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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INPP4B
Full Name:
Type II inositol-3,4-bisphosphate 4-phosphatase
Alias:
Inositol polyphosphate 4-phosphatase type II; Inositol polyphosphate-4-phosphatase, type II, 105kDa; INP4B
Type:
EC 3.1.3.66; Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid
Mass (Da):
104738
Number AA:
924
UniProt ID:
O15327
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0034597
GO:0016316
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
I
K
E
E
G
A
S
E
E
G
Q
H
F
L
Site 2
S31
P
G
D
C
Q
F
T
S
I
Q
K
T
P
N
E
Site 3
T35
Q
F
T
S
I
Q
K
T
P
N
E
P
Q
L
E
Site 4
S74
V
I
H
P
V
E
Q
S
L
T
R
Y
S
S
T
Site 5
T76
H
P
V
E
Q
S
L
T
R
Y
S
S
T
E
I
Site 6
Y78
V
E
Q
S
L
T
R
Y
S
S
T
E
I
V
E
Site 7
S79
E
Q
S
L
T
R
Y
S
S
T
E
I
V
E
G
Site 8
S80
Q
S
L
T
R
Y
S
S
T
E
I
V
E
G
T
Site 9
T94
T
R
D
P
L
F
L
T
G
V
T
F
P
S
E
Site 10
Y102
G
V
T
F
P
S
E
Y
P
I
Y
E
E
T
K
Site 11
Y105
F
P
S
E
Y
P
I
Y
E
E
T
K
I
K
L
Site 12
T113
E
E
T
K
I
K
L
T
V
Y
D
V
K
D
K
Site 13
Y115
T
K
I
K
L
T
V
Y
D
V
K
D
K
S
H
Site 14
S121
V
Y
D
V
K
D
K
S
H
D
T
V
R
T
S
Site 15
T124
V
K
D
K
S
H
D
T
V
R
T
S
V
L
P
Site 16
S128
S
H
D
T
V
R
T
S
V
L
P
E
H
K
D
Site 17
S143
P
P
P
E
V
G
R
S
F
L
G
Y
A
S
F
Site 18
Y147
V
G
R
S
F
L
G
Y
A
S
F
K
V
G
E
Site 19
S166
K
E
Q
L
L
V
L
S
L
R
T
S
D
G
G
Site 20
T198
D
G
E
A
D
H
I
T
T
D
V
Q
G
Q
K
Site 21
S217
C
E
C
T
A
P
E
S
V
S
G
K
D
N
L
Site 22
Y239
K
N
P
V
C
K
L
Y
R
F
P
T
S
D
N
Site 23
S256
M
R
I
R
E
Q
M
S
E
S
I
L
S
F
H
Site 24
S258
I
R
E
Q
M
S
E
S
I
L
S
F
H
I
P
Site 25
S261
Q
M
S
E
S
I
L
S
F
H
I
P
K
E
L
Site 26
S270
H
I
P
K
E
L
I
S
L
H
I
K
E
D
L
Site 27
S290
I
K
E
L
G
E
L
S
P
H
W
D
N
L
R
Site 28
T316
N
M
Y
Q
D
I
L
T
E
L
S
K
E
T
G
Site 29
S319
Q
D
I
L
T
E
L
S
K
E
T
G
S
S
F
Site 30
S324
E
L
S
K
E
T
G
S
S
F
K
S
S
S
S
Site 31
S325
L
S
K
E
T
G
S
S
F
K
S
S
S
S
K
Site 32
S328
E
T
G
S
S
F
K
S
S
S
S
K
G
E
K
Site 33
S329
T
G
S
S
F
K
S
S
S
S
K
G
E
K
T
Site 34
S330
G
S
S
F
K
S
S
S
S
K
G
E
K
T
L
Site 35
S331
S
S
F
K
S
S
S
S
K
G
E
K
T
L
E
Site 36
T336
S
S
S
K
G
E
K
T
L
E
F
V
P
I
N
Site 37
S353
L
Q
R
M
Q
V
H
S
P
H
L
K
D
A
L
Site 38
T390
K
L
L
H
R
F
E
T
E
R
R
N
T
G
Y
Site 39
T395
F
E
T
E
R
R
N
T
G
Y
Q
F
I
Y
Y
Site 40
Y397
T
E
R
R
N
T
G
Y
Q
F
I
Y
Y
S
P
Site 41
Y401
N
T
G
Y
Q
F
I
Y
Y
S
P
E
N
T
A
Site 42
Y402
T
G
Y
Q
F
I
Y
Y
S
P
E
N
T
A
K
Site 43
S403
G
Y
Q
F
I
Y
Y
S
P
E
N
T
A
K
A
Site 44
S415
A
K
A
K
E
V
L
S
N
I
N
Q
L
Q
P
Site 45
S434
H
A
D
L
L
L
N
S
A
S
Q
H
S
P
D
Site 46
S436
D
L
L
L
N
S
A
S
Q
H
S
P
D
S
L
Site 47
S439
L
N
S
A
S
Q
H
S
P
D
S
L
K
N
S
Site 48
S442
A
S
Q
H
S
P
D
S
L
K
N
S
L
K
M
Site 49
S446
S
P
D
S
L
K
N
S
L
K
M
L
S
E
K
Site 50
S468
F
K
D
Q
L
V
R
S
A
L
L
A
L
Y
T
Site 51
Y474
R
S
A
L
L
A
L
Y
T
A
R
P
G
G
I
Site 52
S487
G
I
L
K
K
P
P
S
P
K
S
S
T
E
E
Site 53
S490
K
K
P
P
S
P
K
S
S
T
E
E
S
S
P
Site 54
S491
K
P
P
S
P
K
S
S
T
E
E
S
S
P
Q
Site 55
T492
P
P
S
P
K
S
S
T
E
E
S
S
P
Q
D
Site 56
S495
P
K
S
S
T
E
E
S
S
P
Q
D
Q
P
P
Site 57
S496
K
S
S
T
E
E
S
S
P
Q
D
Q
P
P
V
Site 58
S509
P
V
M
R
G
Q
D
S
I
P
H
H
S
D
Y
Site 59
S514
Q
D
S
I
P
H
H
S
D
Y
D
E
E
E
W
Site 60
Y516
S
I
P
H
H
S
D
Y
D
E
E
E
W
D
R
Site 61
S549
L
I
E
R
D
G
G
S
E
G
S
G
G
N
N
Site 62
S563
N
D
G
E
K
E
P
S
L
T
D
A
I
P
S
Site 63
T565
G
E
K
E
P
S
L
T
D
A
I
P
S
H
P
Site 64
S570
S
L
T
D
A
I
P
S
H
P
R
E
D
W
Y
Site 65
Y577
S
H
P
R
E
D
W
Y
E
Q
L
Y
P
L
I
Site 66
Y581
E
D
W
Y
E
Q
L
Y
P
L
I
L
T
L
K
Site 67
T603
N
R
A
K
Q
S
L
T
F
V
L
L
Q
E
L
Site 68
Y648
I
K
L
Q
T
S
L
Y
D
P
G
F
L
Q
Q
Site 69
S670
V
Q
Y
E
G
L
L
S
T
Y
S
D
E
I
G
Site 70
S673
E
G
L
L
S
T
Y
S
D
E
I
G
M
L
E
Site 71
T709
N
D
V
L
P
V
I
T
G
R
R
E
H
Y
V
Site 72
Y715
I
T
G
R
R
E
H
Y
V
V
E
V
K
L
P
Site 73
T755
V
G
I
N
E
Q
Q
T
L
A
E
R
F
G
D
Site 74
S764
A
E
R
F
G
D
V
S
L
Q
E
S
I
N
Q
Site 75
S768
G
D
V
S
L
Q
E
S
I
N
Q
E
N
F
E
Site 76
Y780
N
F
E
L
L
Q
E
Y
Y
K
I
F
M
E
K
Site 77
Y792
M
E
K
M
P
P
D
Y
I
S
H
F
Q
E
Q
Site 78
S815
N
L
L
Q
N
I
Q
S
K
K
R
K
N
V
E
Site 79
T840
K
L
N
G
I
R
F
T
C
C
K
S
A
K
D
Site 80
S850
K
S
A
K
D
R
T
S
M
S
V
T
L
E
Q
Site 81
S852
A
K
D
R
T
S
M
S
V
T
L
E
Q
C
S
Site 82
T854
D
R
T
S
M
S
V
T
L
E
Q
C
S
I
L
Site 83
S859
S
V
T
L
E
Q
C
S
I
L
R
D
E
H
Q
Site 84
Y898
K
N
I
K
C
R
K
Y
A
F
N
M
L
Q
L
Site 85
Y911
Q
L
M
A
F
P
K
Y
Y
R
P
P
E
G
T
Site 86
Y912
L
M
A
F
P
K
Y
Y
R
P
P
E
G
T
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation