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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MID1
Full Name:
Midline-1
Alias:
BBBG1; FXY; GBBB1; MIDIN; Midline 1 (Opitz/BBB syndrome); Midline 1 RING finger protein; Midline-1; OGS1; OS; OSX; RING finger 59; RNF59; Transcription factor XPRF; TRI18; TRIM18; Tripartite motif-containing protein 18; XPRF; ZNFXY
Type:
Cytoskeletal protein; EC 6.3.2.-; Ligase
Mass (Da):
75251
Number AA:
667
UniProt ID:
O15344
International Prot ID:
IPI00029324
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
GO:0005875
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0000226
GO:0019941
GO:0007389
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
S
H
C
A
T
N
E
S
V
E
S
I
T
A
F
Site 2
S50
A
T
N
E
S
V
E
S
I
T
A
F
Q
C
P
Site 3
T64
P
T
C
R
H
V
I
T
L
S
Q
R
G
L
D
Site 4
S66
C
R
H
V
I
T
L
S
Q
R
G
L
D
G
L
Site 5
T78
D
G
L
K
R
N
V
T
L
Q
N
I
I
D
R
Site 6
S90
I
D
R
F
Q
K
A
S
V
S
G
P
N
S
P
Site 7
S92
R
F
Q
K
A
S
V
S
G
P
N
S
P
S
E
Site 8
S96
A
S
V
S
G
P
N
S
P
S
E
T
R
R
E
Site 9
S98
V
S
G
P
N
S
P
S
E
T
R
R
E
R
A
Site 10
T100
G
P
N
S
P
S
E
T
R
R
E
R
A
F
D
Site 11
T110
E
R
A
F
D
A
N
T
M
T
S
A
E
K
V
Site 12
S213
D
H
Q
V
A
A
L
S
E
R
Y
D
K
L
K
Site 13
T228
Q
N
L
E
S
N
L
T
N
L
I
K
R
N
T
Site 14
T235
T
N
L
I
K
R
N
T
E
L
E
T
L
L
A
Site 15
T263
S
R
Q
E
A
K
L
T
E
E
C
D
L
L
I
Site 16
T282
Q
R
R
Q
I
I
G
T
K
I
K
E
G
K
V
Site 17
S309
C
K
Q
C
I
E
R
S
A
S
L
I
S
Q
A
Site 18
S311
Q
C
I
E
R
S
A
S
L
I
S
Q
A
E
H
Site 19
S314
E
R
S
A
S
L
I
S
Q
A
E
H
S
L
K
Site 20
S319
L
I
S
Q
A
E
H
S
L
K
E
N
D
H
A
Site 21
T336
L
Q
T
A
K
N
I
T
E
R
V
S
M
A
T
Site 22
S340
K
N
I
T
E
R
V
S
M
A
T
A
S
S
Q
Site 23
T358
P
E
I
N
L
N
D
T
F
D
T
F
A
L
D
Site 24
T361
N
L
N
D
T
F
D
T
F
A
L
D
F
S
R
Site 25
S367
D
T
F
A
L
D
F
S
R
E
K
K
L
L
E
Site 26
Y378
K
L
L
E
C
L
D
Y
L
T
A
P
N
P
P
Site 27
T386
L
T
A
P
N
P
P
T
I
R
E
E
L
C
T
Site 28
T393
T
I
R
E
E
L
C
T
A
S
Y
D
T
I
T
Site 29
Y396
E
E
L
C
T
A
S
Y
D
T
I
T
V
H
W
Site 30
T400
T
A
S
Y
D
T
I
T
V
H
W
T
S
D
D
Site 31
S405
T
I
T
V
H
W
T
S
D
D
E
F
S
V
V
Site 32
S410
W
T
S
D
D
E
F
S
V
V
S
Y
E
L
Q
Site 33
T419
V
S
Y
E
L
Q
Y
T
I
F
T
G
Q
A
N
Site 34
S429
T
G
Q
A
N
V
V
S
L
C
N
S
A
D
S
Site 35
Y448
P
N
I
K
Q
N
H
Y
T
V
H
G
L
Q
S
Site 36
T449
N
I
K
Q
N
H
Y
T
V
H
G
L
Q
S
G
Site 37
S471
K
A
I
N
Q
A
G
S
R
S
S
E
P
G
K
Site 38
S473
I
N
Q
A
G
S
R
S
S
E
P
G
K
L
K
Site 39
S474
N
Q
A
G
S
R
S
S
E
P
G
K
L
K
T
Site 40
T481
S
E
P
G
K
L
K
T
N
S
Q
P
F
K
L
Site 41
S483
P
G
K
L
K
T
N
S
Q
P
F
K
L
D
P
Site 42
S492
P
F
K
L
D
P
K
S
A
H
R
K
L
K
V
Site 43
S500
A
H
R
K
L
K
V
S
H
D
N
L
T
V
E
Site 44
T505
K
V
S
H
D
N
L
T
V
E
R
D
E
S
S
Site 45
S511
L
T
V
E
R
D
E
S
S
S
K
K
S
H
T
Site 46
S512
T
V
E
R
D
E
S
S
S
K
K
S
H
T
P
Site 47
S513
V
E
R
D
E
S
S
S
K
K
S
H
T
P
E
Site 48
S516
D
E
S
S
S
K
K
S
H
T
P
E
R
F
T
Site 49
T518
S
S
S
K
K
S
H
T
P
E
R
F
T
S
Q
Site 50
T523
S
H
T
P
E
R
F
T
S
Q
G
S
Y
G
V
Site 51
S524
H
T
P
E
R
F
T
S
Q
G
S
Y
G
V
A
Site 52
S527
E
R
F
T
S
Q
G
S
Y
G
V
A
G
N
V
Site 53
Y528
R
F
T
S
Q
G
S
Y
G
V
A
G
N
V
F
Site 54
Y542
F
I
D
S
G
R
H
Y
W
E
V
V
I
S
G
Site 55
S572
H
E
W
I
G
K
N
S
A
S
W
A
L
C
R
Site 56
S590
N
W
V
V
R
H
N
S
K
E
I
P
I
E
P
Site 57
Y618
D
N
G
S
I
A
F
Y
D
A
L
N
S
I
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation