
S
Q
R
Site 56
T569
Q
P
A
S
L
P
T
T
S
Q
R
K
N
S
V
Site 57
S570
P
A
S
L
P
T
T
S
Q
R
K
N
S
V
K
Site 58
S575
T
T
S
Q
R
K
N
S
V
K
L
T
M
R
R
Site 59
T579
R
K
N
S
V
K
L
T
M
R
R
R
L
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation